Melatonin on Delirium in Hospitalized Patients

We are all trying to combat delirium by all possible means. Getting pts their glasses and hearing aides. Keeping the lights on during the day. Having family around to speak to them. We’ve also had recent trials which have been quite disappointing using medications. Could there be a good cheap medication to prevent #delirium? This paper on using melatonin for delirium is a strong meta analysis that looks into this and could potentially change my practice… but not for the reasons on the surface. I’ve even recently heard of using melatonin for sepsis, not in delirium, but that’s a discussion for another day and something else I’m going to dig into. Either way, a 🎩 tip to the authors. Check out my work-in-progress full post on delirium HERE.


Ng KT, Teoh WY, Khor AJ. The effect of melatonin on delirium in hospitalised patients: A systematic review and meta-analyses with trial sequential analysis. J Clin Anesth. 2020 Feb;59:74-81. doi: 10.1016/j.jclinane.2019.06.027. Epub 2019 Jul 3. PMID: 31279283.
Link to Article

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