This page contains a lengthy collection of fun/exciting (to me at least) FOAMed articles I have shared on Instagram, X (Twitter), LinkedIn, and Facebook. Many have been discussed on The Saving Lives Podcast. Consider subscribing to my monthly newsletter to receive everything I posted that month. Many articles were obtained from Rob Mac Sweeney’s newsletter.

Sepsis-Induced Coagulopathy (12/22/24)

Iba T, Helms J, Levy JH. Sepsis-induced coagulopathy (SIC) in the management of sepsis. Ann Intensive Care. 2024 Sep 20;14(1):148. doi: 10.1186/s13613-024-01380-5. PMID: 39302568; PMCID: PMC11415329.
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Consider purchasing my book, ‘The Vasopressor & Inotrope Handbook’!

I have written “The Vasopressor & Inotrope Handbook: A Practical Guide for Healthcare Professionals,” a must-read for anyone caring for critically ill patients (check out the reviews)! You have several options to get a physical copy. If you’re in the US, you can order A SIGNED & PERSONALIZED COPY for $29.99 or via AMAZON (for orders in or outside the US).
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When you use these affiliate links, I earn an additional commission at no extra cost to you, which is a great way to support my work.

Nutrition is not one-size-fits-all (12/18/24)

Stoppe C, Hill A, Christopher KB, Kristof AS. Toward Precision in Nutrition Therapy. Crit Care Med. 2024 Dec 17. doi: 10.1097/CCM.0000000000006537. Epub ahead of print. PMID: 39688452.
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Angiotensin II and RAAS (12/17/24)

Legrand M, Khanna AK, Ostermann M, Kotani Y, Ferrer R, Girardis M, Leone M, DePascale G, Pickkers P, Tissieres P, Annoni F, Kotfis K, Landoni G, Zarbock A, Wieruszewski PM, De Backer D, Vincent JL, Bellomo R. The renin-angiotensin-aldosterone-system in sepsis and its clinical modulation with exogenous angiotensin II. Crit Care. 2024 Nov 26;28(1):389. doi: 10.1186/s13054-024-05123-7. PMID: 39593182; PMCID: PMC11590289.
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Continuous Glucose Monitoring in the ICU? (12/23/24)

Chu C, Li J, Yang X, Zhao H, Wu Z, Xu R, Gao J. Continuous glucose monitoring versus conventional glucose monitoring in the ICU: A randomized controlled trial. J Crit Care. 2024 Dec;84:154894. doi: 10.1016/j.jcrc.2024.154894. Epub 2024 Aug 5. PMID: 39106581.
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Link to my YouTube video on this paper
Link to my Saving Lives Podcast episode on this paper

Cytokine Removal after Cardiac Surgery (12/14/24)

Hohn A, Malewicz-Oeck NM, Buchwald D, Annecke T, Zahn PK, Baumann A. REmoval of cytokines during CArdiac surgery (RECCAS): a randomised controlled trial. Crit Care. 2024 Dec 12;28(1):406. doi: 10.1186/s13054-024-05175-9. PMID: 39668341.
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HFNC vs. NIV (12/12/24)

RENOVATE Investigators and the BRICNet Authors; Maia IS, Kawano-Dourado L, Tramujas L, de Oliveira NE, Souza RN, Signorini DF, Pincelli MP, Zandonai CL, Blasius RT, Freires F, Ferreira VM, Romano MLP, Miura MC, de Censo CM, Caser EB, Silva B, Santos Bonomo DC, Arraes JA, de Alencar Filho MS, Álvares Horta JG, Oliveira DC, Boschi E, Costa RL, Westphal GA, Ramos J, Lacerda FH, Filho CRH, Pinheiro BV, de Andrade Neumamm LB, Guimarães Júnior MRR, de Souza DT, Ferreira JC, Ohe LN, Schettini DA, Thompson MM, de Oliveira MCF, Veiga VC, Negrelli KL, Santos RHN, Damiani L, Gurgel RM, Gomes SPC, Lima LM, Miranda TA, Laranjeira LN, de Barros E Silva PGM, Machado FR, Fitzgerald M, Bosse A, Marion J, Carvalho CRR, Brochard L, Lewis RJ, Biasi Cavalcanti A. High-Flow Nasal Oxygen vs Noninvasive Ventilation in Patients With Acute Respiratory Failure: The RENOVATE Randomized Clinical Trial. JAMA. 2024 Dec 10. doi: 10.1001/jama.2024.26244. Epub ahead of print. PMID: 39657981.
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SGLT2i and Heart Failure (12/11/24)

McMurray JJV, Solomon SD, Inzucchi SE, Køber L, Kosiborod MN, Martinez FA, Ponikowski P, Sabatine MS, Anand IS, Bělohlávek J, Böhm M, Chiang CE, Chopra VK, de Boer RA, Desai AS, Diez M, Drozdz J, Dukát A, Ge J, Howlett JG, Katova T, Kitakaze M, Ljungman CEA, Merkely B, Nicolau JC, O’Meara E, Petrie MC, Vinh PN, Schou M, Tereshchenko S, Verma S, Held C, DeMets DL, Docherty KF, Jhund PS, Bengtsson O, Sjöstrand M, Langkilde AM; DAPA-HF Trial Committees and Investigators. Dapagliflozin in Patients with Heart Failure and Reduced Ejection Fraction. N Engl J Med. 2019 Nov 21;381(21):1995-2008. doi: 10.1056/NEJMoa1911303. Epub 2019 Sep 19. PMID: 31535829.
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Packer M, Anker SD, Butler J, Filippatos G, Pocock SJ, Carson P, Januzzi J, Verma S, Tsutsui H, Brueckmann M, Jamal W, Kimura K, Schnee J, Zeller C, Cotton D, Bocchi E, Böhm M, Choi DJ, Chopra V, Chuquiure E, Giannetti N, Janssens S, Zhang J, Gonzalez Juanatey JR, Kaul S, Brunner-La Rocca HP, Merkely B, Nicholls SJ, Perrone S, Pina I, Ponikowski P, Sattar N, Senni M, Seronde MF, Spinar J, Squire I, Taddei S, Wanner C, Zannad F; EMPEROR-Reduced Trial Investigators. Cardiovascular and Renal Outcomes with Empagliflozin in Heart Failure. N Engl J Med. 2020 Oct 8;383(15):1413-1424. doi: 10.1056/NEJMoa2022190. Epub 2020 Aug 28. PMID: 32865377.
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Anker SD, Butler J, Filippatos G, Ferreira JP, Bocchi E, Böhm M, Brunner-La Rocca HP, Choi DJ, Chopra V, Chuquiure-Valenzuela E, Giannetti N, Gomez-Mesa JE, Janssens S, Januzzi JL, Gonzalez-Juanatey JR, Merkely B, Nicholls SJ, Perrone SV, Piña IL, Ponikowski P, Senni M, Sim D, Spinar J, Squire I, Taddei S, Tsutsui H, Verma S, Vinereanu D, Zhang J, Carson P, Lam CSP, Marx N, Zeller C, Sattar N, Jamal W, Schnaidt S, Schnee JM, Brueckmann M, Pocock SJ, Zannad F, Packer M; EMPEROR-Preserved Trial Investigators. Empagliflozin in Heart Failure with a Preserved Ejection Fraction. N Engl J Med. 2021 Oct 14;385(16):1451-1461. doi: 10.1056/NEJMoa2107038. Epub 2021 Aug 27. PMID: 34449189.
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Solomon SD, McMurray JJV, Claggett B, de Boer RA, DeMets D, Hernandez AF, Inzucchi SE, Kosiborod MN, Lam CSP, Martinez F, Shah SJ, Desai AS, Jhund PS, Belohlavek J, Chiang CE, Borleffs CJW, Comin-Colet J, Dobreanu D, Drozdz J, Fang JC, Alcocer-Gamba MA, Al Habeeb W, Han Y, Cabrera Honorio JW, Janssens SP, Katova T, Kitakaze M, Merkely B, O’Meara E, Saraiva JFK, Tereshchenko SN, Thierer J, Vaduganathan M, Vardeny O, Verma S, Pham VN, Wilderäng U, Zaozerska N, Bachus E, Lindholm D, Petersson M, Langkilde AM; DELIVER Trial Committees and Investigators. Dapagliflozin in Heart Failure with Mildly Reduced or Preserved Ejection Fraction. N Engl J Med. 2022 Sep 22;387(12):1089-1098. doi: 10.1056/NEJMoa2206286. Epub 2022 Aug 27. PMID: 36027570.
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Managing COPD and Asthma Exacerbations (12/10/24)

Management of Asthma and COPD Exacerbations in Adults in the ICU. Mein, Stephen A. et al. CHEST Critical Care, Volume 0, Issue 0, 100107
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Bleeding after Cardiac Surgery (12/8/24)

Raphael J, Mazer CD, Subramani S, Schroeder A, Abdalla M, Ferreira R, Roman PE, Patel N, Welsby I, Greilich PE, Harvey R, Ranucci M, Heller LB, Boer C, Wilkey A, Hill SE, Nuttall GA, Palvadi RR, Patel PA, Wilkey B, Gaitan B, Hill SS, Kwak J, Klick J, Bollen BA, Shore-Lesserson L, Abernathy J, Schwann N, Lau WT. Society of Cardiovascular Anesthesiologists Clinical Practice Improvement Advisory for Management of Perioperative Bleeding and Hemostasis in Cardiac Surgery Patients. J Cardiothorac Vasc Anesth. 2019 Nov;33(11):2887-2899. doi: 10.1053/j.jvca.2019.04.003. Epub 2019 Apr 19. Erratum in: J Cardiothorac Vasc Anesth. 2020 Mar;34(3):840-841. doi: 10.1053/j.jvca.2019.11.004. PMID: 31604540.
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Midodrine (12/5/24)

Kilcommons SJ, Hammal F, Kamaleldin M, Opgenorth DL, Fiest KM, Karvellas CJ, Kutsogiannis DJ, Lau VI, MacIntyre EJ, Rochwerg B, Senaratne JM, Slemko JM, Sligl WI, Wang XXM, Bagshaw SM, Rewa OG. Adjunctive Midodrine Therapy for Vasopressor-Dependent Shock in the ICU: A Systematic Review and Meta-Analysis. Crit Care Med. 2024 Dec 4. doi: 10.1097/CCM.0000000000006519. Epub ahead of print. PMID: 39631091.
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There is a whole chapter dedicated to midodrine in my book if you would like more info.

Vent Weaning Strategies (12/4/24)

Burns KEA, Wong J, Rizvi L, Lafreniere-Roula M, Thorpe K, Devlin JW, Cook DJ, Seely A, Dodek PM, Tanios M, Piraino T, Gouskos A, Kiedrowski KC, Kay P, Mitchell S, Merner GW, Mayette M, D’Aragon F, Lamontagne F, Rochwerg B, Turgeon A, Sia YT, Charbonney E, Aslanian P, Criner GJ, Hyzy RC, Beitler JR, Kassis EB, Kutsogiannis DJ, Meade MO, Liebler J, Iyer-Kumar S, Tsang J, Cirone R, Shanholtz C, Hill NS; Canadian Critical Care Trials Group. Frequency of Screening and Spontaneous Breathing Trial Techniques: A Randomized Clinical Trial. JAMA. 2024 Dec 3;332(21):1808-1821. doi: 10.1001/jama.2024.20631. PMID: 39382222; PMCID: PMC11581551.
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Pancytopenia (12/3/24)

Chew S, Kamangar M. Approach to pancytopenia: From blood tests to the bedside. Clin Med (Lond). 2024 Sep;24(5):100235. doi: 10.1016/j.clinme.2024.100235. Epub 2024 Aug 17. PMID: 39159748; PMCID: PMC11399640.
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Beta-blocker in Sepsis (12/2/24)

Alexandru MG, Niewald P, Krüger S, Borgstedt R, Whitehouse T, Singer M, Rehberg S, Scholz SS. Mortality in septic patients treated with short-acting betablockers: a comprehensive meta-analysis of randomized controlled trials. Crit Care. 2024 Nov 27;28(1):392. doi: 10.1186/s13054-024-05174-w. PMID: 39605034; PMCID: PMC11603935.
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Patient Blood Management Guidelines in Cardiac Surgery (11/27/24)

Irving AH, Harris A, Petrie D, Higgins A, Smith J, McQuilten ZK. Impact of patient blood management guidelines on blood transfusions and patient outcomes during cardiac surgery. J Thorac Cardiovasc Surg. 2020 Aug;160(2):437-445.e20. doi: 10.1016/j.jtcvs.2019.08.102. Epub 2019 Oct 7. PMID: 31711621.
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The mitochondria and sepsis (11/26/24)

Nedel W, Strogulski NR, Kopczynski A, Portela LV. Assessment of mitochondrial function and its prognostic role in sepsis: a literature review. Intensive Care Med Exp. 2024 Nov 25;12(1):107. doi: 10.1186/s40635-024-00694-9. PMID: 39585590.
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Cardiac Surgery-Associated AKI (11/24/24)

Yu, P., Bocchieri, K., & Cassiere, H. (2023). Prevention of Cardiac Surgery-Associated Acute Kidney Injury: Commentary on the 2023 STS/SCA/AmSECT Guidelines. Kidney News, 15(4), 19-19. Retrieved Nov 24, 2024, from https://www.kidneynews.org/view/journals/kidney-news/15/4/article-p19_10.xml
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Cardiac Arrest and Myoclonus (11/23/24)

De Stefano, Pia MD^1,2; Leitinger, Markus MD, MSc³; Misirocchi, Francesco MD^2,4; Quintard, Hervé PhD²; Degano, Giulio PhD²; Trinka, Eugen MD, MSc^3,5,6. Myoclonus After Cardiac Arrest: Need for Standardization—A Systematic Review and Research Proposal on Terminology. Critical Care Medicine ():10.1097/CCM.0000000000006521, November 22, 2024. | DOI: 10.1097/CCM.0000000000006521
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AI for post-cardiac surgery resuscitation (11/22/24)

Reddy VS, Stout DM, Fletcher R, Barksdale A, Parikshak M, Johns C, Gerdisch M. Advanced artificial intelligence-guided hemodynamic management within cardiac enhanced recovery after surgery pathways: A multi-institution review. JTCVS Open. 2023 Aug 7;16:480-489. doi: 10.1016/j.xjon.2023.06.023. PMID: 38204636; PMCID: PMC10774974.
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Prehospital Septic Shock (11/20/24)

Pinto-Villalba RS, Balseca-Arellano D, Leon-Rojas JE. Septic shock in the prehospital setting: a scoping review. Scand J Trauma Resusc Emerg Med. 2024 Nov 14;32(1):113. doi: 10.1186/s13049-024-01282-2. PMID: 39543643; PMCID: PMC11566175.
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Lipoprotein(a) (11/19/24)

Nissen SE, Wang Q, Nicholls SJ, Navar AM, Ray KK, Schwartz GG, Szarek M, Stroes ESG, Troquay R, Dorresteijn JAN, Fok H, Rider DA, Romano S, Wolski K, Rambaran C. Zerlasiran-A Small-Interfering RNA Targeting Lipoprotein(a): A Phase 2 Randomized Clinical Trial. JAMA. 2024 Nov 18. doi: 10.1001/jama.2024.21957. Epub ahead of print. PMID: 39556769.
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Mechanical Complications after AMI (11/18/24)

Damluji AA, van Diepen S, Katz JN, Menon V, Tamis-Holland JE, Bakitas M, Cohen MG, Balsam LB, Chikwe J; American Heart Association Council on Clinical Cardiology; Council on Arteriosclerosis, Thrombosis and Vascular Biology; Council on Cardiovascular Surgery and Anesthesia; and Council on Cardiovascular and Stroke Nursing. Mechanical Complications of Acute Myocardial Infarction: A Scientific Statement From the American Heart Association. Circulation. 2021 Jul 13;144(2):e16-e35. doi: 10.1161/CIR.0000000000000985. Epub 2021 Jun 15. PMID: 34126755; PMCID: PMC9364424.
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Cardiogenic Shock (11/16/24)

Enzo Lüsebrink, MD ∙ Leonhard Binzenhöfer, MD ∙ Prof Marianna Adamo, MDb,c ∙ Prof Roberto Lorusso, MDd,e ∙ Prof Alexandre Mebazaa, MDf ∙ Prof David A Morrow, MDg ∙ Prof Susanna Price, MDh,i ∙ Prof Jacob C Jentzer, MDj ∙ Prof Daniel Brodie, MDk ∙ Prof Alain Combes, MDl,m,† ∙ Prof Holger Thiele, MD. Cardiogenic shock. Volume 404, Issue 10466. P2006-2020 November 16, 2024.
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US for Hemodynamic Monitoring (11/14/24)

Evaluación y monitorización hemodinámica por ultrasonido en el shock.
Susy A. López-Laaz, Ruth L. Torres-Vélez, Oswaldo A. Bolaños-Ladinez y Cristian R. Macanchi-Namicela.
Revista de Educación en Cuidados Críticos
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Lipoprotein Apheresis (11/09/24)

Gianos E, Duell PB, Toth PP, Moriarty PM, Thompson GR, Brinton EA, Hudgins LC, Nametka M, Byrne KH, Raghuveer G, Nedungadi P, Sperling LS; American Heart Association Council on Arteriosclerosis, Thrombosis and Vascular Biology; Council on Cardiovascular and Stroke Nursing; Council on Clinical Cardiology; Council on Lifelong Congenital Heart Disease and Heart Health in the Young; and Council on Peripheral Vascular Disease. Lipoprotein Apheresis: Utility, Outcomes, and Implementation in Clinical Practice: A Scientific Statement From the American Heart Association. Arterioscler Thromb Vasc Biol. 2024 Oct 7. doi: 10.1161/ATV.0000000000000177. Epub ahead of print. PMID: 39370995.
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Cardiogenic Shock Management (11/08/24)

Jung C, Bruno RR, Jumean M, Price S, Krychtiuk KA, Ramanathan K, Dankiewicz J, French J, Delmas C, Mendoza AA, Thiele H, Soussi S. Management of cardiogenic shock: state-of-the-art. Intensive Care Med. 2024 Nov;50(11):1814-1829. doi: 10.1007/s00134-024-07618-x. Epub 2024 Sep 10. PMID: 39254735.
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Glucose Management. Sweet, but not too sweet. (11/04/24)

Gunst J, Umpierrez GE, Van den Berghe G. Managing blood glucose control in the intensive care unit. Intensive Care Med. 2024 Oct 29. doi: 10.1007/s00134-024-07687-y. Epub ahead of print. PMID: 39470800.
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Left atrial appendage closure and post-op afib (11/03/24)

Shuhaiber JH, Abbas M, Morland T, Kirchner HL, El-Manzalawy Y. Atrial appendage closure is associated with increased risk for postoperative atrial fibrillation. J Cardiothorac Surg. 2024 Nov 2;19(1):619. doi: 10.1186/s13019-024-03119-6. PMID: 39488696.
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Link to Podcast Episode on YouTube
Listen to the Podcast Episode on Spotify
Listen to the Podcast Episode on Apple Podcasts

Bacteriophage Therapy (11/02/24)

Sawa T, Moriyama K, Kinoshita M. Current status of bacteriophage therapy for severe bacterial infections. J Intensive Care. 2024 Nov 1;12(1):44. doi: 10.1186/s40560-024-00759-7. PMID: 39482746.
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Acute Lung Injury (11/01/24)

Fan W, Gui B, Zhou X, Li L, Chen H. A narrative review on lung injury: mechanisms, biomarkers, and monitoring. Crit Care. 2024 Oct 31;28(1):352. doi: 10.1186/s13054-024-05149-x. PMID: 39482752.
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Severe Tricuspid Regurgitation Treatment: Transcatheter Tricuspid-Valve Replacement (TRISCEND II) (10/31/24)

Hahn RT, Makkar R, Thourani VH, Makar M, Sharma RP, Haeffele C, Davidson CJ, Narang A, O’Neill B, Lee J, Yadav P, Zahr F, Chadderdon S, Eleid M, Pislaru S, Smith R, Szerlip M, Whisenant B, Sekaran NK, Garcia S, Stewart-Dehner T, Thiele H, Kipperman R, Koulogiannis K, Lim DS, Fowler D, Kapadia S, Harb SC, Grayburn PA, Sannino A, Mack MJ, Leon MB, Lurz P, Kodali SK; TRISCEND II Trial Investigators. Transcatheter Valve Replacement in Severe Tricuspid Regurgitation. N Engl J Med. 2024 Oct 30. doi: 10.1056/NEJMoa2401918. Epub ahead of print. PMID: 39475399.
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Link to YouTube Video
Link to Podcast Episode on Spotify
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Trauma Cardiac Arrest (10/29/24)

Carenzo L, Calgaro G, Rehn M, Perkins Z, Qasim ZA, Gamberini L, Ter Avest E. Contemporary management of traumatic cardiac arrest and peri-arrest states: a narrative review. J Anesth Analg Crit Care. 2024 Sep 26;4(1):66. doi: 10.1186/s44158-024-00197-9. PMID: 39327636; PMCID: PMC11426104.
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Autophagy (10/26/24)

Iba T, Helms J, Maier CL, Ferrer R, Levy JH. Autophagy and autophagic cell death in sepsis: friend or foe? J Intensive Care. 2024 Oct 25;12(1):41. doi: 10.1186/s40560-024-00754-y. PMID: 39449054.
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Awake on Paralytics (10/23/24)

Romagnoli, S., Matta, B., Driver, B.E. et al. A plea for enhanced monitoring of depth of sedation in patients who are intubated and ventilated. Crit Care 28, 342 (2024). https://doi.org/10.1186/s13054-024-05105-9
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TEG as SOC in the ICU (10/16/24)

Natasha Passi N, Parker T. Should viscoelastic testing be a standard point-of-care test on all intensive care units? Journal of the Intensive Care Society. 2024;0(0). doi:10.1177/17511437241290154
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Cardiac Critical Care (10/14/24)

Gage A, Higgins A, Lee R. Cardiac Critical Care: The Evolution of a Novel Subspecialty. Methodist Debakey Cardiovasc J. 2022 Jun 3;18(3):24-29. doi: 10.14797/mdcvj.1092. PMID: 35734159; PMCID: PMC9165666.
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Lung Ultrasound (10/08/24)

Beshara M, Bittner EA, Goffi A, Berra L, Chang MG. Nuts and bolts of lung ultrasound: utility, scanning techniques, protocols, and findings in common pathologies. Crit Care. 2024 Oct 7;28(1):328. doi: 10.1186/s13054-024-05102-y. PMID: 39375782.
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Analgosedation for NIV? (10/07/24)

Spinazzola G, Spadaro S, Ferrone G, Grasso S, Maggiore SM, Cinnella G, Cabrini L, Cammarota G, Maugeri JG, Simonte R, Patroniti N, Ball L, Conti G, De Luca D, Cortegiani A, Giarratano A, Gregoretti C. Management of analgosedation during noninvasive respiratory support: an expert Delphi consensus document developed by the Italian Society of Anesthesia, Analgesia, Resuscitation and Intensive Care (SIAARTI). J Anesth Analg Crit Care. 2024 Sep 30;4(1):68. doi: 10.1186/s44158-024-00203-0. PMID: 39350290; PMCID: PMC11441104.
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Why does your septic patient have lymphopenia? (10/06/24)

Wang Z, Zhang W, Chen L, Lu X, Tu Y. Lymphopenia in sepsis: a narrative review. Crit Care. 2024 Sep 20;28(1):315. doi: 10.1186/s13054-024-05099-4. PMID: 39304908; PMCID: PMC11414153.
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Hypoactive Delirium (10/03/24)

Kotfis K, Mesa P, Ely EW. How to end quiet suffering in the intensive care unit? Identifying and treating hypoactive delirium. Intensive Care Med. 2024 Oct;50(10):1695-1698. doi: 10.1007/s00134-024-07534-0. Epub 2024 Jul 22. PMID: 39037606.
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Blood Transfusion Guidelines from CHEST (09/29/24)

Coz Yataco AO, Soghier I, Hébert PC, Belley-Cote E, Disselkamp M, Flynn D, Halvorson K, Iaccarino JM, Lim W, Lindenmeyer CC, Miller PJ, O’Neil K, Pendleton KM, Vusse LV, Ouellette DR. Red Blood Cell Transfusion in Critically Ill Adults An American College of Chest Physicians Clinical Practice Guideline. Chest. 2024 Sep 26:S0012-3692(24)05272-3. doi: 10.1016/j.chest.2024.09.016. Epub ahead of print. PMID: 39341492.
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Renal Cell Carcinoma (09/26/24)

Rose TL, Kim WY. Renal Cell Carcinoma: A Review. JAMA. 2024;332(12):1001–1010. doi:10.1001/jama.2024.12848
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Therapies for Acute Pulmonary Embolism (09/23/24)

Mojaddedi, S.; Jamil, J.; Bishev, D.; Essilfie-Quaye, K.; Elgendy, I.Y. Risk Stratification and Management of Intermediate- and High-Risk Pulmonary Embolism. J. Clin. Med. 2024, 13, 5583. https://doi.org/10.3390/jcm13185583
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Acute Kidney Injury and Biomarkers (09/16/24)

Ostermann, M., Legrand, M., Meersch, M. et al. Biomarkers in acute kidney injury. Ann. Intensive Care 14, 145 (2024). https://doi.org/10.1186/s13613-024-01360-9
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Tumor Necrosis Factor in Sepsis (09/14/24)

Kassasseya C, Torsin LI, Musset C, Benhamou M, Chaudry IH, Cavaillon JM, Grall N, Monteiro R, de Chaisemartin L, Longrois D, Montravers P, de Tymowski C. Divergent effects of tumor necrosis factor (TNF) in sepsis: a meta-analysis of experimental studies. Crit Care. 2024 Sep 4;28(1):293. doi: 10.1186/s13054-024-05057-0. PMID: 39227889; PMCID: PMC11373197.
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Toxic Shock Syndrome (09/13/24)

Atchade, Enora, Christian De Tymowski, Nathalie Grall, Sébastien Tanaka, and Philippe Montravers. 2024. “Toxic Shock Syndrome: A Literature Review” Antibiotics 13, no. 1: 96. https://doi.org/10.3390/antibiotics13010096
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Post-arrest Acute Lung Injury (09/12/24)

Endo Y, Aoki T, Jafari D, Rolston DM, Hagiwara J, Ito-Hagiwara K, Nakamura E, Kuschner CE, Becker LB, Hayashida K. Acute lung injury and post-cardiac arrest syndrome: a narrative review. J Intensive Care. 2024 Sep 3;12(1):32. doi: 10.1186/s40560-024-00745-z. PMID: 39227997; PMCID: PMC11370287.
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Stop making patients NPO prior to the Cath or EP Lab (09/11/24)

Ferreira D, Hardy J, Meere W, Butel-Simoes L, Sritharan S, Ray M, French M, McGee M, O’Connor S, Whitehead N, Turner S, Healey P, Davies A, Morris G, Jackson N, Barlow M, Ford T, Leask S, Oldmeadow C, Attia J, Sverdlov A, Collins N, Boyle A, Wilsmore B. Fasting vs no fasting prior to catheterisation laboratory procedures: the SCOFF trial. Eur Heart J. 2024 Sep 1:ehae573. doi: 10.1093/eurheartj/ehae573. Epub ahead of print. PMID: 39217604.
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Less is more: IV Fluids in Sepsis (09/10/24)

Taniguchi TM, Taniguchi LU. Fluid management in sepsis: 5 reasons why less fluid might be more rational. Crit Care Sci. 2024 Aug 30;36:e20240111en. English, Portuguese. doi: 10.62675/2965-2774.20240111-en. PMID: 39230073.
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Acute on chronic liver failure (09/09/24)

Passi NN, McPhail MJ. The patient with cirrhosis in the intensive care unit and the management of acute-on-chronic liver failure. J Intensive Care Soc. 2022 Feb;23(1):78-86. doi: 10.1177/1751143720978849. Epub 2020 Dec 28. PMID: 37593538; PMCID: PMC10427846.
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Palliative Care in the ICU (09/08/24)

Salins N, Dhyani VS, Mathew M, Prasad A, Rao AP, Damani A, Rao K, Nair S, Shanbhag V, Rao S, Iyer S, Gursahani R, Mani RK, Bhatnagar S, Simha S. Assessing palliative care practices in intensive care units and interpreting them using the lens of appropriate care concepts. An umbrella review. Intensive Care Med. 2024 Sep;50(9):1438-1458. doi: 10.1007/s00134-024-07565-7. Epub 2024 Aug 14. PMID: 39141091; PMCID: PMC11377469.
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Paralytics in ARDS: Practice Guidelines. (09/07/24)

Alhazzani W, Belley-Cote E, Møller MH, Angus DC, Papazian L, Arabi YM, Citerio G, Connolly B, Denehy L, Fox-Robichaud A, Hough CL, Laake JH, Machado FR, Ostermann M, Piraino T, Sharif S, Szczeklik W, Young PJ, Gouskos A, Kiedrowski K, Burns KEA. Neuromuscular blockade in patients with ARDS: a rapid practice guideline. Intensive Care Med. 2020 Nov;46(11):1977-1986. doi: 10.1007/s00134-020-06227-8. Epub 2020 Oct 26. PMID: 33104824; PMCID: PMC7585991.
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ICU-acquired Weakness (09/06/24)

Fuentes-Aspe R, Gutierrez-Arias R, González-Seguel F, Marzuca-Nassr GN, Torres-Castro R, Najum-Flores J, Seron P. Which factors are associated with acquired weakness in the ICU? An overview of systematic reviews and meta-analyses. J Intensive Care. 2024 Sep 5;12(1):33. doi: 10.1186/s40560-024-00744-0. PMID: 39232808; PMCID: PMC11375885.
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The Innate Immune Response (09/05/24)

Stiel L, Gaudet A, Thietart S, Vallet H, Bastard P, Voiriot G, Oualha M, Sarton B, Kallel H, Brechot N, Kreitmann L, Benghanem S, Joffre J, Jouan Y; la Commission de Recherche Translationnelle de la Société de Réanimation en Langue Française. Innate immune response in acute critical illness: a narrative review. Ann Intensive Care. 2024 Sep 4;14(1):137. doi: 10.1186/s13613-024-01355-6. PMID: 39227416; PMCID: PMC11371990.
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How Echo can help us manage Heart Failure (09/04/24)

Naddaf N, Dianati Maleki N, Goldschmidt ME, Kalogeropoulos AP. Point of Care Ultrasound (POCUS) in the Management of Heart Failure: A Narrative Review. J Pers Med. 2024 Jul 18;14(7):766. doi: 10.3390/jpm14070766. PMID: 39064020; PMCID: PMC11277924.
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Indirect Calorimetry (09/03/24)

De Waele E, van Zanten ARH. Routine use of indirect calorimetry in critically ill patients: pros and cons. Crit Care. 2022 May 5;26(1):123. doi: 10.1186/s13054-022-04000-5. PMID: 35513872; PMCID: PMC9069947.
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PEEP in ARDS (09/02/24)

Boesing C, Rocco PRM, Luecke T, Krebs J. Positive end-expiratory pressure management in patients with severe ARDS: implications of prone positioning and extracorporeal membrane oxygenation. Crit Care. 2024 Aug 26;28(1):277. doi: 10.1186/s13054-024-05059-y. PMID: 39187853; PMCID: PMC11348554.
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Initial Antimicrobial Management of Sepsis (09/01/24)

Niederman MS, Baron RM, Bouadma L, Calandra T, Daneman N, DeWaele J, Kollef MH, Lipman J, Nair GB. Initial antimicrobial management of sepsis. Crit Care. 2021 Aug 26;25(1):307. doi: 10.1186/s13054-021-03736-w. PMID: 34446092; PMCID: PMC8390082.
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Cardiogenic Shock Patients with Multiorgan Failure Do Worse (08/31/24)

Vallabhajosyula S, Dunlay SM, Prasad A, Kashani K, Sakhuja A, Gersh BJ, Jaffe AS, Holmes DR Jr, Barsness GW. Acute Noncardiac Organ Failure in Acute Myocardial Infarction With Cardiogenic Shock. J Am Coll Cardiol. 2019 Apr 16;73(14):1781-1791. doi: 10.1016/j.jacc.2019.01.053. PMID: 30975295.
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Severe Aortic Stenosis: TAVR vs. SAVR (08/30/24)

Chen, Shmuel et al. Lifetime Management for Aortic Stenosis: Strategy and Decision Making in the Current Era. The Annals of Thoracic Surgery, Volume 0, Issue 0
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Platelet Transfusions (08/29/24)

Pène F, Aubron C, Russell L. Ten things ICU specialists need to know about platelet transfusions. Intensive Care Med. 2024 Aug 22. doi: 10.1007/s00134-024-07597-z. Epub ahead of print. PMID: 39172239.
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Manage Volume Overload in Cirrhosis (08/28/24)

Kwong AJ, Norman J, Biggins SW. Management of ascites and volume overload in patients with cirrhosis. Clin Liver Dis (Hoboken). 2024 Feb 9;23(1):e0115. doi: 10.1097/CLD.0000000000000115. PMID: 38343635; PMCID: PMC10857675.
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A Review of Vasopressin (08/27/24)

García-Álvarez R, Arboleda-Salazar R. Vasopressin in Sepsis and Other Shock States: State of the Art. J Pers Med. 2023 Oct 29;13(11):1548. doi: 10.3390/jpm13111548. PMID: 38003863; PMCID: PMC10672256.
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ICU Nutrition and Post-Intensive Care Syndrome (08/26/24)

Oshima T, Hatakeyama J. Nutritional therapy for the prevention of post-intensive care syndrome. J Intensive Care. 2024 Jul 29;12(1):29. doi: 10.1186/s40560-024-00734-2. PMID: 39075627; PMCID: PMC11285132.
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Acute Liver Failure (08/25/24)

Ozturk NB, Herdan E, Saner FH, Gurakar A. A Comprehensive Review of the Diagnosis and Management of Acute Liver Failure. J Clin Med. 2023 Nov 30;12(23):7451. doi: 10.3390/jcm12237451. PMID: 38068503; PMCID: PMC10707329.
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Balanced Salt Solutions in DKA (08/24/24)

Szabó GV, Szigetváry C, Turan C, Engh MA, Terebessy T, Fazekas A, Farkas N, Hegyi P, Molnár Z. Fluid resuscitation with balanced electrolyte solutions results in faster resolution of diabetic ketoacidosis than with 0.9% saline in adults – A systematic review and meta-analysis. Diabetes Metab Res Rev. 2024 Jul;40(5):e3831. doi: 10.1002/dmrr.3831. PMID: 38925619.
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Saving Lives Podcast Episode on Spotify
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O2 Target in Shock (08/23/24)

Sigg AA, Zivkovic V, Bartussek J, Schuepbach RA, Ince C, Hilty MP. The physiological basis for individualized oxygenation targets in critically ill patients with circulatory shock. Intensive Care Med Exp. 2024 Aug 22;12(1):72. doi: 10.1186/s40635-024-00651-6. PMID: 39174691.
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Angiotensin II Consensus Statement (08/22/24)

Landoni G, Cortegiani A, Bignami E, De Pascale G, Donadello K, Donati A, Grasselli G, Guarracino F, Monti G, Paternoster G, Tritapepe L, Girardis M. The use of angiotensin II for the management of distributive shock: expert consensus statements. J Anesth Analg Crit Care. 2024 Aug 16;4(1):56. doi: 10.1186/s44158-024-00186-y. PMID: 39152516; PMCID: PMC11328364.
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AKI and Heart Failure (08/21/24)

Debasish Banerjee, Mahrukh Ayesha Ali, Angela Yee-Moon Wang, Vivekanand Jha, Acute kidney injury in acute heart failure–when to worry and when not to worry?, Nephrology Dialysis Transplantation, 2024;, gfae146, https://doi.org/10.1093/ndt/gfae146
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Sleep Stuff (08/20/24)

Perry H, Alight A, Wilcox ME. Light, sleep and circadian rhythm in critical illness. Curr Opin Crit Care. 2024 Aug 1;30(4):283-289. doi: 10.1097/MCC.0000000000001163. Epub 2024 May 28. PMID: 38841914.
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Acute Encephalitis (08/19/24)

Thakur, K.T., Legouy, C. & Sonneville, R. Treating acute encephalitis. Intensive Care Med(2024). https://doi.org/10.1007/s00134-024-07569-3
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Atrial fibrillation after surgery (08/18/24)

Gaudino M, Di Franco A, Rong LQ, Piccini J, Mack M. Postoperative atrial fibrillation: from mechanisms to treatment. Eur Heart J. 2023 Mar 21;44(12):1020-1039. doi: 10.1093/eurheartj/ehad019. PMID: 36721960; PMCID: PMC10226752.
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Why do patients developed AKI after Cardiac Surgery? (08/17/24)

Beaver TM, Dass B, Patel AM, Ejaz AA. Acute Kidney Injury after Cardiac Surgery. Cardiorenal Med. 2024;14(1):437-442. doi: 10.1159/000540396. Epub 2024 Jul 18. PMID: 39025046.
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Albumin Recommendations (08/16/24)

Callum J, Skubas NJ, Bathla A, Keshavarz H, Clark EG, Rochwerg B, Fergusson D, Arbous S, Bauer SR, China L, Fung M, Jug R, Neill M, Paine C, Pavenski K, Shah PS, Robinson S, Shan H, Szczepiorkowski ZM, Thevenot T, Wu B, Stanworth S, Shehata N; International Collaboration for Transfusion Medicine Guidelines Intravenous Albumin Guideline Group. Use of Intravenous Albumin: A Guideline From the International Collaboration for Transfusion Medicine Guidelines. Chest. 2024 Aug;166(2):321-338. doi: 10.1016/j.chest.2024.02.049. Epub 2024 Mar 4. PMID: 38447639; PMCID: PMC11317816.
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Esophageal Hemorrhage Management (08/15/24)

An Update on the Management of Esophageal Variceal Hemorrhage. Hassaan A. Zia, Elizabeth S. Aby, Atoosa Rabiee. First published: 27 October 2021 https://doi.org/10.1002/cld.1108
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Heart-Lung Interactions (08/14/24)

Jozwiak M, Teboul JL. Heart-Lungs interactions: the basics and clinical implications. Ann Intensive Care. 2024 Aug 12;14(1):122. doi: 10.1186/s13613-024-01356-5. PMID: 39133379.
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Strategies to Monitor Cardiac Output (08/13/24)

De Backer D, Hajjar L, Monnet X. Monitoring cardiac output. Intensive Care Med. 2024 Aug 5. doi: 10.1007/s00134-024-07566-6. Epub ahead of print. PMID: 39102028.
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POCUS (08/12/24)

Kameda T, Ishii H, Oya S, Katabami K, Kodama T, Sera M, Takei H, Taniguchi H, Nakao S, Funakoshi H, Yamaga S, Senoo S, Kimura A. Guidance for clinical practice using emergency and point-of-care ultrasonography. Acute Med Surg. 2024 Jun 26;11(1):e974. doi: 10.1002/ams2.974. PMID: 38933992; PMCID: PMC11201855.
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All About Hypertensive Emergencies (08/11/24)

Miller JB, Hrabec D, Krishnamoorthy V, Kinni H, Brook RD. Evaluation and management of hypertensive emergency. BMJ. 2024 Jul 26;386:e077205. doi: 10.1136/bmj-2023-077205. PMID: 39059997.
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Diuretics (08/10/24)

Palazzuoli A, Mazzeo P, Fortunato M, Cadeddu Dessalvi C, Mariano E, Salzano A, Severino P, Fedele F. The Changing Role of Loop Diuretics in Heart Failure Management across the Last Century. J Clin Med. 2024 Mar 14;13(6):1674. doi: 10.3390/jcm13061674. PMID: 38541899; PMCID: PMC10970945.
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More on Fluid Tolerance (08/09/24)

Melo RH, Santos MHCD, Ramos FJDS. Beyond fluid responsiveness: the concept of fluid tolerance and its potential implication in hemodynamic management. Crit Care Sci. 2023 Apr-Jun;35(2):226-229. doi: 10.5935/2965-2774.20230012-en. PMID: 37712813; PMCID: PMC10406410.
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Procalcitonin to Deescalate Antibiotics (08/08/24)

Papp M, Kiss N, Baka M, Trásy D, Zubek L, Fehérvári P, Harnos A, Turan C, Hegyi P, Molnár Z. Procalcitonin-guided antibiotic therapy may shorten length of treatment and may improve survival-a systematic review and meta-analysis. Crit Care. 2023 Oct 13;27(1):394. doi: 10.1186/s13054-023-04677-2. PMID: 37833778; PMCID: PMC10576288.
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Cardiogenic Shock Teams (08/07/24)

Kruit N, Hambly J, Ong A, French J, Bowcock E, Kushwaha V, Jain P, Dennis M. Protocolised Management of Cardiogenic Shock and Shock Teams: A Narrative Review. Heart Lung Circ. 2023 Oct;32(10):1148-1157. doi: 10.1016/j.hlc.2023.08.014. Epub 2023 Oct 8. PMID: 37813747.
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Surviving Sepsis and Hemodynamics (08/06/24)

Suh GJ, Shin TG, Kwon WY, Kim K, Jo YH, Choi SH, Chung SP, Kim WY; Korean Shock Society investigators. Hemodynamic management of septic shock: beyond the Surviving Sepsis Campaign guidelines. Clin Exp Emerg Med. 2023 Sep;10(3):255-264. doi: 10.15441/ceem.23.065. Epub 2023 Jul 13. PMID: 37439141; PMCID: PMC10579730.
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Dexmedetomidine is not all that (08/05/24)

Pérez-Nieto OR, Reyes-Monge RA, Rodríguez-Guevara I, Zamarrón-López EI, Meade-Aguilar JA. Use of dexmedetomidine in critical-ill patients: is it time to look to the actual evidence? Crit Care. 2023 Aug 29;27(1):332. doi: 10.1186/s13054-023-04618-z. PMID: 37644608; PMCID: PMC10463279.
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Takotsubo syndrome (08/04/24)

Kato K, Di Vece D, Kitagawa M, Yamamoto K, Aoki S, Goto H, Kitahara H, Kobayashi Y, Templin C. Cardiogenic shock in takotsubo syndrome: etiology and treatment. Cardiovasc Interv Ther. 2024 Jul 22. doi: 10.1007/s12928-024-01031-3. Epub ahead of print. PMID: 39039401.
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Immediate Management of Undifferentiated Shock (08/03/24)

Hasanin A, Sanfilippo F, Dünser MW, Ahmed HM, Zieleskiewicz L, Myatra SN, Mostafa M. The MINUTES bundle for the initial 30 min management of undifferentiated circulatory shock: an expert opinion. Int J Emerg Med. 2024 Jul 25;17(1):96. doi: 10.1186/s12245-024-00660-y. PMID: 39054461; PMCID: PMC11270766.
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Thrombocytopenia and Sepsis (08/02/24)

Satoh K, Wada T, Tampo A, Takahashi G, Hoshino K, Matsumoto H, Taira T, Kazuma S, Masuda T, Tagami T, Ishikura H; J-STAD (JAPAN Sepsis Treatment and Diagnosis) Study Group. Practical approach to thrombocytopenia in patients with sepsis: a narrative review. Thromb J. 2024 Jul 22;22(1):67. doi: 10.1186/s12959-024-00637-0. PMID: 39039520; PMCID: PMC11265094.
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Small Bowel Obstruction (08/01/24)

Walshaw J, Smith HG, Lee MJ. Small bowel obstruction. Br J Surg. 2024 Jul 2;111(7):znae167. doi: 10.1093/bjs/znae167. PMID: 39041721.
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ABCDE vs. H’s and T’s for Cardiac Arrest (07/31/24)

Djärv T, Kloeck W. Reversible causes: After three decades with 4H4Ts, might we be ready for the generic ABCDE approach? Resuscitation. 2023 Dec;193:110019. doi: 10.1016/j.resuscitation.2023.110019. Epub 2023 Oct 27. PMID: 37890577.
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Echo for Undifferentiated Shock (07/30/24)

Pedro Salinas, Jacqueline Sohn, José L. Díaz-Gómez; A Critical Care Echocardiography—Driven Approach to Undifferentiated Shock. Tex Heart Inst J 1 September 2023; 50 (5): e228075. doi:https://doi.org/10.14503/THIJ-22-8075
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Sleep in the ICU? (07/29/24)

Eschbach E, Wang J. Sleep and critical illness: a review. Front Med (Lausanne). 2023 Sep 19;10:1199685. doi: 10.3389/fmed.2023.1199685. PMID: 37828946; PMCID: PMC10566646.
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Amniotic Fluid Embolism (07/28/24)

Baxter, Frederick J. Amniotic Fluid Embolism: A Narrative Review. Journal of Obstetric Anaesthesia and Critical Care 13(2):p 130-141, Jul–Dec 2023. | DOI: 10.4103/JOACC.JOACC_12_23
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This paper was in Rob Mac Sweeney’s Weekly Newsletter.

Fluid Tolerance (07/27/24)

Kattan E, Castro R, Miralles-Aguiar F, Hernández G, Rola P. The emerging concept of fluid tolerance: A position paper. J Crit Care. 2022 Oct;71:154070. doi: 10.1016/j.jcrc.2022.154070. Epub 2022 Jun 2. PMID: 35660844.
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Heparin-induced Thrombocytopenia (07/26/24)

May J, Westbrook B, Cuker A. Heparin-induced thrombocytopenia: An illustrated review. Res Pract Thromb Haemost. 2023 Jun 22;7(5):100283. doi: 10.1016/j.rpth.2023.100283. PMID: 37601013; PMCID: PMC10439402.
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Alcoholic Hepatitis (07/25/24)

Kasper P, Lang S, Steffen HM, Demir M. Management of alcoholic hepatitis: A clinical perspective. Liver Int. 2023 Oct;43(10):2078-2095. doi: 10.1111/liv.15701. Epub 2023 Aug 22. PMID: 37605624.
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What’s that device on the CXR? (07/24/24)

Kyaw Soe Tun, Donnchadh Reidy, Una Buckley, How to: a practical guide to cardiac conduction devices on chest radiograph, European Heart Journal – Imaging Methods and Practice, Volume 1, Issue 1, May 2023, qyad009, https://doi.org/10.1093/ehjimp/qyad009
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DRESS Syndrome (07/23/24)

Arora N, Chalasani N, Rahnama-Moghadam S. A review of drug-induced liver injury with rash, eosinophilia, and systemic symptoms (DRESS) syndrome: Cutaneous manifestations, clinical features, and management. Clin Liver Dis (Hoboken). 2024 May 31;23(1):e0198. doi: 10.1097/CLD.0000000000000198. PMID: 38831764; PMCID: PMC11146467.
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This paper was in Rob Mac Sweeney’s Weekly Newsletter.

Plasma for Sepsis? (07/22/24)

Kravitz MS, Kattouf N, Stewart IJ, Ginde AA, Schmidt EP, Shapiro NI. Plasma for prevention and treatment of glycocalyx degradation in trauma and sepsis. Crit Care. 2024 Jul 20;28(1):254. doi: 10.1186/s13054-024-05026-7. PMID: 39033135.
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Fluid Accumulation Syndrome (07/21/24)

Pfortmueller, C.A., Dabrowski, W., Wise, R. et al. Fluid accumulation syndrome in sepsis and septic shock: pathophysiology, relevance and treatment—a comprehensive review.Ann. Intensive Care 14, 115 (2024). https://doi.org/10.1186/s13613-024-01336-9
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Almost 200 years worth of crystalloids (07/20/24)

Fernández-Sarmiento J, Casas-Certain C, Ferro-Jackaman S, Solano-Vargas FH, Domínguez-Rojas JÁ, Pilar-Orive FJ. A brief history of crystalloids: the origin of the controversy. Front Pediatr. 2023 Jul 3;11:1202805. doi: 10.3389/fped.2023.1202805. PMID: 37465421; PMCID: PMC10351043.
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Pericardial Tamponade (07/19/24)

Kaemmerer AS, Alkhalaileh K, Suleiman MN, Kopp M, Hauer C, May MS, Uder M, Weyand M, Harig F. Pericardial tamponade, a diagnostic chameleon: from the historical perspectives to contemporary management. J Cardiothorac Surg. 2023 Feb 4;18(1):60. doi: 10.1186/s13019-023-02174-9. PMID: 36739433; PMCID: PMC9898697.
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More on adrenergic receptors (07/20/24)

Geevarghese M 3rd, Patel K, Gulati A, Ranjan AK. Role of adrenergic receptors in shock. Front Physiol. 2023 Jan 16;14:1094591. doi: 10.3389/fphys.2023.1094591. PMID: 36726848; PMCID: PMC9885157.
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Vasopressors, Inotropes & Cardiogenic Shock (07/18/24)

Bloom JE, Chan W, Kaye DM, Stub D. State of Shock: Contemporary Vasopressor and Inotrope Use in Cardiogenic Shock. J Am Heart Assoc. 2023 Aug;12(15):e029787. doi: 10.1161/JAHA.123.029787. Epub 2023 Jul 25. PMID: 37489740; PMCID: PMC10492962.
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Continuous EEGs (07/17/24)

Bitar R, Khan UM, Rosenthal ES. Utility and rationale for continuous EEG monitoring: a primer for the general intensivist. Crit Care. 2024 Jul 16;28(1):244. doi: 10.1186/s13054-024-04986-0. PMID: 39014421.
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Booze and the Heart (07/16/24)

Domínguez F, Adler E, García-Pavía P. Alcoholic cardiomyopathy: an update. Eur Heart J. 2024 Jun 7:ehae362. doi: 10.1093/eurheartj/ehae362. Epub ahead of print. PMID: 38848133.
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Metformin-Associated Lactic Acidosis (07/15/24)

See KC. Metformin-associated lactic acidosis: A mini review of pathophysiology, diagnosis and management in critically ill patients. World J Diabetes. 2024 Jun 15;15(6):1178-1186. doi: 10.4239/wjd.v15.i6.1178. PMID: 38983827; PMCID: PMC11229964.
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This paper was in Rob Mac Sweeney’s Weekly Newsletter.

Echo for Fluid Responsiveness (07/14/24)

Vieillard-Baron A, Boissier F, Slama M. Using echocardiography to predict fluid-responsiveness and manage the need for fluids. Intensive Care Med. 2024 Jul;50(7):1137-1142. doi: 10.1007/s00134-024-07407-6. Epub 2024 May 15. PMID: 38748267.
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Nutrition in the ICU (07/13/24)

de Man AME, Gunst J, Reintam Blaser A. Nutrition in the intensive care unit: from the acute phase to beyond. Intensive Care Med. 2024 May 21. doi: 10.1007/s00134-024-07458-9. Epub ahead of print. PMID: 38771368.
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Crystalloid Composition (07/12/24)

Fernández-Sarmiento J, Casas-Certain C, Ferro-Jackaman S, Solano-Vargas FH, Domínguez-Rojas JÁ, Pilar-Orive FJ. A brief history of crystalloids: the origin of the controversy. Front Pediatr. 2023 Jul 3;11:1202805. doi: 10.3389/fped.2023.1202805. PMID: 37465421; PMCID: PMC10351043.
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Right Heart Caths (07/11/24)

Del Rio-Pertuz G, Nugent K, Argueta-Sosa E. Right heart catheterization in clinical practice: a review of basic physiology and important issues relevant to interpretation. Am J Cardiovasc Dis. 2023 Jun 25;13(3):122-137. PMID: 37469534; PMCID: PMC10352814.
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Early Mobilization (07/10/24)

Hodgson CL, Schaller SJ, Nydahl P, Timenetsky KT, Needham DM. Ten strategies to optimize early mobilization and rehabilitation in intensive care. Crit Care. 2021 Sep 3;25(1):324. doi: 10.1186/s13054-021-03741-z. PMID: 34479621; PMCID: PMC8414658.
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DILI DILI (07/09/24)

Hosack T, Damry D, Biswas S. Drug-induced liver injury: a comprehensive review. Therap Adv Gastroenterol. 2023 Mar 21;16:17562848231163410. doi: 10.1177/17562848231163410. PMID: 36968618; PMCID: PMC10031606.
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Personalized fluid management in septic shock (07/08/24)

Monnet X, Lai C, Teboul JL. How I personalize fluid therapy in septic shock? Crit Care. 2023 Mar 24;27(1):123. doi: 10.1186/s13054-023-04363-3. PMID: 36964573; PMCID: PMC10039545.
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IVC measurements. Not all that. (07/07/24)

Di Nicolò P, Tavazzi G, Nannoni L, Corradi F. Inferior Vena Cava Ultrasonography for Volume Status Evaluation: An Intriguing Promise Never Fulfilled. J Clin Med. 2023 Mar 13;12(6):2217. doi: 10.3390/jcm12062217. PMID: 36983218; PMCID: PMC10053997.
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Sepsis-Associated Encephalopathy (07/06/24)

Sonneville R, Benghanem S, Jeantin L, de Montmollin E, Doman M, Gaudemer A, Thy M, Timsit JF. The spectrum of sepsis-associated encephalopathy: a clinical perspective. Crit Care. 2023 Oct 5;27(1):386. doi: 10.1186/s13054-023-04655-8. PMID: 37798769; PMCID: PMC10552444.
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Methylene Blue Adverse Effects (07/06/24)

Fernando SM, Tran A, Soliman K, Flynn B, Oommen T, Wenzhe L, Adhikari NKJ, Kanji S, Seely AJE, Fox-Robichaud AE, Wax RS, Cook DJ, Lamontagne F, Rochwerg B. Methylene Blue in Septic Shock: A Systematic Review and Meta-Analysis. Crit Care Explor. 2024 Jun 21;6(7):e1110. doi: 10.1097/CCE.0000000000001110. PMID: 38904978; PMCID: PMC11196076.
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Vasopressor Goodies (07/05/24)

Russell JA. Vasopressor therapy in critically ill patients with shock. Intensive Care Med. 2019 Nov;45(11):1503-1517. doi: 10.1007/s00134-019-05801-z. Epub 2019 Oct 23. PMID: 31646370.
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Nasal High Flow Goodies (07/04/24)

Ricard JD, Roca O, Lemiale V, et al. Use of nasal high flow oxygen during acute respiratory failure [published online ahead of print, 2020 Sep 8]. Intensive Care Med. 2020;10.1007/s00134-020-06228-7. doi:10.1007/s00134-020-06228-7. FOAMed
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Vitamin K Goodies (07/02/24)

Paulus, M.C., Drent, M., Kouw, I.W.K. et al. Vitamin K: a potential missing link in critical illness–a scoping review. Crit Care 28, 212 (2024). https://doi.org/10.1186/s13054-024-05001-2
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Reversing Anticoagulants (07/01/24)

Bekka E, Liakoni E. Anticoagulation reversal (vitamin K, prothrombin complex concentrates, idarucizumab, andexanet-α, protamine). Br J Clin Pharmacol. 2024 Jun 26. doi: 10.1111/bcp.16142. Epub ahead of print. PMID: 38926082.
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This paper was in Rob Mac Sweeney’s Weekly Newsletter.

Hypothyroidism in the ICU (06/30/24)

Bourcier S, Coutrot M, Ferré A, Van Grunderbeeck N, Charpentier J, Hraiech S, Azoulay E, Nseir S, Aissaoui N, Messika J, Fillatre P, Persichini R, Carreira S, Lautrette A, Delmas C, Terzi N, Mégarbane B, Lascarrou JB, Razazi K, Repessé X, Pichereau C, Contou D, Frérou A, Barbier F, Ehrmann S, de Montmollin E, Sztrymf B, Morawiec E, Bigé N, Reuter D, Schnell D, Ellrodt O, Dellamonica J, Combes A, Schmidt M. Critically ill severe hypothyroidism: a retrospective multicenter cohort study. Ann Intensive Care. 2023 Mar 9;13(1):15. doi: 10.1186/s13613-023-01112-1. PMID: 36892784.
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Troubleshooting O2 issues in VV ECMO (06/29/24)

Staudacher DL, Schmidt M, Wengenmayer T. Practical considerations on hypoxemia and hypoxia in V-V ECMO patients. Crit Care. 2024 Jun 24;28(1):205. doi: 10.1186/s13054-024-04972-6. PMID: 38915061; PMCID: PMC11197216.
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Don’t break the Gut Microbiome (06/28/24)

Kain T, Dionne JC, Marshall JC. Critical illness and the gut microbiome. Intensive Care Med. 2024 Jun 20. doi: 10.1007/s00134-024-07513-5. Epub ahead of print. PMID: 38900282.
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Shock (06/27/24)

Kislitsina ON, Rich JD, Wilcox JE, Pham DT, Churyla A, Vorovich EB, Ghafourian K, Yancy CW. Shock – Classification and Pathophysiological Principles of Therapeutics. Curr Cardiol Rev. 2019;15(2):102-113. doi: 10.2174/1573403X15666181212125024. PMID: 30543176; PMCID: PMC6520577.
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Euglycemic DKA (06/26/24)

Koceva, Andrijana, and Nika Aleksandra Kravos Tramšek. 2024. “From Sweet to Sour: SGLT-2-Inhibitor-Induced Euglycemic Diabetic Ketoacidosis” Journal of Personalized Medicine 14, no. 7: 665. https://doi.org/10.3390/jpm14070665
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Heart Failure Management (06/25/24)

Heidenreich P, Sandhu A. Advances in management of heart failure BMJ  2024;  385 :e077025 doi:10.1136/bmj-2023-077025
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This paper was in Rob Mac Sweeney’s Weekly Newsletter.

Ventricular Septal Defects after MI (06/24/24)

Schlotter F, Huber K, Hassager C, Halvorsen S, Vranckx P, Pöss J, Krychtiuk K, Lorusso R, Bonaros N, Calvert PA, Montorfano M, Thiele H. Ventricular septal defect complicating acute myocardial infarction: diagnosis and management. A Clinical Consensus Statement of the Association for Acute CardioVascular Care (ACVC) of the ESC, the European Association of Percutaneous Cardiovascular Interventions (EAPCI) of the ESC and the ESC Working Group on Cardiovascular Surgery. Eur Heart J. 2024 Jun 18:ehae363. doi: 10.1093/eurheartj/ehae363. Epub ahead of print. PMID: 38888906.
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This paper was in Rob Mac Sweeney’s Weekly Newsletter.

Management after death by neurologic criteria (06/23/24)

Gunst J, Souter MJ. Management of the brain-dead donor in the intensive care unit. Intensive Care Med. 2024 Jun;50(6):964-967. doi: 10.1007/s00134-024-07409-4. Epub 2024 Apr 10. PMID: 38598128.
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Acute Liver Failure (06/22/24)

Beck J, Bolina JK, Boyd LH. Acute liver failure. JAAPA. 2024 May 1;37(5):22-27. doi: 10.1097/01.JAA.0000000000000001. Epub 2024 Apr 25. PMID: 38595172.
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Vasopressin for Cardiac Surgery-Related Vasoplegia (06/21/24)

Hajjar LA, Vincent JL, Barbosa Gomes Galas FR, Rhodes A, Landoni G, Osawa EA, Melo RR, Sundin MR, Grande SM, Gaiotto FA, Pomerantzeff PM, Dallan LO, Franco RA, Nakamura RE, Lisboa LA, de Almeida JP, Gerent AM, Souza DH, Gaiane MA, Fukushima JT, Park CL, Zambolim C, Rocha Ferreira GS, Strabelli TM, Fernandes FL, Camara L, Zeferino S, Santos VG, Piccioni MA, Jatene FB, Costa Auler JO Jr, Filho RK. Vasopressin versus Norepinephrine in Patients with Vasoplegic Shock after Cardiac Surgery: The VANCS Randomized Controlled Trial. Anesthesiology. 2017 Jan;126(1):85-93. doi: 10.1097/ALN.0000000000001434. PMID: 27841822.
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Mottling is bad, m’kay? (06/20/24)

Merdji H, Bataille V, Curtiaud A, Bonello L, Roubille F, Levy B, Lim P, Schneider F, Khachab H, Dib JC, Seronde MF, Schurtz G, Harbaoui B, Vanzetto G, Marchand S, Gebhard CE, Henry P, Combaret N, Marchandot B, Lattuca B, Biendel C, Leurent G, Gerbaud E, Puymirat E, Bonnefoy E, Meziani F, Delmas C. Mottling as a prognosis marker in cardiogenic shock. Ann Intensive Care. 2023 Sep 6;13(1):80. doi: 10.1186/s13613-023-01175-0. PMID: 37672139; PMCID: PMC10482815.
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Frailty in the ICU (06/19/24)

Moïsi L, Mino JC, Guidet B, Vallet H. Frailty assessment in critically ill older adults: a narrative review. Ann Intensive Care. 2024 Jun 18;14(1):93. doi: 10.1186/s13613-024-01315-0. PMID: 38888743.
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Navigating End-Of-Life Care (06/18/24)

Choi HR, Ho MH, Lin CC. Navigating tensions when life-sustaining treatment is withdrawn: A thematic synthesis of nurses’ and physicians’ experiences. J Clin Nurs. 2024 Jun;33(6):2337-2356. doi: 10.1111/jocn.17059. Epub 2024 Feb 7. PMID: 38323726.
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Vasopressors & Cardiogenic Shock (06/17/24)

Bloom JE, Chan W, Kaye DM, Stub D. State of Shock: Contemporary Vasopressor and Inotrope Use in Cardiogenic Shock. J Am Heart Assoc. 2023 Aug;12(15):e029787. doi: 10.1161/JAHA.123.029787. Epub 2023 Jul 25. PMID: 37489740; PMCID: PMC10492962.
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Vasopressor Tips (06/14/24)

Legrand M, Zarbock A. Ten tips to optimize vasopressors use in the critically ill patient with hypotension. Intensive Care Med. 2022 Jun;48(6):736-739. doi: 10.1007/s00134-022-06708-y. Epub 2022 May 3. PMID: 35504977.
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Vasoplegia in Mechanical Circulatory Support (06/13/24)

Ortoleva J, Dalia AA, Pisano DV, Shapeton A. Diagnosis and Management of Vasoplegia in Temporary Mechanical Circulatory Support: A Narrative Review. J Cardiothorac Vasc Anesth. 2024 Jun;38(6):1378-1389. doi: 10.1053/j.jvca.2024.02.028. Epub 2024 Feb 23. PMID: 38490900.
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Managing Post-Op Bleeding (06/12/24)

Kleinveld DJB, Curry N, Levy JH. Coagulation support during perioperative bleeding management. Intensive Care Med. 2023 Sep;49(9):1110-1113. doi: 10.1007/s00134-023-07089-6. Epub 2023 May 13. PMID: 37178147; PMCID: PMC10499712.
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Is esophageal manometry ready for prime time? (06/11/24)

Piquilloud L, Beitler JR, Beloncle FM. Monitoring esophageal pressure. Intensive Care Med. 2024 Jun;50(6):953-956. doi: 10.1007/s00134-024-07401-y. Epub 2024 Apr 11. PMID: 38602514.
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Balloon Pump Goodies (06/10/24)

Parissis H, Graham V, Lampridis S, Lau M, Hooks G, Mhandu PC. IABP: history-evolution-pathophysiology-indications: what we need to know. J Cardiothorac Surg. 2016 Aug 4;11(1):122. doi: 10.1186/s13019-016-0513-0. PMID: 27487772; PMCID: PMC4972967.
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Managing Patients with Heart Failure (06/09/24)

Beghini A, Sammartino AM, Papp Z, von Haehling S, Biegus J, Ponikowski P, Adamo M, Falco L, Lombardi CM, Pagnesi M, Savarese G, Metra M, Tomasoni D. 2024 update in heart failure. ESC Heart Fail. 2024 May 28. doi: 10.1002/ehf2.14857. Epub ahead of print. PMID: 38806171.
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Cardiac Arrest + ECMO = eCPR (06/08/24)

Tonna JE, Cho SM. Extracorporeal Cardiopulmonary Resuscitation. Crit Care Med. 2024 Jun 1;52(6):963-973. doi: 10.1097/CCM.0000000000006185. Epub 2024 Jan 15. PMID: 38224260; PMCID: PMC11098703.
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Managing Cardiogenic Shock due to Heart Failure (06/07/24)

Williams S, Kalakoutas A, Olusanya S, Schrage B, Tavazzi G, Carnicelli AP, Montero S, Vandenbriele C, Luk A, Lim HS, Bhagra S, Ott SC, Farrero M, Samsky MD, Kennedy JLW, Sen S, Agrawal R, Rampersad P, Coniglio A, Pappalardo F, Barnett C, Proudfoot AG. The management of heart failure cardiogenic shock: an international RAND appropriateness panel. Crit Care. 2024 Apr 2;28(1):105. doi: 10.1186/s13054-024-04884-5. PMID: 38566212; PMCID: PMC10988801.
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Cardiac Arrest Duration (06/06/24)

Okubo M, Komukai S, Andersen LW, Berg RA, Kurz MC, Morrison LJ, Callaway CW; American Heart Association’s Get With The Guidelines—Resuscitation Investigators. Duration of cardiopulmonary resuscitation and outcomes for adults with in-hospital cardiac arrest: retrospective cohort study. BMJ. 2024 Feb 7;384:e076019. doi: 10.1136/bmj-2023-076019. Erratum in: BMJ. 2024 Apr 18;385:q900. PMID: 38325874; PMCID: PMC10847985.
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Avoid the vent with non-invasive ventilation (06/05/24)

Ferreyro BL, De Jong A, Grieco DL. How to use facemask noninvasive ventilation. Intensive Care Med. 2024 May 27. doi: 10.1007/s00134-024-07471-y. Epub ahead of print. PMID: 38801519.
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Obesity and ICU Nutrition (06/04/24)

Dickerson RN, Andromalos L, Brown JC, Correia MITD, Pritts W, Ridley EJ, Robinson KN, Rosenthal MD, van Zanten ARH. Obesity and critical care nutrition: current practice gaps and directions for future research. Crit Care. 2022 Sep 20;26(1):283. doi: 10.1186/s13054-022-04148-0. Erratum in: Crit Care. 2023 May 8;27(1):177. PMID: 36127715; PMCID: PMC9486775.
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Magnesium and Cardiac Arrest (06/03/24)

Liu B, Li M, Wang J, Zhang F, Wang F, Jin C, Li J, Wang Y, Sanderson TH, Zhang R. The role of magnesium in cardiac arrest. Front Nutr. 2024 May 15;11:1387268. doi: 10.3389/fnut.2024.1387268. PMID: 38812935; PMCID: PMC11133868.
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Pulmonary Emboli Management in the ICU (06/02/24)

McGuire WC, Sullivan L, Odish MF, Desai B, Morris TA, Fernandes TM, Management Strategies for Acute Pulmonary Embolism in the Intensive Care Unit, CHEST (2024), doi: https://doi.org/10.1016/j.chest.2024.04.032.
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Tidal Volume and ARDS (06/01/24)

Pellegrini M, Del Sorbo L, Ranieri VM. Finding the optimal tidal volume in acute respiratory distress syndrome. Intensive Care Med. 2024 May 13. doi: 10.1007/s00134-024-07440-5. Epub ahead of print. PMID: 38740616.
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Hemodynamics and Volume Status (05/31/24)

De Backer D, Aissaoui N, Cecconi M, Chew MS, Denault A, Hajjar L, Hernandez G, Messina A, Myatra SN, Ostermann M, Pinsky MR, Teboul JL, Vignon P, Vincent JL, Monnet X. How can assessing hemodynamics help to assess volume status? Intensive Care Med. 2022 Oct;48(10):1482-1494. doi: 10.1007/s00134-022-06808-9. Epub 2022 Aug 10. PMID: 35945344; PMCID: PMC9363272.
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Will AI be managing our vents? (05/30/24)

Zwerwer LR, van der Pol S, Zacharowski K, Postma MJ, Kloka J, Friedrichson B, van Asselt ADI. The value of artificial intelligence for the treatment of mechanically ventilated intensive care unit patients: An early health technology assessment. J Crit Care. 2024 Apr 6;82:154802. doi: 10.1016/j.jcrc.2024.154802. Epub ahead of print. PMID: 38583302.
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Podcast Episode on Spotify
Immunotherapy is the future of sepsis (05/29/24)

Slim MA, van Mourik N, Bakkerus L, Fuller K, Acharya L, Giannidis T, Dionne JC, Oczkowski SJW, Netea MG, Pickkers P, Giamarellos-Bourboulis EJ, Müller MCA, van der Poll T, Wiersinga WJ; ImmunoSep Consortium; Vlaar APJ, van Vught LA. Towards personalized medicine: a scoping review of immunotherapy in sepsis. Crit Care. 2024 May 28;28(1):183. doi: 10.1186/s13054-024-04964-6. PMID: 38807151.
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ARDS and the gut microbiome (05/28/24)

Ziaka M, Exadaktylos A. Exploring the lung-gut direction of the gut-lung axis in patients with ARDS. Crit Care. 2024 May 27;28(1):179. doi: 10.1186/s13054-024-04966-4. PMID: 38802959.
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Do you use checklists in your daily practice? (05/25/24)

Erikson EJ, Edelman DA, Brewster FM, Marshall SD, Turner MC, Sarode VV, Brewster DJ. The use of checklists in the intensive care unit: a scoping review. Crit Care. 2023 Nov 30;27(1):468. doi: 10.1186/s13054-023-04758-2. PMID: 38037056; PMCID: PMC10691022.
https://doi.org/10.1186/s13054-023-04758-2
https://ccforum.biomedcentral.com/counter/pdf/10.1186/s13054-023-04758-2.pdf

Sepsis-induced thrombocytopenia (05/24/24)

Leone M, Nielsen ND, Russell L. Ten tips on sepsis-induced thrombocytopenia. Intensive Care Med. 2024 May 13. doi: 10.1007/s00134-024-07478-5. Epub ahead of print. PMID: 38739278.
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Renin: how could it help us manage ICU patients (05/23/24)

Kotani, Y., Chappell, M., Landoni, G. et al. Renin in critically ill patients. Ann. Intensive Care 14, 79 (2024). https://doi.org/10.1186/s13613-024-01304-3
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Don’t ignore the base deficit/base excess (05/20/24)

Zander R. Base excess (BE): reloaded. Eur J Med Res. 2024 May 12;29(1):281. doi: 10.1186/s40001-024-01796-6. PMID: 38735983; PMCID: PMC11089692.
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This article was discovered thanks to Rob Mac Sweeney’s Weekly Newsletter.

2021 Surviving Sepsis Guidelines (05/19/24)

Evans L, Rhodes A, Alhazzani W, Antonelli M, Coopersmith CM, French C, Machado FR, Mcintyre L, Ostermann M, Prescott HC, Schorr C, Simpson S, Wiersinga WJ, Alshamsi F, Angus DC, Arabi Y, Azevedo L, Beale R, Beilman G, Belley-Cote E, Burry L, Cecconi M, Centofanti J, Coz Yataco A, De Waele J, Dellinger RP, Doi K, Du B, Estenssoro E, Ferrer R, Gomersall C, Hodgson C, Møller MH, Iwashyna T, Jacob S, Kleinpell R, Klompas M, Koh Y, Kumar A, Kwizera A, Lobo S, Masur H, McGloughlin S, Mehta S, Mehta Y, Mer M, Nunnally M, Oczkowski S, Osborn T, Papathanassoglou E, Perner A, Puskarich M, Roberts J, Schweickert W, Seckel M, Sevransky J, Sprung CL, Welte T, Zimmerman J, Levy M. Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021. Intensive Care Med. 2021 Nov;47(11):1181-1247. doi: 10.1007/s00134-021-06506-y. Epub 2021 Oct 2. PMID: 34599691; PMCID: PMC8486643.
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ECMO and Ethics (05/18/24)

SchouSchou A, Mølgaard J, Andersen LW, Holm S, Sørensen M. Ethics in extracorporeal life support: a narrative review. Crit Care. 2021 Jul 21;25(1):256. doi: 10.1186/s13054-021-03689-0. PMID: 34289885; PMCID: PMC8293515.
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Fluid Challenges by Louis Vincent (05/17/24)

Vincent JL, Cecconi M, De Backer D. The fluid challenge. Crit Care. 2020 Dec 28;24(1):703. doi: 10.1186/s13054-020-03443-y. PMID: 33371895; PMCID: PMC7771055.
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Diuretics in the ICU (05/16/24)

Ostermann M, Awdishu L, Legrand M. Using diuretic therapy in the critically ill patient. Intensive Care Med. 2024 May 2. doi: 10.1007/s00134-024-07441-4. Epub ahead of print. PMID: 38695931.
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Placing central lines (05/15/24)

Saugel B, Scheeren TWL, Teboul JL. Ultrasound-guided central venous catheter placement: a structured review and recommendations for clinical practice. Crit Care. 2017 Aug 28;21(1):225. doi: 10.1186/s13054-017-1814-y. PMID: 28844205; PMCID: PMC5572160.
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Managing Acute Pancreatitis (05/14/24)

Finkenstedt A, Jaber S, Joannidis M. Ten tips to manage severe acute pancreatitis in an intensive care unit. Intensive Care Med. 2023 Sep;49(9):1127-1130. doi: 10.1007/s00134-023-07121-9. Epub 2023 Jun 30. PMID: 37389603.
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Sorting out Post-Resuscitation Shock (05/13/24)

Jozwiak M, Bougouin W, Geri G, Grimaldi D, Cariou A. Post-resuscitation shock: recent advances in pathophysiology and treatment. Ann Intensive Care. 2020 Dec 14;10(1):170. doi: 10.1186/s13613-020-00788-z. PMID: 33315152; PMCID: PMC7734609.
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Happy Mother’s Day! (05/12/24)

No article today as I took the morning off.

Monitoring Hemodynamics in Cardiogenic Shock (05/11/24)

Hamzaoui O, Boissier F. Hemodynamic monitoring in cardiogenic shock. J Intensive Med. 2022 Dec 5;3(2):104-113. doi: 10.1016/j.jointm.2022.10.003. PMID: 37188114; PMCID: PMC10175734.
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Management and Prevention of Anemia in the ICU (05/10/24)

Lasocki S, Pène F, Ait-Oufella H, Aubron C, Ausset S, Buffet P, Huet O, Launey Y, Legrand M, Lescot T, Mekontso Dessap A, Piagnerelli M, Quintard H, Velly L, Kimmoun A, Chanques G. Management and prevention of anemia (acute bleeding excluded) in adult critical care patients. Ann Intensive Care. 2020 Jul 22;10(1):97. doi: 10.1186/s13613-020-00711-6. PMID: 32700082; PMCID: PMC7374293.
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An elevated lactate should not be met with a fluid bolus (05/09/24)

Legrand M, van der Horst ICC, De Jong A. Serial lactate measurements to guide resuscitation: more evidence not to? Intensive Care Med. 2024 May;50(5):728-730. doi: 10.1007/s00134-024-07411-w. Epub 2024 Apr 18. PMID: 38635045.
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Link to my post on Lactate in the Critically Ill

Learning the Intra-aortic balloon pump (05/08/24)

Lauren E. Gillespie, Bennett H. Lane, Christopher R. Shaw, Kari Gorder, Anne Grisoli, Matthew Lavallee, Olivia Gobble, Jacqueline Vidosh, Diana Deimling, Saad Ahmad, William R. Hinckley, Christine M. Brent, Michael J. Lauria, Adam L. Gottula. The Intra-aortic Balloon Pump: A Focused Review of Physiology, Transport Logistics, Mechanics, and Complications. Journal of the Society for Cardiovascular Angiography & Interventions. VOLUME 3, ISSUE 5, 101337, MAY 2024.
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Bandemia in the CBC (05/07/24)

Prasanna N, DelPrete B, Ho G, Yamane D, Elshikh A, Rashed A, Sparks A, Davison D, Hawkins K. The utility of bandemia in prognostication and prediction of mortality in sepsis. J Intensive Care Soc. 2023 May;24(2):201-205. doi: 10.1177/17511437211069307. Epub 2022 Jan 28. PMID: 37260424; PMCID: PMC10227906.
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ARDS: Tackle the Vent and Hemodynamics (05/06/24)

Chiumello D, Fioccola A. Recent advances in cardiorespiratory monitoring in acute respiratory distress syndrome patients. J Intensive Care. 2024 May 5;12(1):17. doi: 10.1186/s40560-024-00727-1. PMID: 38706001.
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Albumin in the ICU (05/05/24)

Melia D, Post B. Human albumin solutions in intensive care: A review. J Intensive Care Soc. 2021 Aug;22(3):248-254. doi: 10.1177/1751143720961245. Epub 2020 Sep 30. PMID: 34422108; PMCID: PMC8373284.
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Managing Seizures in the ICU (05/04/24)

Boggs JG. Seizure Management in the Intensive Care Unit. Curr Treat Options Neurol. 2021;23(11):36. doi: 10.1007/s11940-021-00692-2. Epub 2021 Oct 21. PMID: 34697528; PMCID: PMC8528936.
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Unnecessary Daily Chest X-rays (05/03/24)

Keveson B, Clouser RD, Hamlin MP, Stevens P MSN, RN, Stinnett-Donnelly JM, Allen GB. Adding value to daily chest X-rays in the ICU through education, restricted daily orders and indication-based prompting. BMJ Open Qual. 2017 Nov 25;6(2):e000072. doi: 10.1136/bmjoq-2017-000072. PMID: 29435503; PMCID: PMC5717964.
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Let’s get better at IV Fluids (05/02/24)

Malbrain MLNG, Caironi P, Hahn RG, Llau JV, McDougall M, Patrão L, Ridley E, Timmins A. Multidisciplinary expert panel report on fluid stewardship: perspectives and practice. Ann Intensive Care. 2023 Sep 25;13(1):89. doi: 10.1186/s13613-023-01177-y. PMID: 37747558; PMCID: PMC10519908.
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de novo Heart Failure Cardiogenic Shock (04/30/24)

Bhatt AS, Berg DD, Bohula EA, Alviar CL, Baird-Zars VM, Barnett CF, Burke JA, Carnicelli AP, Chaudhry SP, Daniels LB, Fang JC, Fordyce CB, Gerber DA, Guo J, Jentzer JC, Katz JN, Keller N, Kontos MC, Lawler PR, Menon V, Metkus TS, Nativi-Nicolau J, Phreaner N, Roswell RO, Sinha SS, Jeffrey Snell R, Solomon MA, Van Diepen S, Morrow DA. De Novo vs Acute-on-Chronic Presentations of Heart Failure-Related Cardiogenic Shock: Insights from the Critical Care Cardiology Trials Network Registry. J Card Fail. 2021 Oct;27(10):1073-1081. doi: 10.1016/j.cardfail.2021.08.014. PMID: 34625127; PMCID: PMC8514080.
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Mechanical Support for Pulmonary Embolism (04/29/24)

Kadri, Amer N., Razan Alrawashdeh, Mohamad K. Soufi, Adam J. Elder, Zachary Elder, Tamam Mohamad, Eric Gnall, and Mahir Elder. 2024. “Mechanical Support in High-Risk Pulmonary Embolism: Review Article” Journal of Clinical Medicine 13, no. 9: 2468. https://doi.org/10.3390/jcm13092468
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Let’s get the patients we can’t fix home (04/28/24)

Sudunagunta V, Singh N, Khan P, Beaumont PO. End of life care at home: The role of critical care transfer services. Journal of the Intensive Care Society. 2023;0(0). doi:10.1177/17511437231217878
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Anticoagulation for CRRT (04/27/24)

Zhou Z, Liu C, Yang Y, Wang F, Zhang L, Fu P. Anticoagulation options for continuous renal replacement therapy in critically ill patients: a systematic review and network meta-analysis of randomized controlled trials. Crit Care. 2023 Jun 7;27(1):222. doi: 10.1186/s13054-023-04519-1. PMID: 37287084; PMCID: PMC10249230.
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Why do our ICU patients become malnourished? (04/26/24)

Moisey LL, Merriweather JL, Drover JW. The role of nutrition rehabilitation in the recovery of survivors of critical illness: underrecognized and underappreciated. Crit Care. 2022 Sep 8;26(1):270. doi: 10.1186/s13054-022-04143-5. PMID: 36076215; PMCID: PMC9461151.
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Mechanical Circulatory Support for Cardiogenic Shock from Valvular Issues (04/25/24)

Eftychiou S, Kalakoutas A, Proudfoot A. The role of temporary mechanical circulatory support in de novoheart failure syndromes with cardiogenic shock: A contemporary review. J Intensive Med. 2022 Nov 29;3(2):89-103. doi: 10.1016/j.jointm.2022.10.002. PMID: 37188124; PMCID: PMC10175707.
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Land the plane on VA-ECMO Patients (04/24/24)

Charbonneau F, Chahinian K, Bebawi E, Lavigueur O, Lévesque É, Lamarche Y, Serri K, Albert M, Noly PE, Cournoyer A, Cavayas YA. Parameters associated with successful weaning of veno-arterial extracorporeal membrane oxygenation: a systematic review. Crit Care. 2022 Dec 5;26(1):375. doi: 10.1186/s13054-022-04249-w. PMID: 36471408; PMCID: PMC9724323.
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Understanding Breathing (04/23/24)

Georgopoulos, D., Bolaki, M., Stamatopoulou, V. et al. Respiratory drive: a journey from health to disease. j intensive care 12, 15 (2024). https://doi.org/10.1186/s40560-024-00731-5
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Acute-on-chronic liver failure (04/22/24)

Luo J, Li J, Li P, Liang X, Hassan HM, Moreau R, Li J. Acute-on-chronic liver failure: far to go-a review. Crit Care. 2023 Jul 1;27(1):259. doi: 10.1186/s13054-023-04540-4. PMID: 37393351; PMCID: PMC10315037.
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ICU admission criteria (04/21/24)

Soares J, Leung C, Campbell V, Van Der Vegt A, Malycha J, Andersen C. Intensive care unit admission criteria: a scoping review. Journal of the Intensive Care Society. 2024;0(0). doi:10.1177/17511437241246901
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90% of Clinicians will use a PIV to start vasopressors (04/20/24)

Munroe ES, Weinstein J, Gershengorn HB, Karlic KJ, Seelye S, Sjoding MW, Valley TS, Prescott HC. Understanding How Clinicians Personalize Fluid and Vasopressor Decisions in Early Sepsis Management. JAMA Netw Open. 2024 Apr 1;7(4):e247480. doi: 10.1001/jamanetworkopen.2024.7480. PMID: 38639934.
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Norepinephrine Goodies (04/19/24)

Kattan E, Ibarra-Estrada M, Jung C. Knowing the ropes of vasopressor dosing: a focus on norepinephrine. Intensive Care Med. 2024 Apr;50(4):587-589. doi: 10.1007/s00134-024-07374-y. Epub 2024 Mar 18. PMID: 38498164; PMCID: PMC11018687.
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Atypical Cannulation strategies for ECMO (04/18/24)

Anthony Calhoun CPP , Christopher Szabo MD , David Convissar MD , Dominic V. Pisano MD , Jamel Ortoleva MD, FASE , Beyond Venoarterial and Venovenous ECMO: Novel Cannulation Strategies, Journal of Cardiothoracic and Vascular Anesthesia (2024)
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The Sepsis Chain starts Prehospital (04/17/24)

Jouffroy R, Djossou F, Neviere R, Jaber S, Vivien B, Heming N, Gueye P. The chain of survival and rehabilitation for sepsis: concepts and proposals for healthcare trajectory optimization. Ann Intensive Care. 2024 Apr 16;14(1):58. doi: 10.1186/s13613-024-01282-6. PMID: 38625453.
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LVAD Emergency Algorithm (04/16/24)

Akhtar W, Baston VR, Berman M, Bhagra S, Chue C, Deakin CD, Dalzell JR, Dunning J, Dunning J, Gardner RS, Kiff K, Kore S, Lim S, MacGowan G, Naldrett I, Ostermann M, Pinto S, Pettit S, Gil FR, Rosenberg A, Rubino A, Sayeed R, Sequeira J, Swanson N, Tsui S, Walker C, Webb S, Woods A, Ventkateswaran R, Bowles CT. British societies guideline on the management of emergencies in implantable left ventricular assist device recipients in transplant centres. Intensive Care Med. 2024 Apr;50(4):493-501. doi: 10.1007/s00134-024-07382-y. Epub 2024 Mar 25. PMID: 38526578.
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Pulmonary Hypertension and Right Heart Failure in the ICU (04/15/24)

Vaidy A, O’Corragain O, Vaidya A. Diagnosis and Management of Pulmonary Hypertension and Right Ventricular Failure in the Cardiovascular Intensive Care Unit. Crit Care Clin. 2024 Jan;40(1):121-135. doi: 10.1016/j.ccc.2023.05.003. Epub 2023 Sep 7. PMID: 37973349.
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Defining Massive Transfusion (04/14/24)

Lin VS, Sun E, Yau S, Abeyakoon C, Seamer G, Bhopal S, Tucker H, Doree C, Brunskill SJ, McQuilten ZK, Stanworth SJ, Wood EM, Green L. Definitions of massive transfusion in adults with critical bleeding: a systematic review. Crit Care. 2023 Jul 5;27(1):265. doi: 10.1186/s13054-023-04537-z. PMID: 37407998; PMCID: PMC10324127.
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Personalized Nutrition for ICU Patients (04/13/24)

Wischmeyer PE, Bear DE, Berger MM, De Waele E, Gunst J, McClave SA, Prado CM, Puthucheary Z, Ridley EJ, Van den Berghe G, van Zanten ARH. Personalized nutrition therapy in critical care: 10 expert recommendations. Crit Care. 2023 Jul 4;27(1):261. doi: 10.1186/s13054-023-04539-x. PMID: 37403125; PMCID: PMC10318839.
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High-sensitivity Troponin (04/12/24)

Krychtiuk KA, Newby LK. High-Sensitivity Cardiac Troponin Assays: Ready for Prime Time! Annu Rev Med. 2024 Jan 29;75:459-474. doi: 10.1146/annurev-med-051022-113931. Epub 2023 Sep 18. PMID: 37722708.
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Determining a definitive strategy for Peripheral Vasopressors (04/11/24)

Evangelia Samara MD , Petros G. Tzimas , Mohamed R. El Tahan MD. How to “endgame” the safe peripheral vasopressor administration. J Cardiothorac Vasc Anesth. 2024 Apr;36(7):2228-2231. doi:10.1053/j.jvca.2024.04.004.
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Bicarb (04/10/24)

Coppola S, Caccioppola A, Froio S, Chiumello D. Sodium Bicarbonate in Different Critically Ill Conditions: From Physiology to Clinical Practice. Anesthesiology. 2021 May 1;134(5):774-783. doi: 10.1097/ALN.0000000000003733. PMID: 33721887.
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Too much IV Fluids is Not Benign (04/09/24)

Hofer DM, Ruzzante L, Waskowski J, Messmer AS, Pfortmueller CA. Influence of fluid accumulation on major adverse kidney events in critically ill patients – an observational cohort study. Ann Intensive Care. 2024 Apr 8;14(1):52. doi: 10.1186/s13613-024-01281-7. PMID: 38587575.
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Nasal High-Flow Oxygen (04/08/24)

Roca O, Li J, Mauri T. High-flow nasal cannula: evolving practices and novel clinical and physiological insights. Intensive Care Med. 2024 Apr 4. doi: 10.1007/s00134-024-07386-8. Epub ahead of print. PMID: 38573402.
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Starting respiratory support in the ED (04/07/24)

Noninvasive respiratory support in the emergency department: Controversies and state-of-the-art recommendations. Mosier JM, Tidswell M, Wang HE. Noninvasive respiratory support in the emergency department: Controversies and state-of-the-art recommendations. J Am Coll Emerg Physicians Open. 2024 Mar 7;5(2):e13118. doi: 10.1002/emp2.13118. PMID: 38464331; PMCID: PMC10920951.
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Vasopressin in Septic Shock: 0.03 or 0.04 U/min? (04/06/24)

Bauer SR, Sacha GL, Lam SW, Wang L, Reddy AJ, Duggal A, Vachharajani V. Hemodynamic Response to Vasopressin Dosage of 0.03 Units/Min vs. 0.04 Units/Min in Patients With Septic Shock. J Intensive Care Med. 2022 Jan;37(1):92-99. doi: 10.1177/0885066620977181. Epub 2020 Nov 28. PMID: 33251906; PMCID: PMC10243460.
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Loop Diuretics and Heart Failure (04/05/24)

Diuretic Treatment in Patients with Heart Failure: Current Evidence and Future Directions – Part I: Loop Diuretics. Cuthbert JJ, Clark AL. Diuretic Treatment in Patients with Heart Failure: Current Evidence and Future Directions – Part I: Loop Diuretics. Curr Heart Fail Rep. 2024 Apr;21(2):101-114. doi: 10.1007/s11897-024-00643-3. Epub 2024 Jan 19. PMID: 38240883; PMCID: PMC10924023.
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Mitral Regurgitation (04/04/24)

Duncan CF, Bowcock E, Pathan F, Orde SR. Mitral regurgitation in the critically ill: the devil is in the detail. Ann Intensive Care. 2023 Aug 2;13(1):67. doi: 10.1186/s13613-023-01163-4. PMID: 37530859; PMCID: PMC10397171.
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Postoperative Atrial Fibrillation in Cardiac Surgery Patients (04/03/24)

Suero OR, Ali AK, Barron LR, Segar MW, Moon MR, Chatterjee S. Postoperative atrial fibrillation (POAF) after cardiac surgery: clinical practice review. J Thorac Dis. 2024 Feb 29;16(2):1503-1520. doi: 10.21037/jtd-23-1626. Epub 2024 Feb 23. PMID: 38505057; PMCID: PMC10944787.
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Is anyone still doing 33 for everyone? (04/02/24)

Granfeldt A, Holmberg MJ, Nolan JP, Soar J, Andersen LW; International Liaison Committee on Resuscitation ILCOR Advanced Life Support Task Force. Temperature control after adult cardiac arrest: An updated systematic review and meta-analysis. Resuscitation. 2023 Oct;191:109928. doi: 10.1016/j.resuscitation.2023.109928. Epub 2023 Aug 7. Erratum in: Resuscitation. 2024 Jan;194:110052. PMID: 37558083.
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NAC in Non-APAP Acute Liver Failure (04/01/24)

Popescu M, Bratu A, Agapie M, Borjog T, Jafal M, Sima R-M, Orban C. The Use and Potential Benefits of N-Acetylcysteine in Non-Acetaminophen Acute Liver Failure: An Etiology-Based Review. Biomedicines. 2024; 12(3):676. https://doi.org/10.3390/biomedicines12030676
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Classify Cardiogenic Shock (03/31/24)

Laghlam D, Benghanem S, Ortuno S, Bouabdallaoui N, Manzo-Silberman S, Hamzaoui O, Aissaoui N. Management of cardiogenic shock: a narrative review. Ann Intensive Care. 2024 Mar 30;14(1):45. doi: 10.1186/s13613-024-01260-y. PMID: 38553663.
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Acute Mesenteric Ischemia (03/30/24)

Reintam Blaser A, Coopersmith CM, Acosta S. Managing acute mesenteric ischaemia. Intensive Care Med. 2024 Mar 13. doi: 10.1007/s00134-024-07363-1. Epub ahead of print. PMID: 38478026.
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Midlines vs. PICCs (03/29/24)

Thomsen SL, Boa R, Vinter-Jensen L, Rasmussen BS. Safety and Efficacy of Midline vs Peripherally Inserted Central Catheters Among Adults Receiving IV Therapy: A Randomized Clinical Trial. JAMA Netw Open. 2024 Feb 5;7(2):e2355716. doi: 10.1001/jamanetworkopen.2023.55716. PMID: 38349655; PMCID: PMC10865154.
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Diagnose Heparin-Induced Thrombocytopenia Better (03/28/24)

Larsen EL, Nilius H, Studt JD, Tsakiris DA, Greinacher A, Mendez A, Schmidt A, Wuillemin WA, Gerber B, Vishnu P, Graf L, Kremer Hovinga JA, Goetze JP, Bakchoul T, Nagler M. Accuracy of Diagnosing Heparin-Induced Thrombocytopenia. JAMA Netw Open. 2024 Mar 4;7(3):e243786. doi: 10.1001/jamanetworkopen.2024.3786. PMID: 38530310; PMCID: PMC10966416.
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Fluid Responsiveness (03/27/24)

Alvarado Sánchez JI, Caicedo Ruiz JD, Diaztagle Fernández JJ, Cruz Martínez LE, Carreño Hernández FL, Santacruz Herrera CA, Ospina-Tascón GA. Variables influencing the prediction of fluid responsiveness: a systematic review and meta-analysis. Crit Care. 2023 Sep 20;27(1):361. doi: 10.1186/s13054-023-04629-w. PMID: 37730622; PMCID: PMC10510289.
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Link to my post on End-Expiratory Occlusion Pressure

Dobutamine vs. Milrinone in Cardiogenic Shock (03/26/24)

Abdel-Razek O, Di Santo P, Jung RG, Parlow S, Motazedian P, Prosperi-Porta G, Visintini S, Marbach JA, Ramirez FD, Simard T, Labinaz M, Mathew R, Hibbert B. Efficacy of Milrinone and Dobutamine in Cardiogenic Shock: An Updated Systematic Review and Meta-Analysis. Crit Care Explor. 2023 Aug 28;5(9):e0962. doi: 10.1097/CCE.0000000000000962. PMID: 37649849; PMCID: PMC10465094.
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Bad breath and ARDS (03/25/24)

Zhang S, Hagens LA, Heijnen NFL, Smit MR, Brinkman P, Fenn D, van der Poll T, Schultz MJ, Bergmans DCJJ, Schnabel RM, Bos LDJ; DARTS Consortium. Breath metabolomics for diagnosis of acute respiratory distress syndrome. Crit Care. 2024 Mar 23;28(1):96. doi: 10.1186/s13054-024-04882-7. PMID: 38521944.
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Vascular Leak in Sepsis (03/24/24)

McMullan, R.R., McAuley, D.F., O’Kane, C.M. et al. Vascular leak in sepsis: physiological basis and potential therapeutic advances. Crit Care 28, 97 (2024). https://doi.org/10.1186/s13054-024-04875-6
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Adrenal Insufficiency (03/23/24)

Charoensri S, Auchus RJ. A Contemporary Approach to the Diagnosis and Management of Adrenal Insufficiency. Endocrinol Metab (Seoul). 2024 Feb;39(1):73-82. doi: 10.3803/EnM.2024.1894. Epub 2024 Jan 22. PMID: 38253474; PMCID: PMC10901672.
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Sepsis-associated AKI (03/22/24)

Legrand, M., Bagshaw, S.M., Bhatraju, P.K. et al. Sepsis-associated acute kidney injury: recent advances in enrichment strategies, sub-phenotyping and clinical trials. Crit Care28, 92 (2024). https://doi.org/10.1186/s13054-024-04877-4
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Fluid responsive BUT ALSO with venous congestion? (03/21/24)

Muñoz F, Born P, Bruna M, Ulloa R, González C, Philp V, Mondaca R, Blanco JP, Valenzuela ED, Retamal J, Miralles F, Wendel-Garcia PD, Ospina-Tascón GA, Castro R, Rola P, Bakker J, Hernández G, Kattan E. Coexistence of a fluid responsive state and venous congestion signals in critically ill patients: a multicenter observational proof-of-concept study. Crit Care. 2024 Feb 19;28(1):52. doi: 10.1186/s13054-024-04834-1. PMID: 38374167; PMCID: PMC10877871.
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I took a hiatus for my birthday (03/19 & 3/20/24)

Propofol > Versed, but still not perfect (03/18/24)

van Gelder TG, van Diem-Zaal IJ, Dijkstra-Kersten SMA, de Mul N, Lalmohamed A, Slooter AJC. The risk of delirium after sedation with propofol or midazolam in intensive care unit patients. Br J Clin Pharmacol. 2024 Mar 14. doi: 10.1111/bcp.16031. Epub ahead of print. PMID: 38482541.
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Hypercapnia (03/17/24)

Tregidgo L, D’Cruz RF. Supporting patients with hypercapnia. Clin Med (Lond). 2024 Jan;24(1):100007. doi: 10.1016/j.clinme.2023.100007. Epub 2024 Jan 18. PMID: 38382181.
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Survey Says…. (03/14/24)

Scheeren TWL, Bakker J, De Backer D, Annane D, Asfar P, Boerma EC, Cecconi M, Dubin A, Dünser MW, Duranteau J, Gordon AC, Hamzaoui O, Hernández G, Leone M, Levy B, Martin C, Mebazaa A, Monnet X, Morelli A, Payen D, Pearse R, Pinsky MR, Radermacher P, Reuter D, Saugel B, Sakr Y, Singer M, Squara P, Vieillard-Baron A, Vignon P, Vistisen ST, van der Horst ICC, Vincent JL, Teboul JL. Current use of vasopressors in septic shock. Ann Intensive Care. 2019 Jan 30;9(1):20. doi: 10.1186/s13613-019-0498-7. PMID: 30701448; PMCID: PMC6353977.
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Vasopressor Tables 01 (03/13/24)

Overgaard CB, Dzavík V. Inotropes and vasopressors: review of physiology and clinical use in cardiovascular disease. Circulation. 2008 Sep 2;118(10):1047-56. doi: 10.1161/CIRCULATIONAHA.107.728840. PMID: 18765387.
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Pacing Wires in Cardiac Surgery Patients (03/12/24)

Waqanivavalagi SWFR. Temporary pacing following cardiac surgery – a reference guide for surgical teams. J Cardiothorac Surg. 2024 Mar 11;19(1):115. doi: 10.1186/s13019-024-02619-9. PMID: 38468357.
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PO rather than IV fluids for resuscitation? (03/11/24)

Keil N, Rathkolb V, Waller M, Krenn S, Hinterholzer G, Druml W, Hiesmayr M, Schmaldienst S, Hecking M. Challenging the common practice of intravenous fluid administration : Viewpoint on the need for an enteral fluid therapy trial in critically ill patients. Wien Klin Wochenschr. 2024 Mar 8. doi: 10.1007/s00508-024-02335-3. Epub ahead of print. PMID: 38456939.
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Selenium for Cardiac Surgery Patients (03/10/24)

Stoppe C, McDonald B, Meybohm P, Christopher KB, Fremes S, Whitlock R, Mohammadi S, Kalavrouziotis D, Elke G, Rossaint R, Helmer P, Zacharowski K, Günther U, Parotto M, Niemann B, Böning A, Mazer CD, Jones PM, Ferner M, Lamarche Y, Lamontagne F, Liakopoulos OJ, Cameron M, Müller M, Zarbock A, Wittmann M, Goetzenich A, Kilger E, Schomburg L, Day AG, Heyland DK; SUSTAIN CSX Study Collaborators. Effect of High-Dose Selenium on Postoperative Organ Dysfunction and Mortality in Cardiac Surgery Patients: The SUSTAIN CSX Randomized Clinical Trial. JAMA Surg. 2023 Mar 1;158(3):235-244. doi: 10.1001/jamasurg.2022.6855. PMID: 36630120; PMCID: PMC9857635.
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Arterial line complications (03/09/24)

Schults, J.A., Young, E.R., Marsh, N. et al. Risk factors for arterial catheter failure and complications during critical care hospitalisation: a secondary analysis of a multisite, randomised trial. j intensive care 12, 12 (2024). https://doi.org/10.1186/s40560-024-00719-1
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Should every sepsis patient be treated the same? Nope. (03/08/24)

Vincent JL, van der Poll T, Marshall JC. The End of “One Size Fits All” Sepsis Therapies: Toward an Individualized Approach. Biomedicines. 2022 Sep 12;10(9):2260. doi: 10.3390/biomedicines10092260. PMID: 36140361; PMCID: PMC9496597.
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MAP/Norepinephrine-equivalent Dose Index (03/07/24)

Yang J, Zou X, Wang R, Kang Y, Ou X, Wang B. MEAN ARTERIAL PRESSURE/NOREPINEPHRINE EQUIVALENT DOSE INDEX AS AN EARLY MEASURE FOR MORTALITY RISK IN PATIENTS WITH SHOCK ON VASOPRESSORS. Shock. 2024 Feb 1;61(2):253-259. doi: 10.1097/SHK.0000000000002298. Epub 2023 Dec 29. PMID: 38157472.
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Do the IV fluids we provide patients destroy the glycocalyx? (03/06/24)

Sukudom S, Smart L, Macdonald S. Association between intravenous fluid administration and endothelial glycocalyx shedding in humans: a systematic review. Intensive Care Med Exp. 2024 Feb 26;12(1):16. doi: 10.1186/s40635-024-00602-1. PMID: 38403742; PMCID: PMC10894789.
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AI and hemodynamic monitoring (03/05/24)

Myatra SN, Jagiasi BG, Singh NP, Divatia JV. Role of artificial intelligence in haemodynamic monitoring. Indian J Anaesth. 2024 Jan;68(1):93-99. doi: 10.4103/ija.ija_1260_23. Epub 2024 Jan 18. PMID: 38406336; PMCID: PMC10893816.
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Levosimendan in Septic Shock (03/04/24)

Ge Z, Gao Y, Lu X, Yu S, Qin M, Gong C, Walline JH, Zhu H, Li Y. The association between levosimendan and mortality in patients with sepsis or septic shock: a systematic review and meta-analysis. Eur J Emerg Med. 2024 Apr 1;31(2):90-97. doi: 10.1097/MEJ.0000000000001105. Epub 2023 Nov 27. PMID: 38015719; PMCID: PMC10901220.
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Cognitive issues post-ICU stay (03/03/24)

Liu K, Tronstad O, Flaws D, Churchill L, Jones AYM, Nakamura K, Fraser JF. From bedside to recovery: exercise therapy for prevention of post-intensive care syndrome. J Intensive Care. 2024 Feb 29;12(1):11. doi: 10.1186/s40560-024-00724-4. PMID: 38424645; PMCID: PMC10902959.
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Are renin levels crucial in determining patient outcomes? (03/02/24)

Busse LW, Schaich CL, Chappell MC, McCurdy MT, Staples EM, Ten Lohuis CC, Hinson JS, Sevransky JE, Rothman RE, Wright DW, Martin GS, Khanna AK; Vitamin C, Thiamine, and Steroids in Sepsis (VICTAS) Investigators. Association of Active Renin Content With Mortality in Critically Ill Patients: A Post hoc Analysis of the Vitamin C, Thiamine, and Steroids in Sepsis (VICTAS) Trial. Crit Care Med. 2024 Mar 1;52(3):441-451. doi: 10.1097/CCM.0000000000006095. Epub 2023 Nov 10. PMID: 37947484; PMCID: PMC10876175.
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Blood glucose control in the ICU (03/01/24)

Honarmand K, Sirimaturos M, Hirshberg EL, Bircher NG, Agus MSD, Carpenter DL, Downs CR, Farrington EA, Freire AX, Grow A, Irving SY, Krinsley JS, Lanspa MJ, Long MT, Nagpal D, Preiser JC, Srinivasan V, Umpierrez GE, Jacobi J. Society of Critical Care Medicine Guidelines on Glycemic Control for Critically Ill Children and Adults 2024. Crit Care Med. 2024 Jan 19. doi: 10.1097/CCM.0000000000006174. Epub ahead of print. PMID: 38240484.
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Ketamine infusions for sedation on intubated patients (02/29/24)

Richards ND, Weatherhead W, Howell S, Bellamy M, Mujica-Mota R. Continuous infusion ketamine for sedation of mechanically ventilated adults in the intensive care unit: A scoping review. Journal of the Intensive Care Society. 2024;25(1):59-77. doi:10.1177/17511437231182507
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Empiric Calcium During Cardiac Arrest? (02/28/24)

Dillon DG, Wang RC, Shetty P, Douchee J, Rodriguez RM, Montoy JCC. Efficacy of emergency department calcium administration in cardiac arrest: A 9-year retrospective evaluation. Resuscitation. 2023 Oct;191:109933. doi: 10.1016/j.resuscitation.2023.109933. Epub 2023 Aug 9. PMID: 37562663; PMCID: PMC10529187.
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Violence Experienced by ICU Staff (02/27/24)

Berger S, Grzonka P, Frei AI, Hunziker S, Baumann SM, Amacher SA, Gebhard CE, Sutter R. Violence against healthcare professionals in intensive care units: a systematic review and meta-analysis of frequency, risk factors, interventions, and preventive measures. Crit Care. 2024 Feb 26;28(1):61. doi: 10.1186/s13054-024-04844-z. PMID: 38409034.
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Is eCPR the way to go? (02/26/24)

Low CJW, Ling RR, Ramanathan K, Chen Y, Rochwerg B, Kitamura T, Iwami T, Ong MEH, Okada Y. Extracorporeal cardiopulmonary resuscitation versus conventional CPR in cardiac arrest: an updated meta-analysis and trial sequential analysis. Crit Care. 2024 Feb 21;28(1):57. doi: 10.1186/s13054-024-04830-5. PMID: 38383506; PMCID: PMC10882798.
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Frail patient and their 6 month prognosis (02/25/24)

Wozniak H, Beckmann TS, Dos Santos Rocha A, Pugin J, Heidegger CP, Cereghetti S. Long-stay ICU patients with frailty: mortality and recovery outcomes at 6 months. Ann Intensive Care. 2024 Feb 24;14(1):31. doi: 10.1186/s13613-024-01261-x. PMID: 38401034.
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The consequences of our ARDS management (02/24/24)

Latronico N, Eikermann M, Ely EW, Needham DM. Improving management of ARDS: uniting acute management and long-term recovery. Crit Care. 2024 Feb 23;28(1):58. doi: 10.1186/s13054-024-04810-9. PMID: 38395902.
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Still not convinced about glucocorticoids in septic shock? (2/23/24)

Pitre T, Drover K, Chaudhuri D, Zeraaktkar D, Menon K, Gershengorn HB, Jayaprakash N, Spencer-Segal JL, Pastores SM, Nei AM, Annane D, Rochwerg B. Corticosteroids in Sepsis and Septic Shock: A Systematic Review, Pairwise, and Dose-Response Meta-Analysis. Crit Care Explor. 2024 Jan 19;6(1):e1000. doi: 10.1097/CCE.0000000000001000. PMID: 38250247; PMCID: PMC10798738.
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Restrictive Cardiomyopathy (02/22/24)

Rapezzi C, Aimo A, Barison A, Emdin M, Porcari A, Linhart A, Keren A, Merlo M, Sinagra G. Restrictive cardiomyopathy: definition and diagnosis. Eur Heart J. 2022 Dec 1;43(45):4679-4693. doi: 10.1093/eurheartj/ehac543. PMID: 36269634; PMCID: PMC9712030.
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Advance Directives in the ICU: Challenges and Challenges (02/21/24)

Baumann SM, Kruse NJ, Kliem PSC, Amacher SA, Hunziker S, Dittrich TD, Renetseder F, Grzonka P, Sutter R. Translation of patients’ advance directives in intensive care units: are we there yet? J Intensive Care. 2023 Nov 15;11(1):53. doi: 10.1186/s40560-023-00705-z. PMID: 37968692; PMCID: PMC10648602.
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Link to Saving Lives Podcast episode on Spotify
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Methylene Blue Pros and Cons (02/20/24)

Arias-Ortiz J, Vincent JL. Administration of methylene blue in septic shock: pros and cons. Crit Care. 2024 Feb 16;28(1):46. doi: 10.1186/s13054-024-04839-w. PMID: 38365828; PMCID: PMC10870439.
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Order a copy of my book directly from me.
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VA-ECMO in Cardiogenic Shock: Complications (02/19/24)

Beer BN, Kellner C, Goßling A, Sundermeyer J, Besch L, Dettling A, Kirchhof P, Blankenberg S, Bernhardt AM, Brunner S, Colson P, Eckner D, Frank D, Eitel I, Frey N, Eden M, Graf T, Kupka D, Landmesser U, Majunke N, Maniuc O, Möbius-Winkler S, Morrow DA, Mourad M, Noel C, Nordbeck P, Orban M, Pappalardo F, Patel SM, Pauschinger M, Reichenspurner H, Schulze PC, Schwinger RHG, Wechsler A, Skurk C, Thiele H, Varshney AS, Sag CM, Krais J, Westermann D, Schrage B. Complications in patients with cardiogenic shock on veno-arterial extracorporeal membrane oxygenation therapy: distribution and relevance. Results from an international, multicentre cohort study. Eur Heart J Acute Cardiovasc Care. 2024 Feb 16;13(2):203-212. doi: 10.1093/ehjacc/zuad129. PMID: 37875127.
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Ketamine vs. Etomidate (02/18/24)

Koroki T, Kotani Y, Yaguchi T, Shibata T, Fujii M, Fresilli S, Tonai M, Karumai T, Lee TC, Landoni G, Hayashi Y. Ketamine versus etomidate as an induction agent for tracheal intubation in critically ill adults: a Bayesian meta-analysis. Crit Care. 2024 Feb 17;28(1):48. doi: 10.1186/s13054-024-04831-4. PMID: 38368326.
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Music and Anxiety in the ICU (02/16/24)

Kakar E, Ottens T, Stads S, Wesselius S, Gommers DAMPJ, Jeekel J, van der Jagt M. Effect of a music intervention on anxiety in adult critically ill patients: a multicenter randomized clinical trial. J Intensive Care. 2023 Aug 17;11(1):36. doi: 10.1186/s40560-023-00684-1. PMID: 37592358; PMCID: PMC10433648.
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“Music gives a soul to the universe, wings to the mind, flight to the imagination, and life to everything.” – Plato

Mitraclip Complications (02/15/24)

Schnitzler K, Hell M, Geyer M, Kreidel F, Münzel T, von Bardeleben RS. Complications Following MitraClip Implantation. Curr Cardiol Rep. 2021 Aug 13;23(9):131. doi: 10.1007/s11886-021-01553-9. PMID: 34387748; PMCID: PMC8363549.
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Podcast Episode: Spotify. Apple Podcasts

ARDS 101 (02/12/24, 02/13/24, 02/14/24)

Grotberg JC, Reynolds D, Kraft BD. Management of severe acute respiratory distress syndrome: a primer. Crit Care. 2023 Jul 18;27(1):289. doi: 10.1186/s13054-023-04572-w. PMID: 37464381; PMCID: PMC10353255.
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Using Procalcitonin to Guide Duration of Antibiotic Therapy (02/11/24)

Papp M, Kiss N, Baka M, Trásy D, Zubek L, Fehérvári P, Harnos A, Turan C, Hegyi P, Molnár Z. Procalcitonin-guided antibiotic therapy may shorten length of treatment and may improve survival-a systematic review and meta-analysis. Crit Care. 2023 Oct 13;27(1):394. doi: 10.1186/s13054-023-04677-2. PMID: 37833778; PMCID: PMC10576288.
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Putting the mycobiome from the microbiome on your radar (02/10/24)

Park G, Munley JA, Kelly LS, Kannan KB, Mankowski RT, Sharma A, Upchurch G, Casadesus G, Chakrabarty P, Wallet SM, Maile R, Bible LE, Wang B, Moldawer LL, Mohr AM, Efron PA, Nagpal R. Gut mycobiome dysbiosis after sepsis and trauma. Crit Care. 2024 Jan 11;28(1):18. doi: 10.1186/s13054-023-04780-4. PMID: 38212826; PMCID: PMC10785534.
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My liver, my liver! – Beavis (02/09/24)

Perez Ruiz de Garibay A, Kortgen A, Leonhardt J, Zipprich A, Bauer M. Critical care hepatology: definitions, incidence, prognosis and role of liver failure in critically ill patients. Crit Care. 2022 Sep 26;26(1):289. doi: 10.1186/s13054-022-04163-1. PMID: 36163253; PMCID: PMC9511746.
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Beavis and Butthead Reference (YouTube Link)

When will start adopting thiamine supplementation? (02/08/24)

Vine J, Lee JH, Kravitz MS, Grossestreuer AV, Balaji L, Leland SB, Berlin N, Moskowitz A, Donnino MW. Thiamine administration in septic shock: a post hoc analysis of two randomized trials. Crit Care. 2024 Feb 6;28(1):41. doi: 10.1186/s13054-024-04818-1. PMID: 38321529.
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Check out my 2023 podcast episode on IV Thiamine on Apple Podcasts or Spotify
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Desperate times call for desperate measures, but let’s not do this again. (02/07/24)

Wang RC, Degesys NF, Fahimi J, Jin C, Rosenthal E, Lazar AA, Yaffee AQ, Peterson S, Rothmann RE, Jones CMC, Tolia V, Shah MN, Raven MC; Reuse N95 Group. Incidence of Fit Test Failure During N95 Respirator Reuse and Extended Use. JAMA Netw Open. 2024 Jan 2;7(1):e2353631. doi: 10.1001/jamanetworkopen.2023.53631. PMID: 38277142.
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POCUS for ALL the Organs (02/06/24)

Hobbs H, Millington S, Wiskar K. Multiorgan Point-of-Care Ultrasound Assessment in Critically Ill Adults. J Intensive Care Med. 2024 Mar;39(3):187-195. doi: 10.1177/08850666231192047. Epub 2023 Aug 8. PMID: 37552930.
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Sprinkle in Long-Acting Insulin for our DKA patients in the ED. (02/05/24)

Rao P, Jiang SF, Kipnis P, Patel DM, Katsnelson S, Madani S, Liu VX. Evaluation of Outcomes Following Hospital-Wide Implementation of a Subcutaneous Insulin Protocol for Diabetic Ketoacidosis. JAMA Netw Open. 2022 Apr 1;5(4):e226417. doi: 10.1001/jamanetworkopen.2022.6417. PMID: 35389497; PMCID: PMC8990349.
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Hyperdynamic Left Ventricular Function in Sepsis (02/04/24)

Sato R, Sanfilippo F, Hasegawa D, Prasitlumkum N, Duggal A, Dugar S. Prevalence and prognosis of hyperdynamic left ventricular systolic function in septic patients: a systematic review and meta-analysis. Ann Intensive Care. 2024 Feb 3;14(1):22. doi: 10.1186/s13613-024-01255-9. PMID: 38308701.
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Link to Instagram Post on this topic.

The Glycocalyx (02/03/24)

Dull RO, Hahn RG. The glycocalyx as a permeability barrier: basic science and clinical evidence. Crit Care. 2022 Sep 12;26(1):273. doi: 10.1186/s13054-022-04154-2. PMID: 36096866; PMCID: PMC9469578.
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Hemorrhagic Shock Management (02/02/24)

Bonanno FG. Management of Hemorrhagic Shock: Physiology Approach, Timing and Strategies. J Clin Med. 2022 Dec 29;12(1):260. doi: 10.3390/jcm12010260. PMID: 36615060; PMCID: PMC9821021.
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Corticosteroids and the Critically Ill (02/01/24)

Chaudhuri D, Nei AM, Rochwerg B, Balk RA, Asehnoune K, Cadena RS, Carcillo JA, Correa R, Drover K, Esper AM, Gershengorn HB, Hammond NE, Jayaprakash N, Menon K, Nazer L, Pitre T, Qasim ZA, Russell JA, Santos AP, Sarwal A, Spencer-Segal J, Tilouche N, Annane D, Pastores SM. Executive Summary: Guidelines on Use of Corticosteroids in Critically Ill Patients With Sepsis, Acute Respiratory Distress Syndrome, and Community-Acquired Pneumonia Focused Update 2024. Crit Care Med. 2024 Jan 19. doi: 10.1097/CCM.0000000000006171. Epub ahead of print. PMID: 38240490.
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Push-dose Vasopressors (01/30/24)

Kubena A, Weston S, Alvey H. Push-dose vasopressors in the Emergency Department: a narrative review. J Emerg Crit Care Med 2022;6:22. doi: 10.21037/jeccm-21-98
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A Must-Read for those who care for Cardiac Surgery patients (01/29/24)

Grant MC, Crisafi C, Alvarez A, Arora RC, Brindle ME, Chatterjee S, Ender J, Fletcher N, Gregory AJ, Gunaydin S, Jahangiri M, Ljungqvist O, Lobdell KW, Morton V, Reddy VS, Salenger R, Sander M, Zarbock A, Engelman DT. Perioperative Care in Cardiac Surgery: A Joint Consensus Statement by the Enhanced Recovery After Surgery (ERAS) Cardiac Society, ERAS International Society, and The Society of Thoracic Surgeons (STS). Ann Thorac Surg. 2024 Jan 18:S0003-4975(23)01317-6. doi: 10.1016/j.athoracsur.2023.12.006. Epub ahead of print. PMID: 38284956.
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End-Tidal CO2 for Fluid Responsiveness (01/28/24)

Huang H, Wu C, Shen Q, Fang Y, Xu H. Value of variation of end-tidal carbon dioxide for predicting fluid responsiveness during the passive leg raising test in patients with mechanical ventilation: a systematic review and meta-analysis. Crit Care. 2022 Jan 14;26(1):20. doi: 10.1186/s13054-022-03890-9. PMID: 35031070; PMCID: PMC8760720.
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The Nutrition We Provide Our Patients Isn’t Good Enough (01/27/24)

Berger MM, Amrein K, Barazzoni R, Bindels L, Bretón I, Calder PC, Cappa S, Cuerda C, D’Amelio P, de Man A, Delzenne NM, Forbes A, Genton L, Gombart AF, Joly F, Laviano A, Matthys C, Phyo PP, Ravasco P, Serlie MJ, Shenkin A, Stoffel NU, Talwar D, van Zanten ARH. The science of micronutrients in clinical practice – Report on the ESPEN symposium. Clin Nutr. 2024 Jan;43(1):268-283. doi: 10.1016/j.clnu.2023.12.006. Epub 2023 Dec 9. PMID: 38104489.
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AKI in Cardiac Surgery (01/26/24)

Brown JK, Shaw AD, Mythen MG, Guzzi L, Reddy VS, Crisafi C, Engelman DT; PeriOperative Quality Initiative and the Enhanced Recovery After Surgery Cardiac Workgroup. Adult Cardiac Surgery-Associated Acute Kidney Injury: Joint Consensus Report. J Cardiothorac Vasc Anesth. 2023 Sep;37(9):1579-1590. doi: 10.1053/j.jvca.2023.05.032. Epub 2023 May 23. PMID: 37355415.
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Managing Digoxin Toxicity (01/25/24)

Andrews P, Anseeuw K, Kotecha D, Lapostolle F, Thanacoody R. Diagnosis and practical management of digoxin toxicity: a narrative review and consensus. Eur J Emerg Med. 2023 Dec 1;30(6):395-401. doi: 10.1097/MEJ.0000000000001065. Epub 2023 Aug 25. PMID: 37650725; PMCID: PMC10599802.
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Acute Mesenteric Ischemia (01/24/24)

Reintam Blaser A, Mändul M, Björck M, Acosta S, Bala M, Bodnar Z, Casian D, Demetrashvili Z, D’Oria M, Durán Muñoz-Cruzado V, Forbes A, Fuglseth H, Hellerman Itzhaki M, Hess B, Kase K, Kirov M, Lein K, Lindner M, Loudet CI, Mole DJ, Murruste M, Nuzzo A, Saar S, Scheiterle M, Starkopf J, Talving P, Voomets AL, Voon KKT, Yunus MA, Tamme K; AMESI Investigators (Collaborators). Incidence, diagnosis, management and outcome of acute mesenteric ischaemia: a prospective, multicentre observational study (AMESI Study). Crit Care. 2024 Jan 23;28(1):32. doi: 10.1186/s13054-024-04807-4. PMID: 38263058.
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A game changer in cardiac arrest (01/22/24)

Bachista KM, Moore JC, Labarère J, Crowe RP, Emanuelson LD, Lick CJ, Debaty GP, Holley JE, Quinn RP, Scheppke KA, Pepe PE. Survival for Nonshockable Cardiac Arrests Treated With Noninvasive Circulatory Adjuncts and Head/Thorax Elevation. Crit Care Med. 2024 Feb 1;52(2):170-181. doi: 10.1097/CCM.0000000000006055. Epub 2024 Jan 19. PMID: 38240504.
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Finding the best PEEP (01/21/24)

Gattinoni L, Marini JJ. In search of the Holy Grail: identifying the best PEEP in ventilated patients. Intensive Care Med. 2022 Jun;48(6):728-731. doi: 10.1007/s00134-022-06698-x. Epub 2022 May 5. PMID: 35513707; PMCID: PMC9205826.
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NG Tube Insertion Tricks (01/20/24)

Taylor SJ, Sayer K, White P. Nasointestinal tube placement: Techniques that increase success. J Intensive Care Soc. 2023 Feb;24(1):62-70. doi: 10.1177/17511437221095336. Epub 2022 May 27. PMID: 36874290; PMCID: PMC9975804.
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Vascular Leak Index (01/19/24)

Chandra J, Armengol de la Hoz MA, Lee G, Lee A, Thoral P, Elbers P, Lee HC, Munger JS, Celi LA, Kaufman DA. A novel Vascular Leak Index identifies sepsis patients with a higher risk for in-hospital death and fluid accumulation. Crit Care. 2022 Apr 11;26(1):103. doi: 10.1186/s13054-022-03968-4. PMID: 35410278; PMCID: PMC9003991.
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Good ‘ol dogma in critical care medicine (01/18/24)

Hofmaenner DA, Singer M. Challenging management dogma where evidence is non-existent, weak or outdated. Intensive Care Med. 2022 May;48(5):548-558. doi: 10.1007/s00134-022-06659-4. Epub 2022 Mar 18. PMID: 35303116; PMCID: PMC8931587.
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Stop the bleeding! (01/17/24)

Backus B, Beyer-Westendorf J, Body R, Lindner T, Möckel M, Sehgal V, Parry-Jones A, Seiffge D, Gibler B. Management of major bleeding for anticoagulated patients in the Emergency Department: an European experts consensus statement. Eur J Emerg Med. 2023 Oct 1;30(5):315-323. doi: 10.1097/MEJ.0000000000001049. Epub 2023 Jul 7. PMID: 37427548.
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We check too many labs (01/16/24)

Devis L, Catry E, Honore PM, Mansour A, Lippi G, Mullier F, Closset M. Interventions to improve appropriateness of laboratory testing in the intensive care unit: a narrative review. Ann Intensive Care. 2024 Jan 15;14(1):9. doi: 10.1186/s13613-024-01244-y. PMID: 38224401.
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How does DNR status change our perceptions of management? (01/15/24)

Driggers KE, Dishman SE, Chung KK, Olsen CH, Ryan AB, McLawhorn MM, Johnson LS. Perceptions of care following initiation of do-not-resuscitate orders. J Crit Care. 2022 Jun;69:154008. doi: 10.1016/j.jcrc.2022.154008. Epub 2022 Mar 10. PMID: 35278875.
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Do not just brush off New-Onset A.fib in the ICU. (01/14/24)

Garside T, Bedford JP, Vollam S, Gerry S, Rajappan K, Watkinson PJ. Increased long-term mortality following new-onset atrial fibrillation in the intensive care unit: A systematic review and meta-analysis. J Crit Care. 2022 Dec;72:154161. doi: 10.1016/j.jcrc.2022.154161. Epub 2022 Oct 7. PMID: 36215944.
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Pancreatitis Management (01/13/24)

Palumbo R, Schuster KM. Contemporary management of acute pancreatitis: What you need to know. J Trauma Acute Care Surg. 2024 Jan 1;96(1):156-165. doi: 10.1097/TA.0000000000004143. Epub 2023 Dec 11. PMID: 37722072.
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Could your blood type save your life? (01/12/24)

Itenov TS, Sessler DI, Khanna AK, Ostrowski SR, Johansson PI, Erikstrup C, Pedersen OB, Rygård SL, Holst LB, Bestle MH, Hein L, Lindhardt A, Tousi H, Andersen MH, Mohr T, Lundgren JD, Jensen JU. ABO blood types and sepsis mortality. Ann Intensive Care. 2021 Apr 20;11(1):61. doi: 10.1186/s13613-021-00844-2. PMID: 33877463; PMCID: PMC8056100.
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Sepsis in the Elderly (01/11/24)

Ibarz M, Haas LEM, Ceccato A, Artigas A. The critically ill older patient with sepsis: a narrative review. Ann Intensive Care. 2024 Jan 10;14(1):6. doi: 10.1186/s13613-023-01233-7. PMID: 38200360.
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How I manage Cardiogenic Shock 2/2 Acute Myocardial Infarction (01/10/24)

Basir MB, Lemor A, Gorgis S, Patel KC, Kolski BC, Bharadwaj AS, Todd JW, Tehrani BN, Truesdell AG, Lasorda DM, Lalonde TA, Kaki A, Schrieber TL, Patel NC, Senter SR, Gelormini JL, Marso SP, Rahman AM, Federici RE, Wilkins CE, Thomas McRae A 3rd, Nsair A, Caputo CP, Khuddus MA, Chahin JJ, Dupont AG, Goldsweig AM, Lim MJ, Kapur NK, Wohns DHW, Zhou Y, Hacala MJ, O’Neill WW. Early Utilization of Mechanical Circulatory Support in Acute Myocardial Infarction Complicated by Cardiogenic Shock: The National Cardiogenic Shock Initiative. J Am Heart Assoc. 2023 Dec 5;12(23):e031401. doi: 10.1161/JAHA.123.031401. Epub 2023 Nov 28. PMID: 38014676; PMCID: PMC10727311.
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Link to my post on Pulmonary Artery Pulsatility Index (PAPi)
Link to my post on Aortic Pulsatility Index (API)

For how long does 20% albumin cause volume expansion? (01/09/24)

Zdolsek M, Wuethrich PY, Gunnström M, Zdolsek JH, Hasselgren E, Beilstein CM, Engel D, Hahn RG. Plasma disappearance rate of albumin when infused as a 20% solution. Crit Care. 2022 Apr 11;26(1):104. doi: 10.1186/s13054-022-03979-1. PMID: 35410365; PMCID: PMC9003982.
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What to do with PEA Arrests? (01/08/24)

Norvik A, Unneland E, Bergum D, Buckler DG, Bhardwaj A, Eftestøl T, Aramendi E, Nordseth T, Abella BS, Kvaløy JT, Skogvoll E. Pulseless electrical activity in in-hospital cardiac arrest – A crossroad for decisions. Resuscitation. 2022 Jul;176:117-124. doi: 10.1016/j.resuscitation.2022.04.024. Epub 2022 Apr 28. PMID: 35490937.
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Plasma exchange for septic shock (01/07/24)

Kuklin V, Sovershaev M, Bjerner J, Keith P, Scott LK, Thomas OMT, Szpirt W, Rock G, Stegmayr B. Influence of therapeutic plasma exchange treatment on short-term mortality of critically ill adult patients with sepsis-induced organ dysfunction: a systematic review and meta-analysis. Crit Care. 2024 Jan 4;28(1):12. doi: 10.1186/s13054-023-04795-x. PMID: 38178170; PMCID: PMC10768220.
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Brain Stuff (01/06/24)

Robba, C., Zanier, E.R., Lopez Soto, C. et al. Mastering the brain in critical conditions: an update. ICMx 12, 1 (2024). https://doi.org/10.1186/s40635-023-00587-3
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Reducing Opioids (01/05/24)

McKenzie, C., Skrobik, Y. & Devlin, J.W. Scheduled intravenous opioids. Intensive Care Med 49, 1541–1543 (2023).
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Palliative Care in the ICU (01/04/24)

Neukirchen, M., Metaxa, V. & Schaefer, M.S. Palliative care in intensive care. Intensive Care Med 49, 1538–1540 (2023).
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Link to another article on palliative care

Ultrasound in Cardiac Arrest (01/03/24)

Wong, A., Vignon, P. & Robba, C. How I use ultrasound in cardiac arrest. Intensive Care Med 49, 1531–1534 (2023).
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Physical Restraints in the ICU (01/02/24)

Sebastian Berger, Pascale Grzonka, Simon A. Amacher, Sabina Hunziker, Anja I. Frei, Raoul Sutter,
Adverse events related to physical restraint use in intensive care units: A review of the literature,
Journal of Intensive Medicine, 2023,ISSN 2667-100X, https://doi.org/10.1016/j.jointm.2023.11.005.
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Venous PCO2 vs. Arterial PaCO2 (12/31/23)

Jörg M, Öster M, Wretborn J, Wilhelms DB. Agreement of pCO₂ in venous to arterial blood gas conversion models in undifferentiated emergency patients. Intensive Care Med Exp. 2023 Nov 21;11(1):80. doi: 10.1186/s40635-023-00564-w. PMID: 37989791; PMCID: PMC10663424.
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Link to Dr. Josh Farkas’ work on PCO2

One-stop-shop for Mechanical Circulatory Support in Cardiogenic Shock (12/29/23)

Nakata, J., Yamamoto, T., Saku, K. et al. Mechanical circulatory support in cardiogenic shock. j intensive care 11, 64 (2023). https://doi.org/10.1186/s40560-023-00710-2
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It’s time to learn how Semaglutide will behave in our patients. (12/28/23)

Jure Marijic, J. Prince Neelankavil. Semaglutide: A New Medical Swiss Army Knife? 
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Pneumomediastinum & Pneumothorax in ARDS 12/27/23

Teo, Yi & Shanmugavel Geetha, Harinivaas & Mishra, Ajay & Lal, Amos. (2023). Pneumomediastinum and pneumothorax in acute respiratory distress syndrome (ARDS) patients: a narrative review. Mediastinum. 10.21037/med-23-39.
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RV Dysfunction in Cor Pulmonale (12/24/23)

Arrigo M, Price S, Harjola VP, Huber LC, Schaubroeck HAI, Vieillard-Baron A, Masip J, Mebazaa A. Diagnosis and treatment of right ventricular failure secondary to acutely increased right ventricular afterload (acute cor pulmonale). A Clinical Consensus Statement of the Association for Acute CardioVascular Care (ACVC) of the ESC. Eur Heart J Acute Cardiovasc Care. 2023 Dec 22:zuad157. doi: 10.1093/ehjacc/zuad157. Epub ahead of print. PMID: 38135288.
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New Stuff in Cardiogenic Shock after AMI (12/22/23)

Pepe M, Bortone AS, Giordano A, Cecere A, Burattini O, Nestola PL, Patti G, Di Cillo O, Signore N, Forleo C, Favale S. Cardiogenic Shock Following Acute Myocardial Infarction: What’s New? Shock. 2020 Apr;53(4):391-399. doi: 10.1097/SHK.0000000000001377. PMID: 31090679.
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Free Book on IV Fluids written by Legends! (12/8/23)

Rational Use of Intravenous Fluids in Critically Ill Patients
Manu L.N.G. Malbrain, Adrian Wong, Prashant Nasa, Supradip Ghosh
https://doi.org/10.1007/978-3-031-42205-8
Springer Cham
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The Interstitium in Sepsis (10/11/23)

Dargent A, Dumargne H, Labruyère M, Brezillon S, Brassart-Pasco S, Blot M, Charles PE, Fournel I, Quenot JP, Jacquier M. Role of the interstitium during septic shock: a key to the understanding of fluid dynamics? J Intensive Care. 2023 Oct 10;11(1):44. doi: 10.1186/s40560-023-00694-z. PMID: 37817235.
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Furosemide Stress Test

McMahon BA, Chawla LS. The furosemide stress test: current use and future potential. Ren Fail. 2021 Dec;43(1):830-839. doi: 10.1080/0886022X.2021.1906701. PMID: 33971784; PMCID: PMC8118439.
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How Will Critical Care be Organized in the Future?

Esper AM, Arabi YM, Cecconi M, Du B, Giamarellos-Bourboulis EJ, Juffermans N, Machado F, Peake S, Phua J, Rowan K, Suh GY, Martin GS. Systematized and efficient: organization of critical care in the future. Crit Care. 2022 Nov 28;26(1):366. doi: 10.1186/s13054-022-04244-1. PMID: 36443764; PMCID: PMC9707068.
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DIC Sucks. Here’s what we can do about it.

Iba T, Helms J, Connors JM, Levy JH. The pathophysiology, diagnosis, and management of sepsis-associated disseminated intravascular coagulation. J Intensive Care. 2023 May 23;11(1):24. doi: 10.1186/s40560-023-00672-5. PMID: 37221630; PMCID: PMC10202753.
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ARDS Goodies

Bos LDJ, de Grooth HJ, Tuinman PR. A structured diagnostic algorithm for patients with ARDS. Crit Care. 2023 Mar 21;27(1):94. doi: 10.1186/s13054-023-04368-y. PMID: 36941668; PMCID: PMC10027589.
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CLICK HERE to learn about Driving Pressure

Are you ready for Human-centered visualization technologies?

Gasciauskaite, G., Lunkiewicz, J., Roche, T.R. et al. Human-centered visualization technologies for patient monitoring are the future: a narrative review. Crit Care 27, 254 (2023). https://doi.org/10.1186/s13054-023-04544-0
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Red Meat Bad?

Lescinsky H, Afshin A, Ashbaugh C, Bisignano C, Brauer M, Ferrara G, Hay SI, He J, Iannucci V, Marczak LB, McLaughlin SA, Mullany EC, Parent MC, Serfes AL, Sorensen RJD, Aravkin AY, Zheng P, Murray CJL. Health effects associated with consumption of unprocessed red meat: a Burden of Proof study. Nat Med. 2022 Oct;28(10):2075-2082. doi: 10.1038/s41591-022-01968-z. Epub 2022 Oct 10. PMID: 36216940; PMCID: PMC9556326.
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An Algorithm for ARDS? Don’t Mind if I do.

Bos LDJ, de Grooth HJ, Tuinman PR. A structured diagnostic algorithm for patients with ARDS. Crit Care. 2023 Mar 21;27(1):94. doi: 10.1186/s13054-023-04368-y. PMID: 36941668; PMCID: PMC10027589.
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Acute Aortic Dissection

Flower L, Arrowsmith JE, Bewley J, et al. Management of acute aortic dissection in critical care. Journal of the Intensive Care Society. 2023;0(0). doi:10.1177/17511437231162219
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Can We Use PEEP To Determine Fluid Responsiveness?

Lai C, Shi R, Beurton A, Moretto F, Ayed S, Fage N, Gavelli F, Pavot A, Dres M, Teboul JL, Monnet X. The increase in cardiac output induced by a decrease in positive end-expiratory pressure reliably detects volume responsiveness: the PEEP-test study. Crit Care. 2023 Apr 9;27(1):136. doi: 10.1186/s13054-023-04424-7. PMID: 37031182; PMCID: PMC10082988.
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Link to MY POST on Fluid Responsiveness
CLICK HERE for my quick summary of the paper.

Lactic Alkalosis: Should we start caring?

Dargent A, Wallet F, Friggeri A, Bohe J, Vacheron CH. Lactic alkalosis in intensive care: a red flag? Crit Care. 2023 May 12;27(1):184. doi: 10.1186/s13054-023-04464-z. PMID: 37173749; PMCID: PMC10176709.
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Link to my post on Lactic Acidosis

MCS Guidelines

Bernhardt AM, Copeland H, Deswal A, Gluck J, Givertz MM; Chairs:; Co-Chairs:; Contributing Writers:; Chair:; Co-Chair:; Contributing Writers:; Chair:; Co-Chairs:; Contributing Writers:; Chair:; Co-Chair:; Contributing Writers:. The International Society for Heart and Lung Transplantation/Heart Failure Society of America Guideline on Acute Mechanical Circulatory Support. J Heart Lung Transplant. 2023 Apr;42(4):e1-e64. doi: 10.1016/j.healun.2022.10.028. Epub 2023 Feb 6. PMID: 36805198.
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Link to my dedicated post on ECMO
Link to my post on Mechanical Circulatory Support

Other uses for creatine?

Prokopidis K, Giannos P, Triantafyllidis KK, Kechagias KS, Forbes SC, Candow DG. Effects of creatine supplementation on memory in healthy individuals: a systematic review and meta-analysis of randomized controlled trials. Nutr Rev. 2023 Mar 10;81(4):416-427. doi: 10.1093/nutrit/nuac064. PMID: 35984306; PMCID: PMC9999677.
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EEG After Cardiac Arrest

Sandroni C, Skrifvars MB, Taccone FS. Brain monitoring after cardiac arrest. Curr Opin Crit Care. 2023 Feb 18. doi: 10.1097/MCC.0000000000001023. Epub ahead of print. PMID: 36762679.
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Thoracic ultrasound in the ICU

Heldeweg MLA, Lopez Matta JE, Pisani L, Slot S, Haaksma ME, Smit JM, Mousa A, Magnesa G, Massaro F, Touw HRW, Schouten V, Elzo Kraemer CV, van Westerloo DJ, Heunks LMA, Tuinman PR. The Impact of Thoracic Ultrasound on Clinical Management of Critically Ill Patients (UltraMan): An International Prospective Observational Study. Crit Care Med. 2022 Dec 23. doi: 10.1097/CCM.0000000000005760. Epub ahead of print. PMID: 36562620.
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Did you put the probe on the patients chest?

Peach M, Milne J, Diegelmann L, Lamprecht H, Stander M, Lussier D, Pham C, Henneberry R, Fraser J, Chandra K, Howlett M, Mekwan J, Ramrattan B, Middleton J, van Hoving N, Taylor L, Dahn T, Hurley S, MacSween K, Richardson L, Stoica G, Hunter S, Olszynski P, Chandra K, Lewis D, Atkinson P. Does point-of-care ultrasonography improve diagnostic accuracy in emergency department patients with undifferentiated hypotension? An international randomized controlled trial from the SHOC-ED investigators. CJEM. 2022 Dec 29. doi: 10.1007/s43678-022-00431-9. Epub ahead of print. PMID: 36577931.
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Inhaled Anesthetics for ICU Sedation?

Soukup J, Michel P, Christel A, Schittek GA, Wagner NM, Kellner P. Prolonged sedation with sevoflurane in comparison to intravenous sedation in critically ill patients – A randomized controlled trial. J Crit Care. 2023 Jan 12;74:154251. doi: 10.1016/j.jcrc.2022.154251. Epub ahead of print. PMID: 36640476.
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Vent Weaning

Akella P, Voigt LP, Chawla S. To Wean or Not to Wean: A Practical Patient Focused Guide to Ventilator Weaning. J Intensive Care Med. 2022 Nov;37(11):1417-1425. doi: 10.1177/08850666221095436. Epub 2022 Jul 11. PMID: 35815895.
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Heatstroke!

Patel J, Boyer N, Mensah K, et al. Critical illness aspects of heatstroke: A hot topic. Journal of the Intensive Care Society. 2023;0(0). doi:10.1177/17511437221148922
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Don’t forget about the Right Ventricle

Nägele MP, Flammer AJ. Heart Failure After Right Ventricular Myocardial Infarction. Curr Heart Fail Rep. 2022 Dec;19(6):375-385. doi: 10.1007/s11897-022-00577-8. Epub 2022 Oct 5. PMID: 36197627; PMCID: PMC9653315.
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Click here for my post on Cardiogenic Shock

Subphenotypes of AKI

Vaara ST, Bhatraju PK, Stanski NL, McMahon BA, Liu K, Joannidis M, Bagshaw SM. Subphenotypes in acute kidney injury: a narrative review. Crit Care. 2022 Aug 19;26(1):251. doi: 10.1186/s13054-022-04121-x. PMID: 35986336; PMCID: PMC9389711.
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Higher MAP goal in Hypertensive Patients?

Asfar P, Meziani F, Hamel JF, Grelon F, Megarbane B, Anguel N, Mira JP, Dequin PF, Gergaud S, Weiss N, Legay F, Le Tulzo Y, Conrad M, Robert R, Gonzalez F, Guitton C, Tamion F, Tonnelier JM, Guezennec P, Van Der Linden T, Vieillard-Baron A, Mariotte E, Pradel G, Lesieur O, Ricard JD, Hervé F, du Cheyron D, Guerin C, Mercat A, Teboul JL, Radermacher P; SEPSISPAM Investigators. High versus low blood-pressure target in patients with septic shock. N Engl J Med. 2014 Apr 24;370(17):1583-93. doi: 10.1056/NEJMoa1312173. Epub 2014 Mar 18. PMID: 24635770.
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2022 Heart Failure Guidelines

Heidenreich PA, Bozkurt B, Aguilar D, Allen LA, Byun JJ, Colvin MM, Deswal A, Drazner MH, Dunlay SM, Evers LR, Fang JC, Fedson SE, Fonarow GC, Hayek SS, Hernandez AF, Khazanie P, Kittleson MM, Lee CS, Link MS, Milano CA, Nnacheta LC, Sandhu AT, Stevenson LW, Vardeny O, Vest AR, Yancy CW. 2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure: Executive Summary: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation. 2022 May 3;145(18):e876-e894. doi: 10.1161/CIR.0000000000001062. Epub 2022 Apr 1. PMID: 35363500.
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If things get worse, here’s my post on Cardiogenic Shock

The Future of Sepsis Management?

Ronco, C., Chawla, L., Husain-Syed, F. et al. Rationale for sequential extracorporeal therapy (SET) in sepsis. Crit Care 27, 50 (2023). https://doi.org/10.1186/s13054-023-04310-2
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Link to my full post on fluid responsiveness in sepsis

The Future of Cardiac Surgery for the Intensivist

Kopanczyk R, Lester J, Long MT, Kossbiel BJ, Hess AS, Rozycki A, Nunley DR, Habib A, Taylor A, Awad H, Bhatt AM. The Future of Cardiothoracic Surgical Critical Care Medicine as a Medical Science: A Call to Action. Medicina. 2023; 59(1):47. https://doi.org/10.3390/medicina59010047
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My Blog Post on CVICU Essentials
My Blog Post on how I care for Post-Op Cardiac Surgery Patients

Transfusions in Cardiac Surgery Patients

Sanaiha Y, Hadaya J, Verma A, Shemin RJ, Madani M, Young N, Deuse T, Sun J, Benharash P; University of California Cardiac Surgery Consortium. Morbidity and Mortality Associated With Blood Transfusions in Elective Adult Cardiac Surgery. J Cardiothorac Vasc Anesth. 2022 Nov 17:S1053-0770(22)00799-6. doi: 10.1053/j.jvca.2022.11.012. Epub ahead of print. PMID: 36462976.
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Examples of how I take care of Post-Op patients.
My personal comprehensive review on CT surgery patients

I guess Japan is still using dopamine. Are you?

Suzuki R, Uchino S, Sasabuchi Y, Kawarai Lefor A, Sanui M. Dopamine use and its consequences in the intensive care unit: a cohort study utilizing the Japanese Intensive care PAtient Database. Crit Care. 2022 Apr 2;26(1):90. doi: 10.1186/s13054-022-03960-y. PMID: 35366934; PMCID: PMC8977005.
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Link to my post on Vasopressors.

A review of endovascular therapies to be used for PE’s? Don’t Mind if I do!

Rousseau H, Del Giudice C, Sanchez O, Ferrari E, Sapoval M, Marek P, Delmas C, Zadro C, Revel-Mouroz P. Endovascular therapies for pulmonary embolism. Heliyon. 2021 Apr 1;7(4):e06574. doi: 10.1016/j.heliyon.2021.e06574. PMID: 33889762; PMCID: PMC8047492.
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Transesophageal Echos: My New Years Resolution

Prager R, Bowdridge J, Pratte M, Cheng J, McInnes MD, Arntfield R. Indications, Clinical Impact, and Complications of Critical Care Transesophageal Echocardiography: A Scoping Review. J Intensive Care Med. 2023 Mar;38(3):245-272. doi: 10.1177/08850666221115348. Epub 2022 Jul 19. PMID: 35854414.
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ECMO for Cardiac Arrest Patients?

Holmberg MJ, Granfeldt A, Guerguerian AM, Sandroni C, Hsu CH, Gardner RM, Lind PC, Eggertsen MA, Johannsen CM, Andersen LW. Extracorporeal Cardiopulmonary Resuscitation for Cardiac Arrest: An Updated Systematic Review. Resuscitation. 2022 Dec 12:S0300-9572(22)00738-9. doi: 10.1016/j.resuscitation.2022.12.003. Epub ahead of print. PMID: 36521684.
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Link to my content on ECMO

Push-Dose Vasopressors

Kubena A, Weston S, Alvey H. Push-dose vasopressors in the Emergency Department: a narrative review.
J Emerg Crit Care Med 2022;6:22.
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Link to my blog post on Vasopressors

Managing Vents in Cardiac Arrest Patients

Battaglini D, Pelosi P, Robba C. Ten rules for optimizing ventilatory settings and targets in post-cardiac arrest patients. Crit Care. 2022 Dec 17;26(1):390. doi: 10.1186/s13054-022-04268-7. PMID: 36527126; PMCID: PMC9758928.
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In-hospital cardiac arrest

Penketh J, Nolan JP. In-hospital cardiac arrest: the state of the art. Crit Care. 2022 Dec 6;26(1):376. doi: 10.1186/s13054-022-04247-y. PMID: 36474215.
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Drugs for AKI?

Pickkers P, Murray PT, Ostermann M. New drugs for acute kidney injury. Intensive Care Med. 2022 Dec;48(12):1796-1798. doi: 10.1007/s00134-022-06859-y. Epub 2022 Aug 23. PMID: 35999470; PMCID: PMC9705447.
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Personalizing Septic Shock Management

De Backer D, Cecconi M, Chew MS, Hajjar L, Monnet X, Ospina-Tascón GA, Ostermann M, Pinsky MR, Vincent JL. A plea for personalization of the hemodynamic management of septic shock. Crit Care. 2022 Dec 1;26(1):372. doi: 10.1186/s13054-022-04255-y. PMID: 36457089.
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Streptococcal toxic shock syndrome

Schmitz M, Roux X, Huttner B, Pugin J. Streptococcal toxic shock syndrome in the intensive care unit. Ann Intensive Care. 2018 Sep 17;8(1):88. doi: 10.1186/s13613-018-0438-y. PMID: 30225523; PMCID: PMC6141408.
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MAP Goals in Patients with Underlying Hypertension

Tran PNT, Kusirisin P, Kaewdoungtien P, Phannajit J, Srisawat N. Higher blood pressure versus normotension targets to prevent acute kidney injury: a systematic review and meta-regression of randomized controlled trials. Crit Care. 2022 Nov 25;26(1):364. doi: 10.1186/s13054-022-04236-1. PMID: 36434726.
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Check out my full post on Vasopressors!

Kidney Biomarkers

Pan HC, Yang SY, Chiou TT, Shiao CC, Wu CH, Huang CT, Wang TJ, Chen JY, Liao HW, Chen SY, Huang TM, Yang YF, Lin HY, Chan MJ, Sun CY, Chen YT, Chen YC, Wu VC. Comparative accuracy of biomarkers for the prediction of hospital-acquired acute kidney injury: a systematic review and meta-analysis. Crit Care. 2022 Nov 12;26(1):349. doi: 10.1186/s13054-022-04223-6. PMID: 36371256.
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Vasoplegia

Muhammad R, Dharmadjati BB, Mulia EPB, Rachmi DA. Vasoplegia: Mechanism and Management Following Cardiopulmonary Bypass. Eurasian J Med. 2022 Feb;54(1):92-99. doi: 10.5152/eurasianjmed.2022.20394. PMID: 35307639; PMCID: PMC9634875.
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Link to my post on Recovering Patients in the CVICU
Link to my post on Post-Op Management of CABG Patients

Pathophys of Fluids

Messina A, Bakker J, Chew M, De Backer D, Hamzaoui O, Hernandez G, Myatra SN, Monnet X, Ostermann M, Pinsky M, Teboul JL, Cecconi M. Pathophysiology of fluid administration in critically ill patients. Intensive Care Med Exp. 2022 Nov 4;10(1):46. doi: 10.1186/s40635-022-00473-4. PMID: 36329266.
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CLICK HERE for my post on Fluid Responsiveness

Pulse oximetry for ARDS

Wick KD, Matthay MA, Ware LB. Pulse oximetry for the diagnosis and management of acute respiratory distress syndrome. Lancet Respir Med. 2022 Aug 29;10(11):1086–98. doi: 10.1016/S2213-2600(22)00058-3. Epub ahead of print. PMID: 36049490; PMCID: PMC9423770.
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Psilocybin for Depression

riGoodwin GM, Aaronson ST, Alvarez O, Arden PC, Baker A, Bennett JC, Bird C, Blom RE, Brennan C, Brusch D, Burke L, Campbell-Coker K, Carhart-Harris R, Cattell J, Daniel A, DeBattista C, Dunlop BW, Eisen K, Feifel D, Forbes M, Haumann HM, Hellerstein DJ, Hoppe AI, Husain MI, Jelen LA, Kamphuis J, Kawasaki J, Kelly JR, Key RE, Kishon R, Knatz Peck S, Knight G, Koolen MHB, Lean M, Licht RW, Maples-Keller JL, Mars J, Marwood L, McElhiney MC, Miller TL, Mirow A, Mistry S, Mletzko-Crowe T, Modlin LN, Nielsen RE, Nielson EM, Offerhaus SR, O’Keane V, Páleníček T, Printz D, Rademaker MC, van Reemst A, Reinholdt F, Repantis D, Rucker J, Rudow S, Ruffell S, Rush AJ, Schoevers RA, Seynaeve M, Shao S, Soares JC, Somers M, Stansfield SC, Sterling D, Strockis A, Tsai J, Visser L, Wahba M, Williams S, Young AH, Ywema P, Zisook S, Malievskaia E. Single-Dose Psilocybin for a Treatment-tstant Episode of Major Depression. N Engl J Med. 2022 Nov 3;387(18):1637-1648. doi: 10.1056/NEJMoa2206443. PMID: 36322843.
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Hemodynamic Monitoring

Pinsky MR, Cecconi M, Chew MS, De Backer D, Douglas I, Edwards M, Hamzaoui O, Hernandez G, Martin G, Monnet X, Saugel B, Scheeren TWL, Teboul JL, Vincent JL. Effective hemodynamic monitoring. Crit Care. 2022 Sep 28;26(1):294. doi: 10.1186/s13054-022-04173-z. PMID: 36171594; PMCID: PMC9520790.
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CLICK HERE for my post on Fluid Responsiveness

Insanity

Role of spike in the pathogenic and antigenic behavior of SARS-CoV-2 BA.1 Omicron
Da-Yuan Chen, Devin Kenney, Chue Vin Chin, Alexander H. Tavares, Nazimuddin Khan, Hasahn L. Conway, GuanQun Liu, Manish C. Choudhary, Hans P. Gertje, Aoife K. O’Connell, Darrell N. Kotton, Alexandra Herrmann, Armin Ensser, John H. Connor, Markus Bosmann, Jonathan Z. Li, Michaela U. Gack, Susan C. Baker, Robert N. Kirchdoerfer, Yachana Kataria, Nicholas A. Crossland, Florian Douam, Mohsan Saeed.

“We generated chimeric recombinant SARS-CoV-2 encoding the S gene of Omicron in the backbone of an ancestral SARS-CoV-2 isolate and compared this virus with the naturally circulating Omicron variant. ” “Omicron S-carrying virus inflicts severe disease with a mortality rate of 80%.“
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Data About This Helmet Thing

Cesarano M, Grieco DL, Michi T, Munshi L, Menga LS, Delle Cese L, Ruggiero E, Rosà T, Natalini D, Sklar MC, Cutuli SL, Bongiovanni F, De Pascale G, Ferreyro BL, Goligher EC, Antonelli M. Helmet noninvasive support for acute hypoxemic respiratory failure: rationale, mechanism of action and bedside application. Ann Intensive Care. 2022 Oct 14;12(1):94. doi: 10.1186/s13613-022-01069-7. PMID: 36241926; PMCID: PMC9568634.
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CLICK HERE for older data on the helmet.

CAP Guidelines

Metlay JP, Waterer GW, Long AC, Anzueto A, Brozek J, Crothers K, Cooley LA, Dean NC, Fine MJ, Flanders SA, Griffin MR, Metersky ML, Musher DM, Restrepo MI, Whitney CG. Diagnosis and Treatment of Adults with Community-acquired Pneumonia. An Official Clinical Practice Guideline of the American Thoracic Society and Infectious Diseases Society of America. Am J Respir Crit Care Med. 2019 Oct 1;200(7):e45-e67. doi: 10.1164/rccm.201908-1581ST. PMID: 31573350; PMCID: PMC6812437.
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Is Procalcitonin everything you want it to be and more? CLICK HERE for the data.

Is therapeutic hypothermia still a thing?

Wolfrum S, Roedl K, Hanebutte A, Pfeifer R, Kurowski V, Riessen R, Daubmann A, Braune S, Söffker G, Bibiza-Freiwald E, Wegscheider K, Schunkert H, Thiele H, Kluge S. Temperature Control After In-Hospital Cardiac Arrest: A Randomized Clinical Trial. Circulation. 2022 Sep 28:101161CIRCULATIONAHA122060106. doi: 10.1161/CIRCULATIONAHA.122.060106. Epub ahead of print. PMID: 36168956.
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CLICK HERE for my breakdown on a previous normothermia/hypothermia trial.

Do the conventional ways to determine fluid responsiveness bore you? Try these!

Horejsek J, Kunstyr J, Michalek P, Porizka M. Novel Methods for Predicting Fluid Responsiveness in Critically Ill Patients-A Narrative Review. Diagnostics (Basel). 2022 Feb 16;12(2):513. doi: 10.3390/diagnostics12020513. PMID: 35204603; PMCID: PMC8871108.
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Link to my work on Fluid Responsiveness
Link to my work on End-Expiratory Occlusion Testing

Guillain-Barre

Leonhard SE, Mandarakas MR, Gondim FAA, Bateman K, Ferreira MLB, Cornblath DR, van Doorn PA, Dourado ME, Hughes RAC, Islam B, Kusunoki S, Pardo CA, Reisin R, Sejvar JJ, Shahrizaila N, Soares C, Umapathi T, Wang Y, Yiu EM, Willison HJ, Jacobs BC. Diagnosis and management of Guillain-Barré syndrome in ten steps. Nat Rev Neurol. 2019 Nov;15(11):671-683. doi: 10.1038/s41582-019-0250-9. Epub 2019 Sep 20. PMID: 31541214; PMCID: PMC6821638.
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Loop diuretics in the ICU: Where’s the Data?

Wichmann S, Barbateskovic M, Liang N, Itenov TS, Berthelsen RE, Lindschou J, Perner A, Gluud C, Bestle MH. Loop diuretics in adult intensive care patients with fluid overload: a systematic review of randomised clinical trials with meta-analysis and trial sequential analysis. Ann Intensive Care. 2022 Jun 13;12(1):52. doi: 10.1186/s13613-022-01024-6. PMID: 35696008; PMCID: PMC9192894.
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CLICK HERE to learn about Deresuscitation

Dexmedetomidine: Still More Meh.

Zhang T, Mei Q, Dai S, Liu Y, Zhu H. Use of dexmedetomidine in patients with sepsis: a systematic review and meta-analysis of randomized-controlled trials. Ann Intensive Care. 2022 Aug 27;12(1):81. doi: 10.1186/s13613-022-01052-2. PMID: 36029410.
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CLICK HERE for my work on non-opioid ICU care.

Using the Ultrasound Proficiently

Miller, A., Peck, M., Clark, T., Conway, H., Olusanya, S., Fletcher, N., Coleman, N., Parulekar, P., Aron, J., Kirk-Bayley, J., Wilkinson, J. N., Wong, A., Stephens, J., Rubino, A., Attwood, B., Walden, A., Breen, A., Waraich, M., Nix, C., & Hayward, S. (2022). FUSIC HD. Comprehensive haemodynamic assessment with ultrasound. Journal of the Intensive Care Society, 23(3), 325–333. https://doi.org/10.1177/17511437211010032
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The Last 20 Years of Fluid Challenges

Messina A, Calabrò L, Pugliese L, Lulja A, Sopuch A, Rosalba D, Morenghi E, Hernandez G, Monnet X, Cecconi M. Fluid challenge in critically ill patients receiving haemodynamic monitoring: a systematic review and comparison of two decades. Crit Care. 2022 Jun 21;26(1):186. doi: 10.1186/s13054-022-04056-3. PMID: 35729632; PMCID: PMC9210670.
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CVP in 2022

Hamzaoui O, Teboul JL. Central venous pressure (CVP). Intensive Care Med. 2022 Aug 11. doi: 10.1007/s00134-022-06835-6. Epub ahead of print. PMID: 35953675.
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If you want additional articles on CVP, CLICK HERE.

Goodies from the Left Atrium

Bowcock EM, Mclean A. Bedside assessment of left atrial pressure in critical care: a multifaceted gem. Crit Care. 2022 Aug 13;26(1):247. doi: 10.1186/s13054-022-04115-9. PMID: 35964098; PMCID: PMC9375940.
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Base Deficit, Base Excess: Is it a Good Standalone Marker?

Langer T, Brusatori S, Gattinoni L. Understanding base excess (BE): merits and pitfalls. Intensive Care Med. 2022 Aug;48(8):1080-1083. doi: 10.1007/s00134-022-06748-4. Epub 2022 May 31. PMID: 35639122; PMCID: PMC9304040.
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Respiratory Failure in the NeuroICU

Robba C, Poole D, McNett M, Asehnoune K, Bösel J, Bruder N, Chieregato A, Cinotti R, Duranteau J, Einav S, Ercole A, Ferguson N, Guerin C, Siempos II, Kurtz P, Juffermans NP, Mancebo J, Mascia L, McCredie V, Nin N, Oddo M, Pelosi P, Rabinstein AA, Neto AS, Seder DB, Skrifvars MB, Suarez JI, Taccone FS, van der Jagt M, Citerio G, Stevens RD. Mechanical ventilation in patients with acute brain injury: recommendations of the European Society of Intensive Care Medicine consensus. Intensive Care Med. 2020 Dec;46(12):2397-2410. doi: 10.1007/s00134-020-06283-0. Epub 2020 Nov 11. PMID: 33175276; PMCID: PMC7655906.
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IV Fluids in the Critically Ill Guidelines

Joannes-Boyau O, Le Conte P, Bonnet MP, Cesareo E, Chousterman B, Chaiba D, Douay B, Futier E, Harrois A, Huraux C, Ichai C, Meaudre Desgouttes E, Mimoz O, Muller L, Oberlin M, Peschanski N, Quintard H, Rousseau G, Savary D, Tran-Dinh A, Villoing B, Chauvin A, Weiss E. Guidelines for the choice of intravenous fluids for vascular filling in critically ill patients, 2021. Anaesth Crit Care Pain Med. 2022 Jun;41(3):101058. doi: 10.1016/j.accpm.2022.101058. Epub 2022 May 5. PMID: 35526312.
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Extracorporeal Carbon Dioxide Removal for COPD Exacerbations

Barrett NA, Hart N, Daly KJR, Marotti M, Kostakou E, Carlin C, Lua S, Singh S, Bentley A, Douiri A, Camporota L. A randomised controlled trial of non-invasive ventilation compared with extracorporeal carbon dioxide removal for acute hypercapnic exacerbations of chronic obstructive pulmonary disease. Ann Intensive Care. 2022 Apr 21;12(1):36. doi: 10.1186/s13613-022-01006-8. PMID: 35445986; PMCID: PMC9021560.
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2021’s Best POCUS Papers

Millington SJ, Arntfield RT, Koenig SJ, Mayo PH, Vieillard-Baron A. Ten Influential Point-of-Care Ultrasound Papers: 2021 in Review. J Intensive Care Med. 2022 Apr 19:8850666221095050. doi: 10.1177/08850666221095050. Epub ahead of print. PMID: 35440211.
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Basic Critical Care Echocardiography Training

Rajamani A, Galarza L, Sanfilippo F, Wong A, Goffi A, Tuinman P, Mayo P, Arntfield R, Fisher R, Chew M, Slama M, Mackenzie D, Ho E, Smith L, Renner M, Tavares M, Prabu R N, Ramanathan K, Knudsen S, Bhat V, Arvind H, Huang S; SPARTAN Collaborative (Small Projects, Audits and Research Projects-Australia/New Zealand). Criteria, Processes, and Determination of Competence in Basic Critical Care Echocardiography Training: A Delphi Process Consensus Statement by the Learning Ultrasound in Critical Care (LUCC) Initiative. Chest. 2022 Feb;161(2):492-503. doi: 10.1016/j.chest.2021.08.077. Epub 2021 Sep 8. PMID: 34508739.
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Microbiota Stuff

Prevel R, Enaud R, Orieux A, Camino A, Berger P, Boyer A, Delhaes L, Gruson D. Gut bacteriobiota and mycobiota are both associated with Day-28 mortality among critically ill patients. Crit Care. 2022 Apr 13;26(1):105. doi: 10.1186/s13054-022-03980-8. PMID: 35418098; PMCID: PMC9007252.
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Permissive Hypercapnea

Gendreau S, Geri G, Pham T, Vieillard-Baron A, Mekontso Dessap A. The role of acute hypercapnia on mortality and short-term physiology in patients mechanically ventilated for ARDS: a systematic review and meta-analysis. Intensive Care Med. 2022 May;48(5):517-534. doi: 10.1007/s00134-022-06640-1. Epub 2022 Mar 16. PMID: 35294565; PMCID: PMC8924945.
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Challenging Dogma

Hofmaenner DA, Singer M. Challenging management dogma where evidence is non-existent, weak or outdated. Intensive Care Med. 2022 May;48(5):548-558. doi: 10.1007/s00134-022-06659-4. Epub 2022 Mar 18. PMID: 35303116; PMCID: PMC8931587.
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Sepsis in the Emergency Department

Yealy DM, Mohr NM, Shapiro NI, Venkatesh A, Jones AE, Self WH. Early Care of Adults With Suspected Sepsis in the Emergency Department and Out-of-Hospital Environment: A Consensus-Based Task Force Report. Ann Emerg Med. 2021 Jul;78(1):1-19. doi: 10.1016/j.annemergmed.2021.02.006. Epub 2021 Apr 9. Erratum in: Ann Emerg Med. 2021 Sep;78(3):464. PMID: 33840511.
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Weaning Vasopressors and Ventilators

Monnet X. Should We Wean Patients off Vasopressors before Weaning Them off Ventilation? Am J Respir Crit Care Med. 2022 May 1;205(9):980-981. doi: 10.1164/rccm.202201-0175ED. PMID: 35259082.
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Has your ICU been resilient over the last two+ years?

Salluh JIF, Kurtz P, Bastos LSL, Quintairos A, Zampieri FG, Bozza FA. The resilient intensive care unit. Ann Intensive Care. 2022 Apr 26;12(1):37. doi: 10.1186/s13613-022-01011-x. PMID: 35471746.
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Data Comparing Natural Immunity to Vaccine Immunity

Ridgway JP, Tideman S, Wright B, Robicsek A. Rates of COVID-19 Among Unvaccinated Adults With Prior COVID-19. JAMA Netw Open. 2022 Apr 1;5(4):e227650. doi: 10.1001/jamanetworkopen.2022.7650. PMID: 35442459.
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Artificial sweeteners: Real Data.

McGlynn ND, Khan TA, Wang L, Zhang R, Chiavaroli L, Au-Yeung F, Lee JJ, Noronha JC, Comelli EM, Blanco Mejia S, Ahmed A, Malik VS, Hill JO, Leiter LA, Agarwal A, Jeppesen PB, Rahelic D, Kahleová H, Salas-Salvadó J, Kendall CWC, Sievenpiper JL. Association of Low- and No-Calorie Sweetened Beverages as a Replacement for Sugar-Sweetened Beverages With Body Weight and Cardiometabolic Risk: A Systematic Review and Meta-analysis. JAMA Netw Open. 2022 Mar 1;5(3):e222092. doi: 10.1001/jamanetworkopen.2022.2092. PMID: 35285920.
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Time to step up our Echo game. It’s becoming standard of care.

Vieillard-Baron A, Millington SJ, Sanfilippo F, Chew M, Diaz-Gomez J, McLean A, Pinsky MR, Pulido J, Mayo P, Fletcher N. A decade of progress in critical care echocardiography: a narrative review. Intensive Care Med. 2019 Jun;45(6):770-788. doi: 10.1007/s00134-019-05604-2. Epub 2019 Mar 25. Erratum in: Intensive Care Med. 2019 Apr 15;: PMID: 30911808.
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Lung Ultrasound

Stassen J, Bax JJ. How to do lung ultrasound. Eur Heart J Cardiovasc Imaging. 2022 Mar 22;23(4):447-449. doi: 10.1093/ehjci/jeab241. PMID: 34791145.
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Treating Complications of COVID

Maslove DM, Sibley S, Boyd JG, Goligher EC, Munshi L, Bogoch II, Rochwerg B. Complications of Critical COVID-19: Diagnostic and Therapeutic Considerations for the Mechanically Ventilated Patient. Chest. 2021 Oct 13;161(4):989–98. doi: 10.1016/j.chest.2021.10.011. Epub ahead of print. PMID: 34655568; PMCID: PMC8511547.
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POCUS

Kalagara H, Coker B, Gerstein NS, Kukreja P, Deriy L, Pierce A, Townsley MM. Point-of-Care Ultrasound (POCUS) for the Cardiothoracic Anesthesiologist. J Cardiothorac Vasc Anesth. 2022 Apr;36(4):1132-1147. doi: 10.1053/j.jvca.2021.01.018. Epub 2021 Jan 16. PMID: 33563532.
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Death by Neurologic Criteria

Spears, W., Mian, A. & Greer, D. Brain death: a clinical overview. j intensive care 10, 16 (2022). https://doi.org/10.1186/s40560-022-00609-4
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Prognositicating after ROSC from a cardiac arrest

Sandroni C, D’Arrigo S, Cacciola S, Hoedemaekers CWE, Westhall E, Kamps MJA, Taccone FS, Poole D, Meijer FJA, Antonelli M, Hirsch KG, Soar J, Nolan JP, Cronberg T. Prediction of good neurological outcome in comatose survivors of cardiac arrest: a systematic review. Intensive Care Med. 2022 Mar 4. doi: 10.1007/s00134-022-06618-z. Epub ahead of print. PMID: 35244745.
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Adding C’s to the H’s and T’s

L. Mommers, C. Slagt, Introducing the C’s in CPR, Resuscitation (2022), doi: https:// doi.org/10.1016/j.resuscitation.2022.02.022
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When a cirrhotic becomes decompensated in our ICU

Passi, N. N., & McPhail, M. J. (2022). The patient with cirrhosis in the intensive care unit and the management of acute-on-chronic liver failure. Journal of the Intensive Care Society, 23(1), 78–86. https://doi.org/10.1177/1751143720978849
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All the inpatient therapies in one place? Don’t mind if I do!

Chen J-T, Ostermann M, Review of Anti-inflammatory and Anti-viral therapeutics for hospitalized patients infected with SARS-CoV-2, CRITICAL CARE CLINICS (2022), doi: https://doi.org/10.1016/j.ccc.2022.02.002.
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Finally! Guidelines for Anticoagulation from a major Critical Care Society

Moores LK, Tritschler T, Brosnahan S, Carrier M, Collen JF, Doerschug K, Holley AB, Iaccarino J, Jimenez D, LeGal G, Rali P, Wells P, Thromboprophylaxis in Patients with COVID-19. A Brief Update to the CHEST Guideline and Expert Panel Report, CHEST (2022), doi:https://doi.org/10.1016/j.chest.2022.02.006.
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Does iNO actually work or just make us feel better about ourselves that we are doing something?

Bonizzoli M, Lazzeri C, Cianchi G, Guetti C, Fulceri GE, Socci F, Peris A. Effects of rescue inhaled nitric oxide on right ventricle and pulmonary circulation in severe COVID-related acute respiratory distress syndrome. J Crit Care. 2022 Feb 1:153987. doi: 10.1016/j.jcrc.2022.153987. Epub ahead of print. PMID: 35120777; PMCID: PMC8806881.
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When to Trach our COVID Patients

Ji Y, Fang Y, Cheng B, Li L, Fang X. Tracheostomy timing and clinical outcomes in ventilated COVID-19 patients: a systematic review and meta-analysis. Crit Care. 2022 Feb 8;26(1):40. doi: 10.1186/s13054-022-03904-6. PMID: 35135597.
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Keep your patients dry on the vent

Wang W, Zhu S, He Q, Wang M, Kang Y, Zhang R, Ji P, Zou K, Klompas M, Zong Z, Sun X. Fluid Balance and Ventilator-Associated Events Among Patients Admitted to ICUs in China: A Nested Case-Control Study. Crit Care Med. 2022 Feb 1;50(2):307-316. doi: 10.1097/CCM.0000000000005227. PMID: 34473657; PMCID: PMC8797004.
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Surge Responses

Dichter JR, Devereaux AV, Sprung CL, Mukherjee V, Persoff J, Baum KD, Ornoff D, Uppal A, Hossain T, Henry KN, Ghazipura M, Bowden KR, Feldman HJ, Hamele MT, Burry LD, Martland AMO, Huffines M, Tosh PK, Downar J, Hick JL, Christian MD, Maves RC; Task Force for Mass Critical Care Writing Group. Mass Critical Care Surge Response During COVID-19: Implementation of Contingency Strategies – A Preliminary Report of Findings From the Task Force for Mass Critical Care. Chest. 2021 Sep 6;161(2):429–47. doi: 10.1016/j.chest.2021.08.072. Epub ahead of print. PMID: 34499878; PMCID: PMC8420082.
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The Heart and COVID-19 Are NOT BFF’s.

Helms J, Combes A, Aissaoui N. Cardiac injury in COVID-19. Intensive Care Med. 2022 Jan;48(1):111-113. doi: 10.1007/s00134-021-06555-3. Epub 2021 Nov 2. PMID: 34727214; PMCID: PMC8562019.
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Many People Quit Smoking During 2020

Gaffney A, Himmelstein DU, Woolhandler S. Smoking Prevalence during the COVID-19 Pandemic in the United States. Ann Am Thorac Soc. 2022 Jan 19. doi: 10.1513/AnnalsATS.202110-1184RL. Epub ahead of print. PMID: 35044900.
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How severe is Omicron? Let’s look at the actual data from South Africa.

“individuals had a significantly reduced odds of severe disease compared with individuals infected earlier with the delta variant. Some of this reduced severity is probably a result of previous immunity.“
Wolter N, Jassat W, Walaza S, Welch R, Moultrie H, Groome M, Amoako DG, Everatt J, Bhiman JN, Scheepers C, Tebeila N, Chiwandire N, du Plessis M, Govender N, Ismail A, Glass A, Mlisana K, Stevens W, Treurnicht FK, Makatini Z, Hsiao NY, Parboosing R, Wadula J, Hussey H, Davies MA, Boulle A, von Gottberg A, Cohen C. Early assessment of the clinical severity of the SARS-CoV-2 omicron variant in South Africa: a data linkage study. Lancet. 2022 Jan 19:S0140-6736(22)00017-4. doi: 10.1016/S0140-6736(22)00017-4. Epub ahead of print. PMID: 35065011.
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Cardiac Injury 2/2 COVID

Helms J, Combes A, Aissaoui N. Cardiac injury in COVID-19. Intensive Care Med. 2022 Jan;48(1):111-113. doi: 10.1007/s00134-021-06555-3. Epub 2021 Nov 2. PMID: 34727214; PMCID: PMC8562019.
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How to liberate a patient from the ventilator

Ouellette DR. The Decision to Liberate From the Ventilator: More Than Just a Number. Chest. 2022 Jan;161(1):6-7. doi: 10.1016/j.chest.2021.07.016. PMID: 35000708.
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Lung Transplants and COVID: Not enough to go around

King CS, Mannem H, Kukreja J, Aryal S, Tang D, Singer JP, Bharat A, Behr J, Nathan SD. Lung Transplantation of COVID-19 Patients. Chest. 2021 Aug 19;161(1):169–78. doi: 10.1016/j.chest.2021.08.041. Epub ahead of print. PMID: 34418410; PMCID: PMC8373594.
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New/Potential Biomarkers for Sepsis?

Barichello T, Generoso JS, Singer M, Dal-Pizzol F. Biomarkers for sepsis: more than just fever and leukocytosis-a narrative review. Crit Care. 2022 Jan 6;26(1):14. doi: 10.1186/s13054-021-03862-5. PMID: 34991675.
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Hypocalcemia and Blood Transfusions

Hall C, Nagengast AK, Knapp C, Behrens B, Dewey EN, Goodman A, Bommiasamy A, Schreiber M. Massive transfusions and severe hypocalcemia: An opportunity for monitoring and supplementation guidelines. Transfusion. 2021 Jul;61 Suppl 1:S188-S194. doi: 10.1111/trf.16496. PMID: 34269436.
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What to do about the coagulopathy in liver patients?

Lange NW, Salerno DM, Berger K, Cushing MM, Brown RS Jr. Management of Hepatic Coagulopathy in Bleeding and Nonbleeding Patients: An Evidence-Based Review. J Intensive Care Med. 2021 May;36(5):524-541. doi: 10.1177/0885066620903027. Epub 2020 Feb 21. PMID: 32079443.
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Rhabdomyolysis Management

Burgess, Sarah. “Rhabdomyolysis: An Evidence-Based Approach.” Journal of the Intensive Care Society, Dec. 2022, doi:10.1177/17511437211050782.
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A nerdy therefore cool way to look at Sepsis

Bauer M, Shankar-Hari M, Thomas-Rüddel DO, Wetzker R. Towards an ecological definition of sepsis: a viewpoint. Intensive Care Med Exp. 2021 Dec 29;9(1):63. doi: 10.1186/s40635-021-00427-2. PMID: 34964952; PMCID: PMC8715410.
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When should we call the surgeons for abdominal compartment syndrome?

Păduraru DN, Andronic O, Mușat F, Bolocan A, Dumitrașcu MC, Ion D. Abdominal Compartment Syndrome-When Is Surgical Decompression Needed? Diagnostics (Basel). 2021 Dec 7;11(12):2294. doi: 10.3390/diagnostics11122294. PMID: 34943530.
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Hyperoxia: Not Benign

Singer M, Young PJ, Laffey JG, Asfar P, Taccone FS, Skrifvars MB, Meyhoff CS, Radermacher P. Dangers of hyperoxia. Crit Care. 2021 Dec 19;25(1):440. doi: 10.1186/s13054-021-03815-y. PMID: 34924022.
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Pharmacists in the ICU have a fantastic Return on Investment

Rech MA, Gurnani PK, Peppard WJ, Smetana KS, Van Berkel MA, Hammond DA, Flannery AH. PHarmacist Avoidance or Reductions in Medical Costs in CRITically Ill Adults: PHARM-CRIT Study. Crit Care Explor. 2021 Dec 10;3(12):e0594. doi: 10.1097/CCE.0000000000000594. PMID: 34913039; PMCID: PMC8668016.
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Should we discharge COVID patients on anticoagulation?

Rivaroxaban versus no anticoagulation for post-discharge thromboprophylaxis after hospitalisation for COVID-19 (MICHELLE): an open-label, multicentre, randomised controlled trial. Lancet. 2021; (published online Dec 15.)
https://doi.org/10.1016/S0140-6736(21)02392-8
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Further comments
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High-Flow Nasal Cannula Keeps COVID patients off of the vent: NNT of 6

Ospina-Tascón GA, Calderón-Tapia LE, García AF, Zarama V, Gómez-Álvarez F, Álvarez-Saa T, Pardo-Otálvaro S, Bautista-Rincón DF, Vargas MP, Aldana-Díaz JL, Marulanda Á, Gutiérrez A, Varón J, Gómez M, Ochoa ME, Escobar E, Umaña M, Díez J, Tobón GJ, Albornoz LL, Celemín Flórez CA, Ruiz GO, Cáceres EL, Reyes LF, Damiani LP, Cavalcanti AB; HiFLo-Covid Investigators. Effect of High-Flow Oxygen Therapy vs Conventional Oxygen Therapy on Invasive Mechanical Ventilation and Clinical Recovery in Patients With Severe COVID-19: A Randomized Clinical Trial. JAMA. 2021 Dec 7;326(21):2161-2171. doi: 10.1001/jama.2021.20714. PMID: 34874419; PMCID: PMC8652598.
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Is your Critically Ill Patient Bleeding? Here’s how to handle it.

Vlaar APJ, Dionne JC, de Bruin S, Wijnberge M, Raasveld SJ, van Baarle FEHP, Antonelli M, Aubron C, Duranteau J, Juffermans NP, Meier J, Murphy GJ, Abbasciano R, Müller MCA, Lance M, Nielsen ND, Schöchl H, Hunt BJ, Cecconi M, Oczkowski S. Transfusion strategies in bleeding critically ill adults: a clinical practice guideline from the European Society of Intensive Care Medicine. Intensive Care Med. 2021 Dec;47(12):1368-1392. doi: 10.1007/s00134-021-06531-x. Epub 2021 Oct 22. PMID: 34677620; PMCID: PMC8532090.
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Septic Shock Patients Develop Complications like… Brain Atrophy?

Nakae R, Sekine T, Tagami T, Murai Y, Kodani E, Warnock G, Sato H, Morita A, Yokota H, Yokobori S. Rapidly progressive brain atrophy in septic ICU patients: a retrospective descriptive study using semiautomatic CT volumetry. Crit Care. 2021 Nov 29;25(1):411. doi: 10.1186/s13054-021-03828-7. PMID: 34844648.
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We better step up our ultrasound game

Robba C, Wong A, Poole D, Al Tayar A, Arntfield RT, Chew MS, Corradi F, Douflé G, Goffi A, Lamperti M, Mayo P, Messina A, Mongodi S, Narasimhan M, Puppo C, Sarwal A, Slama M, Taccone FS, Vignon P, Vieillard-Baron A; European Society of Intensive Care Medicine task force for critical care ultrasonography*. Basic ultrasound head-to-toe skills for intensivists in the general and neuro intensive care unit population: consensus and expert recommendations of the European Society of Intensive Care Medicine. Intensive Care Med. 2021 Dec;47(12):1347-1367. doi: 10.1007/s00134-021-06486-z. Epub 2021 Oct 5. PMID: 34787687; PMCID: PMC8596353.
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Individualized Sepsis Bundles

Vincent JL, Singer M, Einav S, Moreno R, Wendon J, Teboul JL, Bakker J, Hernandez G, Annane D, de Man AME, Monnet X, Ranieri VM, Hamzaoui O, Takala J, Juffermans N, Chiche JD, Myatra SN, De Backer D. Equilibrating SSC guidelines with individualized care. Crit Care. 2021 Nov 17;25(1):397. doi: 10.1186/s13054-021-03813-0. PMID: 34789298; PMCID: PMC8596086.
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What complications can we expect from a central line?

van de Weerdt EK, Biemond BJ, Baake B, Vermin B, Binnekade JM, van Lienden KP, Vlaar APJ. Central venous catheter placement in coagulopathic patients: risk factors and incidence of bleeding complications. Transfusion. 2017 Oct;57(10):2512-2525. doi: 10.1111/trf.14248. Epub 2017 Aug 30. PMID: 28856685.
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How to place a central line

Saugel B, Scheeren TWL, Teboul JL. Ultrasound-guided central venous catheter placement: a structured review and recommendations for clinical practice. Crit Care. 2017 Aug 28;21(1):225. doi: 10.1186/s13054-017-1814-y. PMID: 28844205; PMCID: PMC5572160.
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How to perform a percutaneous tracheostomy

Rashid AO, Islam S. Percutaneous tracheostomy: a comprehensive review. J Thorac Dis. 2017 Sep;9(Suppl 10):S1128-S1138. doi: 10.21037/jtd.2017.09.33. PMID: 29214070; PMCID: PMC5696543.
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Peri-Induction Hemodynamics: Don’t get stuck.

Nabzdyk CGS, Read MD, Wieruszewski PM, Seelhammer TG. Proactive Approach to Peri-Induction Hemodynamic Management in Critically Ill Patients. J Cardiothorac Vasc Anesth. 2021 Dec;35(12):3489-3492. doi: 10.1053/j.jvca.2021.06.015. Epub 2021 Jun 18. PMID: 34253443.
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Brain Injury after cardiac arrest

Sandroni C, Cronberg T, Sekhon M. Brain injury after cardiac arrest: pathophysiology, treatment, and prognosis. Intensive Care Med. 2021 Oct 27:1–22. doi: 10.1007/s00134-021-06548-2. Epub ahead of print. PMID: 34705079; PMCID: PMC8548866.
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How will our critically ill COVID-19 Patients do at 6 months?

Hodgson CL, Higgins AM, Bailey MJ, Mather AM, Beach L, Bellomo R, Bissett B, Boden IJ, Bradley S, Burrell A, Cooper DJ, Fulcher BJ, Haines KJ, Hopkins J, Jones AYM, Lane S, Lawrence D, van der Lee L, Liacos J, Linke NJ, Gomes LM, Nickels M, Ntoumenopoulos G, Myles PS, Patman S, Paton M, Pound G, Rai S, Rix A, Rollinson TC, Sivasuthan J, Tipping CJ, Thomas P, Trapani T, Udy AA, Whitehead C, Hodgson IT, Anderson S, Neto AS; COVID-Recovery Study Investigators and the ANZICS Clinical Trials Group. The impact of COVID-19 critical illness on new disability, functional outcomes and return to work at 6 months: a prospective cohort study. Crit Care. 2021 Nov 8;25(1):382. doi: 10.1186/s13054-021-03794-0. PMID: 34749756; PMCID: PMC8575157.
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Chest Pain Guidelines 2021

Martha Gulati, Phillip D. Levy, Debabrata Mukherjee, Ezra Amsterdam, Deepak L. Bhatt, Kim K. Birtcher, Ron Blankstein, Jack Boyd, Renee P. Bullock-Palmer, Theresa Conejo, Deborah B. Diercks, Federico Gentile, John P. Greenwood, Erik P. Hess, Steven M. Hollenberg, Wael A. Jaber, Hani Jneid, José A. Joglar, David A. Morrow, Robert E. O’Connor, Michael A. Ross, Leslee J. Shaw, 2021 AHA/ACC/ASE/CHEST/SAEM/SCCT/SCMR Guideline for the Evaluation and Diagnosis of Chest Pain: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines, Journal of the American College of Cardiology, 2021, ISSN 0735-1097, https://doi.org/10.1016/j.jacc.2021.07.053.
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Best method of ventilator weaning?

Jhou HJ, Chen PH, Ou-Yang LJ, Lin C, Tang SE, Lee CH. Methods of Weaning From Mechanical Ventilation in Adult: A Network Meta-Analysis. Front Med (Lausanne). 2021 Oct 4;8:752984. doi: 10.3389/fmed.2021.752984. PMID: 34671629; PMCID: PMC8521009.
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Head up CPR? Wait, What?

Huang CC, Chen KC, Lin ZY, Chou YH, Chen WL, Lee TH, Lin KT, Hsieh PY, Chen CH, Chou CC, Lin YR. The effect of the head-up position on cardiopulmonary resuscitation: a systematic review and meta-analysis. Crit Care. 2021 Oct 30;25(1):376. doi: 10.1186/s13054-021-03797-x. PMID: 34717715.
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Research Priorities for Sepsis

Lat I, Coopersmith CM, De Backer D, Coopersmith CM; Research Committee of the Surviving Sepsis Campaign. The surviving sepsis campaign: fluid resuscitation and vasopressor therapy research priorities in adult patients. Intensive Care Med Exp. 2021 Mar 1;9(1):10. doi: 10.1186/s40635-021-00369-9. PMID: 33644843.
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Is there a thing as too much oxygen?

Ni YN, Wang YM, Liang BM, Liang ZA. The effect of hyperoxia on mortality in critically ill patients: a systematic review and meta analysis. BMC Pulm Med. 2019 Feb 26;19(1):53. doi: 10.1186/s12890-019-0810-1. PMID: 30808337; PMCID: PMC6390560.
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Opioids trash the gut in ICU patients

Yan Y, Chen Y, Zhang X. The effect of opioids on gastrointestinal function in the ICU. Crit Care. 2021 Oct 24;25(1):370. doi: 10.1186/s13054-021-03793-1. PMID: 34689805.
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Can’t we just filter out the CO2 from these patients?

Molina Lobo R, Lobo-Valbuena B, Gordo F. Management of severe ARDS due to SARS-CoV-2 pneumonia using low-flow extracorporeal CO₂ extraction. Crit Care. 2021 Oct 18;25(1):362. doi: 10.1186/s13054-021-03777-1. PMID: 34663415; PMCID: PMC8522120.
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Details about natural immunity!

Does infection with or vaccination against SARS-CoV-2 lead to lasting immunity? Gregory Milne, MSc Thomas Hames, PhD Chris Scotton, PhD Nick Gent, FFPH Alexander Johnsen, MSci Prof Roy M Anderson, FRS Tom Ward, PhD. Published:October 21, 2021 DOI:https://doi.org/10.1016/S2213-2600(21)00407-0
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Do we need to do both SCD’s and pharmacological DVT prophylaxis?

Arabi YM, Al-Hameed F, Burns KEA, Mehta S, Alsolamy SJ, Alshahrani MS, Mandourah Y, Almekhlafi GA, Almaani M, Al Bshabshe A, Finfer S, Arshad Z, Khalid I, Mehta Y, Gaur A, Hawa H, Buscher H, Lababidi H, Al Aithan A, Abdukahil SAI, Jose J, Afesh LY, Al-Dawood A; Saudi Critical Care Trials Group. Adjunctive Intermittent Pneumatic Compression for Venous Thromboprophylaxis. N Engl J Med. 2019 Apr 4;380(14):1305-1315. doi: 10.1056/NEJMoa1816150. Epub 2019 Feb 18. PMID: 30779530.
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Higher PEEP May Not Always be the Answer Due To Hyperinflation

Protti A, Santini A, Pennati F, Chiurazzi C, Cressoni M, Ferrari M, Iapichino GE, Carenzo L, Lanza E, Picardo G, Caironi P, Aliverti A, Cecconi M. Lung response to a higher positive end-expiratory pressure in mechanically ventilated patients with COVID-19. Chest. 2021 Oct 16:S0012-3692(21)04100-3. doi: 10.1016/j.chest.2021.10.012. Epub ahead of print. PMID: 34666011; PMCID: PMC8520168.
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Brain Injuries injure the Lungs

Ziaka M, Exadaktylos A. Brain-lung interactions and mechanical ventilation in patients with isolated brain injury. Crit Care. 2021 Oct 13;25(1):358. doi: 10.1186/s13054-021-03778-0. PMID: 34645485.
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Grip Strength to Determine Extubation Outcome?

Cottereau G, Messika J, Megarbane B, Guérin L, da Silva D, Bornstain C, Santos M, Ricard JD, Sztrymf B. Handgrip strength to predict extubation outcome: a prospective multicenter trial. Ann Intensive Care. 2021 Oct 2;11(1):144. doi: 10.1186/s13613-021-00932-3. PMID: 34601639; PMCID: PMC8487340.
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Monoclonal antibodies in Septic Shock?

Laterre PF, Pickkers P, Marx G, Wittebole X, Meziani F, Dugernier T, Huberlant V, Schuerholz T, François B, Lascarrou JB, Beishuizen A, Oueslati H, Contou D, Hoiting O, Lacherade JC, Chousterman B, Pottecher J, Bauer M, Godet T, Karakas M, Helms J, Bergmann A, Zimmermann J, Richter K, Hartmann O, Pars M, Mebazaa A; AdrenOSS-2 study participants. Safety and tolerability of non-neutralizing adrenomedullin antibody adrecizumab (HAM8101) in septic shock patients: the AdrenOSS-2 phase 2a biomarker-guided trial. Intensive Care Med. 2021 Oct 4:1–11. doi: 10.1007/s00134-021-06537-5. Epub ahead of print. PMID: 34605947; PMCID: PMC8487806.
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Nurses! Need some Evidence-Based Tips on How to place Dobhoff Tubes? Check this out!

Kurisawa K, Yokose M, Tanaka H, Mihara T, Takaki S, Goto T. Multivariate analysis of factors associated with first-pass success in blind placement of a post-pyloric feeding tube: a retrospective study. J Intensive Care. 2021 Oct 7;9(1):59. doi: 10.1186/s40560-021-00577-1. PMID: 34615558.
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Thromboembolism in COVID-19

Poor HD. Pulmonary Thrombosis and Thromboembolism in COVID-19. Chest. 2021 Jun 19;160(4):1471–80. doi: 10.1016/j.chest.2021.06.016. Epub ahead of print. PMID: 34153340; PMCID: PMC8213519.
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2021 Surviving Sepsis Campaign Guidelines

Evans L, Rhodes A, Alhazzani W, Antonelli M, Coopersmith CM, French C, Machado FR, Mcintyre L, Ostermann M, Prescott HC, Schorr C, Simpson S, Wiersinga WJ, Alshamsi F, Angus DC, Arabi Y, Azevedo L, Beale R, Beilman G, Belley-Cote E, Burry L, Cecconi M, Centofanti J, Coz Yataco A, De Waele J, Dellinger RP, Doi K, Du B, Estenssoro E, Ferrer R, Gomersall C, Hodgson C, Møller MH, Iwashyna T, Jacob S, Kleinpell R, Klompas M, Koh Y, Kumar A, Kwizera A, Lobo S, Masur H, McGloughlin S, Mehta S, Mehta Y, Mer M, Nunnally M, Oczkowski S, Osborn T, Papathanassoglou E, Perner A, Puskarich M, Roberts J, Schweickert W, Seckel M, Sevransky J, Sprung CL, Welte T, Zimmerman J, Levy M. Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021. Intensive Care Med. 2021 Nov;47(11):1181-1247. doi: 10.1007/s00134-021-06506-y. Epub 2021 Oct 2. PMID: 34599691; PMCID: PMC8486643.
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When should we trach COVID patients?

Williams T, McGrath BA. Tracheostomy for COVID-19: evolving best practice. Crit Care. 2021 Aug 31;25(1):316. doi: 10.1186/s13054-021-03674-7. PMID: 34461964; PMCID: PMC8405347.
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Severe Encephalopathy in ICU COVID-19 Patients

Helms J, Kremer S, Merdji H, Schenck M, Severac F, Clere-Jehl R, Studer A, Radosavljevic M, Kummerlen C, Monnier A, Boulay C, Fafi-Kremer S, Castelain V, Ohana M, Anheim M, Schneider F, Meziani F. Delirium and encephalopathy in severe COVID-19: a cohort analysis of ICU patients. Crit Care. 2020 Aug 8;24(1):491. doi: 10.1186/s13054-020-03200-1. PMID: 32771053; PMCID: PMC7414289.
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Ragheb J, McKinney A, Zierau M, Brooks J, Hill-Caruthers M, Iskander M, Ahmed Y, Lobo R, Mentz G, Vlisides PE. Delirium and neuropsychological outcomes in critically Ill patients with COVID-19: a cohort study. BMJ Open. 2021 Sep 17;11(9):e050045. doi: 10.1136/bmjopen-2021-050045. PMID: 34535480; PMCID: PMC8450964.
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Multisystem Inflammatory Syndrome in Adults

Patel P, DeCuir J, Abrams J, Campbell AP, Godfred-Cato S, Belay ED. Clinical Characteristics of Multisystem Inflammatory Syndrome in Adults: A Systematic Review. JAMA Netw Open. 2021 Sep 1;4(9):e2126456. doi: 10.1001/jamanetworkopen.2021.26456. PMID: 34550381.
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APRV MAY help SOME COVID-19 Patients

Mahmoud O, Patadia D, Salonia J. Utilization of Airway Pressure Release Ventilation as a Rescue Strategy in COVID-19 Patients: A Retrospective Analysis. J Intensive Care Med. 2021 Oct;36(10):1194-1200. doi: 10.1177/08850666211030899. Epub 2021 Jul 7. PMID: 34231408; PMCID: PMC8266677.
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And if you don’t know how to set up your patients on APRV, here’s the article for you!
Swindin J, Sampson C, Howatson A. Airway pressure release ventilation. BJA Educ. 2020 Mar;20(3):80-88. doi: 10.1016/j.bjae.2019.12.001. Epub 2020 Jan 23. PMID: 33456934; PMCID: PMC7808079.
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Pathophysiology of ARDS and COVID-19 ARDS

Swenson KE, Swenson ER. Pathophysiology of Acute Respiratory Distress Syndrome and COVID-19 Lung Injury. Crit Care Clin. 2021 Oct;37(4):749-776. doi: 10.1016/j.ccc.2021.05.003. Epub 2021 May 28. PMID: 34548132; PMCID: PMC8162817.
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How much fluid should we give ARDS patients?

Fluid Therapy and Acute Respiratory Distress Syndrome. Jisoo Lee, MD Keith Corl, MD, ScM Mitchell M. Levy, MD, MCCM, FCCP
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Regeneron for Outpatient COVID

David M. Weinreich, Sumathi Sivapalasingam, Thomas Norton, Shazia Ali, Haitao Gao, Rafia Bhore, Jing Xiao, Andrea T. Hooper, Jennifer D. Hamilton, Bret J. Musser, DianaRofail, Mohamed Hussein, Joseph Im, Dominique Y. Atmodjo, Christina Perry, CynthiaPan, Adnan Mahmood, Romana Hosain, John D. Davis, Kenneth C. Turner, Alina Baum, Christos A. Kyratsous, Yunji Kim, Amanda Cook, Wendy Kampman, Lilia Roque-Guerrero, Gerard Acloque, Hessam Aazami, Kevin Cannon, J. Abraham Simón-Campos, Joseph A. Bocchini, Bari Kowal, Thomas DiCioccio, Yuhwen Soo, Neil Stahl, Leah Lipsich, Ned Braunstein, Gary Herman, George D. Yancopoulos, for the Trial Investigators medRxiv 2021.05.19.21257469; doi:https://doi.org/10.1101/2021.05.19.21257469
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The Gut and COVID-19

Reintam Blaser A, Gunst J, Arabi YM. The gut in COVID-19. Intensive Care Med. 2021 Sep;47(9):1024-1027. doi: 10.1007/s00134-021-06461-8. Epub 2021 Jul 8. PMID: 34240234; PMCID: PMC8265290.
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What Percentage of Hospitalized COVID-19 Patients End Up with a Pneumothorax

Geraci TC, Williams D, Chen S, Grossi E, Chang S, Cerfolio RJ, Bizekis C, Zervos M. Incidence, Management, and Outcomes of Patients with COVID-19 and Pneumothorax. Ann Thorac Surg. 2021 Sep 2:S0003-4975(21)01545-9. doi: 10.1016/j.athoracsur.2021.07.097. Epub ahead of print. PMID: 34481799; PMCID: PMC8413091.
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What are the chances COVID patients have bacterial co-infection on admission?

Musher DM. Bacterial Coinfection in COVID-19 and Influenza Pneumonia. Am J Respir Crit Care Med. 2021 Sep 1;204(5):498-500. doi: 10.1164/rccm.202106-1467ED. PMID: 34233146.
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The Task Force for this Pandemic has made recommendations… now what do we do about it?

Dichter JR, Devereaux AV, Sprung CL, Mukherjee V, Persoff J, Baum KD, Ornoff D, Uppal A, Hossain T, Henry KN, Ghazipura M, Bowden KR, Feldman HJ, Hamele MT, Burry LD, Martland AMO, Huffines M, Tosh PK, Downar J, Hick JL, Christian MD, Maves RC, for the Task Force for Mass Critical Care Writing Group, Mass Critical Care Surge Response during COVID-19: Implementation of Contingency Strategies A Preliminary Report of findings from the Task Force for Mass Critical Care CHEST (2021), doi: https://doi.org/10.1016/j.chest.2021.08.072.
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We can sometimes do Plateau Pressures > 30? Say it ain’t so!

Diehl, JL., Talmor, D. When could airway plateau pressure above 30 cmH₂O be acceptable in ARDS patients?. Intensive Care Med 47, 1028–1031 (2021). https://doi.org/10.1007/s00134-021-06472-5
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Delirium Systematic Review and Meta-Analysis

Burry, L.D., Cheng, W., Williamson, D.R. et al. Pharmacological and non-pharmacological interventions to prevent delirium in critically ill patients: a systematic review and network meta-analysis. Intensive Care Med 47, 943–960 (2021). https://doi.org/10.1007/s00134-021-06490-3
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Should we keep calling ARDS “ARDS”?

Gattinoni, L., Marini, J.J. Isn’t it time to abandon ARDS? The COVID-19 lesson. Crit Care25, 326 (2021). https://doi.org/10.1186/s13054-021-03748-6
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Metoprolol for COVID-19

Clemente-Moragón A, Martínez-Milla J, Oliver E, Santos A, Flandes J, Fernández I, Rodríguez-González L, Serrano Del Castillo C, Ioan AM, López-Álvarez M, Gómez-Talavera S, Galán-Arriola C, Fuster V, Pérez-Calvo C, Ibáñez B. Metoprolol in Critically Ill Patients With COVID-19. J Am Coll Cardiol. 2021 Sep 7;78(10):1001-1011. doi: 10.1016/j.jacc.2021.07.003. PMID: 34474731; PMCID: PMC8404624.
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Natural Immunity is Worth Something

Comparing SARS-CoV-2 natural immunity to vaccine-induced immunity: reinfections versus breakthrough infectionsSivan Gazit, Roei Shlezinger, Galit Perez, Roni Lotan, Asaf Peretz, Amir Ben-Tov, DaniCohen, Khitam Muhsen, Gabriel Chodick, Tal PatalonmedRxiv 2021.08.24.21262415; doi:https://doi.org/10.1101/2021.08.24.21262415
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Inhaled Budesonide for Outpatient COVID

Yu LM, Bafadhel M, Dorward J, Hayward G, Saville BR, Gbinigie O, Van Hecke O, Ogburn E, Evans PH, Thomas NPB, Patel MG, Richards D, Berry N, Detry MA, Saunders C, Fitzgerald M, Harris V, Shanyinde M, de Lusignan S, Andersson MI, Barnes PJ, Russell REK, Nicolau DV Jr, Ramakrishnan S, Hobbs FDR, Butler CC; PRINCIPLE Trial Collaborative Group. Inhaled budesonide for COVID-19 in people at high risk of complications in the community in the UK (PRINCIPLE): a randomised, controlled, open-label, adaptive platform trial. Lancet. 2021 Aug 10;398(10303):843–55. doi: 10.1016/S0140-6736(21)01744-X. Epub ahead of print. Erratum in: Lancet. 2021 Aug 18;: PMID: 34388395; PMCID: PMC8354567.
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Delta is worse than the other variants

Twohig KA, Nyberg T, Zaidi A, Thelwall S, Sinnathamby MA, Aliabadi S, Seaman SR, Harris RJ, Hope R, Lopez-Bernal J, Gallagher E, Charlett A, De Angelis D, Presanis AM, Dabrera G; COVID-19 Genomics UK (COG-UK) consortium. Hospital admission and emergency care attendance risk for SARS-CoV-2 delta (B.1.617.2) compared with alpha (B.1.1.7) variants of concern: a cohort study. Lancet Infect Dis. 2021 Aug 27:S1473-3099(21)00475-8. doi: 10.1016/S1473-3099(21)00475-8. Epub ahead of print. PMID: 34461056; PMCID: PMC8397301.
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Instagram page of Dr. Michael Daignault

Convalescent Plasma DOES NOT WORK. Stop it already.

Devos T, Van Thillo Q, Compernolle V, Najdovski T, Romano M, Dauby N, Jadot L, Leys M, Maillart E, Loof S, Seyler L, Moonen M, Moutschen M, Van Regenmortel N, Ariën KK, Barbezange C, Betrains A, Garigliany M, Engelen MM, Gyselinck I, Maes P, Schauwvlieghe A, Liesenborghs L, Belmans A, Verhamme P, Meyfroidt G; DAWn-plasma investigators. Early high antibody-titre convalescent plasma for hospitalised COVID-19 patients: DAWn-plasma. Eur Respir J. 2021 Aug 26:2101724. doi: 10.1183/13993003.01724-2021. Epub ahead of print. PMID: 34446469.
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Japanese Sepsis Guidelines 2020

Egi, M., Ogura, H., Yatabe, T. et al. The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2020 (J-SSCG 2020). j intensive care 9, 53 (2021). https://doi.org/10.1186/s40560-021-00555-7
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Is your COVID-19 Patient a Lung Transplant Candidate?

King CS, Mannem H, Kukreja J, Aryal S, Tang D, Singer JP, Bharat A, Behr J, Nathan SD, How I Do It: Considering lung transplantation for patients with COVID-19, CHEST (2021), doi: https://doi.org/10.1016/j.chest.2021.08.041.
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We need to be proning every awake patient with COVID we can!

Awake prone positioning for COVID-19 acute hypoxaemic respiratory failure: a randomised, controlled, multinational, open-label meta-trial. Ehrmann, StephanLi, Jie et al.
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Epinephrine Intervals: Still 3-5 minutes?

Shaffner DH, Callaway CW. Epinephrine Administration Intervals, Seeing the Forest for the Trees. Am J Respir Crit Care Med. 2021 Aug 19. doi: 10.1164/rccm.202107-1667ED. Epub ahead of print. PMID: 34411505.
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Diabetes and bad COVID are BFF’s

Klein, S.J., Mayerhöfer, T., Fries, D. et al. Elevated HbA1c remains a predominant finding in severe COVID-19 and may be associated with increased mortality in patients requiring mechanical ventilation. Crit Care 25, 300 (2021). https://doi.org/10.1186/s13054-021-03730-2
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Should we start checking Renin Levels in the ICU?

Flannery, A.H., Ortiz-Soriano, V., Li, X. et al. Serum renin and major adverse kidney events in critically ill patients: a multicenter prospective study. Crit Care 25, 294 (2021). https://doi.org/10.1186/s13054-021-03725-z
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Ventilator Asynchrony

Kyo, M., Shimatani, T., Hosokawa, K. et al. Patient–ventilator asynchrony, impact on clinical outcomes and effectiveness of interventions: a systematic review and meta-analysis. j intensive care 9, 50 (2021). https://doi.org/10.1186/s40560-021-00565-5
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Should we be doing longer courses of Corticosteroids in COVID-19 ARDS?

Luo, M., Qian, Y., Huang, D., Luo, J., Su, Y., Wang, H., Yu, S., Liu, K., Tu, G., & Luo, Z. (2021). Tailoring glucocorticoids in patients with severe COVID-19: a narrative review. Annals Of Translational Medicine, 9(15), 1261. doi:10.21037/atm-21-1783
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Fenofibrate is so HOT right now!

Davies SP, Mycroft-West CJ, Pagani I, Hill HJ, Chen Y-H, Karlsson R, Bagdonaite I, Guimond SE, Stamataki Z, De Lima MA, Turnbull JE, Yang Z, Vicenzi E, Skidmore MA, Khanim FL and Richardson A (2021) The Hyperlipidaemic Drug Fenofibrate Significantly Reduces Infection by SARS-CoV-2 in Cell Culture Models. Front. Pharmacol. 12:660490. doi: 10.3389/fphar.2021.660490
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Adding PEEP to the PaO2 FiO2 ratio in ARDS

Palanidurai, S., Phua, J., Chan, Y.H. et al. P/FP ratio: incorporation of PEEP into the PaO₂/FiO₂ ratio for prognostication and classification of acute respiratory distress syndrome. Ann. Intensive Care 11, 124 (2021). https://doi.org/10.1186/s13613-021-00908-3
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How to manage families during this pandemic

Hart JL, Taylor SP. Family Presence for Critically Ill Patients During a Pandemic. Chest. 2021 May 8;160(2):549–57. doi: 10.1016/j.chest.2021.05.003. Epub ahead of print. PMID: 33971149; PMCID: PMC8105126.
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AKI and COVID in the ICU

Lumlertgul N, Pirondini L, Cooney E, Kok W, Gregson J, Camporota L, Lane K, Leach R, Ostermann M. Acute kidney injury prevalence, progression and long-term outcomes in critically ill patients with COVID-19: a cohort study. Ann Intensive Care. 2021 Aug 6;11(1):123. doi: 10.1186/s13613-021-00914-5. PMID: 34357478; PMCID: PMC8343342.
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How long to wait after cardiac arrest to prognosticate?

Tsai MS, Chen WJ, Chen WT, Tien YT, Chang WT, Ong HN, Huang CH. Should We Prolong the Observation Period for Neurological Recovery After Cardiac Arrest? Crit Care Med. 2021 Aug 4. doi: 10.1097/CCM.0000000000005264. Epub ahead of print. PMID: 34342303.
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Dex and Toci Screw Up CRP and PCT: Duh.

Kooistra, E.J., van Berkel, M., van Kempen, N.F. et al. Dexamethasone and tocilizumab treatment considerably reduces the value of C-reactive protein and procalcitonin to detect secondary bacterial infections in COVID-19 patients. CKooistra EJ, van Berkel M, van Kempen NF, van Latum CRM, Bruse N, Frenzel T, van den Berg MJW, Schouten JA, Kox M, Pickkers P. Dexamethasone and tocilizumab treatment considerably reduces the value of C-reactive protein and procalcitonin to detect secondary bacterial infections in COVID-19 patients. Crit Care. 2021 Aug 5;25(1):281. doi: 10.1186/s13054-021-03717-z. PMID: 34353339.
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Anti-coagulating COVID Patients: The Flip Flopping Continues

REMAP-CAP Investigators; ACTIV-4a Investigators; ATTACC Investigators, Goligher EC, Bradbury CA, McVerry BJ, Lawler PR, Berger JS, Gong MN, Carrier M, Reynolds HR, Kumar A, Turgeon AF, Kornblith LZ, Kahn SR, Marshall JC, Kim KS, Houston BL, Derde LPG, Cushman M, Tritschler T, Angus DC, Godoy LC, McQuilten Z, Kirwan BA, Farkouh ME, Brooks MM, Lewis RJ, Berry LR, Lorenzi E, Gordon AC, Berry SM, McArthur CJ, Neal MD, Hochman JS, Webb SA, Zarychanski R, Ahuja T, Al-Beidh F, Annane D, Arabi YM, Aryal D, Baumann Kreuziger L, Beane A, Bhimani Z, Bihari S, Billett HH, Bond L, Bonten M, Brunkhorst F, Buxton M, Buzgau A, Castellucci LA, Chekuri S, Chen JT, Cheng AC, Chkhikvadze T, Coiffard B, Contreras A, Costantini TW, de Brouwer S, Detry MA, Duggal A, Džavík V, Effron MB, Eng HF, Escobedo J, Estcourt LJ, Everett BM, Fergusson DA, Fitzgerald M, Fowler RA, Froess JD, Fu Z, Galanaud JP, Galen BT, Gandotra S, Girard TD, Goodman AL, Goossens H, Green C, Greenstein YY, Gross PL, Haniffa R, Hegde SM, Hendrickson CM, Higgins AM, Hindenburg AA, Hope AA, Horowitz JM, Horvat CM, Huang DT, Hudock K, Hunt BJ, Husain M, Hyzy RC, Jacobson JR, Jayakumar D, Keller NM, Khan A, Kim Y, Kindzelski A, King AJ, Knudson MM, Kornblith AE, Kutcher ME, Laffan MA, Lamontagne F, Le Gal G, Leeper CM, Leifer ES, Lim G, Gallego Lima F, Linstrum K, Litton E, Lopez-Sendon J, Lother SA, Marten N, Saud Marinez A, Martinez M, Mateos Garcia E, Mavromichalis S, McAuley DF, McDonald EG, McGlothlin A, McGuinness SP, Middeldorp S, Montgomery SK, Mouncey PR, Murthy S, Nair GB, Nair R, Nichol AD, Nicolau JC, Nunez-Garcia B, Park JJ, Park PK, Parke RL, Parker JC, Parnia S, Paul JD, Pompilio M, Quigley JG, Rosenson RS, Rost NS, Rowan K, Santos FO, Santos M, Santos MO, Satterwhite L, Saunders CT, Schreiber J, Schutgens REG, Seymour CW, Siegal DM, Silva DG Jr, Singhal AB, Slutsky AS, Solvason D, Stanworth SJ, Turner AM, van Bentum-Puijk W, van de Veerdonk FL, van Diepen S, Vazquez-Grande G, Wahid L, Wareham V, Widmer RJ, Wilson JG, Yuriditsky E, Zhong Y. Therapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19. N Engl J Med. 2021 Aug 4. doi: 10.1056/NEJMoa2103417. Epub ahead of print. PMID: 34351722.
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Should we discontinue ACE Inhibitors and ARBs in our Hospitalized COVID patients?

Bauer A, Schreinlechner M, Sappler N, Dolejsi T, Tilg H, Aulinger BA, Weiss G, Bellmann-Weiler R, Adolf C, Wolf D, Pirklbauer M, Graziadei I, Gänzer H, von Bary C, May AE, Wöll E, von Scheidt W, Rassaf T, Duerschmied D, Brenner C, Kääb S, Metzler B, Joannidis M, Kain HU, Kaiser N, Schwinger R, Witzenbichler B, Alber H, Straube F, Hartmann N, Achenbach S, von Bergwelt-Baildon M, von Stülpnagel L, Schoenherr S, Forer L, Embacher-Aichhorn S, Mansmann U, Rizas KD, Massberg S; ACEI-COVID investigators. Discontinuation versus continuation of renin-angiotensin-system inhibitors in COVID-19 (ACEI-COVID): a prospective, parallel group, randomised, controlled, open-label trial. Lancet Respir Med. 2021 Jun 11;9(8):863–72. doi: 10.1016/S2213-2600(21)00214-9. Epub ahead of print. PMID: 34126053; PMCID: PMC8195495.
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COVID-19 and Heart Failure

Yonas E, Alwi I, Pranata R, Huang I, Lim MA, Gutierrez EJ, Yamin M, Siswanto BB, Virani SS. Effect of heart failure on the outcome of COVID-19 – A meta analysis and systematic review. Am J Emerg Med. 2020 Jul 9;46:204–11. doi: 10.1016/j.ajem.2020.07.009. Epub ahead of print. PMID: 33071085; PMCID: PMC7347316.
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Mechanical Ventilation and COVID-19

Kallet RH. 2020 Year in Review: Mechanical Ventilation During the First Year of the COVID-19 Pandemic. Respir Care. 2021 Aug;66(8):1341-1362. doi: 10.4187/respcare.09257. Epub 2021 May 10. PMID: 33972456.
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AKI Pathophys and Management

Pickkers, P., Darmon, M., Hoste, E. et al. Acute kidney injury in the critically ill: an updated review on pPickkers P, Darmon M, Hoste E, Joannidis M, Legrand M, Ostermann M, Prowle JR, Schneider A, Schetz M. Acute kidney injury in the critically ill: an updated review on pathophysiology and management. Intensive Care Med. 2021 Aug;47(8):835-850. doi: 10.1007/s00134-021-06454-7. Epub 2021 Jul 2. PMID: 34213593; PMCID: PMC8249842.
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What’s ARDS in COVID-19?

Brown SM, Peltan ID, Barkauskas C, Rogers AJ, Kan V, Gelijns A, Thompson BT. What Does “ARDS” Mean during the COVID-19 Pandemic? Ann Am Thorac Soc. 2021 Jul 21. doi: 10.1513/AnnalsATS.202105-534PS. Epub ahead of print. PMID: 34288834.
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Preoxygenation in the Obese: High-Flow Oxygen or Non-Invasive Ventilation?

Rodriguez, M., Ragot, S., Coudroy, R. et al. Noninvasive ventilation vs. high-flow nasal cannula oxygen for preoxygenation before intubation in patients with obesity: a post hoc analysis of a randomized controlled trial. Ann. Intensive Care 11, 114 (2021). https://doi.org/10.1186/s13613-021-00892-8
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Treating New-Onset A.Fib in the ICU

Drikite, L., Bedford, J.P., O’Bryan, L. et al. Treatment strategies for new onset atrial fibrillation in patients treated on an intensive care unit: a systematic scoping review. Crit Care 25, 257 (2021). https://doi.org/10.1186/s13054-021-03684-5
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Shots fired! Do some seem to want to regulate MedTwitter?

Munoz-Acuna, R., Leibowitz, A., Hayes, M. et al. Analysis of top influencers in critical care medicine “twitterverse” in the COVID-19 era: a descriptive study. Crit Care 25, 254 (2021). https://doi.org/10.1186/s13054-021-03691-6
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We are getting better at in-hospital cardiac arrest care

Marc Schluep M, Sanne Hoeks SE, Michiel Blans MJ, Bas van den Bogaard B, Ankie Koopman-van Gemert AWMM, Cees Kuijs C, Chris Hukshorn CJ, Nardo van der Meer BJM, Marco Knook AHM, Trudy van Melsen T, René Peters R, Patrick Perik PJ, Koen Simons KS, Gerben Spijkers G, Wytze Vermeijden JW, Evert-Jan Wils EJ, Robert Jan Stolker RJ, Rik Endeman H. Long-term survival and health-related quality of life after in-hospital cardiac arrest. Resuscitation. 2021 Jul 13:S0300-9572(21)00255-0. doi: 10.1016/j.resuscitation.2021.07.006. Epub ahead of print. PMID: 34271127.
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Cirrhosis Guidelines

Yoshiji H, Nagoshi S, Akahane T, Asaoka Y, Ueno Y, Ogawa K, Kawaguchi T, Kurosaki M, Sakaida I, Shimizu M, Taniai M, Terai S, Nishikawa H, Hiasa Y, Hidaka H, Miwa H, Chayama K, Enomoto N, Shimosegawa T, Takehara T, Koike K. Evidence-based clinical practice guidelines for Liver Cirrhosis 2020. J Gastroenterol. 2021 Jul 7. doi: 10.1007/s00535-021-01788-x. Epub ahead of print. PMID: 34231046.
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We’re going to come out of this a little more F’ed up than when we started.

Wozniak, H., Benzakour, L., Moullec, G. et al. Mental health outcomes of ICU and non-ICU healthcare workers during the COVID-19 outbreak: a cross-sectional study. Ann. Intensive Care 11, 106 (2021). https://doi.org/10.1186/s13613-021-00900-x
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We Still Have A LOT to Learn About Sepsis

Nunnally ME, Ferrer R, Martin GS, Martin-Loeches I, Machado FR, De Backer D, Coopersmith CM, Deutschman CS; Surviving Sepsis Campaign Reasearch Committee. The Surviving Sepsis Campaign: research priorities for the administration, epidemiology, scoring and identification of sepsis. Intensive Care Med Exp. 2021 Jul 2;9(1):34. doi: 10.1186/s40635-021-00400-z. PMID: 34212256; PMCID: PMC8249046.
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Is the Mitochondria the Key in Sepsis?

Preau S, Vodovar D, Jung B, Lancel S, Zafrani L, Flatres A, Oualha M, Voiriot G, Jouan Y, Joffre J, Huel F, De Prost N, Silva S, Azabou E, Radermacher P. Energetic dysfunction in sepsis: a narrative review. Ann Intensive Care. 2021 Jul 3;11(1):104. doi: 10.1186/s13613-021-00893-7. PMID: 34216304.
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Time to Abandon 6cc/kg/IBW in ARDS?

Tobin MJ. The Dethroning of 6 ml per kg as the “go-to” Setting in ARDS. Am J Respir Crit Care Med. 2021 Jun 29. doi: 10.1164/rccm.202105-1320LE. Epub ahead of print. PMID: 34186011.
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Goligher EC, Costa ELV; authors of “Effect of Lowering Vt on Mortality in Acute Respiratory Distress Syndrome Varies with Respiratory System Elastance”. Reply to: The Dethroning of 6 ml per kg as the “go-to” Setting in ARDS. Am J Respir Crit Care Med. 2021 Jun 29. doi: 10.1164/rccm.202106-1388LE. Epub ahead of print. PMID: 34186007.
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Ultrasound to Place Post-Pyloric Tubes?

Qian, A., Xu, S., Lu, X. et al. Rapid positioning of nasogastric tube by ultrasound in COVID-19 patients. Crit Care 24, 568 (2020). https://doi.org/10.1186/s13054-020-03285-8
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Ye, R., Cheng, X., Chai, H. et al. A systemic ultrasound positioning protocol for nasointestinal tube in critically ill patients. Crit Care 25, 213 (2021). https://doi.org/10.1186/s13054-021-03641-2
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IV Fluids in Abdominal Surgery

Messina A, Robba C, Calabrò L, Zambelli D, Iannuzzi F, Molinari E, Scarano S, Battaglini D, Baggiani M, De Mattei G, Saderi L, Sotgiu G, Pelosi P, Cecconi M. Perioperative liberal versus restrictive fluid strategies and postoperative outcomes: a systematic review and metanalysis on randomised-controlled trials in major abdominal elective surgery. Crit Care. 2021 Jun 11;25(1):205. doi: 10.1186/s13054-021-03629-y. PMID: 34116707; PMCID: PMC8194047.
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Dicey COVID Intubations

Nauka PC, Chen JT, Shiloh AL, Eisen LA, Fein DG. Practice, Outcomes and Complications of Emergent Endotracheal Intubation By Critical Care Practitioners During the COVID-19 Pandemic. Chest. 2021 Jun 14:S0012-3692(21)01113-2. doi: 10.1016/j.chest.2021.06.008. Epub ahead of print. PMID: 34139207.
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ECMO for COVID-19 Patients

Ramanathan K, Shekar K, Ling RR, Barbaro RP, Wong SN, Tan CS, Rochwerg B, Fernando SM, Takeda S, MacLaren G, Fan E, Brodie D. Extracorporeal membrane oxygenation for COVID-19: a systematic review and meta-analysis. Crit Care. 2021 Jun 14;25(1):211. doi: 10.1186/s13054-021-03634-1. PMID: 34127027.
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Are restrictive fluids the future?

Vaara, S.T., Ostermann, M., Bitker, L. et al. Restrictive fluid management versus usual care in acute kidney injury (REVERSE-AKI): a pilot randomized controlled feasibility trial.Intensive Care Med 47, 665–673 (2021). https://doi.org/10.1007/s00134-021-06401-6
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Family visits in the ICU during a Pandemic

Mistraletti, G., Giannini, A., Gristina, G. et al. Why and how to open intensive care units to family visits during the pandemic. Crit Care 25, 191 (2021). https://doi.org/10.1186/s13054-021-03608-3
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What PaO2 Should We Aim For on Mechanical Ventilation Patients?

Demiselle, J., Calzia, E., Hartmann, C. et al. Target arterial PO₂ according to the underlying pathology: a mini-review of the available data in mechanically ventilated patients. Ann. Intensive Care 11, 88 (2021). https://doi.org/10.1186/s13613-021-00872-y
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High Flow Nasal Cannula Mechanisms

Masclans JR, Pérez-Terán P, Roca O. The role of high flow oxygen therapy in acute respiratory failure. Med Intensiva. 2015 Nov;39(8):505-15. English, Spanish. doi: 10.1016/j.medin.2015.05.009. Epub 2015 Oct 1. PMID: 26429697.
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Ventilator Management and Rescue Therapies for ARDS

Coleman MH, Aldrich JM, Acute Respiratory Distress Syndrome: Ventilator Management and Rescue Therapies, CRITICAL CARE CLINICS (2021), doi: https://doi.org/10.1016/ j.ccc.2021.05.008.
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Pathophysiology of ARDS and COVID-19 Lung Injury

Swenson KE, Swenson ER, Pathophysiology of ARDS and COVID-19 Lung Injury, CRITICAL CARE CLINICS (2021), doi: https://doi.org/10.1016/j.ccc.2021.05.003.
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Convalescent Plasma (RECOVERY): DEAD.

RECOVERY Collaborative Group. Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial. The Lancet. 2021 May 14. https://doi.org/10.1016/ S0140-6736(21)00897-7
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Inhaled Budesonide for Outpatient COVID-19

Ramakrishnan S, Nicolau DV Jr, Langford B, Mahdi M, Jeffers H, Mwasuku C, Krassowska K, Fox R, Binnian I, Glover V, Bright S, Butler C, Cane JL, Halner A, Matthews PC, Donnelly LE, Simpson JL, Baker JR, Fadai NT, Peterson S, Bengtsson T, Barnes PJ, Russell REK, Bafadhel M. Inhaled budesonide in the treatment of early COVID-19 (STOIC): a phase 2, open-label, randomised controlled trial. Lancet Respir Med. 2021 Apr 9:S2213-2600(21)00160-0. doi: 10.1016/S2213-2600(21)00160-0. Epub ahead of print. Erratum in: Lancet Respir Med. 2021 Apr 14;: PMID: 33844996; PMCID: PMC8040526.
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Does Having Positive or Negative Cultures Change Outcomes In Sepsis?

Li Y, Guo J, Yang H, Li H, Shen Y, Zhang D. Comparison of culture-negative and culture-positive sepsis or septic shock: a systematic review and meta-analysis. Crit Care. 2021 May 8;25(1):167. doi: 10.1186/s13054-021-03592-8. PMID: 33964934.
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VV-ECMO in COVID-19

Asad Usman MDMPH , Jacob Gutsche MD , Essential Topics in the Management of Venovenous Extracorporeal Membrane Oxygenation in COVID-19 Acute Res- piratory Distress Syndrome, Journal of Cardiothoracic and Vascular Anesthesia (2021), doi: https://doi.org/10.1053/j.jvca.2021.04.044
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4 Different Phenotypes in Critically Ill COVID Patients

Vasquez CR, Gupta S, Miano TA, Roche M, Hsu J, Yang W, Holena DN, Reilly JP, Schrauben SJ, Leaf DE, Shashaty MGS, for the STOP-COVID Investigators, Identification of distinct clinical subphenotypes in critically ill patients with COVID-19, CHEST (2021), doi: https:// doi.org/10.1016/j.chest.2021.04.062.
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Airway Management

Natt B, Mosier J. Airway Management in the Critically Ill Patient. Curr Anesthesiol Rep. 2021 Apr 19:1-12. doi: 10.1007/s40140-021-00448-3. Epub ahead of print. PMID: 33897302; PMCID: PMC8053895.
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Acute Kidney Injury in the Critically Ill

Jamme M, Legrand M, Geri G. Outcome of acute kidney injury: how to make a difference? Ann Intensive Care. 2021 Apr 15;11(1):60. doi: 10.1186/s13613-021-00849-x. PMID: 33856581; PMCID: PMC8050180.
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Our patients may recover physically, but they unfortunately come out with depression, chronic pain, and PTSD.

Boede, M., Gensichen, J.S., Jackson, J.C. et al. Trajectories of depression in sepsis survivors: an observational cohort study. Crit Care 25, 161 (2021). https://doi.org/10.1186/s13054-021-03577-7
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How Long Will the SARS-CoV-2 RT-PCR be Detectable in our Intubated Patients?

A.G.C. Boef, E.M. van Wezel, L. Gard, et al., Viral load dynamics in intubated patients with COVID-19 admitted to the intensive care unit, Journal of Critical Care (2021), https://doi.org/10.1016/j.jcrc.2021.04.010
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Are the Epidemiology People Mad At You Because of all the VAPs? Here’s why.

Wicky PH, Niedermann MS, Timsit JF. Ventilator-associated pneumonia in the era of COVID-19 pandemic: How common and what is the impact? Crit Care. 2021 Apr 21;25(1):153. doi: 10.1186/s13054-021-03571-z. PMID: 33882991; PMCID: PMC8059113.
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Post-Arrest ICU Care

AS SEEN FIRST ON @critical_care_updates
Nolan JP, Sandroni C, Böttiger BW, Cariou A, Cronberg T, Friberg H, Genbrugge C, Haywood K, Lilja G, Moulaert VRM, Nikolaou N, Mariero Olasveengen T, Skrifvars MB, Taccone F, Soar J. European Resuscitation Council and European Society of Intensive Care Medicine Guidelines 2021: Post-resuscitation care. Resuscitation. 2021 Apr;161:220-269. doi: 10.1016/j.resuscitation.2021.02.012. Epub 2021 Mar 24. PMID: 33773827.
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Corticosteroids for COVID-19

Djillali Annane, Corticosteroids for COVID-19, Journal of Intensive Medicine, 2021, ISSN 2667-100X, https://doi.org/10.1016/j.jointm.2021.01.002
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Anaphylaxis

Krishnaswamy G. Critical Care Management of the Patient With Anaphylaxis: A Concise Definitive Review. Crit Care Med. 2021 Mar 3. doi: 10.1097/CCM.0000000000004893. Epub ahead of print. PMID: 33653974.
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Sedation and COVID-19

Pun BT, Badenes R, Heras La Calle G, Orun OM, Chen W, Raman R, Simpson BK, Wilson-Linville S, Hinojal Olmedillo B, Vallejo de la Cueva A, van der Jagt M, Navarro Casado R, Leal Sanz P, Orhun G, Ferrer Gómez C, Núñez Vázquez K, Piñeiro Otero P, Taccone FS, Gallego Curto E, Caricato A, Woien H, Lacave G, O’Neal HR Jr, Peterson SJ, Brummel NE, Girard TD, Ely EW, Pandharipande PP; COVID-19 Intensive Care International Study Group. Prevalence and risk factors for delirium in critically ill patients with COVID-19 (COVID-D): a multicentre cohort study. Lancet Respir Med. 2021 Jan 8;9(3):239–50. doi: 10.1016/S2213-2600(20)30552-X. Epub ahead of print. Erratum in: Lancet Respir Med. 2021 Jan 27;: PMID: 33428871; PMCID: PMC7832119.
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Page V. Sedation in mechanically ventilated patients with COVID-19. Lancet Respir Med. 2021 Jan 8;9(3):218–9. doi: 10.1016/S2213-2600(20)30570-1. Epub ahead of print. PMID: 33428873; PMCID: PMC7832546.
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Time to Stop Using Convalescent Plasma

Janiaud P, Axfors C, Schmitt AM, et al. Association of Convalescent Plasma Treatment With Clinical Outcomes in Patients With COVID-19: A Systematic Review and Meta-analysis. JAMA. Published online February 26, 2021. doi:10.1001/jama.2021.2747
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My other blog posts on Convalescent Plasma
Convalescent Plasma in COVID-19 Severe Pneumonia: PlasmAr (11/24/20)
Convalescent Plasma for COVID-19: First Update in JAMA (3/28/20)

Phenotypes and Subphenotypes of COVID

Wang X, Jehi L, Ji X, Mazzone PJ, Phenotypes and Subphenotypes of Patients with COVID-19: a Latent Class Modeling Analysis, CHEST (2021), doi: https://doi.org/10.1016/ j.chest.2021.01.057.
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The Future of Critical Care

Arabi YM, Azoulay E, Al-Dorzi HM, Phua J, Salluh J, Binnie A, Hodgson C, Angus DC, Cecconi M, Du B, Fowler R, Gomersall CD, Horby P, Juffermans NP, Kesecioglu J, Kleinpell RM, Machado FR, Martin GS, Meyfroidt G, Rhodes A, Rowan K, Timsit JF, Vincent JL, Citerio G. How the COVID-19 pandemic will change the future of critical care. Intensive Care Med. 2021 Feb 22:1–10. doi: 10.1007/s00134-021-06352-y. Epub ahead of print. PMID: 33616696; PMCID: PMC7898492.
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Incidence of PE’s in the COVID ICU Population

Ng, J.J., Liang, Z.C. & Choong, A.M.T.L. The incidence of pulmonary thromboembolism in COVID-19 patients admitted to the intensive care unit: a meta-analysis and meta-regression of observational studies. j intensive care 9, 20 (2021). https://doi.org/10.1186/s40560-021-00535-x
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Biomarkers for Cognitive Impairment after Cardiac Arrest?

Brønnick K, Evald L, Valdemar Duez CH, Grejs AM, Jeppesen AN, Kirkegaard H, Nielsen JF, Søreide E, Biomarker prognostication of cognitive impairment may be feasible even in out-of hospital cardical arrest survivors with good neurological outcome, Resuscitation (2021), doi: https://doi.org/10.1016/j.resuscitation.2021.02.025
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COVID-19: A year into this. What we’ve learned

Hajjar, L.A., Costa, I.B.S., Rizk, S.I. et al. Intensive care management of patients with COVID-19: a practical approach. Ann. Intensive Care 11, 36 (2021). https://doi.org/10.1186/s13613-021-00820-w
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Patients do better when the ICU is not close to or at capacity. No shit.

Bravata DM, Perkins AJ, Myers LJ, et al. Association of Intensive Care Unit Patient Load and Demand With Mortality Rates in US Department of Veterans Affairs Hospitals During the COVID-19 Pandemic. JAMA Netw Open. 2021;4(1):e2034266. doi:10.1001/jamanetworkopen.2020.34266
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Asymptomatic COVID Infections: More or less what proportion?

Daniel P. Oran, Eric J. Topol. The Proportion of SARS-CoV-2 Infections That Are Asymptomatic: A Systematic Review. Ann Intern Med. [Epub ahead of print 22 January 2021]. doi:10.7326/M20-6976
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6 Month Survival of COVID patients who are placed on ECMO

Fausto Biancari MD, PhD , Giovanni Mariscalco MD, PhD , Enrico Leo MD , Antonio Loforte MD, PhD , Sidney Chocron MD ,Magnus Dale ́n MD, PhD , Nicla Settembre MD, PhD , Henryk Welp MD , Andrea Perrotti MD, PhD , Karsten Wiebe MD , Davide Pacini MD, PhD , Dario Di Perna MD , Juan P. Maureira MD , Svante Zipfel MD, PhD , L. Mikael Broman MD, PhD , Nicolas Mongardon MD , Vito G. Ruggieri MD, PhD , Chris Harvey MD , Lars Falk MD, PhD ,Hakeem Yusuff MD , Bruno Levy MD ,Antonio Fiore MD , Thierry Folliguet MD ,Six-month Survival after Ex- tracorporeal Membrane Oxygenation for Severe COVID-19, Journal of Cardiothoracic and Vascular Anesthesia (2021), doi: https://doi.org/10.1053/j.jvca.2021.01.027
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Convalescent Plasma Based on Titers in COVID-19

Joyner MJ, Carter RE, Senefeld JW, et al. Convalescent plasma antibody levels and the risk of death from Covid-19. N Engl J Med. DOI: 10.1056/NEJMoa2031893.
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Reviewing the Coagulopathy of COVID

Robba C, Battaglini D, Ball L, Valbusa A, Porto I, Della Bona R, La Malfa G, Patroniti N, Brunetti I, Loconte M, Bassetti M, Giacobbe DR, Vena A, Silva CLM, Rocco PRM, Pelosi P. Coagulative Disorders in Critically Ill COVID-19 Patients with Acute Distress Respiratory Syndrome: A Critical Review. Journal of Clinical Medicine. 2021; 10(1):140.
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Procalcitonin to reduce infection-associated adverse events

Kyriazopoulou E, Liaskou-Antoniou L, Adamis G, Panagaki A, Melachroinopoulos N, Drakou E, Marousis K, Chrysos G, Spyrou A, Alexiou N, Symbardi S, Alexiou Z, Lagou S, Kolonia V, Gkavogianni T, Kyprianou M, Anagnostopoulos I, Poulakou G, Lada M, Makkina A, Roulia E, Koupetori M, Apostolopoulos V, Petrou D, Nitsotolis T, Antoniadou A, Giamarellos-Bourboulis EJ. Procalcitonin to Reduce Long-Term Infection-associated Adverse Events in Sepsis: A Randomized Trial. Am J Respir Crit Care Med. 2020 Aug 6. doi: 10.1164/rccm.202004-1201OC. Epub ahead of print. PMID: 32757963.
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Higher Inflammatory Markers = Worse Prognosis. Go Figure.

Lavillegrand, JR., Garnier, M., Spaeth, A. et al. Elevated plasma IL-6 and CRP levels are associated with adverse clinical outcomes and death in critically ill SARS-CoV-2 patients: inflammatory response of SARS-CoV-2 patients. Ann. Intensive Care 11, 9 (2021). https://doi.org/10.1186/s13613-020-00798-x
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High-Dose Vitamin C in COVID (PILOT TRIAL)

Zhang, J., Rao, X., Li, Y. et al. Pilot trial of high-dose vitamin C in critically ill COVID-19 patients. Ann. Intensive Care 11, 5 (2021). https://doi.org/10.1186/s13613-020-00792-3
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Inotropes in Septic Shock

Sato R, Ariyoshi N, Hasegawa D, et al. Effects of Inotropes on the Mortality in Patients With Septic Shock. Journal of Intensive Care Medicine. 2021;36(2):211-219. doi:10.1177/0885066619892218
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Taking care of ICU patients with Cirrhosis and Acute on Chronic Liver Failure

Passi NN, McPhail MJ. The patient with cirrhosis in the intensive care unit and the management of acute-on-chronic liver failure. Journal of the Intensive Care Society. December 2021. doi:10.1177/1751143720978849
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POCUS During COVID

Hussain, A., Via, G., Melniker, L. et al. Multi-organ point-of-care ultrasound for COVID-19 (PoCUS4COVID): international expert consensus. Crit Care 24, 702 (2020). https://doi.org/10.1186/s13054-020-03369-5
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MATH+

Kory P, Meduri GU, Iglesias J, Varon J, Marik PE. Clinical and Scientific Rationale for the “MATH+” Hospital Treatment Protocol for COVID-19. J Intensive Care Med. 2020 Dec 15:885066620973585. doi: 10.1177/0885066620973585. Epub ahead of print. PMID: 33317385.
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Targeted temperature management for postcardiac arrest syndrome

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Managing Hypercapnia in Patients Who Are on the Vent

Tiruvoipati R, Gupta S, Pilcher D, Bailey M. Management of hypercapnia in critically ill mechanically ventilated patients—A narrative review of literature. Journal of the Intensive Care Society. 2020;21(4):327-333. doi:10.1177/1751143720915666
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CPR in Proned Patients: Can it be done?

Douma MJ, MacKenzie E, Loch T, Tan MC, Anderson D, Picard C, Milovanovic L, O’Dochartaigh D, Brindley PG. Prone cardiopulmonary resuscitation: A scoping and expanded grey literature review for the COVID-19 pandemic. Resuscitation. 2020 Oct;155:103-111. doi: 10.1016/j.resuscitation.2020.07.010. Epub 2020 Jul 21. PMID: 32707142; PMCID: PMC7373011.
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How to Manage ARDS: A Review of Reviews

Ervin JN, Rentes VC, Dibble ER, Sjoding MW, Iwashyna TJ, Hough CL, Ng Gong M, Sales AE. Evidence-Based Practices for Acute Respiratory Failure and Acute Respiratory Distress Syndrome: A Systematic Review of Reviews. Chest. 2020 Jul 16:S0012-3692(20)31906-1. doi: 10.1016/j.chest.2020.06.080. Epub ahead of print. PMID: 32682771.
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Netherlands Journal of Critical Care Goodies

POCUS series: Assessment of shock using the rapid ultrasound in shock (RUSH) protocol
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Ultrasound-guided placement of central venous catheters: a comprehensive guide for the clinician
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Code Blue in the COVID World

Stinehart KR, Attar TT, Evans K, Buehler J, Besecker BY, Spitzer CR. Code Team Restructuring During COVID-19: A Modified Pit-Crew Approach. Resuscitation. 2020 Nov 18:S0300-9572(20)30573-6. doi: 10.1016/j.resuscitation.2020.11.018. Epub ahead of print. PMID: 33220349.
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Interleukins and what they mean in COVID

Yonas E, Alwi I, Pranata R, Huang I, Lim MA, Yamin M, Nasution SA, SetiatiS, Virani SS, Elevated interleukin levels are associated with higher severity and mortality in COVID 19– A systematic review, meta-analysis, and meta-regression, Diabetes & Metabolic Syndrome: ClinicalResearch & Reviews (2020), doi: https://doi.org/10.1016/j.dsx.2020.11.011.
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Could a CBC w/diff tell us who’s going to do poorly with COVID?

Li, X., Liu, C., Mao, Z. et al. Predictive values of neutrophil-to-lymphocyte ratio on disease severity and mortality in COVID-19 patients: a systematic review and meta-analysis. Crit Care 24, 647 (2020). https://doi.org/10.1186/s13054-020-03374-8
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New findings regarding interferon beta-1a in COVID. FOAMed

Safety and efficacy of inhaled nebulised interferon beta-1a (SNG001) for treatment of SARS-CoV-2 infection: a randomised, double-blind, placebo-controlled, phase 2 trial. Monk, Phillip DCrooks, Michael G et al.
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Improving Sleep is of utmost importance for our ICU patients!

Andrews JL, Louzon PR, Torres X, et al. Impact of a Pharmacist-Led Intensive Care Unit Sleep Improvement Protocol on Sleep Duration and Quality. Annals of Pharmacotherapy. November 2020. doi:10.1177/1060028020973198. FOAMed
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Do we need to check for a cuff leak prior to extubation?

Kuriyama, A., Jackson, J.L. & Kamei, J. Performance of the cuff leak test in adults in predicting post-extubation airway complications: a systematic review and meta-analysis.Crit Care 24, 640 (2020). https://doi.org/10.1186/s13054-020-03358-8. FOAMed
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Using CPAP in COVID

Wozniak DR, Rubino A, Tan AL, et al. Positive role of continuous positive airway pressure for intensive care unit patients with severe hypoxaemic respiratory failure due to COVID-19 pneumonia: A single centre experience. Journal of the Intensive Care Society. November 2020. doi:10.1177/1751143720971543
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More data suggesting we should ditch using lactate and use capillary refill time instead. FOAMed

Castro, R., Kattan, E., Ferri, G. et al. Effects of capillary refill time-vs. lactate-targeted fluid resuscitation on regional, microcirculatory and hypoxia-related perfusion parameters in septic shock: a randomized controlled trial. Ann. Intensive Care 10, 150 (2020). https://doi.org/10.1186/s13613-020-00767-4. FOAMed
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Managing Adult COVID Patients in the ICU

Clinical guide for the management of critical care for adults with COVID-19 during the Coronavirus pandemic. 28 October 2020, version 4. FOAMed
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Mind the Right Ventricle in Septic Shock!

Vieillard-Baron, A., Prigent, A., Repessé, X. et al. Right ventricular failure in septic shock: characterization, incidence and impact on fluid responsiveness. Crit Care 24, 630 (2020). https://doi.org/10.1186/s13054-020-03345-z
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Glucocorticoids and COVID: Steps in the Right Direction

Cano EJ, Fuentes XF, Campioli CC, O’Horo JC, Saleh OA, Odeyemi Y, Yadav H, Temesgen Z, “Impact of Corticosteroids in COVID-19 Outcomes: Systematic Review and Meta- Analysis”, CHEST (2020), doi: https://doi.org/10.1016/j.chest.2020.10.054.
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More Good News for our COVID Outcomes! Report out of England.

Dennis, John M. PhD; McGovern, Andrew P. MD (Res); Vollmer, Sebastian J. PhD; Mateen, Bilal A. MBBS. Improving Survival of Critical Care Patients With Coronavirus Disease 2019 in England, Critical Care Medicine: October 26, 2020 – Volume Online First – Issue – doi: 10.1097/CCM.0000000000004747
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Continuous Renal Replacement Therapy Anticoagulation: Citrate vs. Heparin FOAMed

Zarbock A, Küllmar M, Kindgen-Milles D, et al. Effect of Regional Citrate Anticoagulation vs Systemic Heparin Anticoagulation During Continuous Kidney Replacement Therapy on Dialysis Filter Life Span and Mortality Among Critically Ill Patients With Acute Kidney Injury: A Randomized Clinical Trial. JAMA. Published online October 23, 2020. doi:10.1001/jama.2020.18618. FOAMed
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Convalescent Plasma: Can we afford to have another therapy fail? FOAMed

Agarwal A, Mukherjee A, Kumar G, Chatterjee P, Bhatnagar T, Malhotra P; PLACID Trial Collaborators. Convalescent plasma in the management of moderate covid-19 in adults in India: open label phase II multicentre randomised controlled trial (PLACID Trial). BMJ. 2020 Oct 22;371:m3939. doi: 10.1136/bmj.m3939. PMID: 33093056.
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More data that we’re getting better at caring for COVID patients!

Zhang P, Duggal A, Sacha GL, Keller J, Griffiths L, Khouli H, System-wide strategies were associated with improved outcome in critically ill COVID-19 patients – experience from a large Healthcare Network, CHEST (2020), doi: https://doi.org/10.1016/j.chest.2020.10.029. FOAMed
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How long do people stay in the ICU with COVID? FOAMed

Lapidus, N., Zhou, X., Carrat, F. et al. Biased and unbiased estimation of the average length of stay in intensive care units in the Covid-19 pandemic. Ann. Intensive Care 10, 135 (2020). https://doi.org/10.1186/s13613-020-00749-6. FOAMed
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Cytokines, cytokines, cytokines! Oh my! FOAMed

Leisman, Daniel E et al. Cytokine elevation in severe and critical COVID-19: a rapid systematic review, meta-analysis, and comparison with other inflammatory syndromes. The Lancet Respiratory Medicine. FOAMed
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Humanizing ICU COVID Care

Marin-Corral J, Garcia-Sanz À, Masclans J, Humanizing ICU COVID care, CHEST (2020), doi: https://doi.org/10.1016/j.chest.2020.10.024.
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Remdesivir in COVID- ACTT-1 Trial

Beigel JH, Tomashek KM, Dodd LE, Mehta AK, Zingman BS, Kalil AC, Hohmann E, Chu HY, Luetkemeyer A, Kline S, Lopez de Castilla D, Finberg RW, Dierberg K, Tapson V, Hsieh L, Patterson TF, Paredes R, Sweeney DA, Short WR, Touloumi G, Lye DC, Ohmagari N, Oh MD, Ruiz-Palacios GM, Benfield T, Fätkenheuer G, Kortepeter MG, Atmar RL, Creech CB, Lundgren J, Babiker AG, Pett S, Neaton JD, Burgess TH, Bonnett T, Green M, Makowski M, Osinusi A, Nayak S, Lane HC; ACTT-1 Study Group Members. Remdesivir for the Treatment of Covid-19 – Final Report. N Engl J Med. 2020 Oct 8:NEJMoa2007764. doi: 10.1056/NEJMoa2007764. Epub ahead of print. PMID: 32445440; PMCID: PMC7262788.
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CRP & Procalcitonin in COVID-19

van Berkel, M., Kox, M., Frenzel, T. et al. Biomarkers for antimicrobial stewardship: a reappraisal in COVID-19 times?. Crit Care 24, 600 (2020). https://doi.org/10.1186/s13054-020-03291-w
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Tracheostomies and COVID-19: The Guidelines

Lamb CR, Desai NR, Angel L, Chaddha U, Sachdeva A, Sethi S, Bencheqroun H, Mehta H, Akulian J, Argento AC, Diaz-Mendoza J, Musani A, Murgu S. Use of Tracheostomy During the COVID-19 Pandemic: American College of Chest Physicians/American Association for Bronchology and Interventional Pulmonology/Association of Interventional Pulmonology Program Directors Expert Panel Report. Chest. 2020 Jun 6;158(4):1499–514. doi: 10.1016/j.chest.2020.05.571. Epub ahead of print. PMID: 32512006; PMCID: PMC7274948.
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Fluid Responsiveness In Sepsis and Shock

Douglas IS, Alapat PM, Corl KA, Exline MC, Forni LG, Holder AL, Kaufman DA, Khan A, Levy MM, Martin GS, Sahatjian JA, Seeley E, Self WH, Weingarten JA, Williams M, Hansell DM. Fluid Response Evaluation in Sepsis Hypotension and Shock: A Randomized Clinical Trial. Chest. 2020 Apr 27:S0012-3692(20)30768-6. doi: 10.1016/j.chest.2020.04.025. Epub ahead of print. PMID: 32353418.
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How to Anticoagulate Severe COVID patients? Full or Prophylactic?

Lemos ACB, do Espírito Santo DA, Salvetti MC, Gilio RN, Agra LB, Pazin-Filho A, Miranda CH. Therapeutic versus prophylactic anticoagulation for severe COVID-19: A randomized phase II clinical trial (HESACOVID). Thromb Res. 2020 Sep 21;196:359-366. doi: 10.1016/j.thromres.2020.09.026. Epub ahead of print. PMID: 32977137; PMCID: PMC7503069.
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Famotidine for COVID- NOT PEER REVIEWED.

Rahul Sethia*, MD1, Manya Prasad*, MD2, Soumya Jagannath Mahapatra, MD1, Neeraj Nischal, MD3, Manish Soneja, MD3, Pramod Garg, MD1, Shalimar, MD1. Efficacy of Famotidine for COVID-19: A Systematic Review and Meta-analysis. https://doi.org/10.1101/2020.09.28.20203463.
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Regeneron’s REGN-COV2 Antibody Cocktail

Unfortunately, it seems this treatment is just starting phase III of a clinical trial. There isn’t a completed published study that I can find as of the time I updated this page. Instead, here are some non-mainstream media posts on the trial.
Directly from Regeneron. CLICK HERE
Regeneron News Release. CLICK HERE

Stop giving fluid boluses for an elevated lactate!

Spiegel R, Gordon D, Marik PE. The origins of the Lacto-Bolo reflex: the mythology of lactate in sepsis. J Thorac Dis. 2020;12(Suppl 1):S48-S53. doi:10.21037/jtd.2019.11.48
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Does starting Tocilizumab help in patients who are on NIV?

Menzella, F., Fontana, M., Salvarani, C. et al. Efficacy of tocilizumab in patients with COVID-19 ARDS undergoing noninvasive ventilation. Crit Care 24, 589 (2020). https://doi.org/10.1186/s13054-020-03306-6
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As an aside, many people call NIV “BiPAP”. For the sake of communication I know it’s embedded in the lexicon to just call it “BiPAP”. NIV (non-invasive ventilation) encompasses bi-level other modes as well. BiPAP is the proprietary name for bi-level on the Philips machines. #FOAMed

We are getting better at caring for COVID patients!

Auld, Sara C. MD, MSc; Caridi-Scheible, Mark MD; Robichaux, Chad MPH; Coopersmith, Craig M. MD; Murphy, David J. MD, PhD The Emory COVID-19 Quality and Clinical Research Collaborative Declines in Mortality Over Time for Critically Ill Adults With Coronavirus Disease 2019, Critical Care Medicine: September 28, 2020 – Volume Online First – Issue – doi: 10.1097/CCM.0000000000004687
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Metformin and Lactate Levels. FOAMed

Posma, R.A., Hulman, A., Thomsen, R.W. et al. Metformin use and early lactate levels in critically ill patients according to chronic and acute renal impairment. Crit Care 24, 585 (2020). https://doi.org/10.1186/s13054-020-03300-y. FOAMed
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The 2018 ESPEN Guidelines for Nutrition in the Critically Ill

Singer P, Blaser AR, Berger MM, Alhazzani W, Calder PC, Casaer MP, Hiesmayr M, Mayer K, Montejo JC, Pichard C, Preiser JC, van Zanten ARH, Oczkowski S, Szczeklik W, Bischoff SC. ESPEN guideline on clinical nutrition in the intensive care unit. Clin Nutr. 2019 Feb;38(1):48-79. doi: 10.1016/j.clnu.2018.08.037. Epub 2018 Sep 29. PMID: 30348463. #FOAMed
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Propofol Infusion Syndrome: known about by many yet not known well enough. FOAMed

Krajčová A, Waldauf P, Anděl M, Duška F. Propofol infusion syndrome: a structured review of experimental studies and 153 published case reports. Crit Care. 2015;19:398. Published 2015 Nov 12. doi:10.1186/s13054-015-1112-5. FOAMed
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Placing Nasogastric Tubes: What’s the better technique?

Sanaie S, Mirzalou N, Shadvar K, Golzari SEJ, Soleimanpour H, Shamekh A, Bettampadi D, Safiri S, Mahmoodpoor A. A comparison of nasogastric tube insertion by SORT maneuver (sniffing position, NGT orientation, contralateral rotation, and twisting movement) versus neck flexion lateral pressure in critically ill patients admitted to ICU: a prospective randomized clinical trial. Ann Intensive Care. 2020 Jun 12;10(1):79. doi: 10.1186/s13613-020-00696-2. PMID: 32533354; PMCID: PMC7289937.
Link to Abstract
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Link to DIRECT DOWNLOAD PDF

Bicarbonate in DKA? What does the data say?

Chua HR, Schneider A, Bellomo R. Bicarbonate in diabetic ketoacidosis – a systematic review. Ann Intensive Care. 2011 Jul 6;1(1):23. doi: 10.1186/2110-5820-1-23. PMID: 21906367; PMCID: PMC3224469. FOAMed
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View this post on Instagram

One of the first lessons in #internalmedicineresidency and #emergencymedicineresidency is how to treat #DKA. We worry about the serum bicarb being low and immediately get itchy to just give some to make the number pretty and fix the pH/acidosis. Side note. If you’re curious about the pH, get a VBG instead of an ABG; less discomfort for the patient. This paper which is from 2011 goes over the data (not robust) behind providing bicarb in these pts and the effect. A 🎩 tip to the authors. Check out the full article on my website: eddyjoemd.com. #diabeticketoacidosis #imresidency #internship #pgy1 #pgy2 #pgy3 #emresident #emresidency #ccrn #criticalcarenurse #criticalcare #criticacaremedicine #criticalcarenursing #criticalcareunit #intensivecare #intensivecareunit #intensivecaremedicine #journalclubish #np #acutecarenursepractitioner #pa #physicianassistant #icu #pccm #foamed #meded #medicaleducation

A post shared by Eddy J. Gutierrez, MD (@eddyjoemd) on Apr 13, 2019 at 5:43am PDT

Recommendations for BiPAP, HFNC, Intubation, Extubation, and Bronchoscopy for COVID Patients. FOAMed

Citation:
Kaur, R., Weiss, T.T., Perez, A. et al. Practical strategies to reduce nosocomial transmission to healthcare professionals providing respiratory care to patients with COVID-19. Crit Care 24, 571 (2020). https://doi.org/10.1186/s13054-020-03231-8
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Do the Mandated Sepsis Protocols Save Lives? Looking at New York.

Bourne, Donald S. MPH¹; Davis, Billie S. PhD¹; Gigli, Kristin H. PhD, RN, CPNP-AC¹; Chang, Chung-Chou H. PhD^2,3; Yabes, Jonathan G. PhD^2,3; Martsolf, Grant R. PhD, MPH, RN, FANN^4,5; Kahn, Jeremy M. MD, MS^1,6 Economic Analysis of Mandated Protocolized Sepsis Care in New York Hospitals*, Critical Care Medicine: October 2020 – Volume 48 – Issue 10 – p 1411-1418 doi: 10.1097/CCM.0000000000004514. FOAMed
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Levy, Mitchell M. MD, MCCM Increasing Quality, Not Costs*, Critical Care Medicine: October 2020 – Volume 48 – Issue 10 – p 1528-1529 doi: 10.1097/CCM.0000000000004527
Link to Editorial
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Two new papers on pulmonary embolism/thrombosis in COVID. FOAMed

Sakr, Y., Giovini, M., Leone, M. et al. Pulmonary embolism in patients with coronavirus disease-2019 (COVID-19) pneumonia: a narrative review. Ann. Intensive Care 10, 124 (2020). https://doi.org/10.1186/s13613-020-00741-0
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Flaczyk, A., Rosovsky, R.P., Reed, C.T. et al. Comparison of published guidelines for management of coagulopathy and thrombosis in critically ill patients with COVID 19: implications for clinical practice and future investigations. Crit Care24, 559 (2020). https://doi.org/10.1186/s13054-020-03273-y. FOAMed
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High Flow Nasal Cannula: A Quick Review #FOAMed

Citation
Ricard JD, Roca O, Lemiale V, et al. Use of nasal high flow oxygen during acute respiratory failure [published online ahead of print, 2020 Sep 8]. Intensive Care Med. 2020;10.1007/s00134-020-06228-7. doi:10.1007/s00134-020-06228-7. FOAMed
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Do you think that DVT prophylaxis in COVID patients is enough? Neither do these guys.

Citation:
K. Stattin, M. Lipcsey, H. Andersson, et al., Inadequate prophylactic effect of low-molecular weight heparin in critically ill COVID-19 patients, Journal of Critical Care(2020), https://doi.org/10.1016/j.jcrc.2020.08.026
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Link to PDF (This one may not work)

Cytokine storm for COVID-19 is old new. Bring in the Bradykinin Storm!

Citation:
Garvin MR, Alvarez C, Miller JI, et al. A mechanistic model and therapeutic interventions for COVID-19 involving a RAS-mediated bradykinin storm. Elife. 2020;9:e59177. Published 2020 Jul 7. doi:10.7554/eLife.59177
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Lactate vs. Capillary Refill Testing Resuscitation Strategies: Which is better? FOAMed

Kattan, E., Hernández, G., Ospina-Tascón, G. et al. A lactate-targeted resuscitation strategy may be associated with higher mortality in patients with septic shock and normal capillary refill time: a post hoc analysis of the ANDROMEDA-SHOCK study. Ann. Intensive Care 10, 114 (2020). https://doi.org/10.1186/s13613-020-00732-1
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New meta-analysis on Tocilizumab in Severe COVID-19. FOAMed

Zhao, J., Cui, W. & Tian, B. Efficacy of tocilizumab treatment in severely ill COVID-19 patients. Crit Care 24, 524 (2020). https://doi.org/10.1186/s13054-020-03224-7. FOAMed
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What are the baseline Vitamin C levels in COVID-ARDS patients?

Chiscano-Camón, L., Ruiz-Rodriguez, J., Ruiz-Sanmartin, A. et al. Vitamin C levels in patients with SARS-CoV-2-associated acute respiratory distress syndrome. Crit Care24, 522 (2020). https://doi.org/10.1186/s13054-020-03249-y. FOAMed
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Plasma Exchange for Sepsis by Dr. Philip Keith. FOAMed

Keith PD, Wells AH, Hodges J, Fast SH, Adams A, Scott LK. The therapeutic efficacy of adjunct therapeutic plasma exchange for septic shock with multiple organ failure: a single-center experience. Crit Care. 2020;24(1):518. Published 2020 Aug 24. doi:10.1186/s13054-020-03241-6. FOAMed
Link to Abstract
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Convalescent Plasma in COVID-19: Data from the Mayo Clinic. FOAMed

Back in March, the first data out of China regarding convalescent plasma in COVID started reaching publications. I covered that data HERE. The data I am going to be covering here regarding convalescent plasma in COVID is from the Mayo Clinic. It is pre-peer review and should not be used to guide therapies. FOAMed

Citation:
Link to Article (Pre-Peer Reviewed)
Link to PDF

Nitric Oxide to Improve Oxygenation in COVID patients? FOAMed

Tavazzi, G., Marco, P., Mongodi, S. et al. Inhaled nitric oxide in patients admitted to intensive care unit with COVID-19 pneumonia. Crit Care 24, 508 (2020). https://doi.org/10.1186/s13054-020-03222-9. FOAMed
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Inhaled nitric oxide in mechanically ventilated patients with COVID-19: FOAMed
Link to Article

A review of the large COVID drug trials FOAMed

Citation
Siemieniuk RA, Bartoszko JJ, Ge L, et al. Drug treatments for covid-19: living systematic review and network meta-analysis. BMJ. 2020;370:m2980. Published 2020 Jul 30. doi:10.1136/bmj.m2980. FOAMed
Link to FULL Article
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Using CRP to help one decide if Dexamethasone is appropriate or not in COVID. FOAMed.

Really quick because I need to go to bed and get some rest before I head back into COVID world tomorrow. This is an observational study out of NYC where they looked at the response of patients to corticosteroids depending on whether on their CRP. This is not a prospective trial and therefore should not be used to guide any management at this point, but it still is quite interesting. Take a look for yourself. It’s FOAMed!

Citation:
Marla J Keller, MD, Elizabeth A Kitsis, MD, MBE, Shitij Arora, MD, Jen-Ting Chen, MD, MS, Shivani Agarwal, MD, MPH, Michael J Ross, MD, Yaron Tomer, MD, William Southern, MD, MS, Effect of Systemic Glucocorticoids on Mortality or Mechanical Ventilation in Patients With COVID-19. J. Hosp. Med 2020;8;489-493. Published Online First July 22, 2020. doi:10.12788/jhm.3497 
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EVMS COVID-19 Management Protocol FOAMed

Dr. Marik has been a significant mentor of mine although he may not know it. In this PDF, which I recommend you check out yourself, they delineate how to approach patients with COVID. It’s called the MATH+ protocol. To the academic purists, there’s no placebo-controlled, double-blind, randomized clinical trial to support this. FOAMed

Link to FULL FREE PDF

Remdesivir for Severe COVID-19. FOAMed.

I like these folks in the BMJ. “The guideline panel makes a weak recommendation for the use of Remdesivir in severe covid-19.” I agree. I am not excited about Remdesivir at this time given the data that I have reviewed. Either way, since I have a clear cut bias, I am not going to speak any further regarding Remdesivir. You came here for the links, they’re down below. Also, keep scrolling down for other FOAMed articles you may be interested in. FOAMed

Citation:
Rochwerg Bram, Agarwal Arnav, Zeng Linan, LeoYee-Sin, Appiah John Adabie, Agoritsas Thomas et al. Remdesivir for severe covid-19: a clinical practice guideline  BMJ  2020;  370 :m2924
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Intensivist Deficiency: FOAMed

This morning, I woke up to an email from “Today’s Hospitalist” with a headline regarding physician workforce. It reads “Intensivists are in short supply in more than a dozen states”. I don’t know about many of my colleagues here, but I get hit with calls from head-hunters all the time for moonlighting/locums opportunities. My phone has been buzzing quite a bit. George Washington University put out a report (CLICK HERE FOR REPORT/PDF) of how critical (pun intended) things are in certain states.

The other cool thing about this PDF is that they have a link to a “Workforce Deficit Estimator” (CLICK HERE FOR THAT LINK). I wouldn’t say that this looks accurate for nurses and other staff, but it appears to be accurate for Intensivists. Are you interested in becoming an Intensivist? We need your help. CLICK HERE to check out my podcast on the matter. FOAMed

Being a Zentensivist

Being on social media has blessed me with the opportunity to be exposed to the works of great people and work with some fascinating brains. I have been on the FOAMed train since I was an intern and have long admired people who I am routinely in contact with today. Recently, I have joined on as an editor on criticalcarenow.com with Haney Mallemat (@criticalcarenow). Amongst the other individuals contributing with content to this website, I have run into the work of Matt Siuba (@msiuba, also an editor on criticalcarenow.com. Being on twitter, despite far less “cool” there, I had run into this concept of “Zentensivist” which was floating around the ether there. Matt is the lead author of this paper. Josh Farkas (@pulmcrit) of pulmcrit.org also contributed to this paper.

This concept of Zentensivist resonated with me because practicing Critical Care, although as chaotic as can be, needs to be performed in the highest state of flow possible. This applies to being the physician, APP, RN, RT, CNA, and other key members of the team. Chaos goes nowhere. Yelling goes nowhere. In my opinion, it reflects a lack of leadership, confidence, emotional intelligence, and self awareness.

The flowchart: #zentensivist. FOAMed

There is a great flowchart in this article which demonstrates the philosophy I innately attempt to go by in a nice visual form. You can download the paper for free to see it for yourself. If you’re a student, trainee (intern, resident, fellow), or anyone taking care of the critically ill, this is what you should aspire to achieve. This also applies to the rest of the team taking care of these patients. FOAMed

It all starts with being a calming presence. Yelling, accusing others, talking smack helps no one. Remember, the #1 priority is the patient, not your ego. The other zentensivist principles will not show up on the first day. They come with years of practice, experience, and self-improvement. Your days of ordering every test under the sun are excusable during training, not as a seasoned veteran. We all need to get better at this. Hat tip to the authors.

-EJ

Citation:
Siuba, M. T., Carroll, C. L., Farkas, J. D., Olusanya, S., Baker, K., & Gajic, O. (2020). The Zentensivist Manifesto. Defining the Art of Critical Care. ATS Scholar. doi:10.34197/ats-scholar.2020-0019ps 
Link to Website
Link to FULL FREE ARTICLE

Heart Failure and COVID-19 Are NOT Friends: FOAMed

I have to tip my hat first and foremost to Dr. Emir Yonas. He invited me to collaborate on this paper and I feel honored to have contributed this FOAMed content.

Citation
E. Yonas, I. Alwi, R. Pranata, et al., Effect of heart failure on the outcome of COVID-19 — A meta analysis and systematic review, American Journal of Emergency Medicine (2020), https://doi.org/10.1016/j.ajem.2020.07.009

Link to Article
Link to FULL FREE PDF

Tocilizumab for COVID-19 Patients on Mechanical Ventilation FOAMed

Thus far, the only thing that has been shown to decrease mortality in patients with COVID-19 is dexamethasone. Now, there appears to be a second agent. Tocilizumab blocks IL-6. This was an observational trial looking at 154 patients. The two groups were NOT evenly matched. That being said, the patients did have improved survival, although they did have a greater amount of secondary infections. Pneumonia was the most common of these. We are currently using this therapy for our patients as well as enrolling many into studies utilizing similar therapeutic medications. Enjoy this piece of FOAMed!

Citation:
Somers EC, Eschenauer GA, Troost JP, et al. Tocilizumab for treatment of mechanically ventilated patients with COVID-19 [published online ahead of print, 2020 Jul 11]. Clin Infect Dis. 2020;ciaa954. doi:10.1093/cid/ciaa954
Link to Abstract
Link to FULL FREE PDF

ARDS and COVID-19: Who cares about making the diagnosis?

We love to write “mild, moderate, or severe ARDS” in the chart based on the P/F ratio of the patient and the Berlin Criteria. It makes us feel smart. Based on the P/F ratio, historically, we perform certain interventions like employing paralytics, proning or intubating the patient. In this paper written by Martin Tobin, he questions this whole concept in the face of ARDS in COVID.

For those of you who do not know who Martin Tobin is, well, he’s the person who literally wrote the book on mechanical ventilation. It’s titled “Principles And Practice of Mechanical Ventilation, Third Edition“. If you are interested in a more to the point book on ventilators, I recommend “The Ventilator Book” by Will Owens. Both of those are affiliate links, by the way. Hosting this website costs monies. Enjoy this piece of FOAMed!

Either way, you came here for a link to the article so here it is.
Tobin MJ, Does making a diagnosis of ARDS in COVID-19 patients matter?, CHEST (2020), doi: https://doi.org/10.1016/j.chest.2020.07.028. FOAMed
Link to Abstract
Link to FULL FREE PDF
FOAMed

Is COVID-19 Airborne? FOAMed

Lidia Morawska, Donald K Milton, It is Time to Address Airborne Transmission of COVID-19, Clinical Infectious Diseases, , ciaa939, https://doi.org/10.1093/cid/ciaa939
Link to FULL FREE PDF
Link to Article Hat tip to @idstewardship

Airway Checklists: Do they help outcomes? FOAMed

Turner JS, Bucca AW, Propst SL, et al. Association of Checklist Use in Endotracheal Intubation With Clinically Important Outcomes: A Systematic Review and Meta-analysis. JAMA Netw Open. 2020;3(7):e209278. doi:10.1001/jamanetworkopen.2020.9278
Link to FULL ARTICLE (with link to FREE PDF)

Two new studies on metabolic resuscitation with Vitamin C, Thiamine, and Stress Dose Steroids: FOAMed

Chang P, Liao Y, Guan J, et al. Combined Treatment With Hydrocortisone, Vitamin C, and Thiamine for Sepsis and Septic Shock: A Randomized Controlled Trial [published online ahead of print, 2020 Mar 31]. Chest. 2020;S0012-3692(20)30552-3. doi:10.1016/j.chest.2020.02.065. FOAMed
HYVCTTSSS

Iglesias J, Vassallo AV, Patel VV, Sullivan JB, Cavanaugh J, Elbaga Y. Outcomes of Metabolic Resuscitation Using Ascorbic Acid, Thiamine, and Glucocorticoids in the Early Treatment of Sepsis: The ORANGES Trial [published online ahead of print, 2020 Mar 17]. Chest. 2020;S0012-3692(20)30455-4. doi:10.1016/j.chest.2020.02.049
ORANGES

Editorial

Hydroxychloroquine: is this setting the stage for a resurgence in use? FOAMed

There’s still plenty of controversy in the us of this medication to treat patients with COVID-19. I am not going to get into the nitty gritty of this paper because I simply do not have time to do so this weekend. Let me know how badly you would like for me to dig into it and I may drop what I am doing. A hat tip to @whatthehellshaker for getting this article to me first. Enjoy this piece of FOAMed!

Will update the citation soon!
Link to FULL TEXT
Link to FULL FREE PDF

A study showing an estimated 8.7 million people had COVID-19 in March. FOAMed

7/2/2020. This is a study out of Penn State and Cornell published on 6/22 found data that “corresponded to more than 8.7 million new SARS-CoV-2 infections across the US during the three-week period from March 8 to March 28, 2020”. Enjoy this piece of FOAMed!

Silverman JD, Hupert N, Washburne AD. Using influenza surveillance networks to estimate state-specific prevalence of SARS-CoV-2 in the United States [published online ahead of print, 2020 Jun 22]. Sci Transl Med. 2020;eabc1126. doi:10.1126/scitranslmed.abc1126
Link to Article
Link to FULL FREE PDF

Self-Proning Protocol for COVID-19 Patients

6/3/2020
This paper was brought to my attention by @critical_care_updates. Link to his/her page HERE. It was written by the Intensive Care Society. It just so happens that Josh Farkas @pulmcrit was credited as a source for this paper as well! He has some great FOAMed as well.

Link to Website
Link to Direct PDF

Summary on IV Fluids: FOAMed

5/26/2020
The paper linked below is from the International Fluid Academy. I did not even know such institutions existed! I want to be part of that team! Some big names on this paper that I would love to be in the same room with. Nonetheless, the fanboy in me needs to digress. I plan on breaking down this paper more in detail but I simply do not have the time this week. I am sure many of you will love it as you’re as fascinated by fluids as much as I am. If you all call for a breakdown loud enough, I’ll get to it. This was published two days ago. Some great FOAMed here!

Citation:
Malbrain, M.L.N.G., Langer, T., Annane, D. et al. Intravenous fluid therapy in the perioperative and critical care setting: Executive summary of the International Fluid Academy (IFA). Ann. Intensive Care 10, 64 (2020). https://doi.org/10.1186/s13613-020-00679-3

Link to Abstract

Direct Link to FULL FREE PDF

Percutaneous Mechanical Circulatory Support Devices #FOAMed

Working on a lecture about mechanical circulatory support in patients with cardiogenic shock where I will be discussing Impella, VA-ECMO, and Tandemhearts. The table you saw on Instagram that brought you here is in the paper below. Some more great FOAMed.
Link to FULL FREE PDF

Citation: Miller PE, Solomon MA, McAreavey D. Advanced Percutaneous Mechanical Circulatory Support Devices for Cardiogenic Shock. Crit Care Med. 2017;45(11):1922‐1929. doi:10.1097/CCM.0000000000002676

I am writing an entire lecture on this topic. Click here for the bibliography and more data. #foamed

Ventilator Guide for COVID-19 Patients #FOAMed

Link to Abstract
Link to FULL PDF

Plenty more COVID data from me here.