Selepressin Citations: The Vasopressor & Inotrope Handbook

Lövgren U, Johansson S, Jensen LS, Ekström C, Carlshaf A. Quantitative determination of peptide drug in human plasma samples at low pg/ml levels using coupled column liquid chromatography-tandem mass spectrometry. J Pharm Biomed Anal. 2010 Nov 2;53(3):537-45. doi: 10.1016/j.jpba.2010.03.024. Epub 2010 Mar 27. PMID: 20456896.
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Rehberg S, Ertmer C, Vincent JL, Morelli A, Schneider M, Lange M, Van Aken H, Traber DL, Westphal M. Role of selective V1a receptor agonism in ovine septic shock. Crit Care Med. 2011 Jan;39(1):119-25. doi: 10.1097/CCM.0b013e3181fa3898. PMID: 20890184.
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Rehberg S, Yamamoto Y, Sousse L, Bartha E, Jonkam C, Hasselbach AK, Traber LD, Cox RA, Westphal M, Enkhbaatar P, Traber DL. Selective V(1a) agonism attenuates vascular dysfunction and fluid accumulation in ovine severe sepsis. Am J Physiol Heart Circ Physiol. 2012 Nov 15;303(10):H1245-54. doi: 10.1152/ajpheart.00390.2012. Epub 2012 Sep 7. PMID: 22961865; PMCID: PMC3517638.
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Maybauer MO, Maybauer DM, Enkhbaatar P, Laporte R, Wiśniewska H, Traber LD, Lin C, Fan J, Hawkins HK, Cox RA, Wiśniewski K, Schteingart CD, Landry DW, Rivière PJ, Traber DL. The selective vasopressin type 1a receptor agonist selepressin (FE 202158) blocks vascular leak in ovine severe sepsis*. Crit Care Med. 2014 Jul;42(7):e525-e533. doi: 10.1097/CCM.0000000000000300. PMID: 24674922; PMCID: PMC4346299.
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He X, Su F, Taccone FS, Laporte R, Kjølbye AL, Zhang J, Xie K, Moussa MD, Reinheimer TM, Vincent JL. A Selective V(1A) Receptor Agonist, Selepressin, Is Superior to Arginine Vasopressin and to Norepinephrine in Ovine Septic Shock. Crit Care Med. 2016 Jan;44(1):23-31. doi: 10.1097/CCM.0000000000001380. PMID: 26496451; PMCID: PMC4684247.
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Russell JA, Vincent JL, Kjølbye AL, Olsson H, Blemings A, Spapen H, Carl P, Laterre PF, Grundemar L. Selepressin, a novel selective vasopressin V1A agonist, is an effective substitute for norepinephrine in a phase IIa randomized, placebo-controlled trial in septic shock patients. Crit Care. 2017 Aug 15;21(1):213. doi: 10.1186/s13054-017-1798-7. PMID: 28807037; PMCID: PMC5557574.
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Laterre PF, Berry SM, Blemings A, Carlsen JE, François B, Graves T, Jacobsen K, Lewis RJ, Opal SM, Perner A, Pickkers P, Russell JA, Windeløv NA, Yealy DM, Asfar P, Bestle MH, Muller G, Bruel C, Brulé N, Decruyenaere J, Dive AM, Dugernier T, Krell K, Lefrant JY, Megarbane B, Mercier E, Mira JP, Quenot JP, Rasmussen BS, Thorsen-Meyer HC, Vander Laenen M, Vang ML, Vignon P, Vinatier I, Wichmann S, Wittebole X, Kjølbye AL, Angus DC; SEPSIS-ACT Investigators. Effect of Selepressin vs Placebo on Ventilator- and Vasopressor-Free Days in Patients With Septic Shock: The SEPSIS-ACT Randomized Clinical Trial. JAMA. 2019 Oct 15;322(15):1476-1485. doi: 10.1001/jama.2019.14607. Erratum in: JAMA. 2019 Nov 12;322(18):1830. PMID: 31577035; PMCID: PMC6802260.
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Barabutis N, Marinova M, Solopov P, Uddin MA, Croston GE, Reinheimer TM, Catravas JD. Protective Mechanism of the Selective Vasopressin V1A Receptor Agonist Selepressin against Endothelial Barrier Dysfunction. J Pharmacol Exp Ther. 2020 Nov;375(2):286-295. doi: 10.1124/jpet.120.000146. Epub 2020 Sep 17. PMID: 32943478.
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Milano SP, Boucheix OB, Reinheimer TM. Selepressin, a novel selective V1A receptor agonist: Effect on mesenteric flow and gastric mucosa perfusion in the endotoxemic rabbit. Peptides. 2020 Jul;129:170318. doi: 10.1016/j.peptides.2020.170318. Epub 2020 Apr 22. PMID: 32330539.
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Antonucci E, Giovini M, Agosta S, Sakr Y, Leone M. Selepressin in Septic Shock. Shock. 2022 Jun 1;57(6):172-179. doi: 10.1097/SHK.0000000000001932. PMID: 35759300.
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Levy B, Fritz C, Tahon E, Jacquot A, Auchet T, Kimmoun A. Vasoplegia treatments: the past, the present, and the future. Crit Care. 2018 Feb 27;22(1):52. doi: 10.1186/s13054-018-1967-3. PMID: 29486781; PMCID: PMC6389278.
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Marks JA, Pascual JL. Selepressin in septic shock: sharpening the VASST effects of vasopressin?*. Crit Care Med. 2014 Jul;42(7):1747-8. doi: 10.1097/CCM.0000000000000420. PMID: 24933060.
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Currigan DA, Hughes RJ, Wright CE, Angus JA, Soeding PF. Vasoconstrictor responses to vasopressor agents in human pulmonary and radial arteries: an in vitro study. Anesthesiology. 2014 Nov;121(5):930-6. doi: 10.1097/ALN.0000000000000430. PMID: 25198173.
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Wallace AW, Tunin CM, Shoukas AA. Effects of vasopressin on pulmonary and systemic vascular mechanics. Am J Physiol. 1989 Oct;257(4 Pt 2):H1228-34. doi: 10.1152/ajpheart.1989.257.4.H1228. PMID: 2801982.
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Ji MH, Yang JJ, Wu J, Li RQ, Li GM, Fan YX, Li WY. Experimental sepsis in pigs–effects of vasopressin on renal, hepatic, and intestinal dysfunction. Ups J Med Sci. 2012 Aug;117(3):257-63. doi: 10.3109/03009734.2011.650796. Epub 2012 Jan 27. PMID: 22283426; PMCID: PMC3410284.
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