Hydroxocobalamin Citations: The Vasopressor & Inotrope Handbook

The following are the citations for my book “The Vasopressor & Inotrope Handbook: A Practical Guide for Healthcare Professionals.” If you stumbled upon this page via a search engine, you have several options to get a copy, as shown below the citations.

  1. CYANOKIT package insert (single 5-g vial), Columbia, MD: Meridian Medical Technologies, Inc.; 2017
    Link to Package Insert
  2. Roderique JD, VanDyck K, Holman B, Tang D, Chui B, Spiess BD. The use of high-dose hydroxocobalamin for vasoplegic syndrome. Ann Thorac Surg. 2014 May;97(5):1785-6. doi: 10.1016/j.athoracsur.2013.08.050. PMID: 24792267.
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  3. Lin Y, Vu TQ. Use of High-Dose Hydroxocobalamin for Septic Shock: A Case Report. A A Pract. 2019 May 1;12(9):332-335. doi: 10.1213/XAA.0000000000000928. PMID: 30431443.
    Link to (NOT FREE) Article
  4. Ortoleva JP, Cobey FC. A Systematic Approach to the Treatment of Vasoplegia Based on Recent Advances in Pharmacotherapy. J Cardiothorac Vasc Anesth. 2019 May;33(5):1310-1314. doi: 10.1053/j.jvca.2018.11.025. Epub 2018 Nov 24. PMID: 30598380.
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  5. Patel JJ, Willoughby R, Peterson J, Carver T, Zelten J, Markiewicz A, Spiegelhoff K, Hipp LA, Canales B, Szabo A, Heyland DK, Stoppe C, Zielonka J, Freed JK. High-Dose IV Hydroxocobalamin (Vitamin B12) in Septic Shock: A Double-Blind, Allocation-Concealed, Placebo-Controlled Single-Center Pilot Randomized Controlled Trial (The Intravenous Hydroxocobalamin in Septic Shock Trial). Chest. 2023 Feb;163(2):303-312. doi: 10.1016/j.chest.2022.09.021. Epub 2022 Sep 26. PMID: 36174744.
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  6. Burnes ML, Boettcher BT, Woehlck HJ, Zundel MT, Iqbal Z, Pagel PS. Hydroxocobalamin as a Rescue Treatment for Refractory Vasoplegic Syndrome After Prolonged Cardiopulmonary Bypass. J Cardiothorac Vasc Anesth. 2017 Jun;31(3):1012-1014. doi: 10.1053/j.jvca.2016.08.019. Epub 2016 Aug 18. PMID: 27838199.
    Link to (NOT FREE) Article
  7. Weinberg JB, Chen Y, Jiang N, Beasley BE, Salerno JC, Ghosh DK. Inhibition of nitric oxide synthase by cobalamins and cobinamides. Free Radic Biol Med. 2009 Jun 15;46(12):1626-32. doi: 10.1016/j.freeradbiomed.2009.03.017. Epub 2009 Mar 27. Erratum in: Free Radic Biol Med. 2011 Oct 1;51(7):1471. PMID: 19328848; PMCID: PMC2745708.
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  8. Roderique JD, VanDyck K, Holman B, Tang D, Chui B, Spiess BD. The use of high-dose hydroxocobalamin for vasoplegic syndrome. Ann Thorac Surg. 2014 May;97(5):1785-6. doi: 10.1016/j.athoracsur.2013.08.050. PMID: 24792267.
    Link to Article
    Link to FULL FREE PDF
  9. Diaz Soto JC, Nabzdyk CGS. Running on (Too Many) Fumes? Gaseous Mediators in Septic Shock: A Possible Role for High-Dose Vitamin B12. Chest. 2023 Feb;163(2):262-263. doi: 10.1016/j.chest.2022.10.012. PMID: 36759109.
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  10. Shapeton AD, Mahmood F, Ortoleva JP. Hydroxocobalamin for the Treatment of Vasoplegia: A Review of Current Literature and Considerations for Use. J Cardiothorac Vasc Anesth. 2019 Apr;33(4):894-901. doi: 10.1053/j.jvca.2018.08.017. Epub 2018 Aug 11. PMID: 30217583.
    Link to (NOT FREE) Article
  11. Busse LW, Barker N, Petersen C. Vasoplegic syndrome following cardiothoracic surgery-review of pathophysiology and update of treatment options. Crit Care. 2020 Feb 4;24(1):36. doi: 10.1186/s13054-020-2743-8. PMID: 32019600; PMCID: PMC7001322.
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  12. Ortoleva J, Shapeton AD. Seeing Red: Hydroxocobalamin and Result Interference. J Cardiothorac Vasc Anesth. 2023 Aug;37(8):1339-1342. doi: 10.1053/j.jvca.2023.03.017. Epub 2023 Mar 17. PMID: 37120323.
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  13. Shah PR, Reynolds PS, Pal N, Tang D, McCarthy H, Spiess BD. Hydroxocobalamin for the treatment of cardiac surgery-associated vasoplegia: a case series. Can J Anaesth. 2018 May;65(5):560-568. English. doi: 10.1007/s12630-017-1029-3. Epub 2017 Dec 5. PMID: 29209927.
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  14. Brokmeier HM, Seelhammer TG, Nei SD, Gerberi DJ, Mara KC, Wittwer ED, Wieruszewski PM. Hydroxocobalamin for Vasodilatory Hypotension in Shock: A Systematic Review With Meta-Analysis for Comparison to Methylene Blue. J Cardiothorac Vasc Anesth. 2023 Sep;37(9):1757-1772. doi: 10.1053/j.jvca.2023.04.006. Epub 2023 Apr 7. PMID: 37147207.
    Link to (NOT FREE) Article
  15. Vollmer N, Wieruszewski PM, Martin N, Seelhammer T, Wittwer E, Nabzdyk C, Mara K, Nei SD. Predicting the Response of Hydroxocobalamin in Postoperative Vasoplegia in Recipients of Cardiopulmonary Bypass. J Cardiothorac Vasc Anesth. 2022 Aug;36(8 Pt B):2908-2916. doi: 10.1053/j.jvca.2022.01.021. Epub 2022 Jan 20. PMID: 35181236.
    Link to (NOT FREE) Article
  16. Ritter LA, Maldarelli M, McCurdy MT, Yamane DP, Davison D, Parrino C, Yim DN, Lee M, Mazzeffi MA, Chow JH. Effects of a single bolus of hydroxocobalamin on hemodynamics in vasodilatory shock. J Crit Care. 2022 Feb;67:66-71. doi: 10.1016/j.jcrc.2021.09.024. Epub 2021 Oct 21. PMID: 34689063.
    Link to (NOT FREE) Article
  17. Sacco AJ, Cunningham CA, Kosiorek HE, Sen A. Hydroxocobalamin in Refractory Septic Shock: A Retrospective Case Series. Crit Care Explor. 2021 Apr 26;3(4):e0408. doi: 10.1097/CCE.0000000000000408. PMID: 33912838; PMCID: PMC8078293.
    Link to Article
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  18. Kumar N, Rahman GR, Falkson S, Lu SY, Dalia A. Hydroxocobalamin in Refractory Vasodilatory Shock: More Questions than Answers. J Cardiothorac Vasc Anesth. 2023 Sep;37(9):1773-1775. doi: 10.1053/j.jvca.2023.05.001. Epub 2023 May 6. PMID: 37225547.
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  19. Legrand M, Michel T, Daudon M, Benyamina M, Ferry A, Soussi S, Maurel V, Chaussard M, Chaouat M, Mimoun M, Verine J, Mallet V, Mebazaa A; PRONOBURN Study Group. Risk of oxalate nephropathy with the use of cyanide antidote hydroxocobalamin in critically ill burn patients. Intensive Care Med. 2016 Jun;42(6):1080-1. doi: 10.1007/s00134-016-4252-4. Epub 2016 Feb 18. PMID: 26891675.
    Link to (NOT FREE) Article

    Boettcher BT, Woehlck HJ, Makker H, Pagel PS, Freed JK. Hydroxocobalamin for treatment of catecholamine-resistant vasoplegia during liver transplantation: A single-center series of 20 cases. Int J Surg Case Rep. 2022 Sep;98:107488. doi: 10.1016/j.ijscr.2022.107488. Epub 2022 Aug 10. PMID: 35981485; PMCID: PMC9399471.
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    Hiruy A, Ciapala S, Donaldson C, Wang L, Hohlfelder B. Hydroxocobalamin Versus Methylene Blue for the Treatment of Vasoplegic Shock Associated With Cardiopulmonary Bypass. J Cardiothorac Vasc Anesth. 2023 Jul 19:S1053-0770(23)00503-7. doi: 10.1053/j.jvca.2023.07.015. Epub ahead of print. PMID: 37586951.
    Link to (NOT FREE) Article
  20. Hydroxocobalamin. Lexicomp online. Hudson, OH, Wolters Kluwer Clinical Drug Information, Inc. Accessed December 6, 2019.