Khanna A, English SW, Wang XS, Ham K, Tumlin J, Szerlip H, Busse LW, Altaweel L, Albertson TE, Mackey C, McCurdy MT, Boldt DW, Chock S, Young PJ, Krell K, Wunderink RG, Ostermann M, Murugan R, Gong MN, Panwar R, Hästbacka J, Favory R, Venkatesh B, Thompson BT, Bellomo R, Jensen J, Kroll S, Chawla LS, Tidmarsh GF, Deane AM; ATHOS-3 Investigators. Angiotensin II for the Treatment of Vasodilatory Shock. N Engl J Med. 2017 Aug 3;377(5):419-430. doi: 10.1056/NEJMoa1704154. Epub 2017 May 21. PMID: 28528561. Link to Article Link to FULL FREE PDF
GIAPREZA (angiotensin II) Injection for Intravenous Infusion. Initial U.S. Approval: 2017 Manufactured for: La Jolla Pharmaceutical Company. San Diego, CA 92121. Revised: 1/2018 Link to Package Insert
Buchtele N, Schwameis M, Jilma B. Angiotensin II for the treatment of vasodilatory shock: enough data to consider angiotensin II safe? Crit Care. 2018 Apr 16;22(1):96. doi: 10.1186/s13054-018-2006-0. PMID: 29661216; PMCID: PMC5902841. Link to Article Link to FULL FREE PDF
Wieruszewski PM, Wittwer ED, Kashani KB, Brown DR, Butler SO, Clark AM, Cooper CJ, Davison DL, Gajic O, Gunnerson KJ, Tendler R, Mara KC, Barreto EF. Angiotensin II Infusion for Shock: A Multicenter Study of Postmarketing Use. Chest. 2021 Feb;159(2):596-605. doi: 10.1016/j.chest.2020.08.2074. Epub 2020 Aug 31. PMID: 32882250; PMCID: PMC7856533. Link to Article Link to FULL FREE PDF
Smith SE, Newsome AS, Guo Y, Hecht J, McCurdy MT, Mazzeffi MA, Chow JH, Kethireddy S. A Multicenter Observational Cohort Study of Angiotensin II in Shock. J Intensive Care Med. 2022 Jan;37(1):75-82. doi: 10.1177/0885066620972943. Epub 2020 Nov 24. PMID: 33231111; PMCID: PMC8559525. Link to Article Link to FULL FREE PDF
Bellomo R, Wunderink RG, Szerlip H, English SW, Busse LW, Deane AM, Khanna AK, McCurdy MT, Ostermann M, Young PJ, Handisides DR, Chawla LS, Tidmarsh GF, Albertson TE. Angiotensin I and angiotensin II concentrations and their ratio in catecholamine-resistant vasodilatory shock. Crit Care. 2020 Feb 6;24(1):43. doi: 10.1186/s13054-020-2733-x. PMID: 32028998; PMCID: PMC7006163. Link to Article Link to FULL FREE PDF
Bellomo R, Forni LG, Busse LW, McCurdy MT, Ham KR, Boldt DW, Hästbacka J, Khanna AK, Albertson TE, Tumlin J, Storey K, Handisides D, Tidmarsh GF, Chawla LS, Ostermann M. Renin and Survival in Patients Given Angiotensin II for Catecholamine-Resistant Vasodilatory Shock. A Clinical Trial. Am J Respir Crit Care Med. 2020 Nov 1;202(9):1253-1261. doi: 10.1164/rccm.201911-2172OC. PMID: 32609011; PMCID: PMC7605187. Link to Article Link to FULL FREE PDF
Chow JH, Wittwer ED, Wieruszewski PM, Khanna AK. Evaluating the evidence for angiotensin II for the treatment of vasoplegia in critically ill cardiothoracic surgery patients. J Thorac Cardiovasc Surg. 2022 Apr;163(4):1407-1414. doi: 10.1016/j.jtcvs.2021.02.097. Epub 2021 Mar 19. PMID: 33875258. Link to Article Link to FULL FREE PDF
Wieruszewski PM, Bellomo R, Busse LW, Ham KR, Zarbock A, Khanna AK, Deane AM, Ostermann M, Wunderink RG, Boldt DW, Kroll S, Greenfeld CR, Hodges T, Chow JH; Angiotensin II for the Treatment of High-Output Shock 3 (ATHOS-3) Investigators. Initiating angiotensin II at lower vasopressor doses in vasodilatory shock: an exploratory post-hoc analysis of the ATHOS-3 clinical trial. Crit Care. 2023 May 5;27(1):175. doi: 10.1186/s13054-023-04446-1. PMID: 37147690; PMCID: PMC10163684. Link to Article Link to FULL FREE PDF
Quan M, Cho N, Bushell T, Mak J, Nguyen N, Litwak J, Rockwood N, Nguyen HB. Effectiveness of Angiotensin II for Catecholamine Refractory Septic or Distributive Shock on Mortality: A Propensity Score Weighted Analysis of Real-World Experience in the Medical ICU. Crit Care Explor. 2022 Jan 18;4(1):e0623. doi: 10.1097/CCE.0000000000000623. PMID: 35072084; PMCID: PMC8769135. Link to Article Link to FULL FREE PDF
Russell JA, Walley KR, Singer J, Gordon AC, Hébert PC, Cooper DJ, Holmes CL, Mehta S, Granton JT, Storms MM, Cook DJ, Presneill JJ, Ayers D; VASST Investigators. Vasopressin versus norepinephrine infusion in patients with septic shock. N Engl J Med. 2008 Feb 28;358(9):877-87. doi: 10.1056/NEJMoa067373. PMID: 18305265. Link to Article Link to FULL FREE PDF
Gordon AC, Mason AJ, Thirunavukkarasu N, Perkins GD, Cecconi M, Cepkova M, Pogson DG, Aya HD, Anjum A, Frazier GJ, Santhakumaran S, Ashby D, Brett SJ; VANISH Investigators. Effect of Early Vasopressin vs Norepinephrine on Kidney Failure in Patients With Septic Shock: The VANISH Randomized Clinical Trial. JAMA. 2016 Aug 2;316(5):509-18. doi: 10.1001/jama.2016.10485. PMID: 27483065. Link to Article Link to FULL FREE PDF
Tumlin JA, Murugan R, Deane AM, Ostermann M, Busse LW, Ham KR, Kashani K, Szerlip HM, Prowle JR, Bihorac A, Finkel KW, Zarbock A, Forni LG, Lynch SJ, Jensen J, Kroll S, Chawla LS, Tidmarsh GF, Bellomo R; Angiotensin II for the Treatment of High-Output Shock 3 (ATHOS-3) Investigators. Outcomes in Patients with Vasodilatory Shock and Renal Replacement Therapy Treated with Intravenous Angiotensin II. Crit Care Med. 2018 Jun;46(6):949-957. doi: 10.1097/CCM.0000000000003092. Erratum in: Crit Care Med. 2018 Aug;46(8):e824. PMID: 29509568; PMCID: PMC5959265. Link to Article Link to FULL FREE PDF
See EJ, Clapham C, Liu J, Khasin M, Liskaser G, Chan JW, Serpa Neto A, Costa Pinto R, Bellomo R. A PILOT STUDY OF ANGIOTENSIN II AS PRIMARY VASOPRESSOR IN CRITICALLY ILL ADULTS WITH VASODILATORY HYPOTENSION: THE ARAMIS STUDY. Shock. 2023 May 1;59(5):691-696. doi: 10.1097/SHK.0000000000002109. Epub 2023 Mar 18. PMID: 36930693. Link to (NOT FREE) Article
Klijian A, Khanna AK, Reddy VS, Friedman B, Ortoleva J, Evans AS, Panwar R, Kroll S, Greenfeld CR, Chatterjee S. Treatment With Angiotensin II Is Associated With Rapid Blood Pressure Response and Vasopressor Sparing in Patients With Vasoplegia After Cardiac Surgery: A Post-Hoc Analysis of Angiotensin II for the Treatment of High-Output Shock (ATHOS-3) Study. J Cardiothorac Vasc Anesth. 2021 Jan;35(1):51-58. doi: 10.1053/j.jvca.2020.08.001. Epub 2020 Aug 7. PMID: 32868152. Link to Article Link to FULL FREE PDF
Coulson TG, Miles LF, Serpa Neto A, Pilcher D, Weinberg L, Landoni G, Zarbock A, Bellomo R. A double-blind, randomised feasibility trial of angiotensin-2 in cardiac surgery. Anaesthesia. 2022 Sep;77(9):999-1009. doi: 10.1111/anae.15802. PMID: 35915923; PMCID: PMC9543254. Link to Article Link to FULL FREE PDF
Chow JH, Wittwer ED, Wieruszewski PM, Khanna AK. Evaluating the evidence for angiotensin II for the treatment of vasoplegia in critically ill cardiothoracic surgery patients. J Thorac Cardiovasc Surg. 2022 Apr;163(4):1407-1414. doi: 10.1016/j.jtcvs.2021.02.097. Epub 2021 Mar 19. PMID: 33875258. Link to Article Link to FULL FREE PDF
WEDEEN R, ZUCKER G. Angiotensin II in the treatment of shock. Am J Cardiol. 1963 Jan;11:82-6. doi: 10.1016/0002-9149(63)90036-5. PMID: 13999441. Link to (NOT FREE) Article
BEANLANDS DS, GUNTON RW. ANGIOTENSIN II IN THE TREATMENT OF SHOCK FOLLOWING MYOCARDIAL INFARCTION. Am J Cardiol. 1964 Sep;14:370-3. doi: 10.1016/0002-9149(64)90081-5. PMID: 14206184. Link to (NOT FREE) Article
Busse LW, McCurdy MT, Ali O, Hall A, Chen H, Ostermann M. The effect of angiotensin II on blood pressure in patients with circulatory shock: a structured review of the literature. Crit Care. 2017 Dec 28;21(1):324. doi: 10.1186/s13054-017-1896-6. PMID: 29282149; PMCID: PMC5745607. Link to Article Link to FULL FREE PDF
Wieruszewski PM, Seelhammer TG, Barreto EF, Busse LW, Chow JH, Davison DL, Gaglani B, Khanna AK, Ten Lohuis CC, Mara KC, Wittwer ED. Angiotensin II for Vasodilatory Hypotension in Patients Requiring Mechanical Circulatory Support. J Intensive Care Med. 2023 May;38(5):464-471. doi: 10.1177/08850666221145864. Epub 2022 Dec 15. PMID: 36524274. Link to (NOT FREE) Article
Mohamed A, Berry TP, Welge JA, Thomas EL, Zhurav L, Kozinn J, Haines MM. Angiotensin II in Patients With Shock on Mechanical Circulatory Support: A Single-Center Retrospective Case Series. J Cardiothorac Vasc Anesth. 2022 Aug;36(8 Pt A):2439-2445. doi: 10.1053/j.jvca.2022.01.002. Epub 2022 Jan 7. PMID: 35144869. Link to (NOT FREE) Article
Alam A, Sovic W, Gill J, Ragula N, Salem M, Hughes GJ, Colbert GB, Mooney JL. Angiotensin II: A Review of Current Literature. J Cardiothorac Vasc Anesth. 2022 Apr;36(4):1180-1187. doi: 10.1053/j.jvca.2021.07.021. Epub 2021 Jul 16. PMID: 34452817. Link to (NOT FREE) Article
Antonucci E, Agosta S, Sakr Y. Angiotensin II in vasodilatory shock: lights and shadows. Crit Care. 2017 Nov 14;21(1):277. doi: 10.1186/s13054-017-1869-9. PMID: 29137677; PMCID: PMC5686834. Link to Article Link to FULL FREE PDF
Page IH, Helmer OM. A CRYSTALLINE PRESSOR SUBSTANCE (ANGIOTONIN) RESULTING FROM THE REACTION BETWEEN RENIN AND RENIN-ACTIVATOR. J Exp Med. 1940 Jan 1;71(1):29-42. doi: 10.1084/jem.71.1.29. PMID: 19870942; PMCID: PMC2134997. Link to Article Link to FULL FREE PDF
Knaus WA, Draper EA, Wagner DP, Zimmerman JE. APACHE II: a severity of disease classification system. Crit Care Med. 1985 Oct;13(10):818-29. PMID: 3928249. Link to (NOT FREE) Article
Lipworth BJ, Dagg KD. Vasoconstrictor effects of angiotensin II on the pulmonary vascular bed. Chest. 1994 May;105(5):1360-4. doi: 10.1378/chest.105.5.1360. PMID: 8181320. Link to (NOT FREE) Article
(2017, December 21). FDA approves drug to treat dangerously low blood pressure. FDA.gov. Retrieved November 6, 2023, from https://www.fda.gov/news-events/press-announcements/fda-approves-drug-treat-dangerously-low-blood-pressure Link to Website
Ham KR, Boldt DW, McCurdy MT, Busse LW, Favory R, Gong MN, Khanna AK, Chock SN, Zeng F, Chawla LS, Tidmarsh GF, Ostermann M. Sensitivity to angiotensin II dose in patients with vasodilatory shock: a prespecified analysis of the ATHOS-3 trial. Ann Intensive Care. 2019 Jun 3;9(1):63. doi: 10.1186/s13613-019-0536-5. PMID: 31161442; PMCID: PMC6546778. Link to Article Link to FULL FREE PDF
