Midodrine [package insert]. Shire US Inc. 300 Shire Way, Lexington, MA 02421, USA. Accessed October 2, 2023. Available at: ProAmatine (midodrine hydrochloride) Label. fda.gov; 2023. Link to Package Insert
Zakir RM, Folefack A, Saric M, Berkowitz RL. The use of midodrine in patients with advanced heart failure. Congest Heart Fail. 2009 May-Jun;15(3):108-11. doi: 10.1111/j.1751-7133.2008.00042.x. PMID: 19522958. Link to Article Link to FULL FREE PDF
Macielak SA, Vollmer NJ, Haddad NA, Nabzdyk CGS, Nei SD. Hemodynamic Effects of an Increased Midodrine Dosing Frequency. Crit Care Explor. 2021 Apr 26;3(4):e0405. doi: 10.1097/CCE.0000000000000405. PMID: 33912835; PMCID: PMC8078337. Link to Article and FULL FREE PDF
Whitson MR, Mo E, Nabi T, Healy L, Koenig S, Narasimhan M, Mayo PH. Feasibility, Utility, and Safety of Midodrine During Recovery Phase From Septic Shock. Chest. 2016 Jun;149(6):1380-3. doi: 10.1016/j.chest.2016.02.657. Epub 2016 Mar 4. PMID: 26953217. Link to Abstract
Hammond DA, Smith MN, Meena N. Considerations on Midodrine Use in Resolving Septic Shock. Chest. 2016 Jun;149(6):1582-3. doi: 10.1016/j.chest.2016.03.054. PMID: 27287581. Link to Article Link to FULL FREE PDF
Hammond DA, Smith MN, Peksa GD, Trivedi AP, Balk RA, Menich BE. Midodrine as an Adjuvant to Intravenous Vasopressor Agents in Adults With Resolving Shock: Systematic Review and Meta-Analysis. J Intensive Care Med. 2020 Nov;35(11):1209-1215. doi: 10.1177/0885066619843279. Epub 2019 Apr 28. PMID: 31030630. Link to Abstract
Rizvi MS, Trivedi V, Nasim F, Lin E, Kashyap R, Andrijasevic N, Gajic O. Trends in Use of Midodrine in the ICU: A Single-Center Retrospective Case Series. Crit Care Med. 2018 Jul;46(7):e628-e633. doi: 10.1097/CCM.0000000000003121. PMID: 29613861. Link to Abstract
Levine AR, Meyer MJ, Bittner EA, Berg S, Kalman R, Stanislaus AB, Ryan C, Ball SA, Eikermann M. Oral midodrine treatment accelerates the liberation of intensive care unit patients from intravenous vasopressor infusions. J Crit Care. 2013 Oct;28(5):756-62. doi: 10.1016/j.jcrc.2013.05.021. Epub 2013 Jul 8. PMID: 23845791. Link to Abstract
Poveromo LB, Michalets EL, Sutherland SE. Midodrine for the weaning of vasopressor infusions. J Clin Pharm Ther. 2016 Jun;41(3):260-5. doi: 10.1111/jcpt.12375. Epub 2016 Mar 4. PMID: 26945564. Link to (NOT FREE) Article
Santer P, Anstey MH, Patrocínio MD, Wibrow B, Teja B, Shay D, Shaefi S, Parsons CS, Houle TT, Eikermann M; MIDAS Study Group. Effect of midodrine versus placebo on time to vasopressor discontinuation in patients with persistent hypotension in the intensive care unit (MIDAS): an international randomised clinical trial. Intensive Care Med. 2020 Oct;46(10):1884-1893. doi: 10.1007/s00134-020-06216-x. Epub 2020 Sep 3. PMID: 32885276; PMCID: PMC8273663. Link to Article Link to FULL FREE PDF
Costa-Pinto R, Yong ZT, Yanase F, Young C, Brown A, Udy A, Young PJ, Eastwood G, Bellomo R. A pilot, feasibility, randomised controlled trial of midodrine as adjunctive vasopressor for low-dose vasopressor-dependent hypotension in intensive care patients: The MAVERIC study. J Crit Care. 2022 Feb;67:166-171. doi: 10.1016/j.jcrc.2021.11.004. Epub 2021 Nov 18. PMID: 34801917. Link to Article (NOT FREE)
Prakash S, Garg AX, Heidenheim AP, House AA. Midodrine appears to be safe and effective for dialysis-induced hypotension: a systematic review. Nephrol Dial Transplant. 2004 Oct;19(10):2553-8. doi: 10.1093/ndt/gfh420. Epub 2004 Jul 27. PMID: 15280522. Link to Article Link to FULL FREE PDF
Angeli P, Volpin R, Gerunda G, Craighero R, Roner P, Merenda R, Amodio P, Sticca A, Caregaro L, Maffei-Faccioli A, Gatta A. Reversal of type 1 hepatorenal syndrome with the administration of midodrine and octreotide. Hepatology. 1999 Jun;29(6):1690-7. doi: 10.1002/hep.510290629. PMID: 10347109. Link to Article Link to FULL FREE PDF
Kalambokis G, Fotopoulos A, Economou M, Pappas K, Tsianos EV. Effects of a 7-day treatment with midodrine in non-azotemic cirrhotic patients with and without ascites. J Hepatol. 2007 Feb;46(2):213-21. doi: 10.1016/j.jhep.2006.09.012. Epub 2006 Nov 10. PMID: 17156883. Link to (NOT FREE) Article
Santer P, Eikermann M. High-dose midodrine is not effective for treatment of persistent hypotension in the intensive care unit. Intensive Care Med. 2021 Feb;47(2):252-253. doi: 10.1007/s00134-020-06333-7. Epub 2021 Jan 8. PMID: 33416917. Link to (NOT FREE) Article
Mazzeffi M, Hammer B, Chen E, Caridi-Scheible M, Ramsay J, Paciullo C. Methylene blue for postcardiopulmonary bypass vasoplegic syndrome: A cohort study. Ann Card Anaesth. 2017 Apr-Jun;20(2):178-181. doi: 10.4103/aca.ACA_237_16. PMID: 28393777; PMCID: PMC5408522. Link to Article Link to FULL FREE PDF
Tremblay JA, Laramée P, Lamarche Y, Denault A, Beaubien-Souligny W, Frenette AJ, Kontar L, Serri K, Charbonney E. Potential risks in using midodrine for persistent hypotension after cardiac surgery: a comparative cohort study. Ann Intensive Care. 2020 Sep 14;10(1):121. doi: 10.1186/s13613-020-00737-w. PMID: 32926256; PMCID: PMC7490305. Link to Article Link to FULL FREE PDF
Rizvi MS, Nei AM, Gajic O, Mara KC, Barreto EF. Continuation of Newly Initiated Midodrine Therapy After Intensive Care and Hospital Discharge: A Single-Center Retrospective Study. Crit Care Med. 2019 Aug;47(8):e648-e653. doi: 10.1097/CCM.0000000000003814. PMID: 31107279. Link to (NOT FREE) Article
Teja B, Bosch NA, Walkey AJ. How We Escalate Vasopressor and Corticosteroid Therapy in Patients With Septic Shock. Chest. 2023 Mar;163(3):567-574. doi: 10.1016/j.chest.2022.09.019. Epub 2022 Sep 23. PMID: 36162481. Link to Article Link to FULL FREE PDF
Reed BN, Gale SE, Ramani G. Continuation of Newly Initiated Midodrine Therapy: Appropriate in Patients With Heart Failure? Crit Care Med. 2019 Oct;47(10):e845. doi: 10.1097/CCM.0000000000003914. PMID: 31524705. Link to (NOT FREE) Article
Steinbach K, Weidinger P. Der Einflubb von Midodrin auf die Orthostase [Effect of midodrin on orthostasis]. Wien Klin Wochenschr. 1973 Sep 21;85(38):621-4. German. PMID: 4148067.
Schramek G, Wolkerstorfer H. Zur Therapie der konstitutionellen Hypotonie. Erfahrungen mit Midodrin [Therapy of constitutional hypotension. Experiences with midodrin]. Wien Med Wochenschr. 1973 Sep 29;123(39):571-3. German. PMID: 4748156.
Mitka M. Trials to address efficacy of midodrine 18 years after it gains FDA approval. JAMA. 2012 Mar 21;307(11):1124, 1127. doi: 10.1001/jama.2012.291. PMID: 22436941. Link to (NOT FREE) Article
Angeli P, Volpin R, Gerunda G, Craighero R, Roner P, Merenda R, Amodio P, Sticca A, Caregaro L, Maffei-Faccioli A, Gatta A. Reversal of type 1 hepatorenal syndrome with the administration of midodrine and octreotide. Hepatology. 1999 Jun;29(6):1690-7. doi: 10.1002/hep.510290629. PMID: 10347109. Link to Article Link to FULL FREE PDF
Sharma S, Lardizabal JA, Bhambi B. Oral midodrine is effective for the treatment of hypotension associated with carotid artery stenting. J Cardiovasc Pharmacol Ther. 2008 Jun;13(2):94-7. doi: 10.1177/1074248408317709. PMID: 18495904. Link to Article Link to FULL FREE PDF
Jensen BC, O’Connell TD, Simpson PC. Alpha-1-adrenergic receptors: targets for agonist drugs to treat heart failure. J Mol Cell Cardiol. 2011 Oct;51(4):518-28. doi: 10.1016/j.yjmcc.2010.11.014. Epub 2010 Nov 28. PMID: 21118696; PMCID: PMC3085055. Link to Article Link to FULL FREE PDF
Sharma S, Bhambi B. Successful treatment of hypotension associated with stunned myocardium with oral midodrine therapy. J Cardiovasc Pharmacol Ther. 2005 Mar;10(1):77-9. doi: 10.1177/107424840501000109. PMID: 15821841. Link to Abstract
