An intensivist on a learning frenzy. Caring for the critically ill using evidence-based medicine.
This is a big impactful study looking at administering Dexamethasone to patients with ARDS. I'm happy it came out, really happy. To start off a big hat tip to my colleagues in España who put this together. ARDS sucks. It's a b-word to treat and patients spend a frustratingly long time to come off of …
Continue reading Dexamethasone in ARDS: DEXA-ARDS Trial Improved Outcomes
Not every patient reads the textbook, but you and I have to know where to start when managing our patients who have hypercapnic respiratory failure that we want to treat with non-invasive ventilation (or what you and I frequently call BiPAP). This NIV algorithm is taken from the British Thoracic Society/Intensive Care Society Acute Hypercapnic …
Continue reading Non-Invasive Ventilation (NIV/BPAP/BiPAP) Algorithm.
Your patient is in septic shock. They've gotten the correct source control, antibiotics, fluids, vasopressors. They remain hypotensive. Getting worse, actually. Could they have relative adrenal insufficiency or one of these fancy-termed conditions such as "critical illness-related corticosteroid insufficiency" (CIRCI)? Some clinicians insist on checking cortisol levels in patients who are in septic shock. Should …
Continue reading Cortisol Levels: Check prior to SDS in Septic Shock?
The VITAMINS trial looking at IV Vitamin C didn’t pan out was not a positive study as it was conducted. It was surprising as intravenous (IV) Vitamin C in sepsis should help decrease vasopressor dose and duration. My contention with that study is that they took too long to initiate the study drug. A median …
Continue reading IV Vitamin C in Sepsis: It Should Decrease Vasopressor Dose & Duration
You’re following along on my page bc you know I’m trying to find the most cutting-edge treatments and therapies for my critically ill patients. I hope to keep on pumping out eye catching content such as this article on melatonin for sepsis. Please share with you’re nerdy friends who would also find this nerdy content …
Continue reading Melatonin for Sepsis: The potential benefits to improve outcomes
You all know my bias. It shouldn't be a surprise given my body of work: I wanted the VITAMINS Trial to be a positive study. I wanted patients to benefit from this therapy and SURVIVE. I cannot understand the vitriol I have received in my direct messages when I shared my initial take on the …
Continue reading VITAMINS Trial: Timing was delayed to administer the “vitamins”
Yesterday, @yournursingeducator created a great post on Code Blue tips. @fobiesme asked a very legitimate question regarding how to proceed in patients who are s/p bypass or any open chest situation in the CVICU. This was something I wondered about myself even as someone who taught ACLS for the AHA at a point in my …
Continue reading Cardiopulmonary Resuscitation: ACLS in the CVICU
I’ve said this on numerous occasions and I’ll repeat it again. I do not do research. I have one study published and that’s because I needed to do it to complete fellowship. Outside of that, I’m a boot on the ground doc. I feel bad criticizing but here we are regarding angiotensin II/Giapreza. Now that …
Continue reading Angiotensin II/ Giapreza in Vasodilatory Shock
Does your friendly neighborhood cardiologist or intensivist start your Cardiogenic Shock patient on dopamine? Do you ever ask them when was the last time they read a study? I don’t mean to be harsh but this data is now almost a decade old. This study placed dopamine far down on the vasopressor selection totem pole. …
Continue reading Dopamine for Cardiogenic Shock: Shown to Increase Mortality.
I don’t know about you all, but I’m constantly working on finding new ways to treat my septic shock patients who, based on the numbers from more extensive studies, have a mortality rate between 25-35%. I have used methylene blue occasionally for post-CPB vasoplegia, but would it work in septic shock? UPDATE: This page was …