Dobutamine Citations: The Vasopressor & Inotrope Handbook

  1. Scheeren TWL, Bakker J, Kaufmann T, Annane D, Asfar P, Boerma EC, Cecconi M, Chew MS, Cholley B, Cronhjort M, De Backer D, Dubin A, Dünser MW, Duranteau J, Gordon AC, Hajjar LA, Hamzaoui O, Hernandez G, Kanoore Edul V, Koster G, Landoni G, Leone M, Levy B, Martin C, Mebazaa A, Monnet X, Morelli A, Payen D, Pearse RM, Pinsky MR, Radermacher P, Reuter DA, Sakr Y, Sander M, Saugel B, Singer M, Squara P, Vieillard-Baron A, Vignon P, Vincent JL, van der Horst ICC, Vistisen ST, Teboul JL. Current use of inotropes in circulatory shock. Ann Intensive Care. 2021 Jan 29;11(1):21. doi: 10.1186/s13613-021-00806-8. PMID: 33512597; PMCID: PMC7846624.
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  2. Hollenberg SM. Vasoactive drugs in circulatory shock. Am J Respir Crit Care Med. 2011 Apr 1;183(7):847-55. doi: 10.1164/rccm.201006-0972CI. Epub 2010 Nov 19. PMID: 21097695.
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  3. Ruffolo RR Jr. The pharmacology of dobutamine. Am J Med Sci. 1987 Oct;294(4):244-8. doi: 10.1097/00000441-198710000-00005. PMID: 3310640.
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  4. Kislitsina ON, Rich JD, Wilcox JE, Pham DT, Churyla A, Vorovich EB, Ghafourian K, Yancy CW. Shock – Classification and Pathophysiological Principles of Therapeutics. Curr Cardiol Rev. 2019;15(2):102-113. doi: 10.2174/1573403X15666181212125024. PMID: 30543176; PMCID: PMC6520577.
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  5. Lescroart M, Pequignot B, Janah D, Levy B. The medical treatment of cardiogenic shock. J Intensive Med. 2023 Jan 19;3(2):114-123. doi: 10.1016/j.jointm.2022.12.001. PMID: 37188116; PMCID: PMC10175741.
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  6. Jentzer JC, Coons JC, Link CB, Schmidhofer M. Pharmacotherapy update on the use of vasopressors and inotropes in the intensive care unit. J Cardiovasc Pharmacol Ther. 2015 May;20(3):249-60. doi: 10.1177/1074248414559838. Epub 2014 Nov 28. PMID: 25432872.
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  7. van Diepen S, Katz JN, Albert NM, Henry TD, Jacobs AK, Kapur NK, Kilic A, Menon V, Ohman EM, Sweitzer NK, Thiele H, Washam JB, Cohen MG; American Heart Association Council on Clinical Cardiology; Council on Cardiovascular and Stroke Nursing; Council on Quality of Care and Outcomes Research; and Mission: Lifeline. Contemporary Management of Cardiogenic Shock: A Scientific Statement From the American Heart Association. Circulation. 2017 Oct 17;136(16):e232-e268. doi: 10.1161/CIR.0000000000000525. Epub 2017 Sep 18. PMID: 28923988.
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  8. Shabana A, Dholoo F, Banerjee P. Inotropic Agents and Vasopressors in the Treatment of Cardiogenic Shock. Curr Heart Fail Rep. 2020 Dec;17(6):438-448. doi: 10.1007/s11897-020-00493-9. Epub 2020 Oct 26. PMID: 33103204.
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  9. Romson JL, Leung JM, Bellows WH, Bronstein M, Keith F, Moores W, Flachsbart K, Richter R, Pastor D, Fisher DM. Effects of dobutamine on hemodynamics and left ventricular performance after cardiopulmonary bypass in cardiac surgical patients. Anesthesiology. 1999 Nov;91(5):1318-28. doi: 10.1097/00000542-199911000-00024. Erratum in: Anesthesiology 2000 Jan;92(1):296. PMID: 10551583.
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  10. Tamaki Y, Yaku H, Morimoto T, Inuzuka Y, Ozasa N, Yamamoto E, Yoshikawa Y, Miyake M, Kondo H, Tamura T, Kitai T, Iguchi M, Nagao K, Nishikawa R, Kawase Y, Morinaga T, Kawato M, Toyofuku M, Sato Y, Kuwahara K, Nakagawa Y, Kato T, Kimura T; KCHF Study Investigators. Lower In-Hospital Mortality With Beta-Blocker Use at Admission in Patients With Acute Decompensated Heart Failure. J Am Heart Assoc. 2021 Jul 6;10(13):e020012. doi: 10.1161/JAHA.120.020012. Epub 2021 Jun 26. PMID: 34180244; PMCID: PMC8403288.
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  11. Hospira Pharmaceuticals. Dobutamine (Package Insert). U.S. Food and Drug Administration website. https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/020201s036lbl.pdf. Revised May 2016. Accessed November 2023.
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  12. Tacon CL, McCaffrey J, Delaney A. Dobutamine for patients with severe heart failure: a systematic review and meta-analysis of randomised controlled trials. Intensive Care Med. 2012 Mar;38(3):359-67. doi: 10.1007/s00134-011-2435-6. Epub 2011 Dec 8. PMID: 22160239.
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  13. Metra M, Nodari S, D’Aloia A, Muneretto C, Robertson AD, Bristow MR, Dei Cas L. Beta-blocker therapy influences the hemodynamic response to inotropic agents in patients with heart failure: a randomized comparison of dobutamine and enoximone before and after chronic treatment with metoprolol or carvedilol. J Am Coll Cardiol. 2002 Oct 2;40(7):1248-58. doi: 10.1016/s0735-1097(02)02134-4. PMID: 12383572.
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  14. Lowes BD, Tsvetkova T, Eichhorn EJ, Gilbert EM, Bristow MR. Milrinone versus dobutamine in heart failure subjects treated chronically with carvedilol. Int J Cardiol. 2001 Dec;81(2-3):141-9. doi: 10.1016/s0167-5273(01)00520-4. PMID: 11744130.
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  15. Overgaard CB, Dzavík V. Inotropes and vasopressors: review of physiology and clinical use in cardiovascular disease. Circulation. 2008 Sep 2;118(10):1047-56. doi: 10.1161/CIRCULATIONAHA.107.728840. PMID: 18765387.
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  16. Uhlig K, Efremov L, Tongers J, Frantz S, Mikolajczyk R, Sedding D, Schumann J. Inotropic agents and vasodilator strategies for the treatment of cardiogenic shock or low cardiac output syndrome. Cochrane Database Syst Rev. 2020 Nov 5;11(11):CD009669. doi: 10.1002/14651858.CD009669.pub4. PMID: 33152122; PMCID: PMC8094388.
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  17. Faggiano P, D’Aloia A, Gualeni A, Ambrosino N, Pagani M, Giordano A. Dobutamine-induced changes in pulmonary artery pressure in patients with congestive heart failure and their relation to abnormalities of lung diffusing capacity. Am J Cardiol. 1998 Nov 15;82(10):1296-8, A10. doi: 10.1016/s0002-9149(98)00622-5. PMID: 9832114.
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  18. Eichhorn EJ, Konstam MA, Weiland DS, Roberts DJ, Martin TT, Stransky NB, Salem DN. Differential effects of milrinone and dobutamine on right ventricular preload, afterload and systolic performance in congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy. Am J Cardiol. 1987 Dec 1;60(16):1329-33. doi: 10.1016/0002-9149(87)90616-3. PMID: 3687783.
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  19. Petersen JW, Felker GM. Inotropes in the management of acute heart failure. Crit Care Med. 2008 Jan;36(1 Suppl):S106-11. doi: 10.1097/01.CCM.0000296273.72952.39. PMID: 18158469.
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  20. Mager G, Klocke RK, Kux A, Höpp HW, Hilger HH. Phosphodiesterase III inhibition or adrenoreceptor stimulation: milrinone as an alternative to dobutamine in the treatment of severe heart failure. Am Heart J. 1991 Jun;121(6 Pt 2):1974-83. doi: 10.1016/0002-8703(91)90834-5. PMID: 1852090.
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  21. Prielipp RC, MacGregor DA, Royster RL, Kon ND, Hines MH, Butterworth JF 4th. Dobutamine antagonizes epinephrine’s biochemical and cardiotonic effects: results of an in vitro model using human lymphocytes and a clinical study in patients recovering from cardiac surgery. Anesthesiology. 1998 Jul;89(1):49-57. doi: 10.1097/00000542-199807000-00010. PMID: 9667293.
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  22. Unverferth DA, Blanford M, Kates RE, Leier CV. Tolerance to dobutamine after a 72 hour continuous infusion. Am J Med. 1980 Aug;69(2):262-6. doi: 10.1016/0002-9343(80)90387-3. PMID: 7405947.
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  23. Evans L, Rhodes A, Alhazzani W, Antonelli M, Coopersmith CM, French C, Machado FR, Mcintyre L, Ostermann M, Prescott HC, Schorr C, Simpson S, Wiersinga WJ, Alshamsi F, Angus DC, Arabi Y, Azevedo L, Beale R, Beilman G, Belley-Cote E, Burry L, Cecconi M, Centofanti J, Coz Yataco A, De Waele J, Dellinger RP, Doi K, Du B, Estenssoro E, Ferrer R, Gomersall C, Hodgson C, Møller MH, Iwashyna T, Jacob S, Kleinpell R, Klompas M, Koh Y, Kumar A, Kwizera A, Lobo S, Masur H, McGloughlin S, Mehta S, Mehta Y, Mer M, Nunnally M, Oczkowski S, Osborn T, Papathanassoglou E, Perner A, Puskarich M, Roberts J, Schweickert W, Seckel M, Sevransky J, Sprung CL, Welte T, Zimmerman J, Levy M. Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021. Intensive Care Med. 2021 Nov;47(11):1181-1247. doi: 10.1007/s00134-021-06506-y. Epub 2021 Oct 2. PMID: 34599691; PMCID: PMC8486643.
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  24. Hasegawa D, Ishisaka Y, Maeda T, Prasitlumkum N, Nishida K, Dugar S, Sato R. Prevalence and Prognosis of Sepsis-Induced Cardiomyopathy: A Systematic Review and Meta-Analysis. J Intensive Care Med. 2023 Jun 4:8850666231180526. doi: 10.1177/08850666231180526. Epub ahead of print. PMID: 37272081.
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  25. Upadhrasta S, Museedi A, Thannoun T, Chaanine AH, Le Jemtel TH. Early Mechanical Circulatory Support for Cardiogenic Shock. Cardiol Rev. 2023 Jul-Aug 01;31(4):215-218. doi: 10.1097/CRD.0000000000000485. Epub 2022 Oct 25. PMID: 36730923; PMCID: PMC10278569.
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  26. Annane D, Vignon P, Renault A, Bollaert PE, Charpentier C, Martin C, Troché G, Ricard JD, Nitenberg G, Papazian L, Azoulay E, Bellissant E; CATS Study Group. Norepinephrine plus dobutamine versus epinephrine alone for management of septic shock: a randomised trial. Lancet. 2007 Aug 25;370(9588):676-84. doi: 10.1016/S0140-6736(07)61344-0. Erratum in: Lancet. 2007 Sep 22;370(9592):1034. PMID: 17720019.
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  27. Farmakis D, Agostoni P, Baholli L, Bautin A, Comin-Colet J, Crespo-Leiro MG, Fedele F, García-Pinilla JM, Giannakoulas G, Grigioni F, Gruchała M, Gustafsson F, Harjola VP, Hasin T, Herpain A, Iliodromitis EK, Karason K, Kivikko M, Liaudet L, Ljubas-Maček J, Marini M, Masip J, Mebazaa A, Nikolaou M, Ostadal P, Põder P, Pollesello P, Polyzogopoulou E, Pölzl G, Tschope C, Varpula M, von Lewinski D, Vrtovec B, Yilmaz MB, Zima E, Parissis J. A pragmatic approach to the use of inotropes for the management of acute and advanced heart failure: An expert panel consensus. Int J Cardiol. 2019 Dec 15;297:83-90. doi: 10.1016/j.ijcard.2019.09.005. Epub 2019 Sep 6. PMID: 31615650.
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  28. Sarma D, Jentzer J. Cardiogenic Shock: Pathogenesis, Classification, and Management. Critical Care Clinics. Published:July 05, 2023DOI:https://doi.org/10.1016/j.ccc.2023.05.001
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  29. Levy B, Buzon J, Kimmoun A. Inotropes and vasopressors use in cardiogenic shock: when, which and how much? Curr Opin Crit Care. 2019 Aug;25(4):384-390. doi: 10.1097/MCC.0000000000000632. PMID: 31166204.
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