Daily FOAMed Articles from eddyjoemd

This page contains a lengthy collection of fun/exciting FOAMed articles I have found and posted on Instagram, X (Twitter), LinkedIn, and Facebook. I intend to share a free article a day. The most recent article is on top; you can scroll down to find others that catch your eye. Consider subscribing to my monthly newsletter to receive everything I posted that month on the last day of the month. Also, consider purchasing a copy of ‘The Vasopressor & Inotrope Handbook’ (which funds all of this now, as I have taken ads off this page). Remember to sign up for Rob MacSweeney’s (paid) newsletter on criticalcarereviews.com.

Get these articles emailed to you by subscribing to my Monthly Newsletter!

* indicates required

Still not convinced about glucocorticoids in septic shock? (2/23/24)

Pitre T, Drover K, Chaudhuri D, Zeraaktkar D, Menon K, Gershengorn HB, Jayaprakash N, Spencer-Segal JL, Pastores SM, Nei AM, Annane D, Rochwerg B. Corticosteroids in Sepsis and Septic Shock: A Systematic Review, Pairwise, and Dose-Response Meta-Analysis. Crit Care Explor. 2024 Jan 19;6(1):e1000. doi: 10.1097/CCE.0000000000001000. PMID: 38250247; PMCID: PMC10798738.
Link to Article
Link to FULL FREE PDF

vasopressor inotrope handbook

Restrictive Cardiomyopathy (02/22/24)

Rapezzi C, Aimo A, Barison A, Emdin M, Porcari A, Linhart A, Keren A, Merlo M, Sinagra G. Restrictive cardiomyopathy: definition and diagnosis. Eur Heart J. 2022 Dec 1;43(45):4679-4693. doi: 10.1093/eurheartj/ehac543. PMID: 36269634; PMCID: PMC9712030.
Link to Article
Link to FULL FREE PDF

Advance Directives in the ICU: Challenges and Challenges (02/21/24)

Baumann SM, Kruse NJ, Kliem PSC, Amacher SA, Hunziker S, Dittrich TD, Renetseder F, Grzonka P, Sutter R. Translation of patients’ advance directives in intensive care units: are we there yet? J Intensive Care. 2023 Nov 15;11(1):53. doi: 10.1186/s40560-023-00705-z. PMID: 37968692; PMCID: PMC10648602.
Link to Article
Link to FULL FREE PDF
Link to Saving Lives Podcast episode on Spotify
Link to Saving Lives Podcast episode on Apple Podcasts

Methylene Blue Pros and Cons (02/20/24)

Arias-Ortiz J, Vincent JL. Administration of methylene blue in septic shock: pros and cons. Crit Care. 2024 Feb 16;28(1):46. doi: 10.1186/s13054-024-04839-w. PMID: 38365828; PMCID: PMC10870439.
Link to Article
Link to FULL FREE PDF
Link to my book on Amazon, which has a chapter dedicated to methylene blue.
Order a copy of my book directly from me.
Link to post on Instagram

VA-ECMO in Cardiogenic Shock: Complications (02/19/24)

Beer BN, Kellner C, Goßling A, Sundermeyer J, Besch L, Dettling A, Kirchhof P, Blankenberg S, Bernhardt AM, Brunner S, Colson P, Eckner D, Frank D, Eitel I, Frey N, Eden M, Graf T, Kupka D, Landmesser U, Majunke N, Maniuc O, Möbius-Winkler S, Morrow DA, Mourad M, Noel C, Nordbeck P, Orban M, Pappalardo F, Patel SM, Pauschinger M, Reichenspurner H, Schulze PC, Schwinger RHG, Wechsler A, Skurk C, Thiele H, Varshney AS, Sag CM, Krais J, Westermann D, Schrage B. Complications in patients with cardiogenic shock on veno-arterial extracorporeal membrane oxygenation therapy: distribution and relevance. Results from an international, multicentre cohort study. Eur Heart J Acute Cardiovasc Care. 2024 Feb 16;13(2):203-212. doi: 10.1093/ehjacc/zuad129. PMID: 37875127.
Link to Article
Link to FULL FREE PDF

Ketamine vs. Etomidate (02/18/24)

Koroki T, Kotani Y, Yaguchi T, Shibata T, Fujii M, Fresilli S, Tonai M, Karumai T, Lee TC, Landoni G, Hayashi Y. Ketamine versus etomidate as an induction agent for tracheal intubation in critically ill adults: a Bayesian meta-analysis. Crit Care. 2024 Feb 17;28(1):48. doi: 10.1186/s13054-024-04831-4. PMID: 38368326.
Link to Article
Link to FULL FREE PDF
Link to Instagram Post

Music and Anxiety in the ICU (02/16/24)

Kakar E, Ottens T, Stads S, Wesselius S, Gommers DAMPJ, Jeekel J, van der Jagt M. Effect of a music intervention on anxiety in adult critically ill patients: a multicenter randomized clinical trial. J Intensive Care. 2023 Aug 17;11(1):36. doi: 10.1186/s40560-023-00684-1. PMID: 37592358; PMCID: PMC10433648.
Link to Article
Link to FULL FREE PDF
Link to Instagram Post
“Music gives a soul to the universe, wings to the mind, flight to the imagination, and life to everything.” – Plato

Mitraclip Complications (02/15/24)

Schnitzler K, Hell M, Geyer M, Kreidel F, Münzel T, von Bardeleben RS. Complications Following MitraClip Implantation. Curr Cardiol Rep. 2021 Aug 13;23(9):131. doi: 10.1007/s11886-021-01553-9. PMID: 34387748; PMCID: PMC8363549.
Link to Article
Link to FULL FREE PDF
Link to Instagram Post
Podcast Episode: Spotify. Apple Podcasts

ARDS 101 (02/12/24, 02/13/24, 02/14/24)

Grotberg JC, Reynolds D, Kraft BD. Management of severe acute respiratory distress syndrome: a primer. Crit Care. 2023 Jul 18;27(1):289. doi: 10.1186/s13054-023-04572-w. PMID: 37464381; PMCID: PMC10353255.
Link to Article
Link to FULL FREE PDF
Link to post on Instagram #1
Link to post on Instagram #2

Using Procalcitonin to Guide Duration of Antibiotic Therapy (02/11/24)

Papp M, Kiss N, Baka M, Trásy D, Zubek L, Fehérvári P, Harnos A, Turan C, Hegyi P, Molnár Z. Procalcitonin-guided antibiotic therapy may shorten length of treatment and may improve survival-a systematic review and meta-analysis. Crit Care. 2023 Oct 13;27(1):394. doi: 10.1186/s13054-023-04677-2. PMID: 37833778; PMCID: PMC10576288.
Link to Article
Link to FULL FREE PDF
Link to my page on Procalcitonin

Putting the mycobiome from the microbiome on your radar (02/10/24)

Park G, Munley JA, Kelly LS, Kannan KB, Mankowski RT, Sharma A, Upchurch G, Casadesus G, Chakrabarty P, Wallet SM, Maile R, Bible LE, Wang B, Moldawer LL, Mohr AM, Efron PA, Nagpal R. Gut mycobiome dysbiosis after sepsis and trauma. Crit Care. 2024 Jan 11;28(1):18. doi: 10.1186/s13054-023-04780-4. PMID: 38212826; PMCID: PMC10785534.
Link to Article
Link to FULL FREE PDF

My liver, my liver! – Beavis (02/09/24)

Perez Ruiz de Garibay A, Kortgen A, Leonhardt J, Zipprich A, Bauer M. Critical care hepatology: definitions, incidence, prognosis and role of liver failure in critically ill patients. Crit Care. 2022 Sep 26;26(1):289. doi: 10.1186/s13054-022-04163-1. PMID: 36163253; PMCID: PMC9511746.
Link to Article
Link to FULL FREE PDF
Beavis and Butthead Reference (YouTube Link)

When will start adopting thiamine supplementation? (02/08/24)

Vine J, Lee JH, Kravitz MS, Grossestreuer AV, Balaji L, Leland SB, Berlin N, Moskowitz A, Donnino MW. Thiamine administration in septic shock: a post hoc analysis of two randomized trials. Crit Care. 2024 Feb 6;28(1):41. doi: 10.1186/s13054-024-04818-1. PMID: 38321529.
Link to Article
Link to FULL FREE PDF
Check out my 2023 podcast episode on IV Thiamine on Apple Podcasts or Spotify
Link to my post on Instagram

Desperate times call for desperate measures, but let’s not do this again. (02/07/24)

Wang RC, Degesys NF, Fahimi J, Jin C, Rosenthal E, Lazar AA, Yaffee AQ, Peterson S, Rothmann RE, Jones CMC, Tolia V, Shah MN, Raven MC; Reuse N95 Group. Incidence of Fit Test Failure During N95 Respirator Reuse and Extended Use. JAMA Netw Open. 2024 Jan 2;7(1):e2353631. doi: 10.1001/jamanetworkopen.2023.53631. PMID: 38277142.
Link to Article and FULL FREE PDF

POCUS for ALL the Organs (02/06/24)

Hobbs H, Millington S, Wiskar K. Multiorgan Point-of-Care Ultrasound Assessment in Critically Ill Adults. J Intensive Care Med. 2024 Mar;39(3):187-195. doi: 10.1177/08850666231192047. Epub 2023 Aug 8. PMID: 37552930.
Link to Article
Link to FULL FREE PDF

Sprinkle in Long-Acting Insulin for our DKA patients in the ED. (02/05/24)

Rao P, Jiang SF, Kipnis P, Patel DM, Katsnelson S, Madani S, Liu VX. Evaluation of Outcomes Following Hospital-Wide Implementation of a Subcutaneous Insulin Protocol for Diabetic Ketoacidosis. JAMA Netw Open. 2022 Apr 1;5(4):e226417. doi: 10.1001/jamanetworkopen.2022.6417. PMID: 35389497; PMCID: PMC8990349.
Link to Article and FULL FREE PDF

Hyperdynamic Left Ventricular Function in Sepsis (02/04/24)

Sato R, Sanfilippo F, Hasegawa D, Prasitlumkum N, Duggal A, Dugar S. Prevalence and prognosis of hyperdynamic left ventricular systolic function in septic patients: a systematic review and meta-analysis. Ann Intensive Care. 2024 Feb 3;14(1):22. doi: 10.1186/s13613-024-01255-9. PMID: 38308701.
Link to Article
Link to FULL FREE PDF
Link to Podcast Episode on Spotify
Link to Podcast Episode on Apple Podcasts
Link to Instagram Post on this topic.

The Glycocalyx (02/03/24)

Dull RO, Hahn RG. The glycocalyx as a permeability barrier: basic science and clinical evidence. Crit Care. 2022 Sep 12;26(1):273. doi: 10.1186/s13054-022-04154-2. PMID: 36096866; PMCID: PMC9469578.
Link to Article
Link to FULL FREE PDF

Hemorrhagic Shock Management (02/02/24)

Bonanno FG. Management of Hemorrhagic Shock: Physiology Approach, Timing and Strategies. J Clin Med. 2022 Dec 29;12(1):260. doi: 10.3390/jcm12010260. PMID: 36615060; PMCID: PMC9821021.
Link to Article
Link to FULL FREE PDF

Corticosteroids and the Critically Ill (02/01/24)

Chaudhuri D, Nei AM, Rochwerg B, Balk RA, Asehnoune K, Cadena RS, Carcillo JA, Correa R, Drover K, Esper AM, Gershengorn HB, Hammond NE, Jayaprakash N, Menon K, Nazer L, Pitre T, Qasim ZA, Russell JA, Santos AP, Sarwal A, Spencer-Segal J, Tilouche N, Annane D, Pastores SM. Executive Summary: Guidelines on Use of Corticosteroids in Critically Ill Patients With Sepsis, Acute Respiratory Distress Syndrome, and Community-Acquired Pneumonia Focused Update 2024. Crit Care Med. 2024 Jan 19. doi: 10.1097/CCM.0000000000006171. Epub ahead of print. PMID: 38240490.
Link to Article AND FULL FREE PDF
Link to Spotify Podcast Episode
Link Podcast Episode on Apple Podcasts
Link to this article on Instagram

Push-dose Vasopressors (01/30/24)

Kubena A, Weston S, Alvey H. Push-dose vasopressors in the Emergency Department: a narrative review. J Emerg Crit Care Med 2022;6:22. doi: 10.21037/jeccm-21-98
Link to Article
Link to FULL FREE PDF

A Must-Read for those who care for Cardiac Surgery patients (01/29/24)

Grant MC, Crisafi C, Alvarez A, Arora RC, Brindle ME, Chatterjee S, Ender J, Fletcher N, Gregory AJ, Gunaydin S, Jahangiri M, Ljungqvist O, Lobdell KW, Morton V, Reddy VS, Salenger R, Sander M, Zarbock A, Engelman DT. Perioperative Care in Cardiac Surgery: A Joint Consensus Statement by the Enhanced Recovery After Surgery (ERAS) Cardiac Society, ERAS International Society, and The Society of Thoracic Surgeons (STS). Ann Thorac Surg. 2024 Jan 18:S0003-4975(23)01317-6. doi: 10.1016/j.athoracsur.2023.12.006. Epub ahead of print. PMID: 38284956.
Link to Article
Link to FULL FREE PDF

End-Tidal CO2 for Fluid Responsiveness (01/28/24)

Huang H, Wu C, Shen Q, Fang Y, Xu H. Value of variation of end-tidal carbon dioxide for predicting fluid responsiveness during the passive leg raising test in patients with mechanical ventilation: a systematic review and meta-analysis. Crit Care. 2022 Jan 14;26(1):20. doi: 10.1186/s13054-022-03890-9. PMID: 35031070; PMCID: PMC8760720.
Link to Article
Link to FULL FREE PDF
Link to my post on Fluid Responsiveness

The Nutrition We Provide Our Patients Isn’t Good Enough (01/27/24)

Berger MM, Amrein K, Barazzoni R, Bindels L, Bretón I, Calder PC, Cappa S, Cuerda C, D’Amelio P, de Man A, Delzenne NM, Forbes A, Genton L, Gombart AF, Joly F, Laviano A, Matthys C, Phyo PP, Ravasco P, Serlie MJ, Shenkin A, Stoffel NU, Talwar D, van Zanten ARH. The science of micronutrients in clinical practice – Report on the ESPEN symposium. Clin Nutr. 2024 Jan;43(1):268-283. doi: 10.1016/j.clnu.2023.12.006. Epub 2023 Dec 9. PMID: 38104489.
Link to Article
Link to FULL FREE PDF

AKI in Cardiac Surgery (01/26/24)

Brown JK, Shaw AD, Mythen MG, Guzzi L, Reddy VS, Crisafi C, Engelman DT; PeriOperative Quality Initiative and the Enhanced Recovery After Surgery Cardiac Workgroup. Adult Cardiac Surgery-Associated Acute Kidney Injury: Joint Consensus Report. J Cardiothorac Vasc Anesth. 2023 Sep;37(9):1579-1590. doi: 10.1053/j.jvca.2023.05.032. Epub 2023 May 23. PMID: 37355415.
Link to Article
Link to FULL FREE PDF

Managing Digoxin Toxicity (01/25/24)

Andrews P, Anseeuw K, Kotecha D, Lapostolle F, Thanacoody R. Diagnosis and practical management of digoxin toxicity: a narrative review and consensus. Eur J Emerg Med. 2023 Dec 1;30(6):395-401. doi: 10.1097/MEJ.0000000000001065. Epub 2023 Aug 25. PMID: 37650725; PMCID: PMC10599802.
Link to Article
Link to FULL FREE PDF

Acute Mesenteric Ischemia (01/24/24)

Reintam Blaser A, Mändul M, Björck M, Acosta S, Bala M, Bodnar Z, Casian D, Demetrashvili Z, D’Oria M, Durán Muñoz-Cruzado V, Forbes A, Fuglseth H, Hellerman Itzhaki M, Hess B, Kase K, Kirov M, Lein K, Lindner M, Loudet CI, Mole DJ, Murruste M, Nuzzo A, Saar S, Scheiterle M, Starkopf J, Talving P, Voomets AL, Voon KKT, Yunus MA, Tamme K; AMESI Investigators (Collaborators). Incidence, diagnosis, management and outcome of acute mesenteric ischaemia: a prospective, multicentre observational study (AMESI Study). Crit Care. 2024 Jan 23;28(1):32. doi: 10.1186/s13054-024-04807-4. PMID: 38263058.
Link to Article
Link to FULL FREE PDF

A game changer in cardiac arrest (01/22/24)

Bachista KM, Moore JC, Labarère J, Crowe RP, Emanuelson LD, Lick CJ, Debaty GP, Holley JE, Quinn RP, Scheppke KA, Pepe PE. Survival for Nonshockable Cardiac Arrests Treated With Noninvasive Circulatory Adjuncts and Head/Thorax Elevation. Crit Care Med. 2024 Feb 1;52(2):170-181. doi: 10.1097/CCM.0000000000006055. Epub 2024 Jan 19. PMID: 38240504.
Link to Article and FULL FREE PDF

Finding the best PEEP (01/21/24)

Gattinoni L, Marini JJ. In search of the Holy Grail: identifying the best PEEP in ventilated patients. Intensive Care Med. 2022 Jun;48(6):728-731. doi: 10.1007/s00134-022-06698-x. Epub 2022 May 5. PMID: 35513707; PMCID: PMC9205826.
Link to Article
Link to FULL FREE PDF

NG Tube Insertion Tricks (01/20/24)

Taylor SJ, Sayer K, White P. Nasointestinal tube placement: Techniques that increase success. J Intensive Care Soc. 2023 Feb;24(1):62-70. doi: 10.1177/17511437221095336. Epub 2022 May 27. PMID: 36874290; PMCID: PMC9975804.
Link to Article
Link to FULL FREE PDF

Vascular Leak Index (01/19/24)

Chandra J, Armengol de la Hoz MA, Lee G, Lee A, Thoral P, Elbers P, Lee HC, Munger JS, Celi LA, Kaufman DA. A novel Vascular Leak Index identifies sepsis patients with a higher risk for in-hospital death and fluid accumulation. Crit Care. 2022 Apr 11;26(1):103. doi: 10.1186/s13054-022-03968-4. PMID: 35410278; PMCID: PMC9003991.
Link to Article
Link to FULL FREE PDF

Good ‘ol dogma in critical care medicine (01/18/24)

Hofmaenner DA, Singer M. Challenging management dogma where evidence is non-existent, weak or outdated. Intensive Care Med. 2022 May;48(5):548-558. doi: 10.1007/s00134-022-06659-4. Epub 2022 Mar 18. PMID: 35303116; PMCID: PMC8931587.
Link to Article
Link to FULL FREE PDF

Stop the bleeding! (01/17/24)

Backus B, Beyer-Westendorf J, Body R, Lindner T, Möckel M, Sehgal V, Parry-Jones A, Seiffge D, Gibler B. Management of major bleeding for anticoagulated patients in the Emergency Department: an European experts consensus statement. Eur J Emerg Med. 2023 Oct 1;30(5):315-323. doi: 10.1097/MEJ.0000000000001049. Epub 2023 Jul 7. PMID: 37427548.
Link to Article and FULL FREE PDF

We check too many labs (01/16/24)

Devis L, Catry E, Honore PM, Mansour A, Lippi G, Mullier F, Closset M. Interventions to improve appropriateness of laboratory testing in the intensive care unit: a narrative review. Ann Intensive Care. 2024 Jan 15;14(1):9. doi: 10.1186/s13613-024-01244-y. PMID: 38224401.
Link to Article
Link to FULL FREE PDF

How does DNR status change our perceptions of management? (01/15/24)

Driggers KE, Dishman SE, Chung KK, Olsen CH, Ryan AB, McLawhorn MM, Johnson LS. Perceptions of care following initiation of do-not-resuscitate orders. J Crit Care. 2022 Jun;69:154008. doi: 10.1016/j.jcrc.2022.154008. Epub 2022 Mar 10. PMID: 35278875.
Link to Article AND FULL FREE PDF

Do not just brush off New-Onset A.fib in the ICU. (01/14/24)

Garside T, Bedford JP, Vollam S, Gerry S, Rajappan K, Watkinson PJ. Increased long-term mortality following new-onset atrial fibrillation in the intensive care unit: A systematic review and meta-analysis. J Crit Care. 2022 Dec;72:154161. doi: 10.1016/j.jcrc.2022.154161. Epub 2022 Oct 7. PMID: 36215944.
Link to Article
Link to FULL FREE PDF

Pancreatitis Management (01/13/24)

Palumbo R, Schuster KM. Contemporary management of acute pancreatitis: What you need to know. J Trauma Acute Care Surg. 2024 Jan 1;96(1):156-165. doi: 10.1097/TA.0000000000004143. Epub 2023 Dec 11. PMID: 37722072.
Link to Article AND FULL FREE PDF

Could your blood type save your life? (01/12/24)

Itenov TS, Sessler DI, Khanna AK, Ostrowski SR, Johansson PI, Erikstrup C, Pedersen OB, Rygård SL, Holst LB, Bestle MH, Hein L, Lindhardt A, Tousi H, Andersen MH, Mohr T, Lundgren JD, Jensen JU. ABO blood types and sepsis mortality. Ann Intensive Care. 2021 Apr 20;11(1):61. doi: 10.1186/s13613-021-00844-2. PMID: 33877463; PMCID: PMC8056100.
Link to Article
Link to FULL FREE PDF

Sepsis in the Elderly (01/11/24)

Ibarz M, Haas LEM, Ceccato A, Artigas A. The critically ill older patient with sepsis: a narrative review. Ann Intensive Care. 2024 Jan 10;14(1):6. doi: 10.1186/s13613-023-01233-7. PMID: 38200360.
Link to Article
Link to FULL FREE PDF

How I manage Cardiogenic Shock 2/2 Acute Myocardial Infarction (01/10/24)

Basir MB, Lemor A, Gorgis S, Patel KC, Kolski BC, Bharadwaj AS, Todd JW, Tehrani BN, Truesdell AG, Lasorda DM, Lalonde TA, Kaki A, Schrieber TL, Patel NC, Senter SR, Gelormini JL, Marso SP, Rahman AM, Federici RE, Wilkins CE, Thomas McRae A 3rd, Nsair A, Caputo CP, Khuddus MA, Chahin JJ, Dupont AG, Goldsweig AM, Lim MJ, Kapur NK, Wohns DHW, Zhou Y, Hacala MJ, O’Neill WW. Early Utilization of Mechanical Circulatory Support in Acute Myocardial Infarction Complicated by Cardiogenic Shock: The National Cardiogenic Shock Initiative. J Am Heart Assoc. 2023 Dec 5;12(23):e031401. doi: 10.1161/JAHA.123.031401. Epub 2023 Nov 28. PMID: 38014676; PMCID: PMC10727311.
Link to Article
Link to FULL FREE PDF
Link to my post on Pulmonary Artery Pulsatility Index (PAPi)
Link to my post on Aortic Pulsatility Index (API)

For how long does 20% albumin cause volume expansion? (01/09/24)

Zdolsek M, Wuethrich PY, Gunnström M, Zdolsek JH, Hasselgren E, Beilstein CM, Engel D, Hahn RG. Plasma disappearance rate of albumin when infused as a 20% solution. Crit Care. 2022 Apr 11;26(1):104. doi: 10.1186/s13054-022-03979-1. PMID: 35410365; PMCID: PMC9003982.
Link to Article
Link to FULL FREE PDF

What to do with PEA Arrests? (01/08/24)

Norvik A, Unneland E, Bergum D, Buckler DG, Bhardwaj A, Eftestøl T, Aramendi E, Nordseth T, Abella BS, Kvaløy JT, Skogvoll E. Pulseless electrical activity in in-hospital cardiac arrest – A crossroad for decisions. Resuscitation. 2022 Jul;176:117-124. doi: 10.1016/j.resuscitation.2022.04.024. Epub 2022 Apr 28. PMID: 35490937.
Link to Article
Link to FULL FREE PDF

Plasma exchange for septic shock (01/07/24)

Kuklin V, Sovershaev M, Bjerner J, Keith P, Scott LK, Thomas OMT, Szpirt W, Rock G, Stegmayr B. Influence of therapeutic plasma exchange treatment on short-term mortality of critically ill adult patients with sepsis-induced organ dysfunction: a systematic review and meta-analysis. Crit Care. 2024 Jan 4;28(1):12. doi: 10.1186/s13054-023-04795-x. PMID: 38178170; PMCID: PMC10768220.
Link to Article
Link to FULL FREE PDF

Brain Stuff (01/06/24)

Robba, C., Zanier, E.R., Lopez Soto, C. et al. Mastering the brain in critical conditions: an update. ICMx 12, 1 (2024). https://doi.org/10.1186/s40635-023-00587-3
Link to Article
Link to FULL FREE PDF

Reducing Opioids (01/05/24)

McKenzie, C., Skrobik, Y. & Devlin, J.W. Scheduled intravenous opioids. Intensive Care Med 49, 1541–1543 (2023).
Link to Article
Link to FULL FREE PDF

Palliative Care in the ICU (01/04/24)

Neukirchen, M., Metaxa, V. & Schaefer, M.S. Palliative care in intensive care. Intensive Care Med 49, 1538–1540 (2023).
Link to Article
Link to FULL FREE PDF
Link to another article on palliative care

Ultrasound in Cardiac Arrest (01/03/24)

Wong, A., Vignon, P. & Robba, C. How I use ultrasound in cardiac arrest. Intensive Care Med 49, 1531–1534 (2023).
Link to Article
Link to FULL FREE PDF

Physical Restraints in the ICU (01/02/24)

Sebastian Berger, Pascale Grzonka, Simon A. Amacher, Sabina Hunziker, Anja I. Frei, Raoul Sutter,
Adverse events related to physical restraint use in intensive care units: A review of the literature,
Journal of Intensive Medicine, 2023,ISSN 2667-100X, https://doi.org/10.1016/j.jointm.2023.11.005.
Link to Article
Link to FULL FREE PDF

Venous PCO2 vs. Arterial PaCO2 (12/31/23)

Jörg M, Öster M, Wretborn J, Wilhelms DB. Agreement of pCO2 in venous to arterial blood gas conversion models in undifferentiated emergency patients. Intensive Care Med Exp. 2023 Nov 21;11(1):80. doi: 10.1186/s40635-023-00564-w. PMID: 37989791; PMCID: PMC10663424.
Link to Article
Link to FULL FREE PDF
Link to Dr. Josh Farkas’ work on PCO2

One-stop-shop for Mechanical Circulatory Support in Cardiogenic Shock (12/29/23)

Nakata, J., Yamamoto, T., Saku, K. et al. Mechanical circulatory support in cardiogenic shock. j intensive care 11, 64 (2023). https://doi.org/10.1186/s40560-023-00710-2
Link to Article
Link to FULL FREE PDF

It’s time to learn how Semaglutide will behave in our patients. (12/28/23)

Jure Marijic, J. Prince Neelankavil. Semaglutide: A New Medical Swiss Army Knife? 
Link to Article
Link to FULL FREE PDF

Pneumomediastinum & Pneumothorax in ARDS 12/27/23

Teo, Yi & Shanmugavel Geetha, Harinivaas & Mishra, Ajay & Lal, Amos. (2023). Pneumomediastinum and pneumothorax in acute respiratory distress syndrome (ARDS) patients: a narrative review. Mediastinum. 10.21037/med-23-39.
Link to Article
Link to FULL FREE PDF

RV Dysfunction in Cor Pulmonale (12/24/23)

Arrigo M, Price S, Harjola VP, Huber LC, Schaubroeck HAI, Vieillard-Baron A, Masip J, Mebazaa A. Diagnosis and treatment of right ventricular failure secondary to acutely increased right ventricular afterload (acute cor pulmonale). A Clinical Consensus Statement of the Association for Acute CardioVascular Care (ACVC) of the ESC. Eur Heart J Acute Cardiovasc Care. 2023 Dec 22:zuad157. doi: 10.1093/ehjacc/zuad157. Epub ahead of print. PMID: 38135288.
Link to Article
Link to FULL FREE PDF

New Stuff in Cardiogenic Shock after AMI (12/22/23)

Pepe M, Bortone AS, Giordano A, Cecere A, Burattini O, Nestola PL, Patti G, Di Cillo O, Signore N, Forleo C, Favale S. Cardiogenic Shock Following Acute Myocardial Infarction: What’s New? Shock. 2020 Apr;53(4):391-399. doi: 10.1097/SHK.0000000000001377. PMID: 31090679.
Link to Article and FULL FREE PDF

Free Book on IV Fluids written by Legends! (12/8/23)

Rational Use of Intravenous Fluids in Critically Ill Patients
Manu L.N.G. Malbrain, Adrian Wong, Prashant Nasa, Supradip Ghosh
https://doi.org/10.1007/978-3-031-42205-8
Springer Cham
Link to Book
Link to FULL FREE PDF

The Interstitium in Sepsis (10/11/23)

Dargent A, Dumargne H, Labruyère M, Brezillon S, Brassart-Pasco S, Blot M, Charles PE, Fournel I, Quenot JP, Jacquier M. Role of the interstitium during septic shock: a key to the understanding of fluid dynamics? J Intensive Care. 2023 Oct 10;11(1):44. doi: 10.1186/s40560-023-00694-z. PMID: 37817235.
Link to Article
Link to FULL FREE PDF

Sepsis Associated Encephalopathy (10/8/23)

Sonneville R, Benghanem S, Jeantin L, de Montmollin E, Doman M, Gaudemer A, Thy M, Timsit JF. The spectrum of sepsis-associated encephalopathy: a clinical perspective. Crit Care. 2023 Oct 5;27(1):386. doi: 10.1186/s13054-023-04655-8. PMID: 37798769; PMCID: PMC10552444.
Link to Article
Link to FULL FREE PDF

Furosemide Stress Test

McMahon BA, Chawla LS. The furosemide stress test: current use and future potential. Ren Fail. 2021 Dec;43(1):830-839. doi: 10.1080/0886022X.2021.1906701. PMID: 33971784; PMCID: PMC8118439.
Link to Article
Link to FULL FREE PDF

How Will Critical Care be Organized in the Future?

Esper AM, Arabi YM, Cecconi M, Du B, Giamarellos-Bourboulis EJ, Juffermans N, Machado F, Peake S, Phua J, Rowan K, Suh GY, Martin GS. Systematized and efficient: organization of critical care in the future. Crit Care. 2022 Nov 28;26(1):366. doi: 10.1186/s13054-022-04244-1. PMID: 36443764; PMCID: PMC9707068.
Link to Article
Link to FULL FREE PDF

DIC Sucks. Here’s what we can do about it.

Iba T, Helms J, Connors JM, Levy JH. The pathophysiology, diagnosis, and management of sepsis-associated disseminated intravascular coagulation. J Intensive Care. 2023 May 23;11(1):24. doi: 10.1186/s40560-023-00672-5. PMID: 37221630; PMCID: PMC10202753.
Link to Article
Link to FULL FREE PDF

ARDS Goodies

Bos LDJ, de Grooth HJ, Tuinman PR. A structured diagnostic algorithm for patients with ARDS. Crit Care. 2023 Mar 21;27(1):94. doi: 10.1186/s13054-023-04368-y. PMID: 36941668; PMCID: PMC10027589.
Link to Article
Link to FULL FREE PDF
CLICK HERE to learn about Driving Pressure

Are you ready for Human-centered visualization technologies?

Gasciauskaite, G., Lunkiewicz, J., Roche, T.R. et al. Human-centered visualization technologies for patient monitoring are the future: a narrative review. Crit Care 27, 254 (2023). https://doi.org/10.1186/s13054-023-04544-0
Link to Article
Link to FULL FREE PDF

Red Meat Bad?

Lescinsky H, Afshin A, Ashbaugh C, Bisignano C, Brauer M, Ferrara G, Hay SI, He J, Iannucci V, Marczak LB, McLaughlin SA, Mullany EC, Parent MC, Serfes AL, Sorensen RJD, Aravkin AY, Zheng P, Murray CJL. Health effects associated with consumption of unprocessed red meat: a Burden of Proof study. Nat Med. 2022 Oct;28(10):2075-2082. doi: 10.1038/s41591-022-01968-z. Epub 2022 Oct 10. PMID: 36216940; PMCID: PMC9556326.
Link to Article
Link to FULL FREE PDF

An Algorithm for ARDS? Don’t Mind if I do.

Bos LDJ, de Grooth HJ, Tuinman PR. A structured diagnostic algorithm for patients with ARDS. Crit Care. 2023 Mar 21;27(1):94. doi: 10.1186/s13054-023-04368-y. PMID: 36941668; PMCID: PMC10027589.
Link to Article
Link to FULL FREE PDF

Acute Aortic Dissection

Flower L, Arrowsmith JE, Bewley J, et al. Management of acute aortic dissection in critical care. Journal of the Intensive Care Society. 2023;0(0). doi:10.1177/17511437231162219
Link to Article
Link to FULL FREE PDF

Can We Use PEEP To Determine Fluid Responsiveness?

Lai C, Shi R, Beurton A, Moretto F, Ayed S, Fage N, Gavelli F, Pavot A, Dres M, Teboul JL, Monnet X. The increase in cardiac output induced by a decrease in positive end-expiratory pressure reliably detects volume responsiveness: the PEEP-test study. Crit Care. 2023 Apr 9;27(1):136. doi: 10.1186/s13054-023-04424-7. PMID: 37031182; PMCID: PMC10082988.
Link to Article
Link to FULL FREE PDF
Link to Correspondence
Link to MY POST on Fluid Responsiveness
CLICK HERE for my quick summary of the paper.

Lactic Alkalosis: Should we start caring?

Dargent A, Wallet F, Friggeri A, Bohe J, Vacheron CH. Lactic alkalosis in intensive care: a red flag? Crit Care. 2023 May 12;27(1):184. doi: 10.1186/s13054-023-04464-z. PMID: 37173749; PMCID: PMC10176709.
Link to Article
Link to FULL FREE PDF
Link to my post on Lactic Acidosis

MCS Guidelines

Bernhardt AM, Copeland H, Deswal A, Gluck J, Givertz MM; Chairs:; Co-Chairs:; Contributing Writers:; Chair:; Co-Chair:; Contributing Writers:; Chair:; Co-Chairs:; Contributing Writers:; Chair:; Co-Chair:; Contributing Writers:. The International Society for Heart and Lung Transplantation/Heart Failure Society of America Guideline on Acute Mechanical Circulatory Support. J Heart Lung Transplant. 2023 Apr;42(4):e1-e64. doi: 10.1016/j.healun.2022.10.028. Epub 2023 Feb 6. PMID: 36805198.
Link to Article
Link to FULL FREE PDF
Link to my dedicated post on ECMO
Link to my post on Mechanical Circulatory Support

Other uses for creatine?

Prokopidis K, Giannos P, Triantafyllidis KK, Kechagias KS, Forbes SC, Candow DG. Effects of creatine supplementation on memory in healthy individuals: a systematic review and meta-analysis of randomized controlled trials. Nutr Rev. 2023 Mar 10;81(4):416-427. doi: 10.1093/nutrit/nuac064. PMID: 35984306; PMCID: PMC9999677.
Link to Article
Link to FULL FREE PDF

Hypothyroidism in the ICU

Bourcier S, Coutrot M, Ferré A, Van Grunderbeeck N, Charpentier J, Hraiech S, Azoulay E, Nseir S, Aissaoui N, Messika J, Fillatre P, Persichini R, Carreira S, Lautrette A, Delmas C, Terzi N, Mégarbane B, Lascarrou JB, Razazi K, Repessé X, Pichereau C, Contou D, Frérou A, Barbier F, Ehrmann S, de Montmollin E, Sztrymf B, Morawiec E, Bigé N, Reuter D, Schnell D, Ellrodt O, Dellamonica J, Combes A, Schmidt M. Critically ill severe hypothyroidism: a retrospective multicenter cohort study. Ann Intensive Care. 2023 Mar 9;13(1):15. doi: 10.1186/s13613-023-01112-1. PMID: 36892784.
Link to Article
Link to FULL FREE PDF

EEG After Cardiac Arrest

Sandroni C, Skrifvars MB, Taccone FS. Brain monitoring after cardiac arrest. Curr Opin Crit Care. 2023 Feb 18. doi: 10.1097/MCC.0000000000001023. Epub ahead of print. PMID: 36762679.
Link to Article
Link to FULL FREE PDF

Thoracic ultrasound in the ICU

Heldeweg MLA, Lopez Matta JE, Pisani L, Slot S, Haaksma ME, Smit JM, Mousa A, Magnesa G, Massaro F, Touw HRW, Schouten V, Elzo Kraemer CV, van Westerloo DJ, Heunks LMA, Tuinman PR. The Impact of Thoracic Ultrasound on Clinical Management of Critically Ill Patients (UltraMan): An International Prospective Observational Study. Crit Care Med. 2022 Dec 23. doi: 10.1097/CCM.0000000000005760. Epub ahead of print. PMID: 36562620.
Link to Article and FULL FREE PDF

Did you put the probe on the patients chest?

Peach M, Milne J, Diegelmann L, Lamprecht H, Stander M, Lussier D, Pham C, Henneberry R, Fraser J, Chandra K, Howlett M, Mekwan J, Ramrattan B, Middleton J, van Hoving N, Taylor L, Dahn T, Hurley S, MacSween K, Richardson L, Stoica G, Hunter S, Olszynski P, Chandra K, Lewis D, Atkinson P. Does point-of-care ultrasonography improve diagnostic accuracy in emergency department patients with undifferentiated hypotension? An international randomized controlled trial from the SHOC-ED investigators. CJEM. 2022 Dec 29. doi: 10.1007/s43678-022-00431-9. Epub ahead of print. PMID: 36577931.
Link to Article
Link to FULL FREE PDF

Inhaled Anesthetics for ICU Sedation?

Soukup J, Michel P, Christel A, Schittek GA, Wagner NM, Kellner P. Prolonged sedation with sevoflurane in comparison to intravenous sedation in critically ill patients – A randomized controlled trial. J Crit Care. 2023 Jan 12;74:154251. doi: 10.1016/j.jcrc.2022.154251. Epub ahead of print. PMID: 36640476.
Link to Article
Link to FULL FREE PDF

Vent Weaning

Akella P, Voigt LP, Chawla S. To Wean or Not to Wean: A Practical Patient Focused Guide to Ventilator Weaning. J Intensive Care Med. 2022 Nov;37(11):1417-1425. doi: 10.1177/08850666221095436. Epub 2022 Jul 11. PMID: 35815895.
Link to Article
Link to FULL FREE PDF

Heatstroke!

Patel J, Boyer N, Mensah K, et al. Critical illness aspects of heatstroke: A hot topic. Journal of the Intensive Care Society. 2023;0(0). doi:10.1177/17511437221148922
Link to Article
Link to FULL FREE PDF

Don’t forget about the Right Ventricle

Nägele MP, Flammer AJ. Heart Failure After Right Ventricular Myocardial Infarction. Curr Heart Fail Rep. 2022 Dec;19(6):375-385. doi: 10.1007/s11897-022-00577-8. Epub 2022 Oct 5. PMID: 36197627; PMCID: PMC9653315.
Link to Article
Link to FULL FREE PDF
Click here for my post on Cardiogenic Shock

Subphenotypes of AKI

Vaara ST, Bhatraju PK, Stanski NL, McMahon BA, Liu K, Joannidis M, Bagshaw SM. Subphenotypes in acute kidney injury: a narrative review. Crit Care. 2022 Aug 19;26(1):251. doi: 10.1186/s13054-022-04121-x. PMID: 35986336; PMCID: PMC9389711.
Link to Article
Link to FULL FREE PDF

Higher MAP goal in Hypertensive Patients?

Asfar P, Meziani F, Hamel JF, Grelon F, Megarbane B, Anguel N, Mira JP, Dequin PF, Gergaud S, Weiss N, Legay F, Le Tulzo Y, Conrad M, Robert R, Gonzalez F, Guitton C, Tamion F, Tonnelier JM, Guezennec P, Van Der Linden T, Vieillard-Baron A, Mariotte E, Pradel G, Lesieur O, Ricard JD, Hervé F, du Cheyron D, Guerin C, Mercat A, Teboul JL, Radermacher P; SEPSISPAM Investigators. High versus low blood-pressure target in patients with septic shock. N Engl J Med. 2014 Apr 24;370(17):1583-93. doi: 10.1056/NEJMoa1312173. Epub 2014 Mar 18. PMID: 24635770.
Link to Article
Link to FULL FREE PDF

2022 Heart Failure Guidelines

Heidenreich PA, Bozkurt B, Aguilar D, Allen LA, Byun JJ, Colvin MM, Deswal A, Drazner MH, Dunlay SM, Evers LR, Fang JC, Fedson SE, Fonarow GC, Hayek SS, Hernandez AF, Khazanie P, Kittleson MM, Lee CS, Link MS, Milano CA, Nnacheta LC, Sandhu AT, Stevenson LW, Vardeny O, Vest AR, Yancy CW. 2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure: Executive Summary: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation. 2022 May 3;145(18):e876-e894. doi: 10.1161/CIR.0000000000001062. Epub 2022 Apr 1. PMID: 35363500.
Link to Article
Link to FULL FREE PDF
If things get worse, here’s my post on Cardiogenic Shock

The Future of Sepsis Management?

Ronco, C., Chawla, L., Husain-Syed, F. et al. Rationale for sequential extracorporeal therapy (SET) in sepsis. Crit Care 27, 50 (2023). https://doi.org/10.1186/s13054-023-04310-2
Link to Article
Link to FULL FREE PDF
Link to my full post on fluid responsiveness in sepsis

The Future of Cardiac Surgery for the Intensivist

Kopanczyk R, Lester J, Long MT, Kossbiel BJ, Hess AS, Rozycki A, Nunley DR, Habib A, Taylor A, Awad H, Bhatt AM. The Future of Cardiothoracic Surgical Critical Care Medicine as a Medical Science: A Call to Action. Medicina. 2023; 59(1):47. https://doi.org/10.3390/medicina59010047
Link to Article
Link to FULL FREE PDF
My Blog Post on CVICU Essentials
My Blog Post on how I care for Post-Op Cardiac Surgery Patients

Transfusions in Cardiac Surgery Patients

Sanaiha Y, Hadaya J, Verma A, Shemin RJ, Madani M, Young N, Deuse T, Sun J, Benharash P; University of California Cardiac Surgery Consortium. Morbidity and Mortality Associated With Blood Transfusions in Elective Adult Cardiac Surgery. J Cardiothorac Vasc Anesth. 2022 Nov 17:S1053-0770(22)00799-6. doi: 10.1053/j.jvca.2022.11.012. Epub ahead of print. PMID: 36462976.
Link to Article
Link to FULL FREE PDF
Examples of how I take care of Post-Op patients.
My personal comprehensive review on CT surgery patients

I guess Japan is still using dopamine. Are you?

Suzuki R, Uchino S, Sasabuchi Y, Kawarai Lefor A, Sanui M. Dopamine use and its consequences in the intensive care unit: a cohort study utilizing the Japanese Intensive care PAtient Database. Crit Care. 2022 Apr 2;26(1):90. doi: 10.1186/s13054-022-03960-y. PMID: 35366934; PMCID: PMC8977005.
Link to Article
Link to FULL FREE PDF
Link to my post on Vasopressors.

A review of endovascular therapies to be used for PE’s? Don’t Mind if I do!

Rousseau H, Del Giudice C, Sanchez O, Ferrari E, Sapoval M, Marek P, Delmas C, Zadro C, Revel-Mouroz P. Endovascular therapies for pulmonary embolism. Heliyon. 2021 Apr 1;7(4):e06574. doi: 10.1016/j.heliyon.2021.e06574. PMID: 33889762; PMCID: PMC8047492.
Link to Article
Link to FULL FREE PDF

Transesophageal Echos: My New Years Resolution

Prager R, Bowdridge J, Pratte M, Cheng J, McInnes MD, Arntfield R. Indications, Clinical Impact, and Complications of Critical Care Transesophageal Echocardiography: A Scoping Review. J Intensive Care Med. 2023 Mar;38(3):245-272. doi: 10.1177/08850666221115348. Epub 2022 Jul 19. PMID: 35854414.
Link to Article
Link to FULL FREE PDF

ECMO for Cardiac Arrest Patients?

Holmberg MJ, Granfeldt A, Guerguerian AM, Sandroni C, Hsu CH, Gardner RM, Lind PC, Eggertsen MA, Johannsen CM, Andersen LW. Extracorporeal Cardiopulmonary Resuscitation for Cardiac Arrest: An Updated Systematic Review. Resuscitation. 2022 Dec 12:S0300-9572(22)00738-9. doi: 10.1016/j.resuscitation.2022.12.003. Epub ahead of print. PMID: 36521684.
Link to Article
Link to FULL FREE PDF
Link to my content on ECMO

Push-Dose Vasopressors

Kubena A, Weston S, Alvey H. Push-dose vasopressors in the Emergency Department: a narrative review.
J Emerg Crit Care Med 2022;6:22.
Link to Article
Link to FULL FREE PDF
Link to my blog post on Vasopressors

Managing Vents in Cardiac Arrest Patients

Battaglini D, Pelosi P, Robba C. Ten rules for optimizing ventilatory settings and targets in post-cardiac arrest patients. Crit Care. 2022 Dec 17;26(1):390. doi: 10.1186/s13054-022-04268-7. PMID: 36527126; PMCID: PMC9758928.
Link to Article
Link to FULL FREE PDF

In-hospital cardiac arrest

Penketh J, Nolan JP. In-hospital cardiac arrest: the state of the art. Crit Care. 2022 Dec 6;26(1):376. doi: 10.1186/s13054-022-04247-y. PMID: 36474215.
Link to Article
Link to FULL FREE PDF

Drugs for AKI?

Pickkers P, Murray PT, Ostermann M. New drugs for acute kidney injury. Intensive Care Med. 2022 Dec;48(12):1796-1798. doi: 10.1007/s00134-022-06859-y. Epub 2022 Aug 23. PMID: 35999470; PMCID: PMC9705447.
Link to Article
Link to FULL FREE PDF

Personalizing Septic Shock Management

De Backer D, Cecconi M, Chew MS, Hajjar L, Monnet X, Ospina-Tascón GA, Ostermann M, Pinsky MR, Vincent JL. A plea for personalization of the hemodynamic management of septic shock. Crit Care. 2022 Dec 1;26(1):372. doi: 10.1186/s13054-022-04255-y. PMID: 36457089.
Link to Article
Link to FULL FREE PDF

Streptococcal toxic shock syndrome

Schmitz M, Roux X, Huttner B, Pugin J. Streptococcal toxic shock syndrome in the intensive care unit. Ann Intensive Care. 2018 Sep 17;8(1):88. doi: 10.1186/s13613-018-0438-y. PMID: 30225523; PMCID: PMC6141408.
Link to Article
Link to FULL FREE PDF

MAP Goals in Patients with Underlying Hypertension

Tran PNT, Kusirisin P, Kaewdoungtien P, Phannajit J, Srisawat N. Higher blood pressure versus normotension targets to prevent acute kidney injury: a systematic review and meta-regression of randomized controlled trials. Crit Care. 2022 Nov 25;26(1):364. doi: 10.1186/s13054-022-04236-1. PMID: 36434726.
Link to Article
Link to FULL FREE PDF
Check out my full post on Vasopressors!

Kidney Biomarkers

Pan HC, Yang SY, Chiou TT, Shiao CC, Wu CH, Huang CT, Wang TJ, Chen JY, Liao HW, Chen SY, Huang TM, Yang YF, Lin HY, Chan MJ, Sun CY, Chen YT, Chen YC, Wu VC. Comparative accuracy of biomarkers for the prediction of hospital-acquired acute kidney injury: a systematic review and meta-analysis. Crit Care. 2022 Nov 12;26(1):349. doi: 10.1186/s13054-022-04223-6. PMID: 36371256.
Link to Article
Link to FULL FREE PDF

Vasoplegia

Muhammad R, Dharmadjati BB, Mulia EPB, Rachmi DA. Vasoplegia: Mechanism and Management Following Cardiopulmonary Bypass. Eurasian J Med. 2022 Feb;54(1):92-99. doi: 10.5152/eurasianjmed.2022.20394. PMID: 35307639; PMCID: PMC9634875.
Link to Article
Link to FULL FREE PDF
Link to my post on Recovering Patients in the CVICU
Link to my post on Post-Op Management of CABG Patients

Pathophys of Fluids

Messina A, Bakker J, Chew M, De Backer D, Hamzaoui O, Hernandez G, Myatra SN, Monnet X, Ostermann M, Pinsky M, Teboul JL, Cecconi M. Pathophysiology of fluid administration in critically ill patients. Intensive Care Med Exp. 2022 Nov 4;10(1):46. doi: 10.1186/s40635-022-00473-4. PMID: 36329266.
Link to Article
Link to FULL FREE PDF
CLICK HERE for my post on Fluid Responsiveness

Pulse oximetry for ARDS

Wick KD, Matthay MA, Ware LB. Pulse oximetry for the diagnosis and management of acute respiratory distress syndrome. Lancet Respir Med. 2022 Aug 29;10(11):1086–98. doi: 10.1016/S2213-2600(22)00058-3. Epub ahead of print. PMID: 36049490; PMCID: PMC9423770.
Link to Article
Link to FULL FREE PDF

Psilocybin for Depression

riGoodwin GM, Aaronson ST, Alvarez O, Arden PC, Baker A, Bennett JC, Bird C, Blom RE, Brennan C, Brusch D, Burke L, Campbell-Coker K, Carhart-Harris R, Cattell J, Daniel A, DeBattista C, Dunlop BW, Eisen K, Feifel D, Forbes M, Haumann HM, Hellerstein DJ, Hoppe AI, Husain MI, Jelen LA, Kamphuis J, Kawasaki J, Kelly JR, Key RE, Kishon R, Knatz Peck S, Knight G, Koolen MHB, Lean M, Licht RW, Maples-Keller JL, Mars J, Marwood L, McElhiney MC, Miller TL, Mirow A, Mistry S, Mletzko-Crowe T, Modlin LN, Nielsen RE, Nielson EM, Offerhaus SR, O’Keane V, Páleníček T, Printz D, Rademaker MC, van Reemst A, Reinholdt F, Repantis D, Rucker J, Rudow S, Ruffell S, Rush AJ, Schoevers RA, Seynaeve M, Shao S, Soares JC, Somers M, Stansfield SC, Sterling D, Strockis A, Tsai J, Visser L, Wahba M, Williams S, Young AH, Ywema P, Zisook S, Malievskaia E. Single-Dose Psilocybin for a Treatment-tstant Episode of Major Depression. N Engl J Med. 2022 Nov 3;387(18):1637-1648. doi: 10.1056/NEJMoa2206443. PMID: 36322843.
Link to Article
Link to FULL FREE PDF

Hemodynamic Monitoring

Pinsky MR, Cecconi M, Chew MS, De Backer D, Douglas I, Edwards M, Hamzaoui O, Hernandez G, Martin G, Monnet X, Saugel B, Scheeren TWL, Teboul JL, Vincent JL. Effective hemodynamic monitoring. Crit Care. 2022 Sep 28;26(1):294. doi: 10.1186/s13054-022-04173-z. PMID: 36171594; PMCID: PMC9520790.
Link to Article
Link to FULL FREE PDF
CLICK HERE for my post on Fluid Responsiveness

Insanity

Role of spike in the pathogenic and antigenic behavior of SARS-CoV-2 BA.1 Omicron
Da-Yuan Chen, Devin Kenney, Chue Vin Chin, Alexander H. Tavares, Nazimuddin Khan, Hasahn L. Conway, GuanQun Liu, Manish C. Choudhary, Hans P. Gertje, Aoife K. O’Connell, Darrell N. Kotton, Alexandra Herrmann, Armin Ensser, John H. Connor, Markus Bosmann, Jonathan Z. Li, Michaela U. Gack, Susan C. Baker, Robert N. Kirchdoerfer, Yachana Kataria, Nicholas A. Crossland, Florian Douam, Mohsan Saeed.

We generated chimeric recombinant SARS-CoV-2 encoding the S gene of Omicron in the backbone of an ancestral SARS-CoV-2 isolate and compared this virus with the naturally circulating Omicron variant. ” “Omicron S-carrying virus inflicts severe disease with a mortality rate of 80%.
Link to FULL FREE ARTICLE

Data About This Helmet Thing

Cesarano M, Grieco DL, Michi T, Munshi L, Menga LS, Delle Cese L, Ruggiero E, Rosà T, Natalini D, Sklar MC, Cutuli SL, Bongiovanni F, De Pascale G, Ferreyro BL, Goligher EC, Antonelli M. Helmet noninvasive support for acute hypoxemic respiratory failure: rationale, mechanism of action and bedside application. Ann Intensive Care. 2022 Oct 14;12(1):94. doi: 10.1186/s13613-022-01069-7. PMID: 36241926; PMCID: PMC9568634.
Link to Article
Link to FULL FREE PDF
CLICK HERE for older data on the helmet.

Cardiogenic Shock Patients with Multiorgan Failure Do Worse.

Vallabhajosyula S, Dunlay SM, Prasad A, Kashani K, Sakhuja A, Gersh BJ, Jaffe AS, Holmes DR Jr, Barsness GW. Acute Noncardiac Organ Failure in Acute Myocardial Infarction With Cardiogenic Shock. J Am Coll Cardiol. 2019 Apr 16;73(14):1781-1791. doi: 10.1016/j.jacc.2019.01.053. PMID: 30975295.
Link to Article
Link to FULL FREE PDF
CLICK HERE to my post on Cardiogenic Shock

CAP Guidelines

Metlay JP, Waterer GW, Long AC, Anzueto A, Brozek J, Crothers K, Cooley LA, Dean NC, Fine MJ, Flanders SA, Griffin MR, Metersky ML, Musher DM, Restrepo MI, Whitney CG. Diagnosis and Treatment of Adults with Community-acquired Pneumonia. An Official Clinical Practice Guideline of the American Thoracic Society and Infectious Diseases Society of America. Am J Respir Crit Care Med. 2019 Oct 1;200(7):e45-e67. doi: 10.1164/rccm.201908-1581ST. PMID: 31573350; PMCID: PMC6812437.
Link to Article
Link to FULL FREE PDF
Is Procalcitonin everything you want it to be and more? CLICK HERE for the data.

Is therapeutic hypothermia still a thing?

Wolfrum S, Roedl K, Hanebutte A, Pfeifer R, Kurowski V, Riessen R, Daubmann A, Braune S, Söffker G, Bibiza-Freiwald E, Wegscheider K, Schunkert H, Thiele H, Kluge S. Temperature Control After In-Hospital Cardiac Arrest: A Randomized Clinical Trial. Circulation. 2022 Sep 28:101161CIRCULATIONAHA122060106. doi: 10.1161/CIRCULATIONAHA.122.060106. Epub ahead of print. PMID: 36168956.
Link to Article
Link to FULL FREE PDF
CLICK HERE for my breakdown on a previous normothermia/hypothermia trial.

Do the conventional ways to determine fluid responsiveness bore you? Try these!

Horejsek J, Kunstyr J, Michalek P, Porizka M. Novel Methods for Predicting Fluid Responsiveness in Critically Ill Patients-A Narrative Review. Diagnostics (Basel). 2022 Feb 16;12(2):513. doi: 10.3390/diagnostics12020513. PMID: 35204603; PMCID: PMC8871108.
Link to Article
Link to FULL FREE PDF
Link to my work on Fluid Responsiveness
Link to my work on End-Expiratory Occlusion Testing

Guillain-Barre

Leonhard SE, Mandarakas MR, Gondim FAA, Bateman K, Ferreira MLB, Cornblath DR, van Doorn PA, Dourado ME, Hughes RAC, Islam B, Kusunoki S, Pardo CA, Reisin R, Sejvar JJ, Shahrizaila N, Soares C, Umapathi T, Wang Y, Yiu EM, Willison HJ, Jacobs BC. Diagnosis and management of Guillain-Barré syndrome in ten steps. Nat Rev Neurol. 2019 Nov;15(11):671-683. doi: 10.1038/s41582-019-0250-9. Epub 2019 Sep 20. PMID: 31541214; PMCID: PMC6821638.
Link to Article
Link to FULL FREE PDF

Loop diuretics in the ICU: Where’s the Data?

Wichmann S, Barbateskovic M, Liang N, Itenov TS, Berthelsen RE, Lindschou J, Perner A, Gluud C, Bestle MH. Loop diuretics in adult intensive care patients with fluid overload: a systematic review of randomised clinical trials with meta-analysis and trial sequential analysis. Ann Intensive Care. 2022 Jun 13;12(1):52. doi: 10.1186/s13613-022-01024-6. PMID: 35696008; PMCID: PMC9192894.
Link to Article
Link to FULL FREE PDF

CLICK HERE to learn about Deresuscitation

Dexmedetomidine: Still More Meh.

Zhang T, Mei Q, Dai S, Liu Y, Zhu H. Use of dexmedetomidine in patients with sepsis: a systematic review and meta-analysis of randomized-controlled trials. Ann Intensive Care. 2022 Aug 27;12(1):81. doi: 10.1186/s13613-022-01052-2. PMID: 36029410.
Link to Article
Link to FULL FREE PDF

CLICK HERE for my work on non-opioid ICU care.

Using the Ultrasound Proficiently

Miller, A., Peck, M., Clark, T., Conway, H., Olusanya, S., Fletcher, N., Coleman, N., Parulekar, P., Aron, J., Kirk-Bayley, J., Wilkinson, J. N., Wong, A., Stephens, J., Rubino, A., Attwood, B., Walden, A., Breen, A., Waraich, M., Nix, C., & Hayward, S. (2022). FUSIC HD. Comprehensive haemodynamic assessment with ultrasound. Journal of the Intensive Care Society, 23(3), 325–333. https://doi.org/10.1177/17511437211010032
Link to Article
Link to FULL FREE PDF

The Last 20 Years of Fluid Challenges

Messina A, Calabrò L, Pugliese L, Lulja A, Sopuch A, Rosalba D, Morenghi E, Hernandez G, Monnet X, Cecconi M. Fluid challenge in critically ill patients receiving haemodynamic monitoring: a systematic review and comparison of two decades. Crit Care. 2022 Jun 21;26(1):186. doi: 10.1186/s13054-022-04056-3. PMID: 35729632; PMCID: PMC9210670.
Link to Article
Link to FULL FREE PDF
Link to my content on fluid responsiveness

CVP in 2022

Hamzaoui O, Teboul JL. Central venous pressure (CVP). Intensive Care Med. 2022 Aug 11. doi: 10.1007/s00134-022-06835-6. Epub ahead of print. PMID: 35953675.
TRY THIS Link to Article FIRST
Link to Article
If you want additional articles on CVP, CLICK HERE.

Goodies from the Left Atrium

Bowcock EM, Mclean A. Bedside assessment of left atrial pressure in critical care: a multifaceted gem. Crit Care. 2022 Aug 13;26(1):247. doi: 10.1186/s13054-022-04115-9. PMID: 35964098; PMCID: PMC9375940.
Link to Article
Link to FULL FREE PDF

Base Deficit, Base Excess: Is it a Good Standalone Marker?

Langer T, Brusatori S, Gattinoni L. Understanding base excess (BE): merits and pitfalls. Intensive Care Med. 2022 Aug;48(8):1080-1083. doi: 10.1007/s00134-022-06748-4. Epub 2022 May 31. PMID: 35639122; PMCID: PMC9304040.
Link to Article
Link to FULL FREE PDF

Respiratory Failure in the NeuroICU

Robba C, Poole D, McNett M, Asehnoune K, Bösel J, Bruder N, Chieregato A, Cinotti R, Duranteau J, Einav S, Ercole A, Ferguson N, Guerin C, Siempos II, Kurtz P, Juffermans NP, Mancebo J, Mascia L, McCredie V, Nin N, Oddo M, Pelosi P, Rabinstein AA, Neto AS, Seder DB, Skrifvars MB, Suarez JI, Taccone FS, van der Jagt M, Citerio G, Stevens RD. Mechanical ventilation in patients with acute brain injury: recommendations of the European Society of Intensive Care Medicine consensus. Intensive Care Med. 2020 Dec;46(12):2397-2410. doi: 10.1007/s00134-020-06283-0. Epub 2020 Nov 11. PMID: 33175276; PMCID: PMC7655906.
Link to Article
Link to FULL FREE PDF

IV Fluids in the Critically Ill Guidelines

Joannes-Boyau O, Le Conte P, Bonnet MP, Cesareo E, Chousterman B, Chaiba D, Douay B, Futier E, Harrois A, Huraux C, Ichai C, Meaudre Desgouttes E, Mimoz O, Muller L, Oberlin M, Peschanski N, Quintard H, Rousseau G, Savary D, Tran-Dinh A, Villoing B, Chauvin A, Weiss E. Guidelines for the choice of intravenous fluids for vascular filling in critically ill patients, 2021. Anaesth Crit Care Pain Med. 2022 Jun;41(3):101058. doi: 10.1016/j.accpm.2022.101058. Epub 2022 May 5. PMID: 35526312.
Link to Article
Link to FULL FREE PDF

Extracorporeal Carbon Dioxide Removal for COPD Exacerbations

Barrett NA, Hart N, Daly KJR, Marotti M, Kostakou E, Carlin C, Lua S, Singh S, Bentley A, Douiri A, Camporota L. A randomised controlled trial of non-invasive ventilation compared with extracorporeal carbon dioxide removal for acute hypercapnic exacerbations of chronic obstructive pulmonary disease. Ann Intensive Care. 2022 Apr 21;12(1):36. doi: 10.1186/s13613-022-01006-8. PMID: 35445986; PMCID: PMC9021560.
Link to Article
Link to FULL FREE PDF

2021’s Best POCUS Papers

Millington SJ, Arntfield RT, Koenig SJ, Mayo PH, Vieillard-Baron A. Ten Influential Point-of-Care Ultrasound Papers: 2021 in Review. J Intensive Care Med. 2022 Apr 19:8850666221095050. doi: 10.1177/08850666221095050. Epub ahead of print. PMID: 35440211.
Link to Article
Link to FULL FREE PDF

Basic Critical Care Echocardiography Training

Rajamani A, Galarza L, Sanfilippo F, Wong A, Goffi A, Tuinman P, Mayo P, Arntfield R, Fisher R, Chew M, Slama M, Mackenzie D, Ho E, Smith L, Renner M, Tavares M, Prabu R N, Ramanathan K, Knudsen S, Bhat V, Arvind H, Huang S; SPARTAN Collaborative (Small Projects, Audits and Research Projects-Australia/New Zealand). Criteria, Processes, and Determination of Competence in Basic Critical Care Echocardiography Training: A Delphi Process Consensus Statement by the Learning Ultrasound in Critical Care (LUCC) Initiative. Chest. 2022 Feb;161(2):492-503. doi: 10.1016/j.chest.2021.08.077. Epub 2021 Sep 8. PMID: 34508739.
Link to Article
Link to FULL FREE PDF

Microbiota Stuff

Prevel R, Enaud R, Orieux A, Camino A, Berger P, Boyer A, Delhaes L, Gruson D. Gut bacteriobiota and mycobiota are both associated with Day-28 mortality among critically ill patients. Crit Care. 2022 Apr 13;26(1):105. doi: 10.1186/s13054-022-03980-8. PMID: 35418098; PMCID: PMC9007252.
Link to Article
Link to FULL FREE PDF

Permissive Hypercapnea

Gendreau S, Geri G, Pham T, Vieillard-Baron A, Mekontso Dessap A. The role of acute hypercapnia on mortality and short-term physiology in patients mechanically ventilated for ARDS: a systematic review and meta-analysis. Intensive Care Med. 2022 May;48(5):517-534. doi: 10.1007/s00134-022-06640-1. Epub 2022 Mar 16. PMID: 35294565; PMCID: PMC8924945.
Link to Article
Link to FULL FREE PDF

Challenging Dogma

Hofmaenner DA, Singer M. Challenging management dogma where evidence is non-existent, weak or outdated. Intensive Care Med. 2022 May;48(5):548-558. doi: 10.1007/s00134-022-06659-4. Epub 2022 Mar 18. PMID: 35303116; PMCID: PMC8931587.
Link to Article
Link to FULL FREE PDF

Sepsis in the Emergency Department

Yealy DM, Mohr NM, Shapiro NI, Venkatesh A, Jones AE, Self WH. Early Care of Adults With Suspected Sepsis in the Emergency Department and Out-of-Hospital Environment: A Consensus-Based Task Force Report. Ann Emerg Med. 2021 Jul;78(1):1-19. doi: 10.1016/j.annemergmed.2021.02.006. Epub 2021 Apr 9. Erratum in: Ann Emerg Med. 2021 Sep;78(3):464. PMID: 33840511.
Link to Article
Link to FULL FREE PDF

Weaning Vasopressors and Ventilators

Monnet X. Should We Wean Patients off Vasopressors before Weaning Them off Ventilation? Am J Respir Crit Care Med. 2022 May 1;205(9):980-981. doi: 10.1164/rccm.202201-0175ED. PMID: 35259082.
Link to Article
Link to FULL FREE PDF

Has your ICU been resilient over the last two+ years?

Salluh JIF, Kurtz P, Bastos LSL, Quintairos A, Zampieri FG, Bozza FA. The resilient intensive care unit. Ann Intensive Care. 2022 Apr 26;12(1):37. doi: 10.1186/s13613-022-01011-x. PMID: 35471746.
Link to Article
Link to FULL FREE PDF

Data Comparing Natural Immunity to Vaccine Immunity

Ridgway JP, Tideman S, Wright B, Robicsek A. Rates of COVID-19 Among Unvaccinated Adults With Prior COVID-19. JAMA Netw Open. 2022 Apr 1;5(4):e227650. doi: 10.1001/jamanetworkopen.2022.7650. PMID: 35442459.
Link to Article and FULL FREE PDF

Artificial sweeteners: Real Data.

McGlynn ND, Khan TA, Wang L, Zhang R, Chiavaroli L, Au-Yeung F, Lee JJ, Noronha JC, Comelli EM, Blanco Mejia S, Ahmed A, Malik VS, Hill JO, Leiter LA, Agarwal A, Jeppesen PB, Rahelic D, Kahleová H, Salas-Salvadó J, Kendall CWC, Sievenpiper JL. Association of Low- and No-Calorie Sweetened Beverages as a Replacement for Sugar-Sweetened Beverages With Body Weight and Cardiometabolic Risk: A Systematic Review and Meta-analysis. JAMA Netw Open. 2022 Mar 1;5(3):e222092. doi: 10.1001/jamanetworkopen.2022.2092. PMID: 35285920.
Link to Article AND FULL FREE PDF

Time to step up our Echo game. It’s becoming standard of care.

Vieillard-Baron A, Millington SJ, Sanfilippo F, Chew M, Diaz-Gomez J, McLean A, Pinsky MR, Pulido J, Mayo P, Fletcher N. A decade of progress in critical care echocardiography: a narrative review. Intensive Care Med. 2019 Jun;45(6):770-788. doi: 10.1007/s00134-019-05604-2. Epub 2019 Mar 25. Erratum in: Intensive Care Med. 2019 Apr 15;: PMID: 30911808.
Link to Article
Link to FULL FREE PDF

Lung Ultrasound

Stassen J, Bax JJ. How to do lung ultrasound. Eur Heart J Cardiovasc Imaging. 2022 Mar 22;23(4):447-449. doi: 10.1093/ehjci/jeab241. PMID: 34791145.
Link to Article
Link to FULL FREE PDF

Treating Complications of COVID

Maslove DM, Sibley S, Boyd JG, Goligher EC, Munshi L, Bogoch II, Rochwerg B. Complications of Critical COVID-19: Diagnostic and Therapeutic Considerations for the Mechanically Ventilated Patient. Chest. 2021 Oct 13;161(4):989–98. doi: 10.1016/j.chest.2021.10.011. Epub ahead of print. PMID: 34655568; PMCID: PMC8511547.
Link to Article
Link to FULL FREE PDF

POCUS

Kalagara H, Coker B, Gerstein NS, Kukreja P, Deriy L, Pierce A, Townsley MM. Point-of-Care Ultrasound (POCUS) for the Cardiothoracic Anesthesiologist. J Cardiothorac Vasc Anesth. 2022 Apr;36(4):1132-1147. doi: 10.1053/j.jvca.2021.01.018. Epub 2021 Jan 16. PMID: 33563532.
Link to Article
Link to FULL FREE PDF

Death by Neurologic Criteria

Spears, W., Mian, A. & Greer, D. Brain death: a clinical overview. j intensive care 10, 16 (2022). https://doi.org/10.1186/s40560-022-00609-4
Link to Article
Link to FULL FREE PDF

Prognositicating after ROSC from a cardiac arrest

Sandroni C, D’Arrigo S, Cacciola S, Hoedemaekers CWE, Westhall E, Kamps MJA, Taccone FS, Poole D, Meijer FJA, Antonelli M, Hirsch KG, Soar J, Nolan JP, Cronberg T. Prediction of good neurological outcome in comatose survivors of cardiac arrest: a systematic review. Intensive Care Med. 2022 Mar 4. doi: 10.1007/s00134-022-06618-z. Epub ahead of print. PMID: 35244745.
Link to Article
Link to FULL FREE PDF

Adding C’s to the H’s and T’s

L. Mommers, C. Slagt, Introducing the C’s in CPR, Resuscitation (2022), doi: https:// doi.org/10.1016/j.resuscitation.2022.02.022
Link to Article
Link to FULL FREE PDF

When a cirrhotic becomes decompensated in our ICU

Passi, N. N., & McPhail, M. J. (2022). The patient with cirrhosis in the intensive care unit and the management of acute-on-chronic liver failure. Journal of the Intensive Care Society23(1), 78–86. https://doi.org/10.1177/1751143720978849
Link to Article
Link to FULL FREE PDF

All the inpatient therapies in one place? Don’t mind if I do!

Chen J-T, Ostermann M, Review of Anti-inflammatory and Anti-viral therapeutics for hospitalized patients infected with SARS-CoV-2, CRITICAL CARE CLINICS (2022), doi: https://doi.org/10.1016/j.ccc.2022.02.002.
Link to Article
Link to FULL FREE PDF

Could we tease out a bit more utility from the bands on a CBC w/diff?

Prasanna N, DelPrete B, Ho G, et al. The utility of bandemia in prognostication and prediction of mortality in sepsis. Journal of the Intensive Care Society. January 2022. doi:10.1177/17511437211069307
Link to Article
Link to FULL FREE PDF

Finally! Guidelines for Anticoagulation from a major Critical Care Society

Moores LK, Tritschler T, Brosnahan S, Carrier M, Collen JF, Doerschug K, Holley AB, Iaccarino J, Jimenez D, LeGal G, Rali P, Wells P, Thromboprophylaxis in Patients with COVID-19. A Brief Update to the CHEST Guideline and Expert Panel Report, CHEST (2022), doi:https://doi.org/10.1016/j.chest.2022.02.006.
Link to Article
Link to FULL FREE PDF

Does iNO actually work or just make us feel better about ourselves that we are doing something?

Bonizzoli M, Lazzeri C, Cianchi G, Guetti C, Fulceri GE, Socci F, Peris A. Effects of rescue inhaled nitric oxide on right ventricle and pulmonary circulation in severe COVID-related acute respiratory distress syndrome. J Crit Care. 2022 Feb 1:153987. doi: 10.1016/j.jcrc.2022.153987. Epub ahead of print. PMID: 35120777; PMCID: PMC8806881.
Link to Article
Link to FULL FREE PDF

When to Trach our COVID Patients

Ji Y, Fang Y, Cheng B, Li L, Fang X. Tracheostomy timing and clinical outcomes in ventilated COVID-19 patients: a systematic review and meta-analysis. Crit Care. 2022 Feb 8;26(1):40. doi: 10.1186/s13054-022-03904-6. PMID: 35135597.
Link to Article
Link to FULL FREE PDF

Keep your patients dry on the vent

Wang W, Zhu S, He Q, Wang M, Kang Y, Zhang R, Ji P, Zou K, Klompas M, Zong Z, Sun X. Fluid Balance and Ventilator-Associated Events Among Patients Admitted to ICUs in China: A Nested Case-Control Study. Crit Care Med. 2022 Feb 1;50(2):307-316. doi: 10.1097/CCM.0000000000005227. PMID: 34473657; PMCID: PMC8797004.
Link to Article
Link to FULL FREE PDF

Surge Responses

Dichter JR, Devereaux AV, Sprung CL, Mukherjee V, Persoff J, Baum KD, Ornoff D, Uppal A, Hossain T, Henry KN, Ghazipura M, Bowden KR, Feldman HJ, Hamele MT, Burry LD, Martland AMO, Huffines M, Tosh PK, Downar J, Hick JL, Christian MD, Maves RC; Task Force for Mass Critical Care Writing Group. Mass Critical Care Surge Response During COVID-19: Implementation of Contingency Strategies – A Preliminary Report of Findings From the Task Force for Mass Critical Care. Chest. 2021 Sep 6;161(2):429–47. doi: 10.1016/j.chest.2021.08.072. Epub ahead of print. PMID: 34499878; PMCID: PMC8420082.
Link to Article
Link to FULL FREE PDF

The Heart and COVID-19 Are NOT BFF’s.

Helms J, Combes A, Aissaoui N. Cardiac injury in COVID-19. Intensive Care Med. 2022 Jan;48(1):111-113. doi: 10.1007/s00134-021-06555-3. Epub 2021 Nov 2. PMID: 34727214; PMCID: PMC8562019.
Link to Article
Link to FULL FREE PDF

Many People Quit Smoking During 2020

Gaffney A, Himmelstein DU, Woolhandler S. Smoking Prevalence during the COVID-19 Pandemic in the United States. Ann Am Thorac Soc. 2022 Jan 19. doi: 10.1513/AnnalsATS.202110-1184RL. Epub ahead of print. PMID: 35044900.
Link to Article
Link to FULL FREE PDF

How severe is Omicron? Let’s look at the actual data from South Africa.

individuals had a significantly reduced odds of severe disease compared with individuals infected earlier with the delta variant. Some of this reduced severity is probably a result of previous immunity.
Wolter N, Jassat W, Walaza S, Welch R, Moultrie H, Groome M, Amoako DG, Everatt J, Bhiman JN, Scheepers C, Tebeila N, Chiwandire N, du Plessis M, Govender N, Ismail A, Glass A, Mlisana K, Stevens W, Treurnicht FK, Makatini Z, Hsiao NY, Parboosing R, Wadula J, Hussey H, Davies MA, Boulle A, von Gottberg A, Cohen C. Early assessment of the clinical severity of the SARS-CoV-2 omicron variant in South Africa: a data linkage study. Lancet. 2022 Jan 19:S0140-6736(22)00017-4. doi: 10.1016/S0140-6736(22)00017-4. Epub ahead of print. PMID: 35065011.
Link to Article
Link to FULL FREE PDF

Cardiac Injury 2/2 COVID

Helms J, Combes A, Aissaoui N. Cardiac injury in COVID-19. Intensive Care Med. 2022 Jan;48(1):111-113. doi: 10.1007/s00134-021-06555-3. Epub 2021 Nov 2. PMID: 34727214; PMCID: PMC8562019.
Link to Article
Link to FULL FREE PDF

Managing Seizures in the ICU

Boggs JG. Seizure Management in the Intensive Care Unit. Curr Treat Options Neurol. 2021;23(11):36. doi: 10.1007/s11940-021-00692-2. Epub 2021 Oct 21. PMID: 34697528; PMCID: PMC8528936.
Link to Article
Link to FREE FULL PDF

How to liberate a patient from the ventilator

Ouellette DR. The Decision to Liberate From the Ventilator: More Than Just a Number. Chest. 2022 Jan;161(1):6-7. doi: 10.1016/j.chest.2021.07.016. PMID: 35000708.
Link to Article
Link to FULL FREE PDF

Lung Transplants and COVID: Not enough to go around

King CS, Mannem H, Kukreja J, Aryal S, Tang D, Singer JP, Bharat A, Behr J, Nathan SD. Lung Transplantation of COVID-19 Patients. Chest. 2021 Aug 19;161(1):169–78. doi: 10.1016/j.chest.2021.08.041. Epub ahead of print. PMID: 34418410; PMCID: PMC8373594.
Link to Article
Link to FULL FREE PDF

New/Potential Biomarkers for Sepsis?

Barichello T, Generoso JS, Singer M, Dal-Pizzol F. Biomarkers for sepsis: more than just fever and leukocytosis-a narrative review. Crit Care. 2022 Jan 6;26(1):14. doi: 10.1186/s13054-021-03862-5. PMID: 34991675.
Link to Article
Link to FULL FREE PDF

Hypocalcemia and Blood Transfusions

Hall C, Nagengast AK, Knapp C, Behrens B, Dewey EN, Goodman A, Bommiasamy A, Schreiber M. Massive transfusions and severe hypocalcemia: An opportunity for monitoring and supplementation guidelines. Transfusion. 2021 Jul;61 Suppl 1:S188-S194. doi: 10.1111/trf.16496. PMID: 34269436.
Link to Article
Link to FULL FREE PDF

What to do about the coagulopathy in liver patients?

Lange NW, Salerno DM, Berger K, Cushing MM, Brown RS Jr. Management of Hepatic Coagulopathy in Bleeding and Nonbleeding Patients: An Evidence-Based Review. J Intensive Care Med. 2021 May;36(5):524-541. doi: 10.1177/0885066620903027. Epub 2020 Feb 21. PMID: 32079443.
Link to Article
Link to FULL FREE PDF

Rhabdomyolysis Management

Burgess, Sarah. “Rhabdomyolysis: An Evidence-Based Approach.” Journal of the Intensive Care Society, Dec. 2022, doi:10.1177/17511437211050782.
Link to Article
Link to FULL FREE PDF

A nerdy therefore cool way to look at Sepsis

Bauer M, Shankar-Hari M, Thomas-Rüddel DO, Wetzker R. Towards an ecological definition of sepsis: a viewpoint. Intensive Care Med Exp. 2021 Dec 29;9(1):63. doi: 10.1186/s40635-021-00427-2. PMID: 34964952; PMCID: PMC8715410.
Link to Article
Link to FULL FREE PDF

When should we call the surgeons for abdominal compartment syndrome?

Păduraru DN, Andronic O, Mușat F, Bolocan A, Dumitrașcu MC, Ion D. Abdominal Compartment Syndrome-When Is Surgical Decompression Needed? Diagnostics (Basel). 2021 Dec 7;11(12):2294. doi: 10.3390/diagnostics11122294. PMID: 34943530.
Link to Article
Link to FULL FREE PDF

Hyperoxia: Not Benign

Singer M, Young PJ, Laffey JG, Asfar P, Taccone FS, Skrifvars MB, Meyhoff CS, Radermacher P. Dangers of hyperoxia. Crit Care. 2021 Dec 19;25(1):440. doi: 10.1186/s13054-021-03815-y. PMID: 34924022.
Link to Article
Link to FULL FREE PDF

Pharmacists in the ICU have a fantastic Return on Investment

Rech MA, Gurnani PK, Peppard WJ, Smetana KS, Van Berkel MA, Hammond DA, Flannery AH. PHarmacist Avoidance or Reductions in Medical Costs in CRITically Ill Adults: PHARM-CRIT Study. Crit Care Explor. 2021 Dec 10;3(12):e0594. doi: 10.1097/CCE.0000000000000594. PMID: 34913039; PMCID: PMC8668016.
Link to Article
Link to FULL FREE PDF

Should we discharge COVID patients on anticoagulation?

Rivaroxaban versus no anticoagulation for post-discharge thromboprophylaxis after hospitalisation for COVID-19 (MICHELLE): an open-label, multicentre, randomised controlled trial. Lancet. 2021; (published online Dec 15.)
https://doi.org/10.1016/S0140-6736(21)02392-8
Link to Article
Link to FULL FREE PDF

Further comments
Link to Article
Link to FULL FREE PDF

High-Flow Nasal Cannula Keeps COVID patients off of the vent: NNT of 6

Ospina-Tascón GA, Calderón-Tapia LE, García AF, Zarama V, Gómez-Álvarez F, Álvarez-Saa T, Pardo-Otálvaro S, Bautista-Rincón DF, Vargas MP, Aldana-Díaz JL, Marulanda Á, Gutiérrez A, Varón J, Gómez M, Ochoa ME, Escobar E, Umaña M, Díez J, Tobón GJ, Albornoz LL, Celemín Flórez CA, Ruiz GO, Cáceres EL, Reyes LF, Damiani LP, Cavalcanti AB; HiFLo-Covid Investigators. Effect of High-Flow Oxygen Therapy vs Conventional Oxygen Therapy on Invasive Mechanical Ventilation and Clinical Recovery in Patients With Severe COVID-19: A Randomized Clinical Trial. JAMA. 2021 Dec 7;326(21):2161-2171. doi: 10.1001/jama.2021.20714. PMID: 34874419; PMCID: PMC8652598.
Link to Article

Is your Critically Ill Patient Bleeding? Here’s how to handle it.

Vlaar APJ, Dionne JC, de Bruin S, Wijnberge M, Raasveld SJ, van Baarle FEHP, Antonelli M, Aubron C, Duranteau J, Juffermans NP, Meier J, Murphy GJ, Abbasciano R, Müller MCA, Lance M, Nielsen ND, Schöchl H, Hunt BJ, Cecconi M, Oczkowski S. Transfusion strategies in bleeding critically ill adults: a clinical practice guideline from the European Society of Intensive Care Medicine. Intensive Care Med. 2021 Dec;47(12):1368-1392. doi: 10.1007/s00134-021-06531-x. Epub 2021 Oct 22. PMID: 34677620; PMCID: PMC8532090.
Link to Article
Link to FULL FREE PDF

Septic Shock Patients Develop Complications like… Brain Atrophy?

Nakae R, Sekine T, Tagami T, Murai Y, Kodani E, Warnock G, Sato H, Morita A, Yokota H, Yokobori S. Rapidly progressive brain atrophy in septic ICU patients: a retrospective descriptive study using semiautomatic CT volumetry. Crit Care. 2021 Nov 29;25(1):411. doi: 10.1186/s13054-021-03828-7. PMID: 34844648.
Link to Article
Link to FULL FREE PDF

We better step up our ultrasound game

Robba C, Wong A, Poole D, Al Tayar A, Arntfield RT, Chew MS, Corradi F, Douflé G, Goffi A, Lamperti M, Mayo P, Messina A, Mongodi S, Narasimhan M, Puppo C, Sarwal A, Slama M, Taccone FS, Vignon P, Vieillard-Baron A; European Society of Intensive Care Medicine task force for critical care ultrasonography*. Basic ultrasound head-to-toe skills for intensivists in the general and neuro intensive care unit population: consensus and expert recommendations of the European Society of Intensive Care Medicine. Intensive Care Med. 2021 Dec;47(12):1347-1367. doi: 10.1007/s00134-021-06486-z. Epub 2021 Oct 5. PMID: 34787687; PMCID: PMC8596353.
Link to Article
Link to FULL FREE PDF

Individualized Sepsis Bundles

Vincent JL, Singer M, Einav S, Moreno R, Wendon J, Teboul JL, Bakker J, Hernandez G, Annane D, de Man AME, Monnet X, Ranieri VM, Hamzaoui O, Takala J, Juffermans N, Chiche JD, Myatra SN, De Backer D. Equilibrating SSC guidelines with individualized care. Crit Care. 2021 Nov 17;25(1):397. doi: 10.1186/s13054-021-03813-0. PMID: 34789298; PMCID: PMC8596086.
Link to Article
Link to FULL FREE PDF

Want to help keep the lights on for my website and all this content free?

You could support my work by clicking on my Amazon Affiliate links prior to ordering things off of Amazon. For example, if you want to learn more about Mechanical Ventilation, I recommend starting off with The Ventilator Book by Will Owens. If you click on that link, a window for Amazon will open up and I will earn between a 1-3% commission at no expense to you. The fun thing is that if you order anything else on Amazon, I will earn that amount off of your shopping cart even if you do not purchase the book. Pretty cool, right? In 2020, Amazon Affiliates helped me pay for the hosting of my website, LLC fees, and Netflix.

What complications can we expect from a central line?

van de Weerdt EK, Biemond BJ, Baake B, Vermin B, Binnekade JM, van Lienden KP, Vlaar APJ. Central venous catheter placement in coagulopathic patients: risk factors and incidence of bleeding complications. Transfusion. 2017 Oct;57(10):2512-2525. doi: 10.1111/trf.14248. Epub 2017 Aug 30. PMID: 28856685.
Link to Article
Link to FULL FREE PDF

How to place a central line

Saugel B, Scheeren TWL, Teboul JL. Ultrasound-guided central venous catheter placement: a structured review and recommendations for clinical practice. Crit Care. 2017 Aug 28;21(1):225. doi: 10.1186/s13054-017-1814-y. PMID: 28844205; PMCID: PMC5572160.
Link to Article
Link to FULL FREE PDF

How to perform a percutaneous tracheostomy

Rashid AO, Islam S. Percutaneous tracheostomy: a comprehensive review. J Thorac Dis. 2017 Sep;9(Suppl 10):S1128-S1138. doi: 10.21037/jtd.2017.09.33. PMID: 29214070; PMCID: PMC5696543.
Link to Article
Link to FULL FREE PDF

Peri-Induction Hemodynamics: Don’t get stuck.

Nabzdyk CGS, Read MD, Wieruszewski PM, Seelhammer TG. Proactive Approach to Peri-Induction Hemodynamic Management in Critically Ill Patients. J Cardiothorac Vasc Anesth. 2021 Dec;35(12):3489-3492. doi: 10.1053/j.jvca.2021.06.015. Epub 2021 Jun 18. PMID: 34253443.
Link to Article
Link to FULL FREE PDF

Esophageal Hemorrhage Management

An Update on the Management of Esophageal Variceal Hemorrhage. Hassaan A. Zia, Elizabeth S. Aby, Atoosa Rabiee. First published: 27 October 2021 https://doi.org/10.1002/cld.1108
Link to Article
Link to FULL FREE PDF

Brain Injury after cardiac arrest

Sandroni C, Cronberg T, Sekhon M. Brain injury after cardiac arrest: pathophysiology, treatment, and prognosis. Intensive Care Med. 2021 Oct 27:1–22. doi: 10.1007/s00134-021-06548-2. Epub ahead of print. PMID: 34705079; PMCID: PMC8548866.
Link to Article
Link to FREE FULL PDF

How will our critically ill COVID-19 Patients do at 6 months?

Hodgson CL, Higgins AM, Bailey MJ, Mather AM, Beach L, Bellomo R, Bissett B, Boden IJ, Bradley S, Burrell A, Cooper DJ, Fulcher BJ, Haines KJ, Hopkins J, Jones AYM, Lane S, Lawrence D, van der Lee L, Liacos J, Linke NJ, Gomes LM, Nickels M, Ntoumenopoulos G, Myles PS, Patman S, Paton M, Pound G, Rai S, Rix A, Rollinson TC, Sivasuthan J, Tipping CJ, Thomas P, Trapani T, Udy AA, Whitehead C, Hodgson IT, Anderson S, Neto AS; COVID-Recovery Study Investigators and the ANZICS Clinical Trials Group. The impact of COVID-19 critical illness on new disability, functional outcomes and return to work at 6 months: a prospective cohort study. Crit Care. 2021 Nov 8;25(1):382. doi: 10.1186/s13054-021-03794-0. PMID: 34749756; PMCID: PMC8575157.
Link to Article
Link to FULL FREE PDF

Chest Pain Guidelines 2021

Martha Gulati, Phillip D. Levy, Debabrata Mukherjee, Ezra Amsterdam, Deepak L. Bhatt, Kim K. Birtcher, Ron Blankstein, Jack Boyd, Renee P. Bullock-Palmer, Theresa Conejo, Deborah B. Diercks, Federico Gentile, John P. Greenwood, Erik P. Hess, Steven M. Hollenberg, Wael A. Jaber, Hani Jneid, José A. Joglar, David A. Morrow, Robert E. O’Connor, Michael A. Ross, Leslee J. Shaw, 2021 AHA/ACC/ASE/CHEST/SAEM/SCCT/SCMR Guideline for the Evaluation and Diagnosis of Chest Pain: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines, Journal of the American College of Cardiology, 2021, ISSN 0735-1097, https://doi.org/10.1016/j.jacc.2021.07.053.
Link to Article
Link to FULL FREE PDF

Best method of ventilator weaning?

Jhou HJ, Chen PH, Ou-Yang LJ, Lin C, Tang SE, Lee CH. Methods of Weaning From Mechanical Ventilation in Adult: A Network Meta-Analysis. Front Med (Lausanne). 2021 Oct 4;8:752984. doi: 10.3389/fmed.2021.752984. PMID: 34671629; PMCID: PMC8521009.
Link to Article
Link to FULL FREE PDF

Head up CPR? Wait, What?

Huang CC, Chen KC, Lin ZY, Chou YH, Chen WL, Lee TH, Lin KT, Hsieh PY, Chen CH, Chou CC, Lin YR. The effect of the head-up position on cardiopulmonary resuscitation: a systematic review and meta-analysis. Crit Care. 2021 Oct 30;25(1):376. doi: 10.1186/s13054-021-03797-x. PMID: 34717715.
Link to Article
Link to FULL FREE PDF

Research Priorities for Sepsis

Lat I, Coopersmith CM, De Backer D, Coopersmith CM; Research Committee of the Surviving Sepsis Campaign. The surviving sepsis campaign: fluid resuscitation and vasopressor therapy research priorities in adult patients. Intensive Care Med Exp. 2021 Mar 1;9(1):10. doi: 10.1186/s40635-021-00369-9. PMID: 33644843.
Link to Article
Link to FULL FREE PDF

Is there a thing as too much oxygen?

Ni YN, Wang YM, Liang BM, Liang ZA. The effect of hyperoxia on mortality in critically ill patients: a systematic review and meta analysis. BMC Pulm Med. 2019 Feb 26;19(1):53. doi: 10.1186/s12890-019-0810-1. PMID: 30808337; PMCID: PMC6390560.
Link to Article
Link to FULL FREE PDF

Opioids trash the gut in ICU patients

Yan Y, Chen Y, Zhang X. The effect of opioids on gastrointestinal function in the ICU. Crit Care. 2021 Oct 24;25(1):370. doi: 10.1186/s13054-021-03793-1. PMID: 34689805.
Link to Article
Link to FULL FREE PDF

Can’t we just filter out the CO2 from these patients?

Molina Lobo R, Lobo-Valbuena B, Gordo F. Management of severe ARDS due to SARS-CoV-2 pneumonia using low-flow extracorporeal CO2 extraction. Crit Care. 2021 Oct 18;25(1):362. doi: 10.1186/s13054-021-03777-1. PMID: 34663415; PMCID: PMC8522120.
Link to Article
Link to FULL FREE PDF

Details about natural immunity!

Does infection with or vaccination against SARS-CoV-2 lead to lasting immunity? Gregory Milne, MSc Thomas Hames, PhD Chris Scotton, PhD Nick Gent, FFPH Alexander Johnsen, MSci Prof Roy M Anderson, FRS Tom Ward, PhD. Published:October 21, 2021 DOI:https://doi.org/10.1016/S2213-2600(21)00407-0
Link to Article
Link to FULL FREE PDF

Do we need to do both SCD’s and pharmacological DVT prophylaxis?

Arabi YM, Al-Hameed F, Burns KEA, Mehta S, Alsolamy SJ, Alshahrani MS, Mandourah Y, Almekhlafi GA, Almaani M, Al Bshabshe A, Finfer S, Arshad Z, Khalid I, Mehta Y, Gaur A, Hawa H, Buscher H, Lababidi H, Al Aithan A, Abdukahil SAI, Jose J, Afesh LY, Al-Dawood A; Saudi Critical Care Trials Group. Adjunctive Intermittent Pneumatic Compression for Venous Thromboprophylaxis. N Engl J Med. 2019 Apr 4;380(14):1305-1315. doi: 10.1056/NEJMoa1816150. Epub 2019 Feb 18. PMID: 30779530.
Link to Article
Link to FULL FREE PDF

Higher PEEP May Not Always be the Answer Due To Hyperinflation

Protti A, Santini A, Pennati F, Chiurazzi C, Cressoni M, Ferrari M, Iapichino GE, Carenzo L, Lanza E, Picardo G, Caironi P, Aliverti A, Cecconi M. Lung response to a higher positive end-expiratory pressure in mechanically ventilated patients with COVID-19. Chest. 2021 Oct 16:S0012-3692(21)04100-3. doi: 10.1016/j.chest.2021.10.012. Epub ahead of print. PMID: 34666011; PMCID: PMC8520168.
Link to Article
Link to FULL FREE PDF

Brain Injuries injure the Lungs

Ziaka M, Exadaktylos A. Brain-lung interactions and mechanical ventilation in patients with isolated brain injury. Crit Care. 2021 Oct 13;25(1):358. doi: 10.1186/s13054-021-03778-0. PMID: 34645485.
Link to Article
Link to FULL FREE PDF

Grip Strength to Determine Extubation Outcome?

Cottereau G, Messika J, Megarbane B, Guérin L, da Silva D, Bornstain C, Santos M, Ricard JD, Sztrymf B. Handgrip strength to predict extubation outcome: a prospective multicenter trial. Ann Intensive Care. 2021 Oct 2;11(1):144. doi: 10.1186/s13613-021-00932-3. PMID: 34601639; PMCID: PMC8487340.
Link to Article
Link to FULL FREE PDF

Monoclonal antibodies in Septic Shock?

Laterre PF, Pickkers P, Marx G, Wittebole X, Meziani F, Dugernier T, Huberlant V, Schuerholz T, François B, Lascarrou JB, Beishuizen A, Oueslati H, Contou D, Hoiting O, Lacherade JC, Chousterman B, Pottecher J, Bauer M, Godet T, Karakas M, Helms J, Bergmann A, Zimmermann J, Richter K, Hartmann O, Pars M, Mebazaa A; AdrenOSS-2 study participants. Safety and tolerability of non-neutralizing adrenomedullin antibody adrecizumab (HAM8101) in septic shock patients: the AdrenOSS-2 phase 2a biomarker-guided trial. Intensive Care Med. 2021 Oct 4:1–11. doi: 10.1007/s00134-021-06537-5. Epub ahead of print. PMID: 34605947; PMCID: PMC8487806.
Link to Article
Link to FULL FREE PDF

Albumin in the ICU

Melia D, Post B. Human albumin solutions in intensive care: A review. J Intensive Care Soc. 2021 Aug;22(3):248-254. doi: 10.1177/1751143720961245. Epub 2020 Sep 30. PMID: 34422108; PMCID: PMC8373284.
Link to Article
Link to FULL FREE PDF

Nurses! Need some Evidence-Based Tips on How to place Dobhoff Tubes? Check this out!

Kurisawa K, Yokose M, Tanaka H, Mihara T, Takaki S, Goto T. Multivariate analysis of factors associated with first-pass success in blind placement of a post-pyloric feeding tube: a retrospective study. J Intensive Care. 2021 Oct 7;9(1):59. doi: 10.1186/s40560-021-00577-1. PMID: 34615558.
Link to Article
Link to FULL FREE PDF

Thromboembolism in COVID-19

Poor HD. Pulmonary Thrombosis and Thromboembolism in COVID-19. Chest. 2021 Jun 19;160(4):1471–80. doi: 10.1016/j.chest.2021.06.016. Epub ahead of print. PMID: 34153340; PMCID: PMC8213519.
Link to Article
Link to FULL FREE PDF

2021 Surviving Sepsis Campaign Guidelines

Evans L, Rhodes A, Alhazzani W, Antonelli M, Coopersmith CM, French C, Machado FR, Mcintyre L, Ostermann M, Prescott HC, Schorr C, Simpson S, Wiersinga WJ, Alshamsi F, Angus DC, Arabi Y, Azevedo L, Beale R, Beilman G, Belley-Cote E, Burry L, Cecconi M, Centofanti J, Coz Yataco A, De Waele J, Dellinger RP, Doi K, Du B, Estenssoro E, Ferrer R, Gomersall C, Hodgson C, Møller MH, Iwashyna T, Jacob S, Kleinpell R, Klompas M, Koh Y, Kumar A, Kwizera A, Lobo S, Masur H, McGloughlin S, Mehta S, Mehta Y, Mer M, Nunnally M, Oczkowski S, Osborn T, Papathanassoglou E, Perner A, Puskarich M, Roberts J, Schweickert W, Seckel M, Sevransky J, Sprung CL, Welte T, Zimmerman J, Levy M. Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021. Intensive Care Med. 2021 Nov;47(11):1181-1247. doi: 10.1007/s00134-021-06506-y. Epub 2021 Oct 2. PMID: 34599691; PMCID: PMC8486643.
Link to Article
Link to FULL FREE PDF

When should we trach COVID patients?

Williams T, McGrath BA. Tracheostomy for COVID-19: evolving best practice. Crit Care. 2021 Aug 31;25(1):316. doi: 10.1186/s13054-021-03674-7. PMID: 34461964; PMCID: PMC8405347.
Link to Article
Link to FULL FREE PDF

Severe Encephalopathy in ICU COVID-19 Patients

Helms J, Kremer S, Merdji H, Schenck M, Severac F, Clere-Jehl R, Studer A, Radosavljevic M, Kummerlen C, Monnier A, Boulay C, Fafi-Kremer S, Castelain V, Ohana M, Anheim M, Schneider F, Meziani F. Delirium and encephalopathy in severe COVID-19: a cohort analysis of ICU patients. Crit Care. 2020 Aug 8;24(1):491. doi: 10.1186/s13054-020-03200-1. PMID: 32771053; PMCID: PMC7414289.
Link to Article
Link to FULL FREE PDF

Ragheb J, McKinney A, Zierau M, Brooks J, Hill-Caruthers M, Iskander M, Ahmed Y, Lobo R, Mentz G, Vlisides PE. Delirium and neuropsychological outcomes in critically Ill patients with COVID-19: a cohort study. BMJ Open. 2021 Sep 17;11(9):e050045. doi: 10.1136/bmjopen-2021-050045. PMID: 34535480; PMCID: PMC8450964.
Link to Article
Link to FULL FREE PDF

Multisystem Inflammatory Syndrome in Adults

Patel P, DeCuir J, Abrams J, Campbell AP, Godfred-Cato S, Belay ED. Clinical Characteristics of Multisystem Inflammatory Syndrome in Adults: A Systematic Review. JAMA Netw Open. 2021 Sep 1;4(9):e2126456. doi: 10.1001/jamanetworkopen.2021.26456. PMID: 34550381.
Link to Article and FULL FREE PDF

Initial Antimicrobial Management of Sepsis

Niederman MS, Baron RM, Bouadma L, Calandra T, Daneman N, DeWaele J, Kollef MH, Lipman J, Nair GB. Initial antimicrobial management of sepsis. Crit Care. 2021 Aug 26;25(1):307. doi: 10.1186/s13054-021-03736-w. PMID: 34446092; PMCID: PMC8390082.
Link to Article
Link to FULL FREE PDF

Early mobilization is key to getting these folks better quicker!

Hodgson CL, Schaller SJ, Nydahl P, Timenetsky KT, Needham DM. Ten strategies to optimize early mobilization and rehabilitation in intensive care. Crit Care. 2021 Sep 3;25(1):324. doi: 10.1186/s13054-021-03741-z. PMID: 34479621; PMCID: PMC8414658.
Link to Article
Link to FULL FREE PDF

APRV MAY help SOME COVID-19 Patients

Mahmoud O, Patadia D, Salonia J. Utilization of Airway Pressure Release Ventilation as a Rescue Strategy in COVID-19 Patients: A Retrospective Analysis. J Intensive Care Med. 2021 Oct;36(10):1194-1200. doi: 10.1177/08850666211030899. Epub 2021 Jul 7. PMID: 34231408; PMCID: PMC8266677.
Link to Article
Link to FULL FREE PDF

And if you don’t know how to set up your patients on APRV, here’s the article for you!
Swindin J, Sampson C, Howatson A. Airway pressure release ventilation. BJA Educ. 2020 Mar;20(3):80-88. doi: 10.1016/j.bjae.2019.12.001. Epub 2020 Jan 23. PMID: 33456934; PMCID: PMC7808079.
Link to Article
Link to FULL FREE PDF

Pathophysiology of ARDS and COVID-19 ARDS

Swenson KE, Swenson ER. Pathophysiology of Acute Respiratory Distress Syndrome and COVID-19 Lung Injury. Crit Care Clin. 2021 Oct;37(4):749-776. doi: 10.1016/j.ccc.2021.05.003. Epub 2021 May 28. PMID: 34548132; PMCID: PMC8162817.
Link to Article
Link to FULL FREE PDF

How much fluid should we give ARDS patients?

Fluid Therapy and Acute Respiratory Distress Syndrome. Jisoo Lee, MD Keith Corl, MD, ScM Mitchell M. Levy, MD, MCCM, FCCP
Link to Article
Link to FULL FREE PDF

Regeneron for Outpatient COVID

David M. Weinreich, Sumathi Sivapalasingam, Thomas Norton, Shazia Ali, Haitao Gao, Rafia Bhore, Jing Xiao, Andrea T. Hooper, Jennifer D. Hamilton, Bret J. Musser, DianaRofail, Mohamed Hussein, Joseph Im, Dominique Y. Atmodjo, Christina Perry, CynthiaPan, Adnan Mahmood, Romana Hosain, John D. Davis, Kenneth C. Turner, Alina Baum, Christos A. Kyratsous, Yunji Kim, Amanda Cook, Wendy Kampman, Lilia Roque-Guerrero, Gerard Acloque, Hessam Aazami, Kevin Cannon, J. Abraham Simón-Campos, Joseph A. Bocchini, Bari Kowal, Thomas DiCioccio, Yuhwen Soo, Neil Stahl, Leah Lipsich, Ned Braunstein, Gary Herman, George D. Yancopoulos, for the Trial Investigators medRxiv 2021.05.19.21257469; doi:https://doi.org/10.1101/2021.05.19.21257469
Link to Article
Link to FULL FREE PDF

The Gut and COVID-19

Reintam Blaser A, Gunst J, Arabi YM. The gut in COVID-19. Intensive Care Med. 2021 Sep;47(9):1024-1027. doi: 10.1007/s00134-021-06461-8. Epub 2021 Jul 8. PMID: 34240234; PMCID: PMC8265290.
Link to Article
Link to FULL FREE PDF

What Percentage of Hospitalized COVID-19 Patients End Up with a Pneumothorax

Geraci TC, Williams D, Chen S, Grossi E, Chang S, Cerfolio RJ, Bizekis C, Zervos M. Incidence, Management, and Outcomes of Patients with COVID-19 and Pneumothorax. Ann Thorac Surg. 2021 Sep 2:S0003-4975(21)01545-9. doi: 10.1016/j.athoracsur.2021.07.097. Epub ahead of print. PMID: 34481799; PMCID: PMC8413091.
Link to Article
Link to FULL FREE PDF

What are the chances COVID patients have bacterial co-infection on admission?

Musher DM. Bacterial Coinfection in COVID-19 and Influenza Pneumonia. Am J Respir Crit Care Med. 2021 Sep 1;204(5):498-500. doi: 10.1164/rccm.202106-1467ED. PMID: 34233146.
Link to Article
Link to FULL FREE PDF

The Task Force for this Pandemic has made recommendations… now what do we do about it?

Dichter JR, Devereaux AV, Sprung CL, Mukherjee V, Persoff J, Baum KD, Ornoff D, Uppal A, Hossain T, Henry KN, Ghazipura M, Bowden KR, Feldman HJ, Hamele MT, Burry LD, Martland AMO, Huffines M, Tosh PK, Downar J, Hick JL, Christian MD, Maves RC, for the Task Force for Mass Critical Care Writing Group, Mass Critical Care Surge Response during COVID-19: Implementation of Contingency Strategies A Preliminary Report of findings from the Task Force for Mass Critical Care CHEST (2021), doi: https://doi.org/10.1016/j.chest.2021.08.072.
Link to Article
Link to FULL FREE PDF

We can sometimes do Plateau Pressures > 30? Say it ain’t so!

Diehl, JL., Talmor, D. When could airway plateau pressure above 30 cmH2O be acceptable in ARDS patients?. Intensive Care Med 47, 1028–1031 (2021). https://doi.org/10.1007/s00134-021-06472-5
Link to Article
Link to FULL FREE PDF

Delirium Systematic Review and Meta-Analysis

Burry, L.D., Cheng, W., Williamson, D.R. et al. Pharmacological and non-pharmacological interventions to prevent delirium in critically ill patients: a systematic review and network meta-analysis. Intensive Care Med 47, 943–960 (2021). https://doi.org/10.1007/s00134-021-06490-3
Link to Article
Link to FULL FREE PDF

Should we keep calling ARDS “ARDS”?

Gattinoni, L., Marini, J.J. Isn’t it time to abandon ARDS? The COVID-19 lesson. Crit Care25, 326 (2021). https://doi.org/10.1186/s13054-021-03748-6
Link to Article
Link to FULL FREE PDF

Metoprolol for COVID-19

Clemente-Moragón A, Martínez-Milla J, Oliver E, Santos A, Flandes J, Fernández I, Rodríguez-González L, Serrano Del Castillo C, Ioan AM, López-Álvarez M, Gómez-Talavera S, Galán-Arriola C, Fuster V, Pérez-Calvo C, Ibáñez B. Metoprolol in Critically Ill Patients With COVID-19. J Am Coll Cardiol. 2021 Sep 7;78(10):1001-1011. doi: 10.1016/j.jacc.2021.07.003. PMID: 34474731; PMCID: PMC8404624.
Link to Article
Link to FULL FREE PDF

Natural Immunity is Worth Something

Comparing SARS-CoV-2 natural immunity to vaccine-induced immunity: reinfections versus breakthrough infectionsSivan Gazit, Roei Shlezinger, Galit Perez, Roni Lotan, Asaf Peretz, Amir Ben-Tov, DaniCohen, Khitam Muhsen, Gabriel Chodick, Tal PatalonmedRxiv 2021.08.24.21262415; doi:https://doi.org/10.1101/2021.08.24.21262415
Link to Article
Link to FULL FREE PDF

Inhaled Budesonide for Outpatient COVID

Yu LM, Bafadhel M, Dorward J, Hayward G, Saville BR, Gbinigie O, Van Hecke O, Ogburn E, Evans PH, Thomas NPB, Patel MG, Richards D, Berry N, Detry MA, Saunders C, Fitzgerald M, Harris V, Shanyinde M, de Lusignan S, Andersson MI, Barnes PJ, Russell REK, Nicolau DV Jr, Ramakrishnan S, Hobbs FDR, Butler CC; PRINCIPLE Trial Collaborative Group. Inhaled budesonide for COVID-19 in people at high risk of complications in the community in the UK (PRINCIPLE): a randomised, controlled, open-label, adaptive platform trial. Lancet. 2021 Aug 10;398(10303):843–55. doi: 10.1016/S0140-6736(21)01744-X. Epub ahead of print. Erratum in: Lancet. 2021 Aug 18;: PMID: 34388395; PMCID: PMC8354567.
Link to Article
Link to FULL FREE PDF

Delta is worse than the other variants

Twohig KA, Nyberg T, Zaidi A, Thelwall S, Sinnathamby MA, Aliabadi S, Seaman SR, Harris RJ, Hope R, Lopez-Bernal J, Gallagher E, Charlett A, De Angelis D, Presanis AM, Dabrera G; COVID-19 Genomics UK (COG-UK) consortium. Hospital admission and emergency care attendance risk for SARS-CoV-2 delta (B.1.617.2) compared with alpha (B.1.1.7) variants of concern: a cohort study. Lancet Infect Dis. 2021 Aug 27:S1473-3099(21)00475-8. doi: 10.1016/S1473-3099(21)00475-8. Epub ahead of print. PMID: 34461056; PMCID: PMC8397301.
Link to Article
Link to FULL FREE PDF
Instagram page of Dr. Michael Daignault

Convalescent Plasma DOES NOT WORK. Stop it already.

Devos T, Van Thillo Q, Compernolle V, Najdovski T, Romano M, Dauby N, Jadot L, Leys M, Maillart E, Loof S, Seyler L, Moonen M, Moutschen M, Van Regenmortel N, Ariën KK, Barbezange C, Betrains A, Garigliany M, Engelen MM, Gyselinck I, Maes P, Schauwvlieghe A, Liesenborghs L, Belmans A, Verhamme P, Meyfroidt G; DAWn-plasma investigators. Early high antibody-titre convalescent plasma for hospitalised COVID-19 patients: DAWn-plasma. Eur Respir J. 2021 Aug 26:2101724. doi: 10.1183/13993003.01724-2021. Epub ahead of print. PMID: 34446469.
Link to Article
Link to FULL FREE PDF

Japanese Sepsis Guidelines 2020

Egi, M., Ogura, H., Yatabe, T. et al. The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2020 (J-SSCG 2020). j intensive care 9, 53 (2021). https://doi.org/10.1186/s40560-021-00555-7
Link to Article
Link to FULL FREE PDF

Is your COVID-19 Patient a Lung Transplant Candidate?

King CS, Mannem H, Kukreja J, Aryal S, Tang D, Singer JP, Bharat A, Behr J, Nathan SD, How I Do It: Considering lung transplantation for patients with COVID-19, CHEST (2021), doi: https://doi.org/10.1016/j.chest.2021.08.041.
Link to Article
Link to FULL FREE PDF

We need to be proning every awake patient with COVID we can!

Awake prone positioning for COVID-19 acute hypoxaemic respiratory failure: a randomised, controlled, multinational, open-label meta-trial. Ehrmann, StephanLi, Jie et al.
Link to Article
Link to FULL FREE PDF

Epinephrine Intervals: Still 3-5 minutes?

Shaffner DH, Callaway CW. Epinephrine Administration Intervals, Seeing the Forest for the Trees. Am J Respir Crit Care Med. 2021 Aug 19. doi: 10.1164/rccm.202107-1667ED. Epub ahead of print. PMID: 34411505.
Link to Article
Link to FULL FREE PDF

Diabetes and bad COVID are BFF’s

Klein, S.J., Mayerhöfer, T., Fries, D. et al. Elevated HbA1c remains a predominant finding in severe COVID-19 and may be associated with increased mortality in patients requiring mechanical ventilation. Crit Care 25, 300 (2021). https://doi.org/10.1186/s13054-021-03730-2
Link to Article
Link to FULL FREE PDF

Should we start checking Renin Levels in the ICU?

Flannery, A.H., Ortiz-Soriano, V., Li, X. et al. Serum renin and major adverse kidney events in critically ill patients: a multicenter prospective study. Crit Care 25, 294 (2021). https://doi.org/10.1186/s13054-021-03725-z
Link to Article
Link to FULL FREE PDF

Ventilator Asynchrony

Kyo, M., Shimatani, T., Hosokawa, K. et al. Patient–ventilator asynchrony, impact on clinical outcomes and effectiveness of interventions: a systematic review and meta-analysis. j intensive care 9, 50 (2021). https://doi.org/10.1186/s40560-021-00565-5
Link to Article
Link to FULL FREE PDF

Should we be doing longer courses of Corticosteroids in COVID-19 ARDS?

Luo, M., Qian, Y., Huang, D., Luo, J., Su, Y., Wang, H., Yu, S., Liu, K., Tu, G., & Luo, Z. (2021). Tailoring glucocorticoids in patients with severe COVID-19: a narrative review. Annals Of Translational Medicine, 9(15), 1261. doi:10.21037/atm-21-1783
Link to Article
Link to FULL FREE PDF

Fenofibrate is so HOT right now!

Davies SP, Mycroft-West CJ, Pagani I, Hill HJ, Chen Y-H, Karlsson R, Bagdonaite I, Guimond SE, Stamataki Z, De Lima MA, Turnbull JE, Yang Z, Vicenzi E, Skidmore MA, Khanim FL and Richardson A (2021) The Hyperlipidaemic Drug Fenofibrate Significantly Reduces Infection by SARS-CoV-2 in Cell Culture Models. Front. Pharmacol. 12:660490. doi: 10.3389/fphar.2021.660490
Link to Article
Link to FULL FREE PDF

Adding PEEP to the PaO2 FiO2 ratio in ARDS

Palanidurai, S., Phua, J., Chan, Y.H. et al. P/FP ratio: incorporation of PEEP into the PaO2/FiO2 ratio for prognostication and classification of acute respiratory distress syndrome. Ann. Intensive Care 11, 124 (2021). https://doi.org/10.1186/s13613-021-00908-3
Link to Article
Link to FULL FREE PDF

How to manage families during this pandemic

Hart JL, Taylor SP. Family Presence for Critically Ill Patients During a Pandemic. Chest. 2021 May 8;160(2):549–57. doi: 10.1016/j.chest.2021.05.003. Epub ahead of print. PMID: 33971149; PMCID: PMC8105126.
Link to Article
Link to FULL FREE PDF

AKI and COVID in the ICU

Lumlertgul N, Pirondini L, Cooney E, Kok W, Gregson J, Camporota L, Lane K, Leach R, Ostermann M. Acute kidney injury prevalence, progression and long-term outcomes in critically ill patients with COVID-19: a cohort study. Ann Intensive Care. 2021 Aug 6;11(1):123. doi: 10.1186/s13613-021-00914-5. PMID: 34357478; PMCID: PMC8343342.
Link to Article
Link to FULL FREE PDF

How long to wait after cardiac arrest to prognosticate?

Tsai MS, Chen WJ, Chen WT, Tien YT, Chang WT, Ong HN, Huang CH. Should We Prolong the Observation Period for Neurological Recovery After Cardiac Arrest? Crit Care Med. 2021 Aug 4. doi: 10.1097/CCM.0000000000005264. Epub ahead of print. PMID: 34342303.
Link to Article AND FULL FREE PDF

Dex and Toci Screw Up CRP and PCT: Duh.

Kooistra, E.J., van Berkel, M., van Kempen, N.F. et al. Dexamethasone and tocilizumab treatment considerably reduces the value of C-reactive protein and procalcitonin to detect secondary bacterial infections in COVID-19 patients. CKooistra EJ, van Berkel M, van Kempen NF, van Latum CRM, Bruse N, Frenzel T, van den Berg MJW, Schouten JA, Kox M, Pickkers P. Dexamethasone and tocilizumab treatment considerably reduces the value of C-reactive protein and procalcitonin to detect secondary bacterial infections in COVID-19 patients. Crit Care. 2021 Aug 5;25(1):281. doi: 10.1186/s13054-021-03717-z. PMID: 34353339.
Link to Article
Link to FULL FREE PDF

Anti-coagulating COVID Patients: The Flip Flopping Continues

REMAP-CAP Investigators; ACTIV-4a Investigators; ATTACC Investigators, Goligher EC, Bradbury CA, McVerry BJ, Lawler PR, Berger JS, Gong MN, Carrier M, Reynolds HR, Kumar A, Turgeon AF, Kornblith LZ, Kahn SR, Marshall JC, Kim KS, Houston BL, Derde LPG, Cushman M, Tritschler T, Angus DC, Godoy LC, McQuilten Z, Kirwan BA, Farkouh ME, Brooks MM, Lewis RJ, Berry LR, Lorenzi E, Gordon AC, Berry SM, McArthur CJ, Neal MD, Hochman JS, Webb SA, Zarychanski R, Ahuja T, Al-Beidh F, Annane D, Arabi YM, Aryal D, Baumann Kreuziger L, Beane A, Bhimani Z, Bihari S, Billett HH, Bond L, Bonten M, Brunkhorst F, Buxton M, Buzgau A, Castellucci LA, Chekuri S, Chen JT, Cheng AC, Chkhikvadze T, Coiffard B, Contreras A, Costantini TW, de Brouwer S, Detry MA, Duggal A, Džavík V, Effron MB, Eng HF, Escobedo J, Estcourt LJ, Everett BM, Fergusson DA, Fitzgerald M, Fowler RA, Froess JD, Fu Z, Galanaud JP, Galen BT, Gandotra S, Girard TD, Goodman AL, Goossens H, Green C, Greenstein YY, Gross PL, Haniffa R, Hegde SM, Hendrickson CM, Higgins AM, Hindenburg AA, Hope AA, Horowitz JM, Horvat CM, Huang DT, Hudock K, Hunt BJ, Husain M, Hyzy RC, Jacobson JR, Jayakumar D, Keller NM, Khan A, Kim Y, Kindzelski A, King AJ, Knudson MM, Kornblith AE, Kutcher ME, Laffan MA, Lamontagne F, Le Gal G, Leeper CM, Leifer ES, Lim G, Gallego Lima F, Linstrum K, Litton E, Lopez-Sendon J, Lother SA, Marten N, Saud Marinez A, Martinez M, Mateos Garcia E, Mavromichalis S, McAuley DF, McDonald EG, McGlothlin A, McGuinness SP, Middeldorp S, Montgomery SK, Mouncey PR, Murthy S, Nair GB, Nair R, Nichol AD, Nicolau JC, Nunez-Garcia B, Park JJ, Park PK, Parke RL, Parker JC, Parnia S, Paul JD, Pompilio M, Quigley JG, Rosenson RS, Rost NS, Rowan K, Santos FO, Santos M, Santos MO, Satterwhite L, Saunders CT, Schreiber J, Schutgens REG, Seymour CW, Siegal DM, Silva DG Jr, Singhal AB, Slutsky AS, Solvason D, Stanworth SJ, Turner AM, van Bentum-Puijk W, van de Veerdonk FL, van Diepen S, Vazquez-Grande G, Wahid L, Wareham V, Widmer RJ, Wilson JG, Yuriditsky E, Zhong Y. Therapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19. N Engl J Med. 2021 Aug 4. doi: 10.1056/NEJMoa2103417. Epub ahead of print. PMID: 34351722.
Link to Article
Link to FULL FREE PDF

Should we discontinue ACE Inhibitors and ARBs in our Hospitalized COVID patients?

Bauer A, Schreinlechner M, Sappler N, Dolejsi T, Tilg H, Aulinger BA, Weiss G, Bellmann-Weiler R, Adolf C, Wolf D, Pirklbauer M, Graziadei I, Gänzer H, von Bary C, May AE, Wöll E, von Scheidt W, Rassaf T, Duerschmied D, Brenner C, Kääb S, Metzler B, Joannidis M, Kain HU, Kaiser N, Schwinger R, Witzenbichler B, Alber H, Straube F, Hartmann N, Achenbach S, von Bergwelt-Baildon M, von Stülpnagel L, Schoenherr S, Forer L, Embacher-Aichhorn S, Mansmann U, Rizas KD, Massberg S; ACEI-COVID investigators. Discontinuation versus continuation of renin-angiotensin-system inhibitors in COVID-19 (ACEI-COVID): a prospective, parallel group, randomised, controlled, open-label trial. Lancet Respir Med. 2021 Jun 11;9(8):863–72. doi: 10.1016/S2213-2600(21)00214-9. Epub ahead of print. PMID: 34126053; PMCID: PMC8195495.
Link to Article
Link to FULL FREE PDF

COVID-19 and Heart Failure

Yonas E, Alwi I, Pranata R, Huang I, Lim MA, Gutierrez EJ, Yamin M, Siswanto BB, Virani SS. Effect of heart failure on the outcome of COVID-19 – A meta analysis and systematic review. Am J Emerg Med. 2020 Jul 9;46:204–11. doi: 10.1016/j.ajem.2020.07.009. Epub ahead of print. PMID: 33071085; PMCID: PMC7347316.
Link to Article
Link to FULL FREE PDF

Mechanical Ventilation and COVID-19

Kallet RH. 2020 Year in Review: Mechanical Ventilation During the First Year of the COVID-19 Pandemic. Respir Care. 2021 Aug;66(8):1341-1362. doi: 10.4187/respcare.09257. Epub 2021 May 10. PMID: 33972456.
Link to Article
Link to FULL FREE PDF

AKI Pathophys and Management

Pickkers, P., Darmon, M., Hoste, E. et al. Acute kidney injury in the critically ill: an updated review on pPickkers P, Darmon M, Hoste E, Joannidis M, Legrand M, Ostermann M, Prowle JR, Schneider A, Schetz M. Acute kidney injury in the critically ill: an updated review on pathophysiology and management. Intensive Care Med. 2021 Aug;47(8):835-850. doi: 10.1007/s00134-021-06454-7. Epub 2021 Jul 2. PMID: 34213593; PMCID: PMC8249842.
Link to Article
Link to FULL FREE PDF

ECMO and Ethics

SchouSchou A, Mølgaard J, Andersen LW, Holm S, Sørensen M. Ethics in extracorporeal life support: a narrative review. Crit Care. 2021 Jul 21;25(1):256. doi: 10.1186/s13054-021-03689-0. PMID: 34289885; PMCID: PMC8293515.
Link to Article
Link to FULL FREE PDF

What’s ARDS in COVID-19?

Brown SM, Peltan ID, Barkauskas C, Rogers AJ, Kan V, Gelijns A, Thompson BT. What Does “ARDS” Mean during the COVID-19 Pandemic? Ann Am Thorac Soc. 2021 Jul 21. doi: 10.1513/AnnalsATS.202105-534PS. Epub ahead of print. PMID: 34288834.
Link to Article
Link to FULL FREE PDF

Preoxygenation in the Obese: High-Flow Oxygen or Non-Invasive Ventilation?

Rodriguez, M., Ragot, S., Coudroy, R. et al. Noninvasive ventilation vs. high-flow nasal cannula oxygen for preoxygenation before intubation in patients with obesity: a post hoc analysis of a randomized controlled trial. Ann. Intensive Care 11, 114 (2021). https://doi.org/10.1186/s13613-021-00892-8
Link to Article
Link to FULL FREE PDF

Treating New-Onset A.Fib in the ICU

Drikite, L., Bedford, J.P., O’Bryan, L. et al. Treatment strategies for new onset atrial fibrillation in patients treated on an intensive care unit: a systematic scoping review. Crit Care 25, 257 (2021). https://doi.org/10.1186/s13054-021-03684-5
Link to Article
Link to FULL FREE PDF

Shots fired! Do some seem to want to regulate MedTwitter?

Munoz-Acuna, R., Leibowitz, A., Hayes, M. et al. Analysis of top influencers in critical care medicine “twitterverse” in the COVID-19 era: a descriptive study. Crit Care 25, 254 (2021). https://doi.org/10.1186/s13054-021-03691-6
Link to Article
Link to FULL FREE PDF

We are getting better at in-hospital cardiac arrest care

Marc Schluep M, Sanne Hoeks SE, Michiel Blans MJ, Bas van den Bogaard B, Ankie Koopman-van Gemert AWMM, Cees Kuijs C, Chris Hukshorn CJ, Nardo van der Meer BJM, Marco Knook AHM, Trudy van Melsen T, René Peters R, Patrick Perik PJ, Koen Simons KS, Gerben Spijkers G, Wytze Vermeijden JW, Evert-Jan Wils EJ, Robert Jan Stolker RJ, Rik Endeman H. Long-term survival and health-related quality of life after in-hospital cardiac arrest. Resuscitation. 2021 Jul 13:S0300-9572(21)00255-0. doi: 10.1016/j.resuscitation.2021.07.006. Epub ahead of print. PMID: 34271127.
Link to Article
Link to FULL FREE PDF

Cirrhosis Guidelines

Yoshiji H, Nagoshi S, Akahane T, Asaoka Y, Ueno Y, Ogawa K, Kawaguchi T, Kurosaki M, Sakaida I, Shimizu M, Taniai M, Terai S, Nishikawa H, Hiasa Y, Hidaka H, Miwa H, Chayama K, Enomoto N, Shimosegawa T, Takehara T, Koike K. Evidence-based clinical practice guidelines for Liver Cirrhosis 2020. J Gastroenterol. 2021 Jul 7. doi: 10.1007/s00535-021-01788-x. Epub ahead of print. PMID: 34231046.
Link to Article
Link to FULL FREE PDF

We’re going to come out of this a little more F’ed up than when we started.

Wozniak, H., Benzakour, L., Moullec, G. et al. Mental health outcomes of ICU and non-ICU healthcare workers during the COVID-19 outbreak: a cross-sectional study. Ann. Intensive Care 11, 106 (2021). https://doi.org/10.1186/s13613-021-00900-x
Link to Article
Link to FULL FREE PDF

We Still Have A LOT to Learn About Sepsis

Nunnally ME, Ferrer R, Martin GS, Martin-Loeches I, Machado FR, De Backer D, Coopersmith CM, Deutschman CS; Surviving Sepsis Campaign Reasearch Committee. The Surviving Sepsis Campaign: research priorities for the administration, epidemiology, scoring and identification of sepsis. Intensive Care Med Exp. 2021 Jul 2;9(1):34. doi: 10.1186/s40635-021-00400-z. PMID: 34212256; PMCID: PMC8249046.
Link to Article
Link to FULL FREE PDF

Is the Mitochondria the Key in Sepsis?

Preau S, Vodovar D, Jung B, Lancel S, Zafrani L, Flatres A, Oualha M, Voiriot G, Jouan Y, Joffre J, Huel F, De Prost N, Silva S, Azabou E, Radermacher P. Energetic dysfunction in sepsis: a narrative review. Ann Intensive Care. 2021 Jul 3;11(1):104. doi: 10.1186/s13613-021-00893-7. PMID: 34216304.
Link to Article
Link to FULL FREE PDF

Time to Abandon 6cc/kg/IBW in ARDS?

Tobin MJ. The Dethroning of 6 ml per kg as the “go-to” Setting in ARDS. Am J Respir Crit Care Med. 2021 Jun 29. doi: 10.1164/rccm.202105-1320LE. Epub ahead of print. PMID: 34186011.
Link to Article
Link to FULL FREE PDF

Goligher EC, Costa ELV; authors of “Effect of Lowering Vt on Mortality in Acute Respiratory Distress Syndrome Varies with Respiratory System Elastance”. Reply to: The Dethroning of 6 ml per kg as the “go-to” Setting in ARDS. Am J Respir Crit Care Med. 2021 Jun 29. doi: 10.1164/rccm.202106-1388LE. Epub ahead of print. PMID: 34186007.
Link to Article
Link to FULL FREE PDF

Ultrasound to Place Post-Pyloric Tubes?

Qian, A., Xu, S., Lu, X. et al. Rapid positioning of nasogastric tube by ultrasound in COVID-19 patients. Crit Care 24, 568 (2020). https://doi.org/10.1186/s13054-020-03285-8
Link to Article
Link to FULL FREE PDF

Ye, R., Cheng, X., Chai, H. et al. A systemic ultrasound positioning protocol for nasointestinal tube in critically ill patients. Crit Care 25, 213 (2021). https://doi.org/10.1186/s13054-021-03641-2
Link to Article
Link to FULL FREE PDF

IV Fluids in Abdominal Surgery

Messina A, Robba C, Calabrò L, Zambelli D, Iannuzzi F, Molinari E, Scarano S, Battaglini D, Baggiani M, De Mattei G, Saderi L, Sotgiu G, Pelosi P, Cecconi M. Perioperative liberal versus restrictive fluid strategies and postoperative outcomes: a systematic review and metanalysis on randomised-controlled trials in major abdominal elective surgery. Crit Care. 2021 Jun 11;25(1):205. doi: 10.1186/s13054-021-03629-y. PMID: 34116707; PMCID: PMC8194047.
Link to Article
Link to FULL FREE PDF

Dicey COVID Intubations

Nauka PC, Chen JT, Shiloh AL, Eisen LA, Fein DG. Practice, Outcomes and Complications of Emergent Endotracheal Intubation By Critical Care Practitioners During the COVID-19 Pandemic. Chest. 2021 Jun 14:S0012-3692(21)01113-2. doi: 10.1016/j.chest.2021.06.008. Epub ahead of print. PMID: 34139207.
Link to Article
Link to FULL FREE PDF

ECMO for COVID-19 Patients

Ramanathan K, Shekar K, Ling RR, Barbaro RP, Wong SN, Tan CS, Rochwerg B, Fernando SM, Takeda S, MacLaren G, Fan E, Brodie D. Extracorporeal membrane oxygenation for COVID-19: a systematic review and meta-analysis. Crit Care. 2021 Jun 14;25(1):211. doi: 10.1186/s13054-021-03634-1. PMID: 34127027.
Link to Article
Link to FULL FREE PDF

Are restrictive fluids the future?

Vaara, S.T., Ostermann, M., Bitker, L. et al. Restrictive fluid management versus usual care in acute kidney injury (REVERSE-AKI): a pilot randomized controlled feasibility trial.Intensive Care Med 47, 665–673 (2021). https://doi.org/10.1007/s00134-021-06401-6
Link to Article
Link to FULL FREE PDF

Family visits in the ICU during a Pandemic

Mistraletti, G., Giannini, A., Gristina, G. et al. Why and how to open intensive care units to family visits during the pandemic. Crit Care 25, 191 (2021). https://doi.org/10.1186/s13054-021-03608-3
Link to Article
Link to FULL FREE PDF

What PaO2 Should We Aim For on Mechanical Ventilation Patients?

Demiselle, J., Calzia, E., Hartmann, C. et al. Target arterial PO2 according to the underlying pathology: a mini-review of the available data in mechanically ventilated patients. Ann. Intensive Care 11, 88 (2021). https://doi.org/10.1186/s13613-021-00872-y
Link to Article
Link to FULL FREE PDF

High Flow Nasal Cannula Mechanisms

Masclans JR, Pérez-Terán P, Roca O. The role of high flow oxygen therapy in acute respiratory failure. Med Intensiva. 2015 Nov;39(8):505-15. English, Spanish. doi: 10.1016/j.medin.2015.05.009. Epub 2015 Oct 1. PMID: 26429697.
Link to Article
Link to FULL FREE PDF

Ventilator Management and Rescue Therapies for ARDS

Coleman MH, Aldrich JM, Acute Respiratory Distress Syndrome: Ventilator Management and Rescue Therapies, CRITICAL CARE CLINICS (2021), doi: https://doi.org/10.1016/ j.ccc.2021.05.008.
Link to Article
Link to FULL FREE PDF

Pathophysiology of ARDS and COVID-19 Lung Injury

Swenson KE, Swenson ER, Pathophysiology of ARDS and COVID-19 Lung Injury, CRITICAL CARE CLINICS (2021), doi: https://doi.org/10.1016/j.ccc.2021.05.003.
Link to Article
Link to FULL FREE PDF

Convalescent Plasma (RECOVERY): DEAD.

RECOVERY Collaborative Group. Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial. The Lancet. 2021 May 14. https://doi.org/10.1016/ S0140-6736(21)00897-7
Link to Article
Link to FULL FREE PDF

Inhaled Budesonide for Outpatient COVID-19

Ramakrishnan S, Nicolau DV Jr, Langford B, Mahdi M, Jeffers H, Mwasuku C, Krassowska K, Fox R, Binnian I, Glover V, Bright S, Butler C, Cane JL, Halner A, Matthews PC, Donnelly LE, Simpson JL, Baker JR, Fadai NT, Peterson S, Bengtsson T, Barnes PJ, Russell REK, Bafadhel M. Inhaled budesonide in the treatment of early COVID-19 (STOIC): a phase 2, open-label, randomised controlled trial. Lancet Respir Med. 2021 Apr 9:S2213-2600(21)00160-0. doi: 10.1016/S2213-2600(21)00160-0. Epub ahead of print. Erratum in: Lancet Respir Med. 2021 Apr 14;: PMID: 33844996; PMCID: PMC8040526.
Link to Article
Link to FULL FREE PDF

Does Having Positive or Negative Cultures Change Outcomes In Sepsis?

Li Y, Guo J, Yang H, Li H, Shen Y, Zhang D. Comparison of culture-negative and culture-positive sepsis or septic shock: a systematic review and meta-analysis. Crit Care. 2021 May 8;25(1):167. doi: 10.1186/s13054-021-03592-8. PMID: 33964934.
Link to Article
Link to FULL FREE PDF

VV-ECMO in COVID-19

Asad Usman MDMPH , Jacob Gutsche MD , Essential Topics in the Management of Venovenous Extracorporeal Membrane Oxygenation in COVID-19 Acute Res- piratory Distress Syndrome, Journal of Cardiothoracic and Vascular Anesthesia (2021), doi: https://doi.org/10.1053/j.jvca.2021.04.044
Link to Article
Link to FULL FREE PDF

4 Different Phenotypes in Critically Ill COVID Patients

Vasquez CR, Gupta S, Miano TA, Roche M, Hsu J, Yang W, Holena DN, Reilly JP, Schrauben SJ, Leaf DE, Shashaty MGS, for the STOP-COVID Investigators, Identification of distinct clinical subphenotypes in critically ill patients with COVID-19, CHEST (2021), doi: https:// doi.org/10.1016/j.chest.2021.04.062.
Link to Article
Link to FULL FREE PDF

Airway Management

Natt B, Mosier J. Airway Management in the Critically Ill Patient. Curr Anesthesiol Rep. 2021 Apr 19:1-12. doi: 10.1007/s40140-021-00448-3. Epub ahead of print. PMID: 33897302; PMCID: PMC8053895.
Link to Article
Link to FULL FREE PDF

Acute Kidney Injury in the Critically Ill

Jamme M, Legrand M, Geri G. Outcome of acute kidney injury: how to make a difference? Ann Intensive Care. 2021 Apr 15;11(1):60. doi: 10.1186/s13613-021-00849-x. PMID: 33856581; PMCID: PMC8050180.
Link to Article
Link to FULL FREE PDF

Our patients may recover physically, but they unfortunately come out with depression, chronic pain, and PTSD.

Boede, M., Gensichen, J.S., Jackson, J.C. et al. Trajectories of depression in sepsis survivors: an observational cohort study. Crit Care 25, 161 (2021). https://doi.org/10.1186/s13054-021-03577-7
Link to Article
Link to FULL FREE PDF

How Long Will the SARS-CoV-2 RT-PCR be Detectable in our Intubated Patients?

A.G.C. Boef, E.M. van Wezel, L. Gard, et al., Viral load dynamics in intubated patients with COVID-19 admitted to the intensive care unit, Journal of Critical Care (2021), https://doi.org/10.1016/j.jcrc.2021.04.010
Link to Article
Link to FULL FREE PDF

Are the Epidemiology People Mad At You Because of all the VAPs? Here’s why.

Wicky PH, Niedermann MS, Timsit JF. Ventilator-associated pneumonia in the era of COVID-19 pandemic: How common and what is the impact? Crit Care. 2021 Apr 21;25(1):153. doi: 10.1186/s13054-021-03571-z. PMID: 33882991; PMCID: PMC8059113.
Link to Article
Link to FULL FREE PDF

Post-Arrest ICU Care

AS SEEN FIRST ON @critical_care_updates
Nolan JP, Sandroni C, Böttiger BW, Cariou A, Cronberg T, Friberg H, Genbrugge C, Haywood K, Lilja G, Moulaert VRM, Nikolaou N, Mariero Olasveengen T, Skrifvars MB, Taccone F, Soar J. European Resuscitation Council and European Society of Intensive Care Medicine Guidelines 2021: Post-resuscitation care. Resuscitation. 2021 Apr;161:220-269. doi: 10.1016/j.resuscitation.2021.02.012. Epub 2021 Mar 24. PMID: 33773827.
Link to Article
Link to FULL FREE PDF

Corticosteroids for COVID-19

Djillali Annane, Corticosteroids for COVID-19, Journal of Intensive Medicine, 2021, ISSN 2667-100X, https://doi.org/10.1016/j.jointm.2021.01.002
Link to Article
Link FULL FREE PDF

Anaphylaxis

Krishnaswamy G. Critical Care Management of the Patient With Anaphylaxis: A Concise Definitive Review. Crit Care Med. 2021 Mar 3. doi: 10.1097/CCM.0000000000004893. Epub ahead of print. PMID: 33653974.
Link to NOT FREE ARTICLE

Sedation and COVID-19

Pun BT, Badenes R, Heras La Calle G, Orun OM, Chen W, Raman R, Simpson BK, Wilson-Linville S, Hinojal Olmedillo B, Vallejo de la Cueva A, van der Jagt M, Navarro Casado R, Leal Sanz P, Orhun G, Ferrer Gómez C, Núñez Vázquez K, Piñeiro Otero P, Taccone FS, Gallego Curto E, Caricato A, Woien H, Lacave G, O’Neal HR Jr, Peterson SJ, Brummel NE, Girard TD, Ely EW, Pandharipande PP; COVID-19 Intensive Care International Study Group. Prevalence and risk factors for delirium in critically ill patients with COVID-19 (COVID-D): a multicentre cohort study. Lancet Respir Med. 2021 Jan 8;9(3):239–50. doi: 10.1016/S2213-2600(20)30552-X. Epub ahead of print. Erratum in: Lancet Respir Med. 2021 Jan 27;: PMID: 33428871; PMCID: PMC7832119.
Link to Article
Link to FULL FREE PDF

Page V. Sedation in mechanically ventilated patients with COVID-19. Lancet Respir Med. 2021 Jan 8;9(3):218–9. doi: 10.1016/S2213-2600(20)30570-1. Epub ahead of print. PMID: 33428873; PMCID: PMC7832546.
Link to Article
Link to FULL FREE PDF

Time to Stop Using Convalescent Plasma

Janiaud P, Axfors C, Schmitt AM, et al. Association of Convalescent Plasma Treatment With Clinical Outcomes in Patients With COVID-19: A Systematic Review and Meta-analysis. JAMA. Published online February 26, 2021. doi:10.1001/jama.2021.2747
Link to Article and FULL FREE PDF

My other blog posts on Convalescent Plasma
Convalescent Plasma in COVID-19 Severe Pneumonia: PlasmAr (11/24/20)
Convalescent Plasma for COVID-19: First Update in JAMA (3/28/20)

Phenotypes and Subphenotypes of COVID

Wang X, Jehi L, Ji X, Mazzone PJ, Phenotypes and Subphenotypes of Patients with COVID-19: a Latent Class Modeling Analysis, CHEST (2021), doi: https://doi.org/10.1016/ j.chest.2021.01.057.
Link to Article
Link to FULL FREE PDF

The Future of Critical Care

Arabi YM, Azoulay E, Al-Dorzi HM, Phua J, Salluh J, Binnie A, Hodgson C, Angus DC, Cecconi M, Du B, Fowler R, Gomersall CD, Horby P, Juffermans NP, Kesecioglu J, Kleinpell RM, Machado FR, Martin GS, Meyfroidt G, Rhodes A, Rowan K, Timsit JF, Vincent JL, Citerio G. How the COVID-19 pandemic will change the future of critical care. Intensive Care Med. 2021 Feb 22:1–10. doi: 10.1007/s00134-021-06352-y. Epub ahead of print. PMID: 33616696; PMCID: PMC7898492.
Link to Article
Link to FULL FREE PDF

Incidence of PE’s in the COVID ICU Population

Ng, J.J., Liang, Z.C. & Choong, A.M.T.L. The incidence of pulmonary thromboembolism in COVID-19 patients admitted to the intensive care unit: a meta-analysis and meta-regression of observational studies. j intensive care 9, 20 (2021). https://doi.org/10.1186/s40560-021-00535-x
Link to Article
Link to FULL FREE PDF

Biomarkers for Cognitive Impairment after Cardiac Arrest?

Brønnick K, Evald L, Valdemar Duez CH, Grejs AM, Jeppesen AN, Kirkegaard H, Nielsen JF, Søreide E, Biomarker prognostication of cognitive impairment may be feasible even in out-of hospital cardical arrest survivors with good neurological outcome, Resuscitation (2021), doi: https://doi.org/10.1016/j.resuscitation.2021.02.025
Link to Article
Link to FULL FREE PDF

COVID-19: A year into this. What we’ve learned

Hajjar, L.A., Costa, I.B.S., Rizk, S.I. et al. Intensive care management of patients with COVID-19: a practical approach. Ann. Intensive Care 11, 36 (2021). https://doi.org/10.1186/s13613-021-00820-w
Link to Article
Link to FULL FREE PDF

Patients do better when the ICU is not close to or at capacity. No shit.

Bravata DM, Perkins AJ, Myers LJ, et al. Association of Intensive Care Unit Patient Load and Demand With Mortality Rates in US Department of Veterans Affairs Hospitals During the COVID-19 Pandemic. JAMA Netw Open. 2021;4(1):e2034266. doi:10.1001/jamanetworkopen.2020.34266
Link to Article and FULL FREE PDF

Asymptomatic COVID Infections: More or less what proportion?

Daniel P. Oran, Eric J. Topol. The Proportion of SARS-CoV-2 Infections That Are Asymptomatic: A Systematic Review. Ann Intern Med. [Epub ahead of print 22 January 2021]. doi:10.7326/M20-6976
Link to Article

6 Month Survival of COVID patients who are placed on ECMO

Fausto Biancari MD, PhD , Giovanni Mariscalco MD, PhD , Enrico Leo MD , Antonio Loforte MD, PhD , Sidney Chocron MD ,Magnus Dale ́n MD, PhD , Nicla Settembre MD, PhD , Henryk Welp MD , Andrea Perrotti MD, PhD , Karsten Wiebe MD , Davide Pacini MD, PhD , Dario Di Perna MD , Juan P. Maureira MD , Svante Zipfel MD, PhD , L. Mikael Broman MD, PhD , Nicolas Mongardon MD , Vito G. Ruggieri MD, PhD , Chris Harvey MD , Lars Falk MD, PhD ,Hakeem Yusuff MD , Bruno Levy MD ,Antonio Fiore MD , Thierry Folliguet MD ,Six-month Survival after Ex- tracorporeal Membrane Oxygenation for Severe COVID-19, Journal of Cardiothoracic and Vascular Anesthesia (2021), doi: https://doi.org/10.1053/j.jvca.2021.01.027
Link to Article
Link to FULL FREE PDF

Convalescent Plasma Based on Titers in COVID-19

Joyner MJ, Carter RE, Senefeld JW, et al. Convalescent plasma antibody levels and the risk of death from Covid-19. N Engl J Med. DOI: 10.1056/NEJMoa2031893.
Link to Article
Link to FULL FREE PDF

Reviewing the Coagulopathy of COVID

Robba C, Battaglini D, Ball L, Valbusa A, Porto I, Della Bona R, La Malfa G, Patroniti N, Brunetti I, Loconte M, Bassetti M, Giacobbe DR, Vena A, Silva CLM, Rocco PRM, Pelosi P. Coagulative Disorders in Critically Ill COVID-19 Patients with Acute Distress Respiratory Syndrome: A Critical Review. Journal of Clinical Medicine. 2021; 10(1):140.
Link to Article
Link to FULL FREE PDF

Procalcitonin to reduce infection-associated adverse events

Kyriazopoulou E, Liaskou-Antoniou L, Adamis G, Panagaki A, Melachroinopoulos N, Drakou E, Marousis K, Chrysos G, Spyrou A, Alexiou N, Symbardi S, Alexiou Z, Lagou S, Kolonia V, Gkavogianni T, Kyprianou M, Anagnostopoulos I, Poulakou G, Lada M, Makkina A, Roulia E, Koupetori M, Apostolopoulos V, Petrou D, Nitsotolis T, Antoniadou A, Giamarellos-Bourboulis EJ. Procalcitonin to Reduce Long-Term Infection-associated Adverse Events in Sepsis: A Randomized Trial. Am J Respir Crit Care Med. 2020 Aug 6. doi: 10.1164/rccm.202004-1201OC. Epub ahead of print. PMID: 32757963.
Link to Article
Link to FULL FREE PDF

Higher Inflammatory Markers = Worse Prognosis. Go Figure.

Lavillegrand, JR., Garnier, M., Spaeth, A. et al. Elevated plasma IL-6 and CRP levels are associated with adverse clinical outcomes and death in critically ill SARS-CoV-2 patients: inflammatory response of SARS-CoV-2 patients. Ann. Intensive Care 11, 9 (2021). https://doi.org/10.1186/s13613-020-00798-x
Link to Article
Link to FULL FREE PDF

High-Dose Vitamin C in COVID (PILOT TRIAL)

Zhang, J., Rao, X., Li, Y. et al. Pilot trial of high-dose vitamin C in critically ill COVID-19 patients. Ann. Intensive Care 11, 5 (2021). https://doi.org/10.1186/s13613-020-00792-3
Link to Article
Link to FULL FREE PDF

Fluid Challenges by Louis Vincent

Vincent JL, Cecconi M, De Backer D. The fluid challenge. Crit Care. 2020 Dec 28;24(1):703. doi: 10.1186/s13054-020-03443-y. PMID: 33371895; PMCID: PMC7771055.
Link to Article
Link to FULL FREE PDF

Inotropes in Septic Shock

Sato R, Ariyoshi N, Hasegawa D, et al. Effects of Inotropes on the Mortality in Patients With Septic Shock. Journal of Intensive Care Medicine. 2021;36(2):211-219. doi:10.1177/0885066619892218
Link to Article
Link to FULL FREE PDF

Taking care of ICU patients with Cirrhosis and Acute on Chronic Liver Failure

Passi NN, McPhail MJ. The patient with cirrhosis in the intensive care unit and the management of acute-on-chronic liver failure. Journal of the Intensive Care Society. December 2021. doi:10.1177/1751143720978849
Link to Article
Link to FULL FREE PDF

POCUS During COVID

Hussain, A., Via, G., Melniker, L. et al. Multi-organ point-of-care ultrasound for COVID-19 (PoCUS4COVID): international expert consensus. Crit Care 24, 702 (2020). https://doi.org/10.1186/s13054-020-03369-5
Link to Article
Link to FULL FREE PDF

MATH+

Kory P, Meduri GU, Iglesias J, Varon J, Marik PE. Clinical and Scientific Rationale for the “MATH+” Hospital Treatment Protocol for COVID-19. J Intensive Care Med. 2020 Dec 15:885066620973585. doi: 10.1177/0885066620973585. Epub ahead of print. PMID: 33317385.
Link to Article
Link to FULL FREE PDF

Post-Resuscitation Shock

Jozwiak, M., Bougouin, W., Geri, G. et al. Post-resuscitation shock: recent advances in pathophysiology and treatment. Ann. Intensive Care 10, 170 (2020). https://doi.org/10.1186/s13613-020-00788-z
Link to Article
Link to FULL FREE PDF

Targeted temperature management for postcardiac arrest syndrome

Link to Article
Link to FULL FREE PDF

Managing Hypercapnia in Patients Who Are on the Vent

Tiruvoipati R, Gupta S, Pilcher D, Bailey M. Management of hypercapnia in critically ill mechanically ventilated patients—A narrative review of literature. Journal of the Intensive Care Society. 2020;21(4):327-333. doi:10.1177/1751143720915666
Link to Article
Link to FULL FREE PDF

CPR in Proned Patients: Can it be done?

Douma MJ, MacKenzie E, Loch T, Tan MC, Anderson D, Picard C, Milovanovic L, O’Dochartaigh D, Brindley PG. Prone cardiopulmonary resuscitation: A scoping and expanded grey literature review for the COVID-19 pandemic. Resuscitation. 2020 Oct;155:103-111. doi: 10.1016/j.resuscitation.2020.07.010. Epub 2020 Jul 21. PMID: 32707142; PMCID: PMC7373011.
Link to Article
Link to FULL FREE PDF

How to Manage ARDS: A Review of Reviews

Ervin JN, Rentes VC, Dibble ER, Sjoding MW, Iwashyna TJ, Hough CL, Ng Gong M, Sales AE. Evidence-Based Practices for Acute Respiratory Failure and Acute Respiratory Distress Syndrome: A Systematic Review of Reviews. Chest. 2020 Jul 16:S0012-3692(20)31906-1. doi: 10.1016/j.chest.2020.06.080. Epub ahead of print. PMID: 32682771.
Link to Article
Link to FULL FREE PDF

Netherlands Journal of Critical Care Goodies

POCUS series: Assessment of shock using the rapid ultrasound in shock (RUSH) protocol
Link to FULL FREE PDF

Ultrasound-guided placement of central venous catheters: a comprehensive guide for the clinician
Link to FULL FREE PDF

Code Blue in the COVID World

Stinehart KR, Attar TT, Evans K, Buehler J, Besecker BY, Spitzer CR. Code Team Restructuring During COVID-19: A Modified Pit-Crew Approach. Resuscitation. 2020 Nov 18:S0300-9572(20)30573-6. doi: 10.1016/j.resuscitation.2020.11.018. Epub ahead of print. PMID: 33220349.
Link to Article
Link to FULL FREE PDF

Interleukins and what they mean in COVID

Yonas E, Alwi I, Pranata R, Huang I, Lim MA, Yamin M, Nasution SA, SetiatiS, Virani SS, Elevated interleukin levels are associated with higher severity and mortality in COVID 19– A systematic review, meta-analysis, and meta-regression, Diabetes & Metabolic Syndrome: ClinicalResearch & Reviews (2020), doi: https://doi.org/10.1016/j.dsx.2020.11.011.
Link to Article
Link to FULL FREE PDF

Could a CBC w/diff tell us who’s going to do poorly with COVID?

Li, X., Liu, C., Mao, Z. et al. Predictive values of neutrophil-to-lymphocyte ratio on disease severity and mortality in COVID-19 patients: a systematic review and meta-analysis. Crit Care 24, 647 (2020). https://doi.org/10.1186/s13054-020-03374-8
Link to Article
Link to FULL FREE PDF

New findings regarding interferon beta-1a in COVID. FOAMed

Safety and efficacy of inhaled nebulised interferon beta-1a (SNG001) for treatment of SARS-CoV-2 infection: a randomised, double-blind, placebo-controlled, phase 2 trial. Monk, Phillip DCrooks, Michael G et al.
Link to Article
Link to FULL FREE PDF

Improving Sleep is of utmost importance for our ICU patients!

Andrews JL, Louzon PR, Torres X, et al. Impact of a Pharmacist-Led Intensive Care Unit Sleep Improvement Protocol on Sleep Duration and Quality. Annals of Pharmacotherapy. November 2020. doi:10.1177/1060028020973198. FOAMed
Link to Article
Link to FULL FREE PDF

Do we need to check for a cuff leak prior to extubation?

Kuriyama, A., Jackson, J.L. & Kamei, J. Performance of the cuff leak test in adults in predicting post-extubation airway complications: a systematic review and meta-analysis.Crit Care 24, 640 (2020). https://doi.org/10.1186/s13054-020-03358-8. FOAMed
Link to Article
Link to FULL FREE PDF

Using CPAP in COVID

Wozniak DR, Rubino A, Tan AL, et al. Positive role of continuous positive airway pressure for intensive care unit patients with severe hypoxaemic respiratory failure due to COVID-19 pneumonia: A single centre experience. Journal of the Intensive Care Society. November 2020. doi:10.1177/1751143720971543
Link to Article
Link to FULL FREE PDF

More data suggesting we should ditch using lactate and use capillary refill time instead. FOAMed

Castro, R., Kattan, E., Ferri, G. et al. Effects of capillary refill time-vs. lactate-targeted fluid resuscitation on regional, microcirculatory and hypoxia-related perfusion parameters in septic shock: a randomized controlled trial. Ann. Intensive Care 10, 150 (2020). https://doi.org/10.1186/s13613-020-00767-4. FOAMed
Link to Article
Link to FULL FREE PDF

Managing Adult COVID Patients in the ICU

Clinical guide for the management of critical care for adults with COVID-19 during the Coronavirus pandemic. 28 October 2020, version 4. FOAMed
Link to Article
Link to FULL FREE PDF

Paralytics in ARDS: Practice Guidelines. FOAMed

Alhazzani, W., Belley-Cote, E., Møller, M.H. et al. Neuromuscular blockade in patients with ARDS: a rapid practice guideline. Intensive Care Med 46, 1977–1986 (2020). https://doi.org/10.1007/s00134-020-06227-8. FOAMed
Link to Article
Link to FULL FREE PDF

Mind the Right Ventricle in Septic Shock!

Vieillard-Baron, A., Prigent, A., Repessé, X. et al. Right ventricular failure in septic shock: characterization, incidence and impact on fluid responsiveness. Crit Care 24, 630 (2020). https://doi.org/10.1186/s13054-020-03345-z
Link to Article
Link to FULL FREE PDF

Glucocorticoids and COVID: Steps in the Right Direction

Cano EJ, Fuentes XF, Campioli CC, O’Horo JC, Saleh OA, Odeyemi Y, Yadav H, Temesgen Z, “Impact of Corticosteroids in COVID-19 Outcomes: Systematic Review and Meta- Analysis”, CHEST (2020), doi: https://doi.org/10.1016/j.chest.2020.10.054.
Link to Article
Link to FULL FREE PDF

More Good News for our COVID Outcomes! Report out of England.

Dennis, John M. PhD; McGovern, Andrew P. MD (Res); Vollmer, Sebastian J. PhD; Mateen, Bilal A. MBBS. Improving Survival of Critical Care Patients With Coronavirus Disease 2019 in England, Critical Care Medicine: October 26, 2020 – Volume Online First – Issue – doi: 10.1097/CCM.0000000000004747
Link to Article and FULL FREE PDF

Continuous Renal Replacement Therapy Anticoagulation: Citrate vs. Heparin FOAMed

Zarbock A, Küllmar M, Kindgen-Milles D, et al. Effect of Regional Citrate Anticoagulation vs Systemic Heparin Anticoagulation During Continuous Kidney Replacement Therapy on Dialysis Filter Life Span and Mortality Among Critically Ill Patients With Acute Kidney Injury: A Randomized Clinical Trial. JAMA. Published online October 23, 2020. doi:10.1001/jama.2020.18618. FOAMed
Link to Article and FULL FREE PDF

Convalescent Plasma: Can we afford to have another therapy fail? FOAMed

Agarwal A, Mukherjee A, Kumar G, Chatterjee P, Bhatnagar T, Malhotra P; PLACID Trial Collaborators. Convalescent plasma in the management of moderate covid-19 in adults in India: open label phase II multicentre randomised controlled trial (PLACID Trial). BMJ. 2020 Oct 22;371:m3939. doi: 10.1136/bmj.m3939. PMID: 33093056.
Link to Article
Link to FULL FREE PDF

More data that we’re getting better at caring for COVID patients!

Zhang P, Duggal A, Sacha GL, Keller J, Griffiths L, Khouli H, System-wide strategies were associated with improved outcome in critically ill COVID-19 patients – experience from a large Healthcare Network, CHEST (2020), doi: https://doi.org/10.1016/j.chest.2020.10.029. FOAMed
Link to Article
Link to FULL FREE PDF

How long do people stay in the ICU with COVID? FOAMed

Lapidus, N., Zhou, X., Carrat, F. et al. Biased and unbiased estimation of the average length of stay in intensive care units in the Covid-19 pandemic. Ann. Intensive Care 10135 (2020). https://doi.org/10.1186/s13613-020-00749-6. FOAMed
Link to Article
Link to FULL FREE PDF

Cytokines, cytokines, cytokines! Oh my! FOAMed

Leisman, Daniel E et al. Cytokine elevation in severe and critical COVID-19: a rapid systematic review, meta-analysis, and comparison with other inflammatory syndromes. The Lancet Respiratory Medicine. FOAMed
Link to Article
Link to FULL FREE PDF

Humanizing ICU COVID Care

Marin-Corral J, Garcia-Sanz À, Masclans J, Humanizing ICU COVID care, CHEST (2020), doi: https://doi.org/10.1016/j.chest.2020.10.024.
Link to Article
Link to FULL FREE PDF

Remdesivir in COVID- ACTT-1 Trial

Beigel JH, Tomashek KM, Dodd LE, Mehta AK, Zingman BS, Kalil AC, Hohmann E, Chu HY, Luetkemeyer A, Kline S, Lopez de Castilla D, Finberg RW, Dierberg K, Tapson V, Hsieh L, Patterson TF, Paredes R, Sweeney DA, Short WR, Touloumi G, Lye DC, Ohmagari N, Oh MD, Ruiz-Palacios GM, Benfield T, Fätkenheuer G, Kortepeter MG, Atmar RL, Creech CB, Lundgren J, Babiker AG, Pett S, Neaton JD, Burgess TH, Bonnett T, Green M, Makowski M, Osinusi A, Nayak S, Lane HC; ACTT-1 Study Group Members. Remdesivir for the Treatment of Covid-19 – Final Report. N Engl J Med. 2020 Oct 8:NEJMoa2007764. doi: 10.1056/NEJMoa2007764. Epub ahead of print. PMID: 32445440; PMCID: PMC7262788.
Link to Article
Link to FULL FREE PDF

CRP & Procalcitonin in COVID-19

van Berkel, M., Kox, M., Frenzel, T. et al. Biomarkers for antimicrobial stewardship: a reappraisal in COVID-19 times?. Crit Care 24, 600 (2020). https://doi.org/10.1186/s13054-020-03291-w
Link to Article
Link to FULL FREE PDF

Tracheostomies and COVID-19: The Guidelines

Lamb CR, Desai NR, Angel L, Chaddha U, Sachdeva A, Sethi S, Bencheqroun H, Mehta H, Akulian J, Argento AC, Diaz-Mendoza J, Musani A, Murgu S. Use of Tracheostomy During the COVID-19 Pandemic: American College of Chest Physicians/American Association for Bronchology and Interventional Pulmonology/Association of Interventional Pulmonology Program Directors Expert Panel Report. Chest. 2020 Jun 6;158(4):1499–514. doi: 10.1016/j.chest.2020.05.571. Epub ahead of print. PMID: 32512006; PMCID: PMC7274948.
Link to Article
Link to FULL FREE PDF

Fluid Responsiveness In Sepsis and Shock

Douglas IS, Alapat PM, Corl KA, Exline MC, Forni LG, Holder AL, Kaufman DA, Khan A, Levy MM, Martin GS, Sahatjian JA, Seeley E, Self WH, Weingarten JA, Williams M, Hansell DM. Fluid Response Evaluation in Sepsis Hypotension and Shock: A Randomized Clinical Trial. Chest. 2020 Apr 27:S0012-3692(20)30768-6. doi: 10.1016/j.chest.2020.04.025. Epub ahead of print. PMID: 32353418.
Link to Article
Link to FULL FREE PDF

How to Anticoagulate Severe COVID patients? Full or Prophylactic?

Lemos ACB, do Espírito Santo DA, Salvetti MC, Gilio RN, Agra LB, Pazin-Filho A, Miranda CH. Therapeutic versus prophylactic anticoagulation for severe COVID-19: A randomized phase II clinical trial (HESACOVID). Thromb Res. 2020 Sep 21;196:359-366. doi: 10.1016/j.thromres.2020.09.026. Epub ahead of print. PMID: 32977137; PMCID: PMC7503069.
Link to Article
Link to FULL FREE PDF

Famotidine for COVID- NOT PEER REVIEWED.

Rahul Sethia*, MD1, Manya Prasad*, MD2, Soumya Jagannath Mahapatra, MD1, Neeraj Nischal, MD3, Manish Soneja, MD3, Pramod Garg, MD1, Shalimar, MD1. Efficacy of Famotidine for COVID-19: A Systematic Review and Meta-analysis. https://doi.org/10.1101/2020.09.28.20203463.
Link to Article
Link to FULL FREE PDF

Regeneron’s REGN-COV2 Antibody Cocktail

Unfortunately, it seems this treatment is just starting phase III of a clinical trial. There isn’t a completed published study that I can find as of the time I updated this page. Instead, here are some non-mainstream media posts on the trial.
Directly from Regeneron. CLICK HERE
Regeneron News Release. CLICK HERE

Stop giving fluid boluses for an elevated lactate!

Spiegel R, Gordon D, Marik PE. The origins of the Lacto-Bolo reflex: the mythology of lactate in sepsis. J Thorac Dis. 2020;12(Suppl 1):S48-S53. doi:10.21037/jtd.2019.11.48
Link to Article
Link to FULL FREE PDF

Does starting Tocilizumab help in patients who are on NIV?

Menzella, F., Fontana, M., Salvarani, C. et al. Efficacy of tocilizumab in patients with COVID-19 ARDS undergoing noninvasive ventilation. Crit Care 24589 (2020). https://doi.org/10.1186/s13054-020-03306-6
Link to Article
Link to FULL FREE PDF

As an aside, many people call NIV “BiPAP”. For the sake of communication I know it’s embedded in the lexicon to just call it “BiPAP”. NIV (non-invasive ventilation) encompasses bi-level other modes as well. BiPAP is the proprietary name for bi-level on the Philips machines. #FOAMed

We are getting better at caring for COVID patients!

Auld, Sara C. MD, MSc; Caridi-Scheible, Mark MD; Robichaux, Chad MPH; Coopersmith, Craig M. MD; Murphy, David J. MD, PhD The Emory COVID-19 Quality and Clinical Research Collaborative Declines in Mortality Over Time for Critically Ill Adults With Coronavirus Disease 2019, Critical Care Medicine: September 28, 2020 – Volume Online First – Issue – doi: 10.1097/CCM.0000000000004687
Link to Article and FULL FREE PDF

Metformin and Lactate Levels. FOAMed

Posma, R.A., Hulman, A., Thomsen, R.W. et al. Metformin use and early lactate levels in critically ill patients according to chronic and acute renal impairment. Crit Care 24585 (2020). https://doi.org/10.1186/s13054-020-03300-y. FOAMed
Link to Article
Link to FULL FREE PDF

The 2018 ESPEN Guidelines for Nutrition in the Critically Ill

Singer P, Blaser AR, Berger MM, Alhazzani W, Calder PC, Casaer MP, Hiesmayr M, Mayer K, Montejo JC, Pichard C, Preiser JC, van Zanten ARH, Oczkowski S, Szczeklik W, Bischoff SC. ESPEN guideline on clinical nutrition in the intensive care unit. Clin Nutr. 2019 Feb;38(1):48-79. doi: 10.1016/j.clnu.2018.08.037. Epub 2018 Sep 29. PMID: 30348463. #FOAMed
Link to Article
Link to FULL FREE PDF

Propofol Infusion Syndrome: known about by many yet not known well enough. FOAMed

Krajčová A, Waldauf P, Anděl M, Duška F. Propofol infusion syndrome: a structured review of experimental studies and 153 published case reports. Crit Care. 2015;19:398. Published 2015 Nov 12. doi:10.1186/s13054-015-1112-5. FOAMed
Link to Article
Link to FULL FREE PDF

Placing Nasogastric Tubes: What’s the better technique?

Sanaie S, Mirzalou N, Shadvar K, Golzari SEJ, Soleimanpour H, Shamekh A, Bettampadi D, Safiri S, Mahmoodpoor A. A comparison of nasogastric tube insertion by SORT maneuver (sniffing position, NGT orientation, contralateral rotation, and twisting movement) versus neck flexion lateral pressure in critically ill patients admitted to ICU: a prospective randomized clinical trial. Ann Intensive Care. 2020 Jun 12;10(1):79. doi: 10.1186/s13613-020-00696-2. PMID: 32533354; PMCID: PMC7289937.
Link to Abstract
Link to FULL FREE ARTICLE & PDF
Link to DIRECT DOWNLOAD PDF

Bicarbonate in DKA? What does the data say?

Chua HR, Schneider A, Bellomo R. Bicarbonate in diabetic ketoacidosis – a systematic review. Ann Intensive Care. 2011 Jul 6;1(1):23. doi: 10.1186/2110-5820-1-23. PMID: 21906367; PMCID: PMC3224469. FOAMed
Link to Article AND FULL FREE PDF

View this post on Instagram

One of the first lessons in #internalmedicineresidency and #emergencymedicineresidency is how to treat #DKA. We worry about the serum bicarb being low and immediately get itchy to just give some to make the number pretty and fix the pH/acidosis. Side note. If you’re curious about the pH, get a VBG instead of an ABG; less discomfort for the patient. This paper which is from 2011 goes over the data (not robust) behind providing bicarb in these pts and the effect. A 🎩 tip to the authors. Check out the full article on my website: eddyjoemd.com. #diabeticketoacidosis #imresidency #internship #pgy1 #pgy2 #pgy3 #emresident #emresidency #ccrn #criticalcarenurse #criticalcare #criticacaremedicine #criticalcarenursing #criticalcareunit #intensivecare #intensivecareunit #intensivecaremedicine #journalclubish #np #acutecarenursepractitioner #pa #physicianassistant #icu #pccm #foamed #meded #medicaleducation

A post shared by Eddy J. Gutierrez, MD (@eddyjoemd) on

Recommendations for BiPAP, HFNC, Intubation, Extubation, and Bronchoscopy for COVID Patients. FOAMed

Citation:
Kaur, R., Weiss, T.T., Perez, A. et al. Practical strategies to reduce nosocomial transmission to healthcare professionals providing respiratory care to patients with COVID-19. Crit Care 24, 571 (2020). https://doi.org/10.1186/s13054-020-03231-8
Link to Article
Link to FULL FREE PDF

Do the Mandated Sepsis Protocols Save Lives? Looking at New York.

Bourne, Donald S. MPH1; Davis, Billie S. PhD1; Gigli, Kristin H. PhD, RN, CPNP-AC1; Chang, Chung-Chou H. PhD2,3; Yabes, Jonathan G. PhD2,3; Martsolf, Grant R. PhD, MPH, RN, FANN4,5; Kahn, Jeremy M. MD, MS1,6 Economic Analysis of Mandated Protocolized Sepsis Care in New York Hospitals*, Critical Care Medicine: October 2020 – Volume 48 – Issue 10 – p 1411-1418 doi: 10.1097/CCM.0000000000004514. FOAMed
Link to Article
Link to FULL FREE PDF

Levy, Mitchell M. MD, MCCM Increasing Quality, Not Costs*, Critical Care Medicine: October 2020 – Volume 48 – Issue 10 – p 1528-1529 doi: 10.1097/CCM.0000000000004527
Link to Editorial
Link to Editorial PDF

Two new papers on pulmonary embolism/thrombosis in COVID. FOAMed

Sakr, Y., Giovini, M., Leone, M. et al. Pulmonary embolism in patients with coronavirus disease-2019 (COVID-19) pneumonia: a narrative review. Ann. Intensive Care 10, 124 (2020). https://doi.org/10.1186/s13613-020-00741-0
Link to Article
Link to FULL FREE PDF

Flaczyk, A., Rosovsky, R.P., Reed, C.T. et al. Comparison of published guidelines for management of coagulopathy and thrombosis in critically ill patients with COVID 19: implications for clinical practice and future investigations. Crit Care24, 559 (2020). https://doi.org/10.1186/s13054-020-03273-y. FOAMed
Link to Article
Link to FULL FREE PDF

High Flow Nasal Cannula: A Quick Review #FOAMed

Citation
Ricard JD, Roca O, Lemiale V, et al. Use of nasal high flow oxygen during acute respiratory failure [published online ahead of print, 2020 Sep 8]. Intensive Care Med. 2020;10.1007/s00134-020-06228-7. doi:10.1007/s00134-020-06228-7. FOAMed
Link to Abstract
Link to FULL FREE PDF

Do you think that DVT prophylaxis in COVID patients is enough? Neither do these guys.

Citation:
K. Stattin, M. Lipcsey, H. Andersson, et al., Inadequate prophylactic effect of low-molecular weight heparin in critically ill COVID-19 patients, Journal of Critical Care(2020), https://doi.org/10.1016/j.jcrc.2020.08.026
Link to Article and FULL FREE PDF
Link to PDF (This one may not work)

Cytokine storm for COVID-19 is old new. Bring in the Bradykinin Storm!

Citation:
Garvin MR, Alvarez C, Miller JI, et al. A mechanistic model and therapeutic interventions for COVID-19 involving a RAS-mediated bradykinin storm. Elife. 2020;9:e59177. Published 2020 Jul 7. doi:10.7554/eLife.59177
Link to Article
Link to FULL FREE PDF

Management and Prevention of Anemia in the ICU. FOAMed

Lasocki, S., Pène, F., Ait-Oufella, H. et al. Management and prevention of anemia (acute bleeding excluded) in adult critical care patients. Ann. Intensive Care 10, 97 (2020). https://doi.org/10.1186/s13613-020-00711-6. FOAMed
Link to Article
Link to FULL FREE PDF

Lactate vs. Capillary Refill Testing Resuscitation Strategies: Which is better? FOAMed

Kattan, E., Hernández, G., Ospina-Tascón, G. et al. A lactate-targeted resuscitation strategy may be associated with higher mortality in patients with septic shock and normal capillary refill time: a post hoc analysis of the ANDROMEDA-SHOCK study. Ann. Intensive Care 10, 114 (2020). https://doi.org/10.1186/s13613-020-00732-1
Link to Article
Link to FULL FREE PDF

New meta-analysis on Tocilizumab in Severe COVID-19. FOAMed

Zhao, J., Cui, W. & Tian, B. Efficacy of tocilizumab treatment in severely ill COVID-19 patients. Crit Care 24, 524 (2020). https://doi.org/10.1186/s13054-020-03224-7. FOAMed
Link to Article
Link to FULL FREE PDF

What are the baseline Vitamin C levels in COVID-ARDS patients?

Chiscano-Camón, L., Ruiz-Rodriguez, J., Ruiz-Sanmartin, A. et al. Vitamin C levels in patients with SARS-CoV-2-associated acute respiratory distress syndrome. Crit Care24522 (2020). https://doi.org/10.1186/s13054-020-03249-y. FOAMed
Link to Article
Link to FULL FREE PDF

Plasma Exchange for Sepsis by Dr. Philip Keith. FOAMed

Keith PD, Wells AH, Hodges J, Fast SH, Adams A, Scott LK. The therapeutic efficacy of adjunct therapeutic plasma exchange for septic shock with multiple organ failure: a single-center experience. Crit Care. 2020;24(1):518. Published 2020 Aug 24. doi:10.1186/s13054-020-03241-6. FOAMed
Link to Abstract
Link to FULL FREE PDF

Convalescent Plasma in COVID-19: Data from the Mayo Clinic. FOAMed

Back in March, the first data out of China regarding convalescent plasma in COVID started reaching publications. I covered that data HERE. The data I am going to be covering here regarding convalescent plasma in COVID is from the Mayo Clinic. It is pre-peer review and should not be used to guide therapies. FOAMed

Citation:
Link to Article (Pre-Peer Reviewed)
Link to PDF

Nitric Oxide to Improve Oxygenation in COVID patients? FOAMed

Tavazzi, G., Marco, P., Mongodi, S. et al. Inhaled nitric oxide in patients admitted to intensive care unit with COVID-19 pneumonia. Crit Care 24, 508 (2020). https://doi.org/10.1186/s13054-020-03222-9. FOAMed
Link to Article
Link to FULL FREE PDF

Inhaled nitric oxide in mechanically ventilated patients with COVID-19: FOAMed
Link to Article

A review of the large COVID drug trials FOAMed

Citation
Siemieniuk RA, Bartoszko JJ, Ge L, et al. Drug treatments for covid-19: living systematic review and network meta-analysis. BMJ. 2020;370:m2980. Published 2020 Jul 30. doi:10.1136/bmj.m2980. FOAMed
Link to FULL Article
Link to FULL FREE PDF

Using CRP to help one decide if Dexamethasone is appropriate or not in COVID. FOAMed.

Really quick because I need to go to bed and get some rest before I head back into COVID world tomorrow. This is an observational study out of NYC where they looked at the response of patients to corticosteroids depending on whether on their CRP. This is not a prospective trial and therefore should not be used to guide any management at this point, but it still is quite interesting. Take a look for yourself. It’s FOAMed!

Citation:
Marla J Keller, MD, Elizabeth A Kitsis, MD, MBE, Shitij Arora, MD, Jen-Ting Chen, MD, MS, Shivani Agarwal, MD, MPH, Michael J Ross, MD, Yaron Tomer, MD, William Southern, MD, MS, Effect of Systemic Glucocorticoids on Mortality or Mechanical Ventilation in Patients With COVID-19. J. Hosp. Med 2020;8;489-493. Published Online First July 22, 2020. doi:10.12788/jhm.3497 
Link to Article
Link to FULL FREE PDF

EVMS COVID-19 Management Protocol FOAMed

Dr. Marik has been a significant mentor of mine although he may not know it. In this PDF, which I recommend you check out yourself, they delineate how to approach patients with COVID. It’s called the MATH+ protocol. To the academic purists, there’s no placebo-controlled, double-blind, randomized clinical trial to support this. FOAMed

Link to FULL FREE PDF

Remdesivir for Severe COVID-19. FOAMed.

I like these folks in the BMJ. “The guideline panel makes a weak recommendation for the use of Remdesivir in severe covid-19.” I agree. I am not excited about Remdesivir at this time given the data that I have reviewed. Either way, since I have a clear cut bias, I am not going to speak any further regarding Remdesivir. You came here for the links, they’re down below. Also, keep scrolling down for other FOAMed articles you may be interested in. FOAMed

Citation:
Rochwerg Bram, Agarwal Arnav, Zeng Linan, LeoYee-Sin, Appiah John Adabie, Agoritsas Thomas et al. Remdesivir for severe covid-19: a clinical practice guideline  BMJ  2020;  370 :m2924
Link to Article
Link to FULL FREE PDF

Intensivist Deficiency: FOAMed

This morning, I woke up to an email from “Today’s Hospitalist” with a headline regarding physician workforce. It reads “Intensivists are in short supply in more than a dozen states”. I don’t know about many of my colleagues here, but I get hit with calls from head-hunters all the time for moonlighting/locums opportunities. My phone has been buzzing quite a bit. George Washington University put out a report (CLICK HERE FOR REPORT/PDF) of how critical (pun intended) things are in certain states.

The other cool thing about this PDF is that they have a link to a “Workforce Deficit Estimator” (CLICK HERE FOR THAT LINK). I wouldn’t say that this looks accurate for nurses and other staff, but it appears to be accurate for Intensivists. Are you interested in becoming an Intensivist? We need your help. CLICK HERE to check out my podcast on the matter. FOAMed

Being a Zentensivist

Being on social media has blessed me with the opportunity to be exposed to the works of great people and work with some fascinating brains. I have been on the FOAMed train since I was an intern and have long admired people who I am routinely in contact with today. Recently, I have joined on as an editor on criticalcarenow.com with Haney Mallemat (@criticalcarenow). Amongst the other individuals contributing with content to this website, I have run into the work of Matt Siuba (@msiuba, also an editor on criticalcarenow.com. Being on twitter, despite far less “cool” there, I had run into this concept of “Zentensivist” which was floating around the ether there. Matt is the lead author of this paper. Josh Farkas (@pulmcrit) of pulmcrit.org also contributed to this paper.

This concept of Zentensivist resonated with me because practicing Critical Care, although as chaotic as can be, needs to be performed in the highest state of flow possible. This applies to being the physician, APP, RN, RT, CNA, and other key members of the team. Chaos goes nowhere. Yelling goes nowhere. In my opinion, it reflects a lack of leadership, confidence, emotional intelligence, and self awareness.

The flowchart: #zentensivist. FOAMed

There is a great flowchart in this article which demonstrates the philosophy I innately attempt to go by in a nice visual form. You can download the paper for free to see it for yourself. If you’re a student, trainee (intern, resident, fellow), or anyone taking care of the critically ill, this is what you should aspire to achieve. This also applies to the rest of the team taking care of these patients. FOAMed

It all starts with being a calming presence. Yelling, accusing others, talking smack helps no one. Remember, the #1 priority is the patient, not your ego. The other zentensivist principles will not show up on the first day. They come with years of practice, experience, and self-improvement. Your days of ordering every test under the sun are excusable during training, not as a seasoned veteran. We all need to get better at this. Hat tip to the authors.

-EJ

Citation:
Siuba, M. T., Carroll, C. L., Farkas, J. D., Olusanya, S., Baker, K., & Gajic, O. (2020). The Zentensivist Manifesto. Defining the Art of Critical Care. ATS Scholar. doi:10.34197/ats-scholar.2020-0019ps 
Link to Website
Link to FULL FREE ARTICLE

Heart Failure and COVID-19 Are NOT Friends: FOAMed

I have to tip my hat first and foremost to Dr. Emir Yonas. He invited me to collaborate on this paper and I feel honored to have contributed this FOAMed content.

Citation
E. Yonas, I. Alwi, R. Pranata, et al., Effect of heart failure on the outcome of COVID-19 — A meta analysis and systematic review, American Journal of Emergency Medicine (2020), https://doi.org/10.1016/j.ajem.2020.07.009

Link to Article
Link to FULL FREE PDF

Tocilizumab for COVID-19 Patients on Mechanical Ventilation FOAMed

Thus far, the only thing that has been shown to decrease mortality in patients with COVID-19 is dexamethasone. Now, there appears to be a second agent. Tocilizumab blocks IL-6. This was an observational trial looking at 154 patients. The two groups were NOT evenly matched. That being said, the patients did have improved survival, although they did have a greater amount of secondary infections. Pneumonia was the most common of these. We are currently using this therapy for our patients as well as enrolling many into studies utilizing similar therapeutic medications. Enjoy this piece of FOAMed!

Citation:
Somers EC, Eschenauer GA, Troost JP, et al. Tocilizumab for treatment of mechanically ventilated patients with COVID-19 [published online ahead of print, 2020 Jul 11]. Clin Infect Dis. 2020;ciaa954. doi:10.1093/cid/ciaa954
Link to Abstract
Link to FULL FREE PDF

ARDS and COVID-19: Who cares about making the diagnosis?

We love to write “mild, moderate, or severe ARDS” in the chart based on the P/F ratio of the patient and the Berlin Criteria. It makes us feel smart. Based on the P/F ratio, historically, we perform certain interventions like employing paralytics, proning or intubating the patient. In this paper written by Martin Tobin, he questions this whole concept in the face of ARDS in COVID.

For those of you who do not know who Martin Tobin is, well, he’s the person who literally wrote the book on mechanical ventilation. It’s titled “Principles And Practice of Mechanical Ventilation, Third Edition“. If you are interested in a more to the point book on ventilators, I recommend “The Ventilator Book” by Will Owens. Both of those are affiliate links, by the way. Hosting this website costs monies. Enjoy this piece of FOAMed!

Either way, you came here for a link to the article so here it is.
Tobin MJ, Does making a diagnosis of ARDS in COVID-19 patients matter?, CHEST (2020), doi: https://doi.org/10.1016/j.chest.2020.07.028. FOAMed
Link to Abstract
Link to FULL FREE PDF
FOAMed

Is COVID-19 Airborne? FOAMed

Lidia Morawska, Donald K Milton, It is Time to Address Airborne Transmission of COVID-19, Clinical Infectious Diseases, , ciaa939, https://doi.org/10.1093/cid/ciaa939
Link to FULL FREE PDF
Link to Article Hat tip to @idstewardship

Airway Checklists: Do they help outcomes? FOAMed

Turner JS, Bucca AW, Propst SL, et al. Association of Checklist Use in Endotracheal Intubation With Clinically Important Outcomes: A Systematic Review and Meta-analysis. JAMA Netw Open. 2020;3(7):e209278. doi:10.1001/jamanetworkopen.2020.9278
Link to FULL ARTICLE (with link to FREE PDF)

Two new studies on metabolic resuscitation with Vitamin C, Thiamine, and Stress Dose Steroids: FOAMed

Chang P, Liao Y, Guan J, et al. Combined Treatment With Hydrocortisone, Vitamin C, and Thiamine for Sepsis and Septic Shock: A Randomized Controlled Trial [published online ahead of print, 2020 Mar 31]. Chest. 2020;S0012-3692(20)30552-3. doi:10.1016/j.chest.2020.02.065. FOAMed
HYVCTTSSS

Iglesias J, Vassallo AV, Patel VV, Sullivan JB, Cavanaugh J, Elbaga Y. Outcomes of Metabolic Resuscitation Using Ascorbic Acid, Thiamine, and Glucocorticoids in the Early Treatment of Sepsis: The ORANGES Trial [published online ahead of print, 2020 Mar 17]. Chest. 2020;S0012-3692(20)30455-4. doi:10.1016/j.chest.2020.02.049
ORANGES

Editorial

Hydroxychloroquine: is this setting the stage for a resurgence in use? FOAMed

There’s still plenty of controversy in the us of this medication to treat patients with COVID-19. I am not going to get into the nitty gritty of this paper because I simply do not have time to do so this weekend. Let me know how badly you would like for me to dig into it and I may drop what I am doing. A hat tip to @whatthehellshaker for getting this article to me first. Enjoy this piece of FOAMed!

Will update the citation soon!
Link to FULL TEXT
Link to FULL FREE PDF

A study showing an estimated 8.7 million people had COVID-19 in March. FOAMed

7/2/2020. This is a study out of Penn State and Cornell published on 6/22 found data that “corresponded to more than 8.7 million new SARS-CoV-2 infections across the US during the three-week period from March 8 to March 28, 2020”. Enjoy this piece of FOAMed!

Silverman JD, Hupert N, Washburne AD. Using influenza surveillance networks to estimate state-specific prevalence of SARS-CoV-2 in the United States [published online ahead of print, 2020 Jun 22]. Sci Transl Med. 2020;eabc1126. doi:10.1126/scitranslmed.abc1126
Link to Article
Link to FULL FREE PDF

Self-Proning Protocol for COVID-19 Patients

6/3/2020
This paper was brought to my attention by @critical_care_updates. Link to his/her page HERE. It was written by the Intensive Care Society. It just so happens that Josh Farkas @pulmcrit was credited as a source for this paper as well! He has some great FOAMed as well.

Link to Website
Link to Direct PDF

Summary on IV Fluids: FOAMed

5/26/2020
The paper linked below is from the International Fluid Academy. I did not even know such institutions existed! I want to be part of that team! Some big names on this paper that I would love to be in the same room with. Nonetheless, the fanboy in me needs to digress. I plan on breaking down this paper more in detail but I simply do not have the time this week. I am sure many of you will love it as you’re as fascinated by fluids as much as I am. If you all call for a breakdown loud enough, I’ll get to it. This was published two days ago. Some great FOAMed here!

Citation:
Malbrain, M.L.N.G., Langer, T., Annane, D. et al. Intravenous fluid therapy in the perioperative and critical care setting: Executive summary of the International Fluid Academy (IFA). Ann. Intensive Care 10, 64 (2020). https://doi.org/10.1186/s13613-020-00679-3

Link to Abstract

Direct Link to FULL FREE PDF

Stop ordering daily chest x-rays without a clear indication in mechanically ventilated patients : FOAMed

5/23/2020
Stop ordering daily chest x-rays! This post came about after @memenurseofficial posted something about radiology messing up the sheets in the ICU at 6am that was quite comical. It also spurred some complaints about daily CXR. I commented about it being somewhat wasteful to mindlessly check daily CXR’s and here is the link to the article:

Link to FULL FREE PDF

Citation: Keveson B, Clouser RD, Hamlin MP, Stevens P MSN, RN, Stinnett-Donnelly JM, Allen GB. Adding value to daily chest X-rays in the ICU through education, restricted daily orders and indication-based prompting. BMJ Open Qual. 2017;6(2):e000072. Published 2017 Nov 25. doi:10.1136/bmjoq-2017-000072

Percutaneous Mechanical Circulatory Support Devices #FOAMed

Working on a lecture about mechanical circulatory support in patients with cardiogenic shock where I will be discussing Impella, VA-ECMO, and Tandemhearts. The table you saw on Instagram that brought you here is in the paper below. Some more great FOAMed.
Link to FULL FREE PDF

Citation: Miller PE, Solomon MA, McAreavey D. Advanced Percutaneous Mechanical Circulatory Support Devices for Cardiogenic Shock. Crit Care Med. 2017;45(11):1922‐1929. doi:10.1097/CCM.0000000000002676

I am writing an entire lecture on this topic. Click here for the bibliography and more data. #foamed

Ventilator Guide for COVID-19 Patients #FOAMed

Link to Abstract
Link to FULL PDF

Plenty more COVID data from me here.