Cytosorb to Absorb Cytokines & Improve ICU Outcomes?

Cytokines tend to break things in critical illness.
Pro-inflammatory cytokines cause vasodilation.
Anti-inflammatory cytokines cause immunosupression.
Inventing a way to get rid of those cytokines sounds like a good idea, right?
Cytosorb has been on out the market and trialed in sepsis, ARDS, cardiac surgery or recovery after cardiac arrest in the ICU.
It sounds expensive, but does it work?
A systematic review and meta-analysis was published in May of 2023 analyzing if Cytosorb is helpful.
Hat tip to the authors. Read these data for yourself as I personally have zero experience with Cytosorb.
Was there a mortality benefit? Nope.
Was there a benefit to ICU or Hospital length of stay? Nope.
The authors also looked at vasopressors and other biomarkers with no clear benefit to our patients.
At least there weren’t any significant adverse effects.
Should we start using this type of technology in our ICU?
It sure doesn’t seem like it.
Do you have any experience using Cytosorb?
CLICK HERE to learn how I care for my patients after cardiac surgery.

Citations for Cytosorb

Becker S, Lang H, Vollmer Barbosa C, Tian Z, Melk A, Schmidt BMW. Efficacy of CytoSorb®: a systematic review and meta-analysis. Crit Care. 2023 May 31;27(1):215. doi: 10.1186/s13054-023-04492-9. PMID: 37259160.
Link to Article

How to Support my Work

I have started using Descript to edit my videos rather than just Final Cut Pro. I have found it to be extremely helpful at saving me time. CLICK HERE to give it a go.

My efforts are at no cost to you and I would like to keep it that way. You have to look at ads on this website, listen to them on my podcast and YouTube content. Thanks for bearing with me. You could also support my work by clicking on my Amazon Affiliate links prior to ordering things off of Amazon.

For example, if you want to learn more about Mechanical Ventilation, I recommend starting off with The Ventilator Book by Will Owens. If you click on that link, a window for Amazon will open up and I will earn between a 1-3% commission at no expense to you. The fun thing is that if you order anything else on Amazon, I will earn that amount off of your shopping cart even if you do not purchase the book. Pretty cool, right? In 2020, Amazon Affiliates helped me pay for the hosting of my website, LLC fees, and Netflix.


Although great care has been taken to ensure that the information in this post is accurate, eddyjoe, LLC shall not be held responsible or in any way liable for the continued accuracy of the information, or for any errors, omissions or inaccuracies, or for any consequences arising therefrom.